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RPN1 Gene

protein-coding   GIFtS: 64

GC03M125722
ribophorin I
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ribophorin I1 2 3     RBPH12
OST11 2     dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit2 3     OTTHUMP000002165752
RPN-I2 3     DKFZp686B161772
oligosaccharyltransferase 1 homolog2     EC 2.4.1.1193
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 12     Ribophorin-13
ribophorin-12     

External Ids:    HGNC: 103811   Entrez Gene: 61842   Ensembl: ENSG000001639027   UniProtKB: P048433   

Export aliases for RPN1 gene to outside databases

Previous GC identifers: GC03M125171 GC03M128535 GC03M129620 GC03M129659 GC03M129821 GC03M128338


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RPN1:
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein
is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues
found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory
subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. (provided by
RefSeq)

UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843
Function: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose
oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus
motif in nascent polypeptide chains

Gene Wiki entry for RPN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RPN1 gene promoter:
         RFX1   AREB6   NF-Y   PPAR-gamma1   PPAR-gamma2   YY1   Pax-6   XBP-1   MIF-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for RPN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RPN1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

RPN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RPN1 gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M125722:  view genomic region     (about GC identifiers)

Start:
125,722,987 bp from pter
End:
125,753,880 bp from pter
Size:
30,894 bases
Orientation:
minus strand

1 alternative location:
Chr3- 128,338,817-128,399,918     
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor  
Size: 607 amino acids; 68569 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain
at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the
Sec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified
by mass spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: B2R5Z0 Q68DT1

Explore the universe of human proteins at neXtProt for RPN1: NX_P04843 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002941.1  

    ENSEMBL proteins: 
    ENSP00000419384 ENSP00000417529 ENSP00000296255 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RPN1
    OriGene Protein Over-expression Lysate: RPN1
    GenScript Custom Purified and Recombinant Proteins Services for RPN1 
    Novus Biologicals Proteins for RPN1
    Novus Biologicals Lysate for RPN1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane TAS--
    GO:0008250 oligosaccharyltransferase complex TAS15835887
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    RPN1 for ontologies           About GeneDecksing



    Antibodies for RPN1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for RPN1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for RPN1 
    Novus Biologicals Antibodies for RPN1
    Epitomics antibodies for RPN1

    Assays for RPN1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RPN1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RPN1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RPN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007676 Ribophorin_I

    Graphical View of Domain Structure for InterPro Entry P04843

    ProtoNet protein and cluster: P04843

    1 Blocks protein family: IPB007676 Ribophorin I

    UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843
    Similarity: Belongs to the OST1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843
    Function: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannose
    oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus
    motif in nascent polypeptide chains
    Catalytic activity: Dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein
    with the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagine
    Enzyme Number (IUBMB): EC 2.4.1.119 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RPN1
    Sigma-Aldrich shRNA for RPN1
    OriGene 29mer shRNA kits in GFP-retroviral vector: RPN1
    OriGene shRNA RFP: RPN1
    OriGene basic RS shRNA: RPN1
    OriGene siRNA: RPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RPN1 
    miRNA:Sigma-Aldrich microRNA Mimics for RPN1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RPN1 
    Search SABiosciences for Assays for microRNAs that regulate RPN1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: RPN1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RPN1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RPN1
    OriGene 3'-UTR clone: RPN1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: RPN1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for RPN1 

    Genatlas biochemistry entry for RPN1:
    ribophorin I,68.6kDa,component with RPN2 and DDOST,of N-oligosaccharyl transferase

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity TAS15835887
    GO:0005515 protein binding IPI19167329
    GO:0016740 transferase activity IEA--
    About this table

    RPN1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    RPN1 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  RPN1
        N-Glycan Biosynthesis

    3 Kegg Pathways  (Kegg details for RPN1):
        hsa00510 N-Glycan biosynthesis
    hsa01100 Metabolic pathways
    hsa04141 Protein processing in endoplasmic reticulum

        SABiosciences Pathway-Focused PCR Array including RPN1: PAHS-089A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RPN1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPN1

