Aliases &
Descriptions
for RNH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ribonuclease/angiogenin inhibitor 11 2 3 | | MGC45692 | | RAI1 2 3 | | MGC182002 | | RNH2 3 5 | | ribonuclease inhibitor2 | | Placental RNase inhibitor2 3 | | MGC540542 | | Placental ribonuclease inhibitor2 3 | | PRI3 | | ribonuclease/angiogenin inhibitor1 | | |
Export aliases for RNH1 gene to outside databasesPrevious GC identifer: GC11M000485 |
Summaries
for RNH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNH1:
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occurin many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 (PubMed3219362)). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation ofangiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form.Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNHmay be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversiblein vivo.(supplied by OMIM)
UniProtKB/Swiss-Prot: RINI_HUMAN, P13489Function: Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities
Gene Wiki entry for RNH1 |
Genomic Views
for RNH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNH1 gene promoter:
c-Myc Max1 LCR-F1 C/EBPalpha AP-4 NRSF form 2 NRSF form 1 c-Myb GR-alpha AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNH1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNH1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5RNH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M000310: view genomic region
(about GC identifiers)
Start:
|
309,154 bp from pter |
End:
|
321,728 bp from pter |
Size:
|
12,575 bases |
Orientation:
|
minus strand |
1 alternative location:
RefSeq DNA sequence:- NC_000011.9 NT_009237.18
|
Proteins
for RNH1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RINI_HUMAN, P13489 (See
protein sequence)Recommended Name: Ribonuclease inhibitor Size: 461 amino acids; 49973 Da
Subunit: Forms a tight one-to-one complex with the RNase
Subcellular location: Cytoplasm
PDB structures from  and Proteopedia  :1A4Y (3D)
1Z7X (3D)
2BEX (3D)
2Q4G (3D)
Explore the universe of human proteins at neXtProt for RNH1: NX_P13489
Post-translational modifications:
The N-terminus is blocked1
At least 30 of the 32 cysteine residues are in the reduced form1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (8 alternative transcripts):
NP_002930.2 NP_976317.1 NP_976318.1 NP_976319.1 NP_976320.1 NP_976321.1 NP_976322.1 NP_976323.1
ENSEMBL proteins: ENSP00000390724 ENSP00000346402 ENSP00000416589 ENSP00000380739 ENSP00000348515 ENSP00000380738 ENSP00000380729
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RNH1 for ontologies About GeneDecksing
Antibodies for RNH1:
Assays for RNH1: |
Protein
Domains/
Families
for RNH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNH1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P13489ProtoNet protein and cluster: P13489 1 Blocks protein family: IPB003590 Leucine-rich repeat
UniProtKB/Swiss-Prot: RINI_HUMAN, P13489Similarity: Contains 15 LRR (leucine-rich) repeats |
Gene Function
for RNH1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RINI_HUMAN, P13489Function: Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
RNH1 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNH1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including RNH1: PAHS-072A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNH1
3 Interacting proteins for RNH1 (ENSP000003485153) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
RNH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RNH1
|
Transcripts
for RNH1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RNH1 gene (8 alternative transcripts): NM_002939.3 NM_203383.1 NM_203384.1 NM_203385.1 NM_203386.1 NM_203387.1 NM_203388.1 NM_203389.1 Additional cDNA sequence: AB209196.1 AK095144.1 AK308340.1 AK310173.1 AK311379.1 AY071904.2 BC000677.2 BC003506.1 BC011186.1 BC011500.1 BC014629.2 BC024037.1 BC047730.1 CR590338.1 CR592118.1 CR592511.1 CR592774.1 CR592892.1 CR592988.1 CR593636.1 CR594328.1 CR595919.1 CR596248.1 CR597292.1 CR597816.1 CR598193.1 CR598663.1 CR598809.1 CR599057.1 CR600355.1 CR600356.1 CR600411.1 CR602999.1 CR604056.1 CR604193.1 CR604995.1 CR606240.1 CR608218.1 CR608690.1 CR611258.1 CR612687.1 CR613396.1 CR613915.1 CR614192.1 CR616098.1 CR619871.1 CR620826.1 CR624221.1 CR624314.1 CR624317.1 CR625171.1 CR626140.1 M22414.1 M36717.1 X13973.1 24/41 DOTS entries (see all 41): DT.91767822 DT.100888996 DT.91767841 DT.100889006 DT.102835588 DT.91805855 DT.91767837 DT.100691026 DT.95113324 DT.91767833 DT.91815635 DT.95113378 DT.100888990 DT.100889007 DT.75192219 DT.95113384 DT.100888987 DT.95113383 DT.95191671 DT.91767834 DT.95361649 DT.100753401 DT.120733649 DT.95313613 24/859 AceView cDNA sequences (see all 859): BM756842 AW069030 CR614192 BF026056 BE386303 BQ068298 BQ650636 BU629698 BQ053869 M22414 BM458722 CR597292 BQ049859 CR613915 BQ679674 AW161918 AU119093 BU730350 BM773175 BM557110 BE276887 AI263925 BF724402 BU160260
