Aliases &
Descriptions
for RPN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ribophorin I1 2 3 | | RBPH12 | | OST11 2 | | dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit2 | | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit2 3 | | OTTHUMP000002165752 | | RPN-I2 3 | | DKFZp686B161772 | | oligosaccharyltransferase 1 homolog2 | | EC 2.4.1.1193 | | dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 12 | | Ribophorin-13 | | ribophorin-12 | | |
Export aliases for RPN1 gene to outside databasesPrevious GC identifers: GC03M125171 GC03M128535 GC03M129620 GC03M129659 GC03M129821 GC03M128338 |
Summaries
for RPN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPN1:
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded proteinis part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residuesfound in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatorysubunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. (provided byRefSeq)
UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843Function: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensusmotif in nascent polypeptide chains
Gene Wiki entry for RPN1 |
Genomic Views
for RPN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPN1 gene promoter:
RFX1 AREB6 NF-Y PPAR-gamma1 PPAR-gamma2 YY1 Pax-6 XBP-1 MIF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPN1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for RPN1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3RPN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M125722: view genomic region
(about GC identifiers)
Start:
|
125,722,987 bp from pter |
End:
|
125,753,880 bp from pter |
Size:
|
30,894 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr3- 128,338,817-128,399,918 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for RPN1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843 (See
protein sequence)Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor Size: 607 amino acids; 68569 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which containat least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with theSec61 complex or with both the Sec61 and TRAP complexes
Subcellular location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identifiedby mass spectrometry in melanosome fractions from stage I to stage IV
Secondary accessions: B2R5Z0 Q68DT1Explore the universe of human proteins at neXtProt for RPN1: NX_P04843
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002941.1
ENSEMBL proteins: ENSP00000419384 ENSP00000417529 ENSP00000296255
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
RPN1 for ontologies About GeneDecksing
Antibodies for RPN1:
Assays for RPN1: |
Protein
Domains/
Families
for RPN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P04843ProtoNet protein and cluster: P04843 1 Blocks protein family: IPB007676 Ribophorin I
UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843Similarity: Belongs to the OST1 family |
Gene Function
for RPN1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843Function: Essential subunit of N-oligosaccharyl transferase enzyme which catalyzes the transfer of a high mannoseoligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensusmotif in nascent polypeptide chainsCatalytic activity: Dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoproteinwith the oligosaccharide chain attached by N-glycosyl linkage to protein L-asparagineEnzyme Number (IUBMB): EC 2.4.1.119
Genatlas biochemistry entry for RPN1:ribophorin I,68.6kDa,component with RPN2 and DDOST,of N-oligosaccharyl transferase3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
RPN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for RPN1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
RPN1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for RPN1
3  Kegg Pathways (Kegg details for RPN1):
SABiosciences Pathway-Focused PCR Array including RPN1: PAHS-089A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for RPN1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RPN1
5/44 Interacting proteins for RPN1 (ENSP000002962553 P048431, 2) via UniProtKB, MINT, and/or STRING (see all 44)About this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
RPN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
RPN1 for compounds About GeneDecksing
 Browse Tocris compounds for RPN1
2  Novoseek chemical compound relationships for RPN1 gene
About this table
|
Transcripts
for RPN1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RPN1 gene: NM_002950.3 Additional cDNA sequence: AK223595.1 AK296905.1 AK297513.1 AK297941.1 AK312369.1 BC007995.1 BC010839.1 CR456742.1 CR621594.1 CR749284.1 24/41 DOTS entries (see all 41): DT.449068 DT.95203947 DT.95286299 DT.100880105 DT.120916820 DT.95286274 DT.100880104 DT.100694218 DT.70100524 DT.100880110 DT.100880115 DT.120916772 DT.100880109 DT.100880112 DT.100880118 DT.120916731 DT.120916749 DT.120916804 DT.120916809 DT.92454498 DT.95286283 DT.100762481 DT.100805039 DT.100844170 24/699 AceView cDNA sequences (see all 699): BM468552 AI028172 CR621594 BP356594 BM711652 BG819105 BP358169 BE264866 BI335752 BG675724 BU951101 BU178287 BQ218994 AU134320 BQ227682 BQ218033 BM830994 AU076622 AA375747 BF791412 AI253541 BM848306 BM761300 BM551350
 highest scoring ESTs for RPN1:AL541902 AL709315 AL710341 AU120261 AU121003 AU121699 AU122177 AU122605 AU124702 AU127860 Unigene Cluster for RPN1: Ribophorin I Hs.518244 [show with all ESTs]Unigene Representative Sequence: NM_002950
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RPN1 (see all 11)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | - | | - | | | | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for RPN1
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000497415 ENST00000476931 ENST00000497289(uc011bkq.1) ENST00000481168
ENST00000495462 ENST00000479113 ENST00000296255(uc003ekr.1) ENST00000490166
|
Expression
for RPN1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RPN1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching RPN1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33424_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
Y00281 |
0.60 |
1.00 |
0.82 |
1 |
| 201011_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_002950 |
0.60 |
1.00 |
0.82 |
1 |
| 201011_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RPN1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGGCCAGTG
SOURCE GeneReport for Unigene cluster: Hs.518244
Expression variation in blood from EXPOLDB for RPN1 UniProtKB/Swiss-Prot: RPN1_HUMAN, P04843Tissue specificity: Expressed in all tissues tested
SABiosciences Expression via Pathway-Focused PCR Array including RPN1: PAHS-089A
|
Orthologs
for RPN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RPN1 gene from 5/16 species (see all 16)
About this table Species with no ortholog for RPN1
ENSEMBL Gene Tree for RPN1 (if available) |
Paralogs
for RPN1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for RPN1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RPN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for RPN1
3 CNVs: 7360 3447 37562 | | QIAGEN SeqTarget long-range PCR primers for resequencing RPN1 |
|
Disorders & Mutations
for RPN1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPN1 for disorders About GeneDecksing
OMIM: 180470
Human Genome Epidemiology (HuGE) Navigator: RPN1 (3 documents)
Export disorders and mutations for RPN1 gene to outside databases
|
Medical News
for RPN1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RPN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/57 PubMed articles for RPN1 gene, integrated from 7 sources (see all 57):
(articles sorted by number of sources associating them with RPN1)- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
- Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 2 Shibatani T.... Skach W.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
- Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. (PubMed id 12643545)1, 2 Basrur V.... Appella E. (2003)
- Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. (PubMed id 3034581)1, 2 Crimaudo C.... Meyer D.I. (1987)
- Ribophorin I regulates substrate delivery to the oligosaccharyltransferase core. (PubMed id 18607003)1, 7 Wilson C.M....High S. (2008)
- Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. (PubMed id 10660554)1, 7 Fu J. and Kreibich G. (2000)
- Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. (PubMed id 9307271)1, 7 Pekarsky Y.... Gardiner K. (1997)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
|
External Searches for RPN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RPN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPN1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RPN1 gene:
Search GeneIP for patents involving RPN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPN1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for RPN1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RPN1 |
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