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RNF34 Gene

protein-coding GIFtS: 51

GC12P118847

ring finger protein 34
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
ring finger protein 34¹ ² ³		RING finger protein RIFF² ³
FLJ21786¹ ²		hRFI² ³
RIF¹ ²		CARP-1² ³
RIFF¹ ²		RFI² ⁵
Human RING finger homologous to inhibitor of apoptosis protein² ³		E3 ubiquitin-protein ligase RNF34²
FYVE-RING finger protein Momo² ³		CARP1²
Caspases-8 and -10-associated RING finger protein 1² ³		EC 6.3.2.-³
Caspase regulator CARP1² ³

External Ids:	HGNC: 17297¹	Entrez Gene: 80196²	Ensembl: ENSG00000170633⁷	UniProtKB: Q969K3³

Export aliases for RNF34 gene to outside databases

Previous GC identifers: GC12P120717 GC12M121524 GC12P121621 GC12P120250 GC12P120251 GC12P120300 GC12P121837

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF34:

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and

protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a

modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha

induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3

during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been

reported. (provided by RefSeq)

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3

Function: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for

proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and

phosphatidylinositol-3-phosphate

Gene Wiki entry for RNF34

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF34 gene promoter:
         NF-kappaB1   JunD   AP-1   c-Fos   c-Jun   Fra-1   JunB   STAT5B   Chx10   Bach1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for RNF34

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF34

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31

RNF34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF34 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P118847: view genomic region (about GC identifiers)

Start:	118,847,691 bp from pter
End:	118,871,945 bp from pter
Size:	24,255 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 121,837,902-121,862,155

RefSeq DNA sequence:

NC_000012.11 NT_009775.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase RNF34

Size: 372 amino acids; 41641 Da

Subunit: Interacts with DNAJA3 (Potential). Interacts with CASP8 and CASP10

Subcellular location: Nucleus speckle. Endomembrane system; Peripheral membrane protein

Caution: Was isolated as potential interaction partner of the mitochondrial protein DNAJA3, but the 2 proteins are not

in the same cellular compartments

Sequence caution: Sequence=BAH14169.1; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: B7Z933 Q8NG47 Q9H6W8

Alternative splicing: 2 isoforms: Q969K3-1 Q969K3-2

Explore the universe of human proteins at neXtProt for RNF34: NX_Q969K3

Post-translational modifications:

Auto-ubiquitinated (in vitro) (By similarity)¹

Proteolytically cleaved by caspases upon induction of apoptosis by TNF¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_079402.2 NP_919247.1

ENSEMBL proteins:

ENSP00000376258 ENSP00000346850 ENSP00000376257 ENSP00000355137

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RNF34 OriGene Protein Over-expression Lysate (see all 2): RNF34
	GenScript Custom Purified and Recombinant Proteins Services for RNF34
	Novus Biologicals Protein for RNF34
	Novus Biologicals Lysates for RNF34
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0012505	endomembrane system	IEA	--
GO:0016020	membrane	IEA	--
GO:0016607	nuclear speck	IEA	--

About this table

RNF34 for ontologies About GeneDecksing

Antibodies for RNF34:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies: RNF34
	GenScript Custom Superior Antibodies Services for RNF34
	Novus Biologicals Antibodies for RNF34
	Browse antibodies at Epitomics

Assays for RNF34:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNF34
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RNF34

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF34 for domains About GeneDecksing

3 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

IPR011011 Znf_FYVE_PHD

Graphical View of Domain Structure for InterPro Entry Q969K3

ProtoNet protein and cluster: Q969K3

2 Blocks protein families:

IPB001841 Zn-finger

IPB003034 DNA-binding SAP

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3

Similarity: Contains 1 FYVE-type zinc finger

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 2 SAP domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3

Function: Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for

proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and

phosphatidylinositol-3-phosphate

Enzyme Number (IUBMB): EC 6.3.2.-

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNF34 Sigma-Aldrich shRNA Panels and shRNA for RNF34
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RNF34 OriGene shRNA RFP (see all 2): RNF34 OriGene basic RS shRNA (see all 2): RNF34 OriGene siRNA (see all 2): RNF34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF34

miRNA:		Sigma-Aldrich microRNA Mimics for RNF34 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF34
		6 SABiosciences Assays for microRNAs that regulate RNF34:
		hsa-miR-223 hsa-miR-181c hsa-miR-129-3p hsa-miR-181a hsa-miR-181d hsa-miR-181b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene untagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene 3'-UTR clone (see all 2): RNF34 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RNF34
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for RNF34

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	--	--
GO:0005515	protein binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