    5/44 Interacting proteins for RPN1 (ENSP000002962553 P048431, 2) via UniProtKB, MINT, and/or STRING (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STT3BQ8TCJ21STRING: ENSP00000295770 EBI-355963,EBI-2256290
    GSTK1Q9Y2Q31EBI-355963,EBI-1053767
    IKBKGQ9Y6K92MINT-48176
    KIAA0087Q146952MINT-63382
    RBBP4Q090282MINT-63379
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464 protein modification process TAS10660554
    GO:0006486 protein glycosylation IEA--
    GO:0018279 protein N-linked glycosylation via asparagine TAS15835887
    GO:0043687 post-translational protein modification TAS--
    GO:0044267 cellular protein metabolic process TAS--
    About this table

    RPN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    RPN1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RPN1
    2 Novoseek chemical compound relationships for RPN1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polysaccharide 23.7 1 12952521 (1)
    sucrose 12.8 1 2269658 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for RPN1
    Sigma-Aldrich shRNA for RPN1
    OriGene 29mer shRNA kits in GFP-retroviral vector: RPN1
    OriGene shRNA RFP: RPN1
    OriGene basic RS shRNA: RPN1
    OriGene siRNA: RPN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of RPN1 
    miRNA: Sigma-Aldrich microRNA Mimics for RPN1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of RPN1 
    Search SABiosciences for Assays for microRNAs that regulate RPN1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: RPN1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: RPN1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): RPN1
    OriGene 3'-UTR Clone: RPN1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: RPN1 
    Primers: OriGene genome-wide validated SYBR primer pairs: RPN1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RPN1: PPH07134A

    REFSEQ mRNAs for RPN1 gene: 

    NM_002950.3  

    Additional cDNA sequence: 

    AK223595.1 AK296905.1 AK297513.1 AK297941.1 AK312369.1 BC007995.1 BC010839.1 CR456742.1 
    CR621594.1 CR749284.1 

    24/41 DOTS entries (see all 41):

    DT.449068  DT.95203947  DT.95286299  DT.100880105  DT.120916820  DT.95286274  DT.100880104  DT.100694218 
    DT.70100524  DT.100880110  DT.100880115  DT.120916772  DT.100880109  DT.100880112  DT.100880118  DT.120916731 
    DT.120916749  DT.120916804  DT.120916809  DT.92454498  DT.95286283  DT.100762481  DT.100805039  DT.100844170 

    24/699 AceView cDNA sequences (see all 699):

    BM468552 AI028172 CR621594 BP356594 BM711652 BG819105 BP358169 BE264866 
    BI335752 BG675724 BU951101 BU178287 BQ218994 AU134320 BQ227682 BQ218033 
    BM830994 AU076622 AA375747 BF791412 AI253541 BM848306 BM761300 BM551350 

    highest scoring ESTs for RPN1:

    AL541902 AL709315 AL710341 AU120261 AU121003 AU121699 AU122177 AU122605 AU124702 AU127860 

    Unigene Cluster for RPN1:

    Ribophorin I
    Hs.518244  [show with all ESTs]
    Unigene Representative Sequence: NM_002950


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RPN1 (see all 11)

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
    SP1:                    -           -     -     -                                                           -                       -                     
    SP2:                                                                                                        -                                             
    SP3:                                                                                                                                -                     
    SP4:                    -           -     -     -                 -     -     -     -     -     -           -                                             
    SP5:                    -           -           -                                                                                                         

    About this scheme

    ECgene alternative splicing isoforms for RPN1
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497415 ENST00000476931 ENST00000497289(uc011bkq.1) ENST00000481168
    ENST00000495462 ENST00000479113 ENST00000296255(uc003ekr.1) ENST00000490166


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    RPN1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching RPN1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33424_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Y00281 0.60 1.00 0.82 1
    201011_at2, 3 U133-A 1 0.82 1.00 -- -- NM_002950 0.60 1.00 0.82 1
    201011_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    RPN1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    RPN1 gene expression
    RPN1 gene electronic northern expression
    RPN1 gene sage expression
    About these images

    CGAP SAGE TAG: GAGGCCAGTG

    SOURCE GeneReport for Unigene cluster: Hs.518244

    Expression variation in blood from EXPOLDB for RPN1

    UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843
    Tissue specificity: Expressed in all tissues tested

