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RPL10 Gene

protein-coding   GIFtS: 64

GC0XP153618
ribosomal protein L10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ribosomal protein L101 2     OTTHUMP000000319452
QM1 2 3 5     OTTHUMP000001835062
DXS648E1 2 3     OTTHUMP000001964472
DXS6481 2 5     FLJ270722
NOV1 2     60S ribosomal protein L102
FLJ235441 2     Wilms tumor-related protein2
Tumor suppressor QM2 3     DKFZp686J18512
Laminin receptor homolog2 3     OTTHUMP000000632132
Protein QM2 3     OTTHUMP000000632122

External Ids:    HGNC: 102981   Entrez Gene: 61342   Ensembl: ENSG000001474037   UniProtKB: P276353   

Export aliases for RPL10 gene to outside databases

Previous GC identifers: GC0XP147690 GC0XP150007 GC0XP151212 GC0XP152096 GC0XP152097 GC0XP153147 GC0XP153279


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPL10:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.
Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene
encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of
ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to
c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in
vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies
determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as
'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the
laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript
variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease
I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is
located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed
pseudogenes of this gene dispersed through the genome. (provided by RefSeq)

Gene Wiki entry for RPL10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPL10 gene promoter:
         NF-kappaB1   AP-1   c-Fos   c-Jun   TBP   p300   MyoD   p53   TFIID   NF-kappaB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RPL10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RPL10 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

RPL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPL10 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP153618:  view genomic region     (about GC identifiers)

Start:
153,618,315 bp from pter
End:
153,637,504 bp from pter
Size:
19,190 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 142,204,017-142,208,069     
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RL10_HUMAN, P27635 (See protein sequence)
Recommended Name: 60S ribosomal protein L10  
Size: 214 amino acids; 24604 Da
Subunit: Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit.
The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49
different proteins and 3 molecules of RNA (28S, 5.8S and 5S)
Developmental stage: Down-regulated during adipocyte, kidney, and heart differentiation
Sequence caution: Sequence=AAB22173.1; Type=Frameshift; Positions=124; Sequence=CAM45852.1; Type=Erroneous gene model
prediction; Sequence=CAM45853.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :
2PA2 (3D)    
Secondary accessions: A3KQT0 Q16470 Q2HXT7 Q53FH7 Q6FGN8 Q8TDA5

Explore the universe of human proteins at neXtProt for RPL10: NX_P27635 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006004.2  

    ENSEMBL proteins: 
    ENSP00000413436 ENSP00000341730 ENSP00000406125 ENSP00000385621 ENSP00000407754 ENSP00000405064 
    ENSP00000398047 ENSP00000388600 ENSP00000358832 ENSP00000395025 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RPL10
    GenScript Custom Purified and Recombinant Proteins Services for RPL10 
    Novus Biologicals Proteins for RPL10
    Novus Biologicals Lysate for RPL10
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005737 cytoplasm IDA18029348
    GO:0005783 endoplasmic reticulum IDA11256614
    GO:0005829 cytosol TAS--
    GO:0005840 ribosome IEA--
    About this table

    RPL10 for ontologies           About GeneDecksing



    Antibodies for RPL10: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RPL10
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for RPL10 
    Novus Biologicals Antibodies for RPL10
    Browse antibodies at Epitomics

    Assays for RPL10: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPL10 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RPL10 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPL10 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001197 Ribosomal_L10e
     IPR016180 Ribosomal_L10e/L16
     IPR018255 Ribosomal_L10e_CS

    Graphical View of Domain Structure for InterPro Entry P27635

    ProtoNet protein and cluster: P27635

    1 Blocks protein family: IPB001197 Ribosomal protein L10E

    UniProtKB/Swiss-Prot: RL10_HUMAN, P27635
    Similarity: Belongs to the ribosomal protein L10e family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RPL10
    Sigma-Aldrich shRNA for RPL10
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): RPL10
    OriGene shRNA RFP (see all 3): RPL10
    OriGene basic RS shRNA (see all 3): RPL10
    OriGene siRNA (see all 2): RPL10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RPL10 
    miRNA:Sigma-Aldrich microRNA Mimics for RPL10
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RPL10 
    1 SABiosciences Assays for microRNA that regulate RPL10:
    hsa-miR-584

