Aliases &
Descriptions
for RNF135 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ring finger protein 1351 2 3 | | RIG-I E3 ubiquitin ligase2 3 | | MGC130611 2 | | E3 ubiquitin-protein ligase RNF1352 | | REUL2 3 | | OTTHUMP000001637672 | | Riplet2 3 | | EC 6.3.2.-3 |
Export aliases for RNF135 gene to outside databasesPrevious GC identifers: GC17P029147 GC17P029443 GC17P026322 GC17P029297 |
Summaries
for RNF135 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNF135:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in achromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcriptvariants encoding distinct isoforms have been reported. (provided by RefSeq)
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production
Gene Wiki entry for RNF135 |
Genomic Views
for RNF135 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF135 gene promoter:
NF-1 MEF-2A RSRFC4 PPAR-gamma2 PPAR-gamma1 p53 POU3F2 Bach2 STAT5B E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF135
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF135  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2RNF135 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P025508: view genomic region
(about GC identifiers)
Start:
|
25,508,635 bp from pter |
End:
|
25,537,506 bp from pter |
Size:
|
28,872 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 29,298,041-29,326,929 |
RefSeq DNA sequence:- NC_000017.10 NT_010799.15
|
Proteins
for RNF135 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF135 Size: 432 amino acids; 47888 Da
Subunit: Interacts with DDX58. Interacts with PCBP2
Subcellular location: Cytoplasm
Secondary accessions: A0AVM5 Q9BSE9Alternative splicing: 2 isoforms: Q8IUD6-1 Q8IUD6-2 Explore the universe of human proteins at neXtProt for RNF135: NX_Q8IUD6
REFSEQ proteins (3 alternative transcripts):
NP_001171921.1 NP_115698.3 NP_922921.1
ENSEMBL proteins: ENSP00000323693 ENSP00000411965 ENSP00000395038 ENSP00000328340
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
RNF135 for ontologies About GeneDecksing
Antibodies for RNF135:
Assays for RNF135: |
Protein
Domains/
Families
for RNF135 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF135 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q8IUD6ProtoNet protein and cluster: Q8IUD6 3 Blocks protein families: IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6Similarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Gene Function
for RNF135 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses.Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta productionEnzyme Number (IUBMB): EC 6.3.2.-
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
RNF135 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF135 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for RNF135
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF135
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
RNF135 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF135 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RNF135
|
Transcripts
for RNF135 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RNF135 gene (3 alternative transcripts): NM_001184992.1 NM_032322.3 NM_197939.1 Additional cDNA sequence: AB470605.1 AJ496729.1 AK092436.1 AK122646.1 AK122709.1 AK123549.1 AK226030.1 AK312979.1 AY598332.1 BC005084.1 BC082262.1 BC126420.1 BC126422.1 BC144143.1 13 DOTS entries: DT.95158248 DT.99933218 DT.97818506 DT.91680698 DT.120972995 DT.97858386 DT.120972848 DT.100698818 DT.101975503 DT.91748333 DT.95079728 DT.99955097 DT.100718079 24/107 AceView cDNA sequences (see all 107): AK122646 BE858801 CD370706 NM_032322 AA688090 AK122709 AA649978 AI609800 AW769813 AI004323 AI984920 BQ008551 NM_197939 BE858430 CA748857 BE893836 CD518654 CB122065 AA769314 CB159108 BG117503 AI810459 BE858714 AI366045
 highest scoring ESTs for RNF135:N45368 AA688090 AA769314 AA827977 AI004323 AI031643 AI038478 AW024717 AW515575 BE336922 Unigene Cluster for RNF135: Ring finger protein 135 Hs.29874 [show with all ESTs]Unigene Representative Sequence: NM_001184992
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNF135 (see all 6)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RNF135
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324689(uc002hga.2 uc002hgb.2) ENST00000443677 ENST00000434242
ENST00000328381(uc002hfz.2 uc010csm.2)
|
Expression
for RNF135 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RNF135 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching RNF135 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 73743_at2, 3
|
U95-E |
1 |
0.94 |
1.00 |
0.90 |
0.80 |
N45368 |
1.00 |
1.00 |
1.00 |
1 |
| 44536_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.95 |
1.15 |
AA523300 |
0.60 |
1.00 |
0.82 |
1 |
| 86371_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
0.51 |
1.09 |
AW024717 |
0.80 |
1.00 |
0.91 |
1 |
| 223592_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC005084 |
0.80 |
0.88 |
0.84 |
1 |
| 223591_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC005084 |
0.80 |
0.88 |
0.84 |
1 |
| 223592_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223591_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RNF135 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGTGAGCTAC
SOURCE GeneReport for Unigene cluster: Hs.29874
UniProtKB/Swiss-Prot: RN135_HUMAN, Q8IUD6Tissue specificity: Expressed in skeletal muscle, spleen, kidney, placenta, prostate, stomach, thyroid and tongue. Alsoweakly expressed in heart, thymus, liver and lung
SABiosciences Custom PCR Arrays for RNF135
|
Orthologs
for RNF135 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RNF135 gene from 5 species
About this table Species with no ortholog for RNF135
ENSEMBL Gene Tree for RNF135 (if available) |
Paralogs
for RNF135 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for RNF135 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RNF135 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNF135
1 CNV: 67172 | | QIAGEN SeqTarget long-range PCR primers for resequencing RNF135 |
|
Disorders & Mutations
for RNF135 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF135 for disorders About GeneDecksing
OMIM: 611358Locus Specific Mutation Databases (LSDB): RNF135
Human Gene Mutation Database (HGMD): RNF135
Human Genome Epidemiology (HuGE) Navigator: RNF135 (2 documents)
Export disorders and mutations for RNF135 gene to outside databases
|
Medical News
for RNF135 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RNF135 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/17 PubMed articles for RNF135 gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with RNF135)- Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-{beta} Induction during the Early Phase of Viral Infection. (PubMed id 19017631)1, 2, 3 Oshiumi H....Seya T. (2009)
- RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1, 2 Visser R....Losekoot M. (2009)
- REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. (PubMed id 19484123)1, 2 Gao D....Chen D.Y. (2009)
- PCBP2 mediates degradation of the adaptor MAVS via th e HECT ubiquitin ligase AIP4. (PubMed id 19881509)1, 2 You F....Jiang Z. (2009)
- Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. (PubMed id 17632510)1, 2 Douglas J.... Rahman N. (2007)
- Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. (PubMed id 12696059)1, 2 Jenne D.E....Kehrer-Sawatzki H. (2003)
- Molecular characterization and gene content of breakpoint boundaries in patients with neurofibromatosis type 1 with 17q11.2 microdeletions. (PubMed id 11468690)1, 3 Jenne D.E....Kehrer-Sawatzki H. (2001)
- The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
|
External Searches for RNF135 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF135 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF135 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF135 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF135 gene:
Search GeneIP for patents involving RNF135
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF135 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for RNF135 |
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