Aliases &
Descriptions
for RPL10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ribosomal protein L101 2 | | OTTHUMP000000319452 | | QM1 2 3 5 | | OTTHUMP000001835062 | | DXS648E1 2 3 | | OTTHUMP000001964472 | | DXS6481 2 5 | | FLJ270722 | | NOV1 2 | | 60S ribosomal protein L102 | | FLJ235441 2 | | Wilms tumor-related protein2 | | Tumor suppressor QM2 3 | | DKFZp686J18512 | | Laminin receptor homolog2 3 | | OTTHUMP000000632132 | | Protein QM2 3 | | OTTHUMP000000632122 |
Export aliases for RPL10 gene to outside databasesPrevious GC identifers: GC0XP147690 GC0XP150007 GC0XP151212 GC0XP152096 GC0XP152097 GC0XP153147 GC0XP153279 |
Summaries
for RPL10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPL10:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family ofribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind toc-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated invivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studiesdetermined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from thelaminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcriptvariants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonucleaseI-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which islocated in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenes of this gene dispersed through the genome. (provided by RefSeq)
Gene Wiki entry for RPL10 |
Genomic Views
for RPL10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPL10 gene promoter:
NF-kappaB1 AP-1 c-Fos c-Jun TBP p300 MyoD p53 TFIID NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPL10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RPL10  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28RPL10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP153618: view genomic region
(about GC identifiers)
Start:
|
153,618,315 bp from pter |
End:
|
153,637,504 bp from pter |
Size:
|
19,190 bases |
Orientation:
|
plus strand |
1 alternative location:
| ChrX+ 142,204,017-142,208,069 |
RefSeq DNA sequence:- NC_000023.10 NT_167198.1
|
Proteins
for RPL10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RL10_HUMAN, P27635 (See
protein sequence)Recommended Name: 60S ribosomal protein L10 Size: 214 amino acids; 24604 Da
Subunit: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit.The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49different proteins and 3 molecules of RNA (28S, 5.8S and 5S)
Developmental stage: Down-regulated during adipocyte, kidney, and heart differentiation
Sequence caution: Sequence=AAB22173.1; Type=Frameshift; Positions=124; Sequence=CAM45852.1; Type=Erroneous gene modelprediction; Sequence=CAM45853.1; Type=Erroneous gene model prediction;
PDB structures from  and Proteopedia  :2PA2 (3D)
Secondary accessions: A3KQT0 Q16470 Q2HXT7 Q53FH7 Q6FGN8 Q8TDA5Explore the universe of human proteins at neXtProt for RPL10: NX_P27635
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006004.2
ENSEMBL proteins: ENSP00000413436 ENSP00000341730 ENSP00000406125 ENSP00000385621 ENSP00000407754 ENSP00000405064 ENSP00000398047 ENSP00000388600 ENSP00000358832 ENSP00000395025
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
RPL10 for ontologies About GeneDecksing
Antibodies for RPL10:
Assays for RPL10: |
Protein
Domains/
Families
for RPL10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPL10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P27635ProtoNet protein and cluster: P27635 1 Blocks protein family: IPB001197 Ribosomal protein L10E
UniProtKB/Swiss-Prot: RL10_HUMAN, P27635Similarity: Belongs to the ribosomal protein L10e family |
Gene Function
for RPL10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
Genatlas biochemistry entry for RPL10:60S ribosomal protein L101 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IDA | 9443083 |
About this table
RPL10 for ontologies About GeneDecksing
|
Pathways & Interactions
for RPL10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
RPL10 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for RPL10):
SABiosciences Custom Pathway-Focused PCR Arrays for RPL10
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPL10
5/161 Interacting proteins for RPL10 (P276352) via UniProtKB, MINT, and/or STRING (see all 161)About this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): About this table
RPL10 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPL10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RPL10
|
Transcripts
for RPL10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RPL10 gene: NM_006013.3 Additional cDNA sequence: AB019572.1 AF486812.1 AK130582.1 AK223309.1 AK307511.1 AY927536.1 AY927570.1 AY927623.1 AY927624.1 BC003358.1 BC018570.1 BC026276.1 BC071918.1 BC095425.1 BX647954.1 CR456797.1 CR542069.1 CR593302.1 CR596152.1 CR596460.1 CR598560.1 CR602212.1 CR603980.1 CR609074.1 CR610011.1 CR610716.1 CR612141.1 CR613467.1 CR614058.1 CR614538.1 CR617177.1 CR621751.1 CR622051.1 CR623994.1 M64241.1 M73791.1 NR_000011.1 S35960.1 X87196.1 Y11164.1 24/174 DOTS entries (see all 174): DT.100846681 DT.121294714 DT.95325374 DT.100739701 DT.95202193 DT.85103592 DT.92071022 DT.100056570 DT.91865037 DT.121449274 DT.100739666 DT.92071218 DT.91807241 DT.91840444 DT.92412815 DT.121449218 DT.102841538 DT.91965656 DT.100060476 DT.100739687 DT.121294698 DT.100739670 DT.92070886 DT.101977215 24/2625 AceView cDNA sequences (see all 2625): BQ278906 BE140517 BE297546 BI856103 BM818420 BM854687 BQ953212 BM767526 BM142669 BQ707270 BM559363 BQ685921 BM014368 AI753626 BM761570 BM667069 BE256825 BM916382 F26550 BF726801 BM850060 BU184562 BE261333 BQ230748
