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RNF25 Gene

protein-coding GIFtS: 52

GC02M211382

ring finger protein 25
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
ring finger protein 25¹ ² ³		ring finger protein AO7²
AO7¹ ²		E3 ubiquitin-protein ligase RNF25²
FLJ13906¹ ²		EC 6.3.2.-³
OTTHUMP00000206471²

External Ids:	HGNC: 14662¹	Entrez Gene: 64320²	Ensembl: ENSG00000163481⁷	UniProtKB: Q96BH1³

Export aliases for RNF25 gene to outside databases

Previous GC identifers: GC02M217544 GC02M218249 GC02M219492 GC02M219731 GC02M219354 GC02M219236

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF25:

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to

interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse

protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. (provided

by RefSeq)

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By

similarity). Stimulates transcription mediated by NF-kappa-B

Gene Wiki entry for RNF25

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF25 gene promoter:
         HNF-4alpha2   deltaCREB   CREB   AP-1   GR-alpha   c-Jun   c-Fos   p53   MIF-1   MEF-2A
         Other transcription factors

Search SABiosciences Chromatin IP Primers for RNF25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF25

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

RNF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF25 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M211382: view genomic region (about GC identifiers)

Start:	211,382,076 bp from pter
End:	211,390,269 bp from pter
Size:	8,194 bases
Orientation:	minus strand

1 alternative location:

Chr2- 219,528,587-219,537,134

RefSeq DNA sequence:

NC_000002.11 NT_005403.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF25

Size: 459 amino acids; 51219 Da

Subunit: Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity).

Interacts with RELA

PDB structure from and Proteopedia :

2DAY (3D)

2DMF (3D)

Secondary accessions: A8K0D6 Q53HQ5 Q9H874

Explore the universe of human proteins at neXtProt for RNF25: NX_Q96BH1

Post-translational modifications:

Ubiquitinated (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_071898.2

ENSEMBL proteins:

ENSP00000295704 ENSP00000403582

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12748188
GO:0005829	cytosol	IDA	12748188

About this table

RNF25 for ontologies About GeneDecksing

Antibodies for RNF25:

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Assays for RNF25:

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	GenScript Custom Assay Services for RNF25
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RNF25

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF25 for domains About GeneDecksing

4 InterPro domains/families:

IPR016135 UBQ-conjugat/RWD-like

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

IPR006575 RWD

Graphical View of Domain Structure for InterPro Entry Q96BH1

ProtoNet protein and cluster: Q96BH1

3 Blocks protein families:

IPB000608 Ubiquitin-conjugating enzymes

IPB001841 Zn-finger

IPB006575 RWD

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates

ubiquitination

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 1 RWD domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By

similarity). Stimulates transcription mediated by NF-kappa-B

Enzyme Number (IUBMB): EC 6.3.2.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNF25 Sigma-Aldrich shRNA Panels and shRNA for RNF25
		OriGene 29mer shRNA kits in GFP-retroviral vector: RNF25 OriGene shRNA RFP: RNF25 OriGene basic RS shRNA: RNF25 OriGene siRNA: RNF25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF25

miRNA:		Sigma-Aldrich microRNA Mimics for RNF25 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF25
		1 SABiosciences Assays for microRNA that regulate RNF25:
		hsa-miR-1274a

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: RNF25 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RNF25 OriGene untagged cDNA clones in CMV expression vector (see all 2): RNF25 OriGene 3'-UTR clone: RNF25 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: RNF25
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for RNF25

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	ISS	--
GO:0005515	protein binding	IPI	19690564
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

RNF25 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: RNF25_HUMAN, Q96BH1

Pathway: Protein modification; protein ubiquitination

SABiosciences Custom Pathway-Focused PCR Arrays for RNF25

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RNF25

5/36 Interacting proteins for RNF25 (ENSP00000295704³ Q96BH1¹) via UniProtKB, MINT, and/or STRING (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2D1	P51668¹	EBI-2129220,EBI-743540
UBE2D2	P62837¹	EBI-2129220,EBI-347677
UBE2D3	P61077¹	EBI-2129220,EBI-348268
UBE2D4	Q9Y2X8¹	EBI-2129220,EBI-745527
UBE2E1	P51965¹	EBI-2129220,EBI-348546

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	ISS	--
GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	12748188

About this table

RNF25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF25

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNF25 Sigma-Aldrich shRNA Panels and shRNA for RNF25
		OriGene 29mer shRNA kits in GFP-retroviral vector: RNF25 OriGene shRNA RFP: RNF25 OriGene basic RS shRNA: RNF25 OriGene siRNA: RNF25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF25

miRNA:		Sigma-Aldrich microRNA Mimics for RNF25 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF25
		1 SABiosciences Assays for microRNA that regulate RNF25:
		hsa-miR-1274a

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: RNF25 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RNF25 OriGene untagged cDNA clones in CMV expression vector (see all 2): RNF25 OriGene 3'-UTR Clone: RNF25 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: RNF25

Primers:		OriGene genome-wide validated SYBR primer pairs: RNF25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RNF25: PPH10620A

REFSEQ mRNAs for RNF25 gene:

NM_022453.2

Additional cDNA sequence:

AK023968.1 AK222525.1 AK289501.1 BC015612.2 BC028167.1 CR603654.1 CR604874.1 CR617443.1

CR624539.1

8 DOTS entries:

DT.112447 DT.99935205 DT.92429592 DT.100645481 DT.100801145 DT.121035332 DT.212370 DT.97842563

24/130 AceView cDNA sequences (see all 130):

