Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



RNH1 Gene

protein-coding   GIFtS: 55

GC11M000310
ribonuclease/angiogenin inhibitor 1
(Previous name: ribonuclease/angiogenin inhibitor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RNH)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ribonuclease/angiogenin inhibitor 11 2 3     MGC45692
RAI1 2 3     MGC182002
RNH2 3 5     ribonuclease inhibitor2
Placental RNase inhibitor2 3     MGC540542
Placental ribonuclease inhibitor2 3     PRI3
ribonuclease/angiogenin inhibitor1     

External Ids:    HGNC: 100741   Entrez Gene: 60502   Ensembl: ENSG000000231917   UniProtKB: P134893   

Export aliases for RNH1 gene to outside databases

Previous GC identifer: GC11M000485


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNH1:
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur
in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 (PubMed
3219362)). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of
angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form.
Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH
may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible
in vivo.(supplied by OMIM)

UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
Function: Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities

Gene Wiki entry for RNH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNH1 gene promoter:
         c-Myc   Max1   LCR-F1   C/EBPalpha   AP-4   NRSF form 2   NRSF form 1   c-Myb   GR-alpha   AML1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RNH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNH1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

RNH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNH1 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000310:  view genomic region     (about GC identifiers)

Start:
309,154 bp from pter
End:
321,728 bp from pter
Size:
12,575 bases
Orientation:
minus strand

1 alternative location:
Chr11- 494,513-507,300     
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RINI_HUMAN, P13489 (See protein sequence)
Recommended Name: Ribonuclease inhibitor  
Size: 461 amino acids; 49973 Da
Subunit: Forms a tight one-to-one complex with the RNase
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1A4Y (3D)    1Z7X (3D)    2BEX (3D)    2Q4G (3D)    

Explore the universe of human proteins at neXtProt for RNH1: NX_P13489 

Post-translational modifications:

  • The N-terminus is blocked1
  • At least 30 of the 32 cysteine residues are in the reduced form1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (8 alternative transcripts): 
    NP_002930.2  NP_976317.1  NP_976318.1  NP_976319.1  NP_976320.1  NP_976321.1  NP_976322.1  NP_976323.1  


    ENSEMBL proteins: 
    ENSP00000390724 ENSP00000346402 ENSP00000416589 ENSP00000380739 ENSP00000348515 ENSP00000380738 
    ENSP00000380729 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for RNH1
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 4): RNH1
    OriGene Protein Over-expression Lysate (see all 5): RNH1
    GenScript Custom Purified and Recombinant Proteins Services for RNH1 
    Novus Biologicals Proteins for RNH1
    Novus Biologicals Lysates for RNH1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0032311 angiogenin-PRI complex IPI3470787
    About this table

    RNH1 for ontologies           About GeneDecksing



    Antibodies for RNH1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RNH1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for RNH1 
    Novus Biologicals Antibodies for RNH1
    Browse antibodies at Epitomics

    Assays for RNH1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNH1 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RNH1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR003590 Leu-rich_rpt_RNase_inh_sub-typ

    Graphical View of Domain Structure for InterPro Entry P13489

    ProtoNet protein and cluster: P13489

    1 Blocks protein family: IPB003590 Leucine-rich repeat

    UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
    Similarity: Contains 15 LRR (leucine-rich) repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RINI_HUMAN, P13489
    Function: Inhibitor of pancreatic RNase and angiogenin. May also function in the modulation of cellular activities

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNH1
    Sigma-Aldrich shRNA for RNH1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): RNH1
    OriGene shRNA RFP (see all 8): RNH1
    OriGene basic RS shRNA (see all 8): RNH1
    OriGene siRNA (see all 8): RNH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNH1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNH1 
    2 SABiosciences Assays for microRNAs that regulate RNH1:
    hsa-miR-142-5p hsa-miR-340