    Primers: OriGene genome-wide validated SYBR primer pairs: RPN1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for RPN1: PPH07134A
        SABiosciences Expression via Pathway-Focused PCR Array including RPN1: PAHS-089A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for RPN1 gene from 5/16 species (see all 16)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RPN11   -- ribophorin I 91.93(n)
    96.21(a)
    476516  XM_843737.1  XP_848830.1 
    chimpanzee
    (Pan troglodytes)
    RPN11   -- ribophorin I 99.73(n)
    99.51(a)
    460673  XM_001139195.1  XP_001139195.1 
    cow
    (Bos taurus)
    RPN11   -- ribophorin I 86.33(n)
    93.9(a)
    507939  XM_584638.3  XP_584638.3 
    rat
    (Rattus norvegicus)
    Rpn11   -- ribophorin I 88.04(n)
    94.55(a)
    25596  NM_013067.1  NP_037199.1 
    mouse
    (Mus musculus)
    Rpn11 , 5 6 (39.13 cM)5
    ribophorin I1, 5 87.86(n)1
    95.06(a)1
    1039631  NM_133933.31  NP_598694.21 
     AA4069985  AI8467085  (see all 29)
    About this table        Species with no ortholog for RPN1

    ENSEMBL Gene Tree for RPN1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/380 NCBI SNPs in RPN1 are shown (see all 380)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs16971,2
    C,F,A,128356852(-) CATCCA/GTATCC 2 P syn1 ref19Minor allele frequency- G:0.34MN NA EA WA 434
    rs145601,2
    --128339227(-) GGGCCC/TAGGGT 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs11268281,2
    C,F,A,128344786(-) CTGGAC/TACATT 2 D ref1 syn1 ese310Minor allele frequency- T:0.25MN NS EA NA WA 826
    rs11268291,2
    --128344415(-) TCACCG/TTTATC 2 V F ref1 mis11Minor allele frequency- T:0.00MN 184
    rs11270201,2
    C,128339056(-) TTTTTA/TAAAAA 1 -- ut311Minor allele frequency- T:0.01EA 88
    rs11270301,2
    C,F,A,H,128338953(-) GTCTAG/AGATAT 1 -- ut319Minor allele frequency- A:0.40MN NA EA WA 408
    rs11270331,2
    --128338906(-) TAATTC/TTGATG 1 -- ut310--------
    rs20028491,2
    C,A128364609(+) gagccA/Gagatt 1 -- int13Minor allele frequency- G:0.17NA 6
    rs23352361,2
    C,F,A,H128341718(-) ctgtcA/Gcccag 1 -- int15Minor allele frequency- G:0.33NA WA 12
    rs27123711,2
    C,F,A,H,128346214(-) CTGTGT/CGGTTT 1 -- int110Minor allele frequency- C:0.34NS NA EA WA 482
    About this table

    HapMap Linkage Disequilibrium images for RPN1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for RPN1
         3 CNVs: 7360 3447 37562

    QIAGEN SeqTarget long-range PCR primers for resequencing RPN1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RPN1 for disorders           About GeneDecksing

    OMIM: 180470

    Human Genome Epidemiology (HuGE) Navigator: RPN1 (3 documents)

    Export disorders and mutations for RPN1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/57 PubMed articles for RPN1 gene, integrated from 7 sources (see all 57):
    (articles sorted by number of sources associating them with RPN1)
    1. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    2. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
    5. Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
    6. Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. (PubMed id 3034581)1, 2 Crimaudo C.... Meyer D.I. (1987)
    7. Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core. (PubMed id 18607003)1, 7 Wilson C.M....High S. (2008)
    8. Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. (PubMed id 10660554)1, 7 Fu J. and Kreibich G. (2000)
    9. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. (PubMed id 9307271)1, 7 Pekarsky Y.... Gardiner K. (1997)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6184 HGNC: 10381 AceView: RPN1 Ensembl:ENSG00000163902 euGenes: HUgn6184
    ECgene: RPN1 Kegg: 6184 H-InvDB: RPN1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    ATLAS Chromosomes in Cancer entry for RPN1 Genetics and Cytogenetics in Oncology and Haematology

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