RNF34 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3

Pathway: Protein modification; protein ubiquitination

SABiosciences Custom Pathway-Focused PCR Arrays for RNF34

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNF34

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--

About this table

RNF34 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF34

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNF34 Sigma-Aldrich shRNA Panels and shRNA for RNF34
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): RNF34 OriGene shRNA RFP (see all 2): RNF34 OriGene basic RS shRNA (see all 2): RNF34 OriGene siRNA (see all 2): RNF34
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF34

miRNA:		Sigma-Aldrich microRNA Mimics for RNF34 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF34
		6 SABiosciences Assays for microRNAs that regulate RNF34:
		hsa-miR-223 hsa-miR-181c hsa-miR-129-3p hsa-miR-181a hsa-miR-181d hsa-miR-181b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene untagged cDNA clones in CMV expression vector (see all 2): RNF34 OriGene 3'-UTR Clone (see all 2): RNF34 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): RNF34

Primers:		OriGene genome-wide validated SYBR primer pairs: RNF34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RNF34: PPH16269A

REFSEQ mRNAs for RNF34 gene (2 alternative transcripts):

NM_025126.2 NM_194271.1

Additional cDNA sequence:

AB084914.1 AF306709.1 AK025439.1 AK225285.1 AK304366.1 AY098934.1 BC007826.2 BC029038.1

BC046174.1 BC059954.1 BT007283.1 CR457342.1 CR592405.1 CR601814.1 CR616780.1

23 DOTS entries:

DT.100655270 DT.416565 DT.92432368 DT.100655267 DT.101983209 DT.100655265 DT.95241592 DT.40107011

DT.434339 DT.91705125 DT.100655268 DT.121128747 DT.95206635 DT.100749593 DT.100779773 DT.40268240

DT.100699341 DT.121128663 DT.121128704 DT.95203625 DT.95291882 DT.95160233 DT.99938684

24/259 AceView cDNA sequences (see all 259):

BX363156 BE742308 CB120192 AW572402 AL555153 AI291755 CK906126 Z38175

BI753327 CA418549 Z44055 BM839804 AI805963 BM709990 BU629743 NM_194271

BM671135 CR616780 AA452121 AL557811 CA776768 CR601814 BM127217 Z41875

highest scoring ESTs for RNF34:

AA135205 AA302367 AA448911 AA449719 AA452121 AA476588 AA504507 AA527070 AA579643 AA625697

Unigene Cluster for RNF34:

Ring finger protein 34

Hs.292804 [show with all ESTs]

Unigene Representative Sequence: NM_194271

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RNF34 (see all 9)

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	·	10c
SP1:									-		-		-				-								-
SP2:									-		-		-		-		-		-		-				-
SP3:											-		-				-								-
SP4:													-				-
SP5:									-		-						-

About this scheme

ECgene alternative splicing isoforms for RNF34
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000392465(uc010szw.1 uc001uak.1 uc001ual.1 uc001uam.1 uc001uan.2)

ENST00000354795 ENST00000392464 ENST00000361234

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

RNF34 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching RNF34 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46229_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	H23103	0.80	1.00	0.91	1
219035_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_025126	0.60	1.00	0.82	1
219035_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

RNF34 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

RNF34 gene electronic northern expression

About these images

CGAP SAGE TAG: TCCATTTTTG

SOURCE GeneReport for Unigene cluster: Hs.292804

UniProtKB/Swiss-Prot: RNF34_HUMAN, Q969K3

Tissue specificity: Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus,

prostate, testis, ovary, colon and leukocytes

Primers:		OriGene genome-wide validated SYBR primer pairs: RNF34 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for RNF34: PPH16269A

SABiosciences Custom PCR Arrays for RNF34

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RNF34 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RNF34¹	--	ring finger protein 34	88.41(n) 88.68(a)	477470 XM_855458.1 XP_860551.1
cow (Bos taurus)	RNF34¹	--	ring finger protein 34	89.07(n) 92.74(a)	506764 NM_001014858.1 NP_001014858.1
rat (Rattus norvegicus)	Rnf34¹	--	ring finger protein 34	86.29(n) 87.9(a)	282845 NM_001004075.1 NP_001004075.1
mouse (Mus musculus)	Rnf34^{1 , 5}	5 (62.62 cM)⁵	ring finger protein 34^{1, 5}	86.83(n)¹ 89.25(a)¹	80751¹ NM_030564.1¹ NP_085041.1¹ AF434815⁵ AI452348⁵ (see all 23)
chicken (Gallus gallus)	RNF34¹	--	ring finger protein 34	75.43(n) 78.9(a)	416843 NM_001006188.1 NP_001006188.1

About this table Species with no ortholog for RNF34

ENSEMBL Gene Tree for RNF34 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RNF34 gene