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): RNH1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): RNH1
    OriGene untagged cDNA clones in CMV expression vector (see all 9): RNH1
    OriGene 3'-UTR clone (see all 8): RNH1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 8): RNH1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for RNH1 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI3064806
    GO:0008428 ribonuclease inhibitor activity IDA3470787
    About this table

    RNH1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including RNH1: PAHS-072A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNH1

    3 Interacting proteins for RNH1 (ENSP000003485153) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANGENSP000003367623STRING: ENSP00000336762
    RNASE1ENSP000003441933STRING: ENSP00000344193
    RNASE2ENSP000003032763STRING: ENSP00000303276
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402 mRNA catabolic process NAS2081593
    GO:0045765 regulation of angiogenesis IDA3470787
    About this table

    RNH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNH1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for RNH1
    Sigma-Aldrich shRNA for RNH1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): RNH1
    OriGene shRNA RFP (see all 8): RNH1
    OriGene basic RS shRNA (see all 8): RNH1
    OriGene siRNA (see all 8): RNH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNH1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNH1 
    2 SABiosciences Assays for microRNAs that regulate RNH1:
    hsa-miR-142-5p hsa-miR-340
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 8): RNH1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 8): RNH1
    OriGene untagged cDNA clones in CMV expression vector (see all 9): RNH1
    OriGene 3'-UTR Clone (see all 8): RNH1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 8): RNH1 
    Primers: OriGene genome-wide validated SYBR primer pairs: RNH1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RNH1: PPH12058A

    REFSEQ mRNAs for RNH1 gene (8 alternative transcripts): 

    NM_002939.3  NM_203383.1  NM_203384.1  NM_203385.1  NM_203386.1  NM_203387.1  NM_203388.1  NM_203389.1  

    Additional cDNA sequence: 

    AB209196.1 AK095144.1 AK308340.1 AK310173.1 AK311379.1 AY071904.2 BC000677.2 BC003506.1 
    BC011186.1 BC011500.1 BC014629.2 BC024037.1 BC047730.1 CR590338.1 CR592118.1 CR592511.1 
    CR592774.1 CR592892.1 CR592988.1 CR593636.1 CR594328.1 CR595919.1 CR596248.1 CR597292.1 
    CR597816.1 CR598193.1 CR598663.1 CR598809.1 CR599057.1 CR600355.1 CR600356.1 CR600411.1 
    CR602999.1 CR604056.1 CR604193.1 CR604995.1 CR606240.1 CR608218.1 CR608690.1 CR611258.1 
    CR612687.1 CR613396.1 CR613915.1 CR614192.1 CR616098.1 CR619871.1 CR620826.1 CR624221.1 
    CR624314.1 CR624317.1 CR625171.1 CR626140.1 M22414.1 M36717.1 X13973.1 

    24/41 DOTS entries (see all 41):

    DT.91767822  DT.100888996  DT.91767841  DT.100889006  DT.102835588  DT.91805855  DT.91767837  DT.100691026 
    DT.95113324  DT.91767833  DT.91815635  DT.95113378  DT.100888990  DT.100889007  DT.75192219  DT.95113384 
    DT.100888987  DT.95113383  DT.95191671  DT.91767834  DT.95361649  DT.100753401  DT.120733649  DT.95313613 

    24/859 AceView cDNA sequences (see all 859):

    BM756842 AW069030 CR614192 BF026056 BE386303 BQ068298 BQ650636 BU629698 
    BQ053869 M22414 BM458722 CR597292 BQ049859 CR613915 BQ679674 AW161918 
    AU119093 BU730350 BM773175 BM557110 BE276887 AI263925 BF724402 BU160260 

    highest scoring ESTs for RNH1:

    AI983884 AL534410 AL539148 AL553177 AL555258 AW956924 BC000677 BC011500 BC014629 BE019752 

    Unigene Cluster for RNH1:

