Aliases &
Descriptions
for RNF180 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ring finger protein 1801 2 3 | | E3 ubiquitin-protein ligase RNF1802 | | MGC1203282 | | MGC1203262 | | OTTHUMP000002218192 | | EC 6.3.2.-3 |
Export aliases for RNF180 gene to outside databasesPrevious GC identifer: GC05P063498 |
Summaries
for RNF180 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway ofZIC2 (By similarity)
|
Genomic Views
for RNF180 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RNF180
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF180
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF180  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q12.3 Ensembl cytogenetic band: 5q12.3 HGNC cytogenetic band: 5q12.3RNF180 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P060416: view genomic region
(about GC identifiers)
Start:
|
60,416,366 bp from pter |
End:
|
60,622,951 bp from pter |
Size:
|
206,586 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr5+ 63,461,671-63,668,696 |
RefSeq DNA sequence:- NC_000005.9 NT_006713.15
|
Proteins
for RNF180 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF180 Size: 592 amino acids; 68254 Da
Subunit: Interacts with ZIC2 (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope (By similarity)
Sequence caution: Sequence=CAD89939.1; Type=Erroneous initiation;
Secondary accessions: Q0JSU3 Q495A8 Q8NBD1Alternative splicing: 3 isoforms: Q86T96-1 Q86T96-2 Q86T96-3 Explore the universe of human proteins at neXtProt for RNF180: NX_Q86T96
REFSEQ proteins (2 alternative transcripts):
NP_001107033.1 NP_848627.1
ENSEMBL proteins: ENSP00000296615 ENSP00000370471 ENSP00000373752 ENSP00000426884
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
RNF180 for ontologies About GeneDecksing
Antibodies for RNF180:
Assays for RNF180: |
Protein
Domains/
Families
for RNF180 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF180 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86T96ProtoNet protein and cluster: Q86T96 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96Domain: The RING-type zinc finger domain mediates polyubiquitination of the interacting proteinSimilarity: Contains 1 RING-type zinc finger |
Gene Function
for RNF180 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway ofZIC2 (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
RNF180 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF180 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN180_HUMAN, Q86T96Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for RNF180
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF180
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
IEA | -- |
About this table
RNF180 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF180 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RNF180
|
Transcripts
for RNF180 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RNF180 gene (2 alternative transcripts): NM_001113561.1 NM_178532.3 Additional cDNA sequence: AK090756.1 AL832580.2 BC101277.2 BC101278.2 BC101279.1 BC101397.2 3 DOTS entries: DT.308885 DT.100020671 DT.307726 24/34 AceView cDNA sequences (see all 34): BX113020 BM728889 BE672684 BI006702 BM718923 CB999963 AX746601 BE218282 BE222198 BF115015 AI273646 AA035198 AI216189 AL832580 AK090756 AI167804 AI431828 BF433928 BV192623 AI521986 CB267379 NM_178532 AA040069 CD356815
 highest scoring ESTs for RNF180:H05502 AA035198 AK090756 AL832580 BG218201 BI006702 BM728889 AA040069 AI167804 AI216189 Unigene Cluster for RNF180: Ring finger protein 180 Hs.657843 [show with all ESTs]Unigene Representative Sequence: NM_001113561
GeneLoc Exon Structure
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296615(uc003jth.3) ENST00000381081(uc010iws.2) ENST00000389100(uc003jti.2)
ENST00000504296
|
Expression
for RNF180 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RNF180 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching RNF180 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 58752_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
0.55 |
0.34 |
AA040069 |
0.60 |
1.00 |
0.82 |
1 |
| 50617_s_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
0.95 |
1.38 |
AI431828 |
0.60 |
1.00 |
0.82 |
1 |
| 61743_at2, 3
|
U95-C |
1 |
0.38 |
1.00 |
0.88 |
1.18 |
H05502 |
1.00 |
1.00 |
1.00 |
1 |
| 50620_r_at2, 3
|
U95-B |
1 |
0.31 |
1.00 |
0.90 |
0.47 |
AI431828 |
0.60 |
1.00 |
0.82 |
1 |
| 242033_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
BE672684 |
0.60 |
1.00 |
0.82 |
1 |
| 236644_at2, 3
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
BF433928 |
0.60 |
1.00 |
0.82 |
1 |
| 242033_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 236644_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RNF180 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGGAATAAAA
SOURCE GeneReport for Unigene cluster: Hs.657843
SABiosciences Custom PCR Arrays for RNF180
|
Orthologs
for RNF180 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RNF180 gene from 5 species
About this table Species with no ortholog for RNF180
ENSEMBL Gene Tree for RNF180 (if available) |
Paralogs
for RNF180 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for RNF180 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RNF180 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNF180
2 CNVs: 99160 99159 | | QIAGEN SeqTarget long-range PCR primers for resequencing RNF180 |
|
Disorders & Mutations
for RNF180 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF180 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: RNF180 (1 document)
Export disorders and mutations for RNF180 gene to outside databases
|
Medical News
for RNF180 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RNF180 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for RNF180 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with RNF180)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Rines/RNF180, a novel RING finger gene-encoded produc t, is a membrane-bound ubiquitin ligase. (PubMed id 18363970)1 Ogawa M....Aruga J. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
|
External Searches for RNF180 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF180 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF180 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF180 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNF180 gene:
Search GeneIP for patents involving RNF180
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF180 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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