BI914900 BI831198 BM717814 AU142237 BC028167 AU119027 BM666406 BX282015

CR604874 AA447724 BX354783 CR624539 CK725204 BM804809 AA383850 BX375518

BG742306 BM977954 NM_022453 BM768871 CR617443 AA424903 BP370924 AL542764

highest scoring ESTs for RNF25:

AA447885 AK023968 AL525047 AL542764 AL546482 AL557042 AU142237 AU280084 BC015612 BC028167

Unigene Cluster for RNF25:

Ring finger protein 25

Hs.471403 [show with all ESTs]

Unigene Representative Sequence: BC028167

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RNF25

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10
SP1:
SP2:
SP3:

About this scheme

ECgene alternative splicing isoforms for RNF25
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000295704(uc002vit.2) ENST00000473034(uc010fvw.2) ENST00000474339

ENST00000463188 ENST00000423170 ENST00000497832

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

RNF25 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching RNF25 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47601_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AA447885	0.80	1.00	0.91	1
218861_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_022453	0.60	1.00	0.82	1
218861_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

RNF25 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

RNF25 gene electronic northern expression

About these images

CGAP SAGE TAG: GACCTAAAGC

SOURCE GeneReport for Unigene cluster: Hs.471403

Primers:		OriGene genome-wide validated SYBR primer pairs: RNF25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RNF25: PPH10620A

SABiosciences Custom PCR Arrays for RNF25

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RNF25 gene from 5/14 species (see all 14)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RNF25¹	--	ring finger protein 25	90.05(n) 89.11(a)	478912 XM_536071.2 XP_536071.2
chimpanzee (Pan troglodytes)	RNF25¹	--	ring finger protein 25	98.91(n) 98.26(a)	459947 XM_001158338.1 XP_001158338.1
cow (Bos taurus)	RNF25¹	--	ring finger protein 25	86.46(n) 82.53(a)	511571 NM_001015575.1 NP_001015575.1
rat (Rattus norvegicus)	Rnf25¹	--	ring finger protein 25	83.87(n) 83.67(a)	301515 NM_001012004.1 NP_001012004.1
mouse (Mus musculus)	Rnf25^{1 , 5}	1 (38.54 cM)⁵	ring finger protein 25^{1, 5}	84.72(n)¹ 82.46(a)¹	57751¹ NM_021313.1¹ NP_067288.1¹ AF171060⁵ AI846292⁵ (see all 19)

About this table Species with no ortholog for RNF25

ENSEMBL Gene Tree for RNF25 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1968346^1,2	C,A,H	219530348(+)	`ataatT/Cccagc`	1	--	int¹		2		WA NA	4
rs2069333^1,2	C,F,O,	219531256(-)	`TGAACA/CTTTTT`	1	--	int¹		9		EA NS NA WA	2046
rs2081744^1,2	C	219529883(+)	`CATGGC/GCTGTT`	2	P A	ref¹ mis¹ ese³		0	--	--	--	--
rs2243911^1,2	C,F,A,	219529348(+)	`GACCAC/TGATCA`	1	--	int¹		10		EA NS NA WA	2130
rs2303562^1,2	C,F,	219529247(+)	`TCCGCA/C/TGGGGC`	3	P	syn¹ ref¹ ese³		8		EA NS NA	2144
rs2303563^1,2	C,F,A,H,	219529838(+)	`AAAATA/GCCATT`	1	--	int¹		11		EA NA NS WA	2164
rs2303564^1,2	C,F,	219529881(+)	`ACCATG/AGGCTG`	2	/P	ref¹ syn¹ ese³		9		EA NA NS WA	2118
rs2556384^1,2	C,A,H,	219532903(+)	`TGAAGC/TGGTCC`	1	--	int¹		4		NA EA WA	212
rs2556385^1,2	C,A,H,	219532905(+)	`AAGCGG/ATCCAC`	1	--	int¹		4		NA EA WA	212
rs2556386^1,2	C,F,A,	219534530(+)	`AGCTTC/TACACC`	1	--	int¹		10		NS EA NA WA	566

About this table

HapMap Linkage Disequilibrium images for RNF25 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF25: --

QIAGEN SeqTarget long-range PCR primers for resequencing RNF25

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/12 PubMed articles for RNF25 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with RNF25)

RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PubMed id 12748188)^{1, 2, 3} Asamitsu K....Okamoto T. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)^{1, 7} Lorick K.L....Weissman A.M. (1999)
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)¹ Markson G....Sanderson C.M. (2009)
A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)¹ van Wijk S.J....Timmers H.T. (2009)
EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. (PubMed id 18757723)¹ Ding W....Coffey R.J. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS spectra. (PubMed id 17924679)² Yu L.-R.... Veenstra T.D. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64320	HGNC: 14662	AceView: RNF25	Ensembl:ENSG00000163481	euGenes: HUgn64320
ECgene: RNF25	H-InvDB: RNF25

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for RNF25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for RNF25 gene:
Search GeneIP for patents involving RNF25

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RNF25		Antibodies for RNF25
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	Lentivirus-delivered shRNAs for RNF25		microRNA Mimics for RNF25
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF25
	SeqTarget long-range PCR primers for resequencing RNF25
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF25
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF25

	GenScript Custom Purified and Recombinant Proteins Services for RNF25		GenScript cDNA clones with any tag delivered in your preferred vector for RNF25
	GenScript Custom Assay Services for RNF25		GenScript Custom Superior Antibodies Services for RNF25
	GenScript Custom overexpressing Cell Line Services for RNF25		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

RNF25 gene at Home site.

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RNF25 Gene

protein-coding GIFtS: 52

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RNF25 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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for RNF25 gene

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