    Ribonuclease/angiogenin inhibitor 1
    Hs.530687  [show with all ESTs]
    Unigene Representative Sequence: AB209196


    GeneLoc Exon Structure

    5/32 Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 (see all 32)

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
    SP1:                                                              -     -     -                             -     -                                   -     -   
    SP2:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -                                   -     -   
    SP4:                                                              -     -     -     -     -     -     -     -     -     -     -                       -     -   
    SP5:                                                                                                        -     -     -     -                       -     -   

    ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
    SP1:                                                        -     -     -     -     -                                                                           
    SP2:                                                        -     -     -     -     -                                                                           
    SP3:                                                        -     -     -     -     -                                                                           
    SP4:                                                        -     -     -     -     -                                                                           
    SP5:                                                                                                                                                            

    ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                

    About this scheme

    ECgene alternative splicing isoforms for RNH1
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426245 ENST00000354420(uc001lpk.1 uc001lpp.1 uc001lpt.1 uc001lpq.1 uc001lpr.1 uc001lps.1 uc009ybx.1)
    ENST00000438658 ENST00000397615(uc001lpl.1 uc001lpm.1 uc001lpn.1 uc001lpo.1 uc009ybw.1)
    ENST00000356187 ENST00000397614 ENST00000397604

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RNH1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching RNH1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36187_at2, 3 U95-A 1 1.00 1.00 0.95 0.87 M36717 0.80 1.00 0.91 1
    90021_s_at2, 3 U95-D 1 1.00 1.00 0.98 1.13 AI983884 0.80 1.00 0.91 1
    206050_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002939 0.60 1.00 0.82 1
    206050_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555529_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    RNH1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RNH1 gene expression
    RNH1 gene electronic northern expression
    RNH1 gene sage expression
    About these images

    CGAP SAGE TAG: CTCTCACCCT

    SOURCE GeneReport for Unigene cluster: Hs.530687

    Expression variation in blood from EXPOLDB for RNH1

    Primers: OriGene genome-wide validated SYBR primer pairs: RNH1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RNH1: PPH12058A
        SABiosciences Expression via Pathway-Focused PCR Array including RNH1: PAHS-072A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for RNH1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RNH11   -- ribonuclease/angiogenin inhibitor 1 82.58(n)
    77.89(a)
    483402  XM_540521.2  XP_540521.2 
    chimpanzee
    (Pan troglodytes)
    RNH11   -- ribonuclease/angiogenin inhibitor 1 99.28(n)
    98.92(a)
    450154  NM_001009060.1  NP_001009060.1 
    rat
    (Rattus norvegicus)
    Rnh11   -- ribonuclease/angiogenin inhibitor 1 78.75(n)
    75.16(a)
    245964  NM_139105.1  NP_620805.1 
    mouse
    (Mus musculus)
    Rnh11 , 5 7 (86.44 cM)5
    ribonuclease/angiogenin inhibitor 11, 5 78.97(n)1
    73.85(a)1
    1077021  NM_145135.21  NP_660117.21 
     AF0715465  AI8488255  (see all 21)
    chicken
    (Gallus gallus)
    RNH11   -- ribonuclease/angiogenin inhibitor 1 59.62(n)
    50(a)
    423111  NM_001006473.1  NP_001006473.1 
    About this table        Species with no ortholog for RNH1

    ENSEMBL Gene Tree for RNH1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for RNH1 gene
    LRRC312  