 highest scoring ESTs for RNH1:AI983884 AL534410 AL539148 AL553177 AL555258 AW956924 BC000677 BC011500 BC014629 BE019752 Unigene Cluster for RNH1: Ribonuclease/angiogenin inhibitor 1 Hs.530687 [show with all ESTs]Unigene Representative Sequence: AB209196
GeneLoc Exon Structure
5/32 Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 (see all 32)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | - | | - | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | - | | - | |
| ExUns: | 10b | · | 10c | · | 10d | · | 10e | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e | · | 11f | · | 11g | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RNH1
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426245 ENST00000354420(uc001lpk.1 uc001lpp.1 uc001lpt.1 uc001lpq.1 uc001lpr.1 uc001lps.1 uc009ybx.1)
ENST00000438658 ENST00000397615(uc001lpl.1 uc001lpm.1 uc001lpn.1 uc001lpo.1 uc009ybw.1)
ENST00000356187 ENST00000397614 ENST00000397604
|
Expression
for RNH1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RNH1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching RNH1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36187_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.95 |
0.87 |
M36717 |
0.80 |
1.00 |
0.91 |
1 |
| 90021_s_at2, 3
|
U95-D |
1 |
1.00 |
1.00 |
0.98 |
1.13 |
AI983884 |
0.80 |
1.00 |
0.91 |
1 |
| 206050_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002939 |
0.60 |
1.00 |
0.82 |
1 |
| 206050_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1555529_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RNH1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTCTCACCCT
SOURCE GeneReport for Unigene cluster: Hs.530687
Expression variation in blood from EXPOLDB for RNH1 SABiosciences Expression via Pathway-Focused PCR Array including RNH1: PAHS-072A
|
Orthologs
for RNH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RNH1 gene from 5 species
About this table Species with no ortholog for RNH1
ENSEMBL Gene Tree for RNH1 (if available) |
Paralogs
for RNH1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RNH1 gene
- LRRC312
RNH1 for paralogs About GeneDecksing
|
Genomic Variants
for RNH1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RNH1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for RNH1
4 CNVs: 3831 29882 29883 29881
3 Indels: 85583 85584 75486 | | QIAGEN SeqTarget long-range PCR primers for resequencing RNH1 |
|
Disorders & Mutations
for RNH1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNH1 for disorders About GeneDecksing
OMIM: 173320
2  Novoseek disease relationships for RNH1 gene
About this table
Genetic Association Database (GAD): RNH1
Human Genome Epidemiology (HuGE) Navigator: RNH1 (2 documents)
Export disorders and mutations for RNH1 gene to outside databases
|
Medical News
for RNH1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RNH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/44 PubMed articles for RNH1 gene, integrated from 7 sources (see all 44):
(articles sorted by number of sources associating them with RNH1)- Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. (PubMed id 15936590)1, 4 Vogel U....Nexo B.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977)1, 2 Papageorgiou A.C.... Acharya K.R. (1997)
- Purification and characterization of human brain ribonuclease inhibitor. (PubMed id 8037455)1, 2 Nadano D.... Kishi K. (1994)
- Primary structure of human placental ribonuclease inhibitor. (PubMed id 3219362)1, 2 Lee F.S.... Vallee B.L. (1988)
- The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. (PubMed id 3243277)1, 2 Schneider R....Schweiger M. (1988)
- Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PubMed id 15592448)1, 7 Fu P....Zhao B. (2005)
- Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 7 Johnson R.J....Raines R.T. (2007)
- Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for RNH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNH1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNH1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RNH1 gene:
Search GeneIP for patents involving RNH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNH1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for RNH1 |
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