RFFL²

RNF34 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs8462^1,2	C,F,O,A,	121862071(-)	`AAACAA/GTGTAA`	2	--	ut3¹		9		MN NS EA NA WA	814
rs750008^1,2	C,F,	121857504(+)	`CTAAAG/CTGTTC`	2	--	int¹		5		NS EA	506
rs889970^1,2	C,F,A,	121856217(-)	`CCTCAT/CTGGGA`	2	--	int¹		13		NA EA NS WA	848
rs1110337^1,2	H	121858533(+)	`TGGTAG/AAGAAA`	4	/K /E	mis¹ ref¹		4		NS EA	402
rs1177625^1,2	--	121846073(-)	`agagaC/Gggggt`	2	--	int¹		0	--	--	--	--
rs1177626^1,2	--	121845993(-)	`gtgttA/Gggatt`	2	--	int¹		0	--	--	--	--
rs1177634^1,2	--	121847873(-)	`ttcaaC/Gcgatt`	2	--	int¹		0	--	--	--	--
rs1182952^1,2	--	121846032(-)	`tcctgA/Gcctca`	2	--	int¹		0	--	--	--	--
rs1305816^1,2	--	121847945(-)	`agtttC/Tgctct`	2	--	int¹		0	--	--	--	--
rs1305817^1,2	--	121847928(-)	`ccaggC/Ttggag`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for RNF34 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF34: --

QIAGEN SeqTarget long-range PCR primers for resequencing RNF34

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNF34 for disorders About GeneDecksing

OMIM: 608299

Export disorders and mutations for RNF34 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/15 PubMed articles for RNF34 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with RNF34)

Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. (PubMed id 12118383)^{1, 2, 3} Sasaki S....Croce C.M. (2002)
Overexpression of hRFI (human RING finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. (PubMed id 15897238)^{1, 2} Konishi T.... Nagawa H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth. (PubMed id 15069192)^{1, 2} McDonald E.R. III and El-Deiry W.S. (2004)
Uncoupling of bait-protein expression from the prey p rotein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. (PubMed id 20564261)¹ Erlbruch A....Bossemeyer D. (2010)
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)¹ Markson G....Sanderson C.M. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2. (PubMed id 18382127)¹ Yang W....El-Deiry W.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80196	HGNC: 17297	AceView: RNF34	Ensembl:ENSG00000170633	euGenes: HUgn80196
ECgene: RNF34	H-InvDB: RNF34

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RNF34	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNF34 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for RNF34 gene:
Search GeneIP for patents involving RNF34

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for RNF34		Antibodies for RNF34
	Super-pooled esiRNAs for RNF34		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RNF34		microRNA Mimics for RNF34
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNF34
	SeqTarget long-range PCR primers for resequencing RNF34
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNF34
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNF34

	GenScript Custom Purified and Recombinant Proteins Services for RNF34		GenScript cDNA clones with any tag delivered in your preferred vector for RNF34
	GenScript Custom Assay Services for RNF34		GenScript Custom Superior Antibodies Services for RNF34
	GenScript Custom overexpressing Cell Line Services for RNF34		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in RNF34 promoter
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ELISAs and CLIAs for RNF34

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

RNF34 gene at Home site.

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RNF34 Gene

protein-coding GIFtS: 51

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Export list of displayed genes

RNF34 Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor RNF34 gene

Summariesfor RNF34 gene

Genomic Viewsfor RNF34 gene

Proteinsfor RNF34 gene

Protein Domains/Familiesfor RNF34 gene

Gene Functionfor RNF34 gene

Pathways & Interactionsfor RNF34 gene

Drugs & Compoundsfor RNF34 gene

Transcriptsfor RNF34 gene

Expression for RNF34 gene

Orthologsfor RNF34 gene

Paralogsfor RNF34 gene

Genomic Variantsfor RNF34 gene

Disorders & Mutationsfor RNF34 gene

Medical Newsfor RNF34 gene

Publicationsfor RNF34 gene

External Searches for RNF34 gene

Genome Databases showing RNF34 gene

Other Databases showing RNF34 gene

Specialized Databases showing RNF34 gene

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Aliases &
Descriptions
for RNF34 gene

Summaries
for RNF34 gene

Genomic Views
for RNF34 gene

Proteins
for RNF34 gene

Protein Domains/
Families
for RNF34 gene

Gene Function
for RNF34 gene

Pathways & Interactions
for RNF34 gene

Drugs & Compounds
for RNF34 gene

Transcripts
for RNF34 gene

Expression
for RNF34 gene

Orthologs
for RNF34 gene

Paralogs
for RNF34 gene

Genomic Variants
for RNF34 gene

Disorders & Mutations
for RNF34 gene

Medical News
for RNF34 gene

Publications
for RNF34 gene

Intellectual Property
for RNF34 gene

Products
for RNF34 gene