    RNH1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/211 NCBI SNPs in RNH1 are shown (see all 211)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs79831,2
    C,F,H,494942(-) GACGCC/GGGCAT 14 A ref1 syn18Minor allele frequency- G:0.35MN NA WA 34
    rs105401,2
    C,F,H,494662(-) CTGGAC/TGACCG 7 -- ut31 ese317Minor allele frequency- T:0.16MN NA NS EA 1358
    rs175841,2
    C,F,H,499059(-) GTGCTG/ATGCCA 14 /L syn1 ref112Minor allele frequency- A:0.18MN EA NA NS 2248
    rs175851,2
    C,F,499120(-) CAAGCC/TGGACT 14 P L ref1 mis1 ese316Minor allele frequency- T:0.24MN NA NS EA WA 1084
    rs1769391,2
    C,F,A,H,496073(-) TTTTTG/CGTGTG 7 -- int113Minor allele frequency- C:0.26NS EA NA WA 996
    rs2115151,2
    --504342(+) AAGGGC/GTGGGA 7 -- int11Minor allele frequency- G:0.00MN 184
    rs2115161,2
    A504380(+) TCTCCC/TCTGCC 7 -- int10--------
    rs2115171,2
    A504441(+) CCGCCC/GCAGAC 7 -- int10--------
    rs2115181,2
    A504451(+) CCCAAA/GGCCAG 7 -- int10--------
    rs2115191,2
    A504505(+) CTCCAG/TGCCGG 7 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for RNH1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for RNH1
         4 CNVs: 3831 29882 29883 29881
         3 Indels: 85583 85584 75486

    QIAGEN SeqTarget long-range PCR primers for resequencing RNH1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNH1 for disorders           About GeneDecksing

    OMIM: 173320

    2 Novoseek disease relationships for RNH1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 15592448 (1), 1544320 (1), 17032310 (1)
    cancer 0 1 11801605 (1)
    About this table

    Genetic Association Database (GAD): RNH1
    Human Genome Epidemiology (HuGE) Navigator: RNH1 (2 documents)

    Export disorders and mutations for RNH1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/44 PubMed articles for RNH1 gene, integrated from 7 sources (see all 44):
    (articles sorted by number of sources associating them with RNH1)
    1. Effect of polymorphisms in XPD, RAI, ASE-1 and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50. (PubMed id 15936590)1, 4 Vogel U....Nexo B.A. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Molecular recognition of human angiogenin by placental ribonuclease inhibitor -- an X-ray crystallographic study at 2.0-A resolution. (PubMed id 9311977)1, 2 Papageorgiou A.C.... Acharya K.R. (1997)
    4. Purification and characterization of human brain ribonuclease inhibitor. (PubMed id 8037455)1, 2 Nadano D.... Kishi K. (1994)
    5. Primary structure of human placental ribonuclease inhibitor. (PubMed id 3219362)1, 2 Lee F.S.... Vallee B.L. (1988)
    6. The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. (PubMed id 3243277)1, 2 Schneider R....Schweiger M. (1988)
    7. Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. (PubMed id 15592448)1, 7 Fu P....Zhao B. (2005)
    8. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 7 Johnson R.J....Raines R.T. (2007)
    9. Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6050 HGNC: 10074 AceView: RNH Ensembl:ENSG00000023191 euGenes: HUgn6050
    ECgene: RNH1 H-InvDB: RNH1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for RNH1 gene:
    Search GeneIP for patents involving RNH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for RNH1 Antibodies for RNH1
     Super-pooled esiRNAs for RNH1 Proteins for RNH1
     Lentivirus-delivered shRNAs for RNH1 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RNH1
     SeqTarget long-range PCR primers for resequencing RNH1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RNH1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RNH1
     GenScript Custom Purified and Recombinant Proteins Services for RNH1 GenScript cDNA clones with any tag delivered in your preferred vector for RNH1
     GenScript Custom Assay Services for RNH1 GenScript Custom Superior Antibodies Services for RNH1
     GenScript Custom overexpressing Cell Line Services for RNH1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNH1 promoter
     Search Chromatin IP Primers for RNH1
     RT2 qPCR Primer Assay for RNH1
     Search GNC Networks for RNH1
     Assays for microRNAs that regulate RNH1
     SABiosciences PCR Arrays including RNH1
     Search Tocris compounds for RNH1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for RNH1
     Proteins for RNH1
     Lysates for RNH1
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    RNH1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4