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: RPL10
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RPL10
    OriGene untagged cDNA clones in CMV expression vector: RPL10
    OriGene 3'-UTR clone: RPL10 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RPL10 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for RPL10 

    Genatlas biochemistry entry for RPL10:
    60S ribosomal protein L10

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735 structural constituent of ribosome IDA9443083
    About this table

    RPL10 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    RPL10 for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for RPL10):
        hsa03010 Ribosome

        SABiosciences Custom Pathway-Focused PCR Arrays for RPL10 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPL10

    5/161 Interacting proteins for RPL10 (P276352) via UniProtKB, MINT, and/or STRING (see all 161)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRCP129312MINT-7145938 MINT-7145955 MINT-7145972 MINT-7146023 MINT-7145921 MINT-7145994
    DHX30Q7L2E32MINT-6488590 MINT-6488791
    DHX36Q9H2U12MINT-6488590 MINT-6488791
    DHX9Q082112MINT-6488590 MINT-6488791
    EEF1A1P681042MINT-6488590 MINT-6488791
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412 translation TAS--
    GO:0006414 translational elongation EXP15189156
    GO:0006415 translational termination TAS--
    GO:0010467 gene expression TAS--
    GO:0016032 viral reproduction TAS--
    About this table

    RPL10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPL10


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RPL10
    Sigma-Aldrich shRNA for RPL10
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): RPL10
    OriGene shRNA RFP (see all 3): RPL10
    OriGene basic RS shRNA (see all 3): RPL10
    OriGene siRNA (see all 2): RPL10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RPL10 
    miRNA: Sigma-Aldrich microRNA Mimics for RPL10
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RPL10 
    1 SABiosciences Assays for microRNA that regulate RPL10:
    hsa-miR-584
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: RPL10
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RPL10
    OriGene untagged cDNA clones in CMV expression vector: RPL10
    OriGene 3'-UTR Clone: RPL10 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for RPL10 
    Primers: OriGene genome-wide validated SYBR primer pairs: RPL10
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RPL10: PPH19107A

    REFSEQ mRNAs for RPL10 gene: 

    NM_006013.3  

    Additional cDNA sequence: 

    AB019572.1 AF486812.1 AK130582.1 AK223309.1 AK307511.1 AY927536.1 AY927570.1 AY927623.1 
    AY927624.1 BC003358.1 BC018570.1 BC026276.1 BC071918.1 BC095425.1 BX647954.1 CR456797.1 
    CR542069.1 CR593302.1 CR596152.1 CR596460.1 CR598560.1 CR602212.1 CR603980.1 CR609074.1 
    CR610011.1 CR610716.1 CR612141.1 CR613467.1 CR614058.1 CR614538.1 CR617177.1 CR621751.1 
    CR622051.1 CR623994.1 M64241.1 M73791.1 NR_000011.1 S35960.1 X87196.1 Y11164.1 

    24/174 DOTS entries (see all 174):

    DT.100846681  DT.121294714  DT.95325374  DT.100739701  DT.95202193  DT.85103592  DT.92071022  DT.100056570 
    DT.91865037  DT.121449274  DT.100739666  DT.92071218  DT.91807241  DT.91840444  DT.92412815  DT.121449218 
    DT.102841538  DT.91965656  DT.100060476  DT.100739687  DT.121294698  DT.100739670  DT.92070886  DT.101977215 

    24/2625 AceView cDNA sequences (see all 2625):

    BQ278906 BE140517 BE297546 BI856103 BM818420 BM854687 BQ953212 BM767526 
    BM142669 BQ707270 BM559363 BQ685921 BM014368 AI753626 BM761570 BM667069 
    BE256825 BM916382 F26550 BF726801 BM850060 BU184562 BE261333 BQ230748 

    highest scoring ESTs for RPL10:

    M64241 AA244252 AA285096 AA321593 AA327380 AA328304 AA333380 AA339458 AA342954 AA359521 

    Unigene Cluster for RPL10:

    Ribosomal protein L10
    Hs.534404  [show with all ESTs]
    Unigene Representative Sequence: NM_006013


    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RPL10 (see all 12)

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8a · 8b · 8c
    SP1:                                            -                                                                                 
    SP2:                                            -                             -     -     -     -                                 
    SP3:                                            -                             -     -     -     -     -     -                     
    SP4:                                            -                             -     -     -     -                                 
    SP5:                                            -                                                                                 

    About this scheme

    ECgene alternative splicing isoforms for RPL10
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000424325 ENST00000344746(uc004fkm.2 uc004fko.2 uc004fkn.1)
    ENST00000451365(uc004fkq.1 uc004fkr.1) ENST00000467168 ENST00000406022
    ENST00000482732 ENST00000489200(uc010nux.1 uc004fkp.1) ENST00000474786
    ENST00000449494 ENST00000427682 ENST00000491035 ENST00000428169 ENST00000485196
    ENST00000436473 ENST00000369817 ENST00000492572 ENST00000479366 ENST00000458500


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RPL10 expression in normal and diseased human tissues

    1  / 2  / 3

    9 probe-sets matching RPL10 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    2016_s_at2, 3 U95-A 8 1.00 0.65 0.79 1.50 M64241 1.00 0.67 0.85 1
    91064_s_at2, 3 U95-E 1 0.88 1.00 0.55 0.65 AW005660 0.40 0.40 0.40 2
    47953_at2, 3 U95-B 1 0.69 1.00 0.85 0.86 AI097271 0.80 0.88 0.84 1
    200724_at2, 3 U133-A 1 1.00 1.00 -- -- BC003358 0.80 0.75 0.78 1
    200725_x_at2, 3 U133-A 7 1.00 0.76 -- -- NM_006013 0.60 0.83 0.73 1
    221989_at2, 3 U133-A 2 0.82 0.94 -- -- AW057781 0.80 0.75 0.78 1
    200724_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    200725_x_at2 U133Plus2 7 1.00 0.76 -- -- -- -- -- -- --
    221989_at2 U133Plus2 2 0.82 0.94 -- -- -- -- -- -- --
    About this table

    RPL10 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RPL10 gene expression
    RPL10 gene electronic northern expression
    RPL10 gene sage expression
    About these images

    CGAP SAGE TAG: AGGGCTTCCA

    SOURCE GeneReport for Unigene cluster: Hs.534404

    Expression variation in blood from EXPOLDB for RPL10

    Primers: OriGene genome-wide validated SYBR primer pairs: RPL10
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RPL10: PPH19107A
        SABiosciences Custom PCR Arrays for RPL10 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for RPL10 gene from 5/14 species (see all 14)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RPL101   -- ribosomal protein L10 91.28(n)
    99.53(a)
    481085  XM_862548.1  XP_867641.1 
    chimpanzee
    (Pan troglodytes)
    RPL101   -- ribosomal protein L10 98.75(n)
    96.73(a)
    465944  XM_521341.2  XP_521341.2 
    rat
    (Rattus norvegicus)
    Rpl101   -- ribosomal protein L10 89.72(n)
    99.53(a)
    81764  NM_031100.1  NP_112362.1 
    mouse
    (Mus musculus)
    Rpl105 X (37.94 cM) ribosomal protein 10   -- X75312 
    zebrafish
    (Danio rerio)
    wufa93d032   -- wufa93d03 83.25(n) 336712  BC045950.1 
    About this table        Species with no ortholog for RPL10

    ENSEMBL Gene Tree for RPL10 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for RPL10 gene
    ENSG000002352102  RPL10L2  