 highest scoring ESTs for RPL10:M64241 AA244252 AA285096 AA321593 AA327380 AA328304 AA333380 AA339458 AA342954 AA359521 Unigene Cluster for RPL10: Ribosomal protein L10 Hs.534404 [show with all ESTs]Unigene Representative Sequence: NM_006013
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 (see all 12)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RPL10
18 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000424325 ENST00000344746(uc004fkm.2 uc004fko.2 uc004fkn.1)
ENST00000451365(uc004fkq.1 uc004fkr.1) ENST00000467168 ENST00000406022
ENST00000482732 ENST00000489200(uc010nux.1 uc004fkp.1) ENST00000474786
ENST00000449494 ENST00000427682 ENST00000491035 ENST00000428169 ENST00000485196
ENST00000436473 ENST00000369817 ENST00000492572 ENST00000479366 ENST00000458500
|
Expression
for RPL10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RPL10 expression in normal and diseased human tissues
1 / 2 / 3 9 probe-sets matching RPL10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 2016_s_at2, 3
|
U95-A |
8 |
1.00 |
0.65 |
0.79 |
1.50 |
M64241 |
1.00 |
0.67 |
0.85 |
1 |
| 91064_s_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.55 |
0.65 |
AW005660 |
0.40 |
0.40 |
0.40 |
2 |
| 47953_at2, 3
|
U95-B |
1 |
0.69 |
1.00 |
0.85 |
0.86 |
AI097271 |
0.80 |
0.88 |
0.84 |
1 |
| 200724_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
BC003358 |
0.80 |
0.75 |
0.78 |
1 |
| 200725_x_at2, 3
|
U133-A |
7 |
1.00 |
0.76 |
-- |
-- |
NM_006013 |
0.60 |
0.83 |
0.73 |
1 |
| 221989_at2, 3
|
U133-A |
2 |
0.82 |
0.94 |
-- |
-- |
AW057781 |
0.80 |
0.75 |
0.78 |
1 |
| 200724_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200725_x_at2
|
U133Plus2 |
7 |
1.00 |
0.76 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221989_at2
|
U133Plus2 |
2 |
0.82 |
0.94 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RPL10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGGGCTTCCA
SOURCE GeneReport for Unigene cluster: Hs.534404
Expression variation in blood from EXPOLDB for RPL10 SABiosciences Custom PCR Arrays for RPL10
|
Orthologs
for RPL10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RPL10 gene from 5/14 species (see all 14)
About this table Species with no ortholog for RPL10
ENSEMBL Gene Tree for RPL10 (if available) |
Paralogs
for RPL10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RPL10 gene
- ENSG000002352102 RPL10L2
RPL10 for paralogs About GeneDecksing
Pseudogenes
- 9 related pseudogenes
|
Genomic Variants
for RPL10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr X pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RPL10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RPL10
2 Inversions: 0674 37365 | | QIAGEN SeqTarget long-range PCR primers for resequencing RPL10 |
|
Disorders & Mutations
for RPL10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPL10 for disorders About GeneDecksing
OMIM: 312173
UniProtKB/Swiss-Prot: RL10_HUMAN, P27635
Note=Two hypomorphic variants with respect to the regulation of the translation process have been found infamilies affected by autism spectrum disorders, suggesting that aberrant processes of ribosome biosynthesis andtranslation may play a role in disease mechanisms
2  Novoseek disease relationships for RPL10 gene
About this table
Locus Specific Mutation Databases (LSDB): RPL10
Human Gene Mutation Database (HGMD): RPL10
Human Genome Epidemiology (HuGE) Navigator: RPL10 (4 documents)
Export disorders and mutations for RPL10 gene to outside databases
|
Medical News
for RPL10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RPL10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/53 PubMed articles for RPL10 gene, integrated from 7 sources (see all 53):
(articles sorted by number of sources associating them with RPL10)- A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
- QM, a putative tumor suppressor, regulates proto-oncogene c-Yes. (PubMed id 12138090)1, 2, 7 Oh H.S.... Yang C.-H. (2002)
- Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PubMed id 18258260)1, 2, 7 Nishimura M....Kobayashi Y. (2008)
- Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. (PubMed id 16940977)1, 2 Klauck S.M.... Poustka A. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
- Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (1996)
- Identification and characterization of a new gene in the human Xq28 region. (PubMed id 1303197)1, 2 van den Ouweland A.M.W.... van Oost B.A. (1992)
- cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene. (PubMed id 1534224)1, 2 Bignon C.... Martin P.M. (1992)
|
External Searches for RPL10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPL10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPL10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPL10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RPL10 gene:
Search GeneIP for patents involving RPL10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPL10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for RPL10 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RPL10 |
| |
|
|
