Aliases &
Descriptions
for RNF133 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ring finger protein 1331 2 3 | | MGC270722 | | E3 ubiquitin-protein ligase RNF1332 | | EC 6.3.2.-3 |
Export aliases for RNF133 gene to outside databasesPrevious GC identifers: GC07M121878 GC07M121892 GC07M121931 GC07M122125 GC07M122337 |
Summaries
for RNF133 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF133:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. (providedby RefSeq)
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Function: Has E3 ubiquitin-protein ligase activity (By similarity)
|
Genomic Views
for RNF133 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF133 gene promoter:
POU2F1 MRF-2 CUTL1 Chx10 Pbx1a SRF FOXC1 Cdc5 E47 FOXJ2 (long isoform)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF133
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.32 Ensembl cytogenetic band: 7q31.32 HGNC cytogenetic band: 7q31.33RNF133 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M116700: view genomic region
(about GC identifiers)
Start:
|
116,700,656 bp from pter |
End:
|
116,702,098 bp from pter |
Size:
|
1,443 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 122,337,766-122,339,210 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079596.2
|
Proteins
for RNF133 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF133 Size: 376 amino acids; 42294 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity)
Secondary accessions: A4D0W2 Q8N7G7Explore the universe of human proteins at neXtProt for RNF133: NX_Q8WVZ7
Post-translational modifications:
Auto-ubiquitinated (By similarity)1
REFSEQ proteins: NP_631914.1
ENSEMBL proteins: ENSP00000344489
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RNF133 for ontologies About GeneDecksing
Antibodies for RNF133:
Assays for RNF133: |
Protein
Domains/
Families
for RNF133 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF133 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WVZ7ProtoNet protein and cluster: Q8WVZ7 2 Blocks protein families: IPB001841 Zn-finger IPB003137 Protease-associated PA
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Similarity: Contains 1 PA (protease associated) domainSimilarity: Contains 1 RING-type zinc finger |
Gene Function
for RNF133 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Function: Has E3 ubiquitin-protein ligase activity (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
RNF133 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF133 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN133_HUMAN, Q8WVZ7Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for RNF133
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF133
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0051865 | protein autoubiquitination |
IEA | -- |
About this table
RNF133 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF133 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RNF133
|
Transcripts
for RNF133 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RNF133 gene: NM_139175.1 Additional cDNA sequence: AF447589.1 AK098524.1 BC022038.2 1 DOTS entry: DT.106052 24/28 AceView cDNA sequences (see all 28): BI828570 AA897680 BX089015 CD171672 AK098524 BI829821 BC022038 BP368897 BI830727 BE500941 BP369600 AA906730 NM_139175 BI829237 BG723185 BP368911 AF447589 BP368988 BE500949 AI969336 BP368855 AW273800 AA916967 AA922265
 highest scoring ESTs for RNF133:AI671149 AW003790 AA812942 AA906730 AA916967 AA922265 AF447589 AI969336 AK098524 AW273800 Unigene Cluster for RNF133: Ring finger protein 133 Hs.126730 [show with all ESTs]Unigene Representative Sequence: AF447589
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340112(uc003vkj.1)
|
Expression
for RNF133 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RNF133 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching RNF133 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 73400_s_at2, 3
|
U95-E |
1 |
0.69 |
1.00 |
1.00 |
1.00 |
AW003790 |
0.80 |
0.80 |
0.80 |
1 |
| 74032_i_at2, 3
|
U95-E |
1 |
0.31 |
1.00 |
-0.15 |
0.26 |
AI671149 |
0.80 |
0.80 |
0.80 |
1 |
| 231373_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
AW273800 |
0.60 |
0.75 |
0.68 |
1 |
| 231373_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RNF133 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACTTTTGAGG
SOURCE GeneReport for Unigene cluster: Hs.126730
SABiosciences Custom PCR Arrays for RNF133
|
Orthologs
for RNF133 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RNF133 gene from 3 species
About this table Species with no ortholog for RNF133
ENSEMBL Gene Tree for RNF133 (if available) |
Paralogs
for RNF133 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RNF133 gene
- RNF1482 RNF1302 RNF1502 RNF1282 RNF1492
RNF133 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for RNF133 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing RNF133 |
|
Disorders & Mutations
for RNF133 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF133 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RNF133 (1 document)
Export disorders and mutations for RNF133 gene to outside databases
|
Medical News
for RNF133 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RNF133 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for RNF133 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with RNF133)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
|
External Searches for RNF133 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF133 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF133 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF133 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF133 gene:
Search GeneIP for patents involving RNF133
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF133 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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