    RPL10 for paralogs           About GeneDecksing


    Pseudogenes
    9 related pseudogenes



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/42 NCBI SNPs in RPL10 are shown (see all 42)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs115931,2
    C,F,O,153627145(-) GTATCT/GAGCGC 1 -- int15Minor allele frequency- G:0.30MN EA NS WA 484
    rs9159411,2
    C,F,O,A,153626649(+) CTTCGA/CCAGGA 1 -- ut51 ese312Minor allele frequency- C:0.21NA EA MN NS 1208
    rs9159421,2
    C,F,O,A,153626738(+) GTGGTG/AAGTAA 1 -- int1 ese314Minor allele frequency- A:0.14NA EA MN NS WA 1181
    rs9159431,2
    C,F,A,153627496(+) GTGTTG/CTCTGT 1 -- int116Minor allele frequency- C:0.40NA EA MN NS WA 1309
    rs18042611,2
    --153628248(+) TCCGCA/GTCAAC 2 I V ref1 mis10--------
    rs20708201,2
    C,F,H153626892(+) AGTCTT/AGAATC 1 -- int14Minor allele frequency- A:0.01NS EA 418
    rs20708211,2
    C,F,A,153627297(+) CGGCTT/CGGAGG 1 -- int15Minor allele frequency- C:0.27NS EA WA 420
    rs32111221,2
    --153628832(+) GCCTTG/TGGAAA 2 L F mis1 ref10--------
    rs38134571,2
    C,F153626441(-) TTGCCC/TTAGGC 1 -- ng514Minor allele frequency- T:0.00NS EA 418
    rs66552871,2
    A153624869(+) GCCACA/GGCGCC 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for RPL10 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RPL10
         2 Inversions: 0674 37365

    QIAGEN SeqTarget long-range PCR primers for resequencing RPL10 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPL10 for disorders           About GeneDecksing

    OMIM: 312173

    UniProtKB/Swiss-Prot: RL10_HUMAN, P27635
  • Note=Two hypomorphic variants with respect to the regulation of the translation process have been found in
  • families affected by autism spectrum disorders, suggesting that aberrant processes of ribosome biosynthesis and
    translation may play a role in disease mechanisms

    2 Novoseek disease relationships for RPL10 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilms tumor 48.5 1 8789260 (1)
    tumors 0 5 12138090 (2), 19307926 (1)
    About this table

    Locus Specific Mutation Databases (LSDB): RPL10
    Human Gene Mutation Database (HGMD): RPL10
    Human Genome Epidemiology (HuGE) Navigator: RPL10 (4 documents)

    Export disorders and mutations for RPL10 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/53 PubMed articles for RPL10 gene, integrated from 7 sources (see all 53):
    (articles sorted by number of sources associating them with RPL10)
    1. A map of 75 human ribosomal protein genes. (PubMed id 9582194)1, 2, 3 Kenmochi N.... Page D.C. (1998)
    2. QM, a putative tumor suppressor, regulates proto-oncogene c-Yes. (PubMed id 12138090)1, 2, 7 Oh H.S.... Yang C.-H. (2002)
    3. Crystal structure of human ribosomal protein L10 core domain reveals eukaryote-specific motifs in addition to the conserved fold. (PubMed id 18258260)1, 2, 7 Nishimura M....Kobayashi Y. (2008)
    4. Mutations in the ribosomal protein gene RPL10 suggest a novel modulating disease mechanism for autism. (PubMed id 16940977)1, 2 Klauck S.M.... Poustka A. (2006)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing. (PubMed id 12962325)1, 2 Odintsova T.I....Karpova G.G. (2003)
    8. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)1, 2 Chen E.Y....D'Urso M. (1996)
    9. Identification and characterization of a new gene in the human Xq28 region. (PubMed id 1303197)1, 2 van den Ouweland A.M.W.... van Oost B.A. (1992)
    10. cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene. (PubMed id 1534224)1, 2 Bignon C.... Martin P.M. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6134 HGNC: 10298 AceView: RPL10 Ensembl:ENSG00000147403 euGenes: HUgn6134
    ECgene: RPL10 Kegg: 6134 H-InvDB: RPL10

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for RPL10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for RPL10 gene:
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