Aliases &
Descriptions
for RPS17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ribosomal protein S171 2 | | RPS17L11 2 5 | | RPS17L21 2 5 | | MGC720071 2 | | DBA42 5 | | 40S ribosomal protein S172 |
Export aliases for RPS17 gene to outside databasesPrevious GC identifers: GC15M079008 GC15M076138 GC15M080395 GC15M080536 GC15M080608 GC15M082821 |
Summaries
for RPS17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RPS17:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This geneencodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family ofribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there aremultiple processed pseudogenes of this gene dispersed through the genome. (provided by RefSeq)
Gene Wiki entry for RPS17 |
Genomic Views
for RPS17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RPS17 gene promoter:
LUN-1 FOXO1a RREB-1 Nkx2-2 Pax-6 LCR-F1 E2F-1 E2F E2F-5 E2F-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for RPS17
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15qRPS17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M059476: view genomic region
(about GC identifiers)
Start:
|
59,476,061 bp from pter |
End:
|
59,479,765 bp from pter |
Size:
|
3,705 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr15- 82,821,158-82,824,972 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for RPS17 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: RS17_HUMAN, P08708 (See
protein sequence)Recommended Name: 40S ribosomal protein S17 Size: 135 amino acids; 15550 Da
Secondary accessions: B2R4U4Explore the universe of human proteins at neXtProt for RPS17: NX_P08708
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001012.1
ENSEMBL proteins: ENSP00000346045
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
RPS17 for ontologies About GeneDecksing
Antibodies for RPS17:
Assays for RPS17: |
Protein
Domains/
Families
for RPS17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RPS17 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08708ProtoNet protein and cluster: P08708 1 Blocks protein family: IPB001210 Ribosomal protein S17e
UniProtKB/Swiss-Prot: RS17_HUMAN, P08708Similarity: Belongs to the ribosomal protein S17e family |
Gene Function
for RPS17 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
Genatlas biochemistry entry for RPS17:40S ribosomal protein S17,15kDa1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 17647292 |
About this table
RPS17 for ontologies About GeneDecksing
|
Pathways & Interactions
for RPS17 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
RPS17 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for RPS17):
SABiosciences Custom Pathway-Focused PCR Arrays for RPS17
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RPS17
5/14 Interacting proteins for RPS17 (P087082) via UniProtKB, MINT, and/or STRING (see all 14)About this table
5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13): About this table
RPS17 for ontologies About GeneDecksing
|
Drugs & Compounds
for RPS17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for RPS17
|
Transcripts
for RPS17 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for RPS17 gene: NM_001021.3 Additional cDNA sequence: AK311951.1 BC009407.2 BC019899.1 BC020453.1 BC022370.1 BC049824.1 BC062715.1 BC070222.1 BC071928.1 CR595559.1 CR602312.1 CR609691.1 CR612555.1 CR615408.1 CR616208.1 CR618328.1 CR618357.1 CR620738.1 M13932.1 24/69 DOTS entries (see all 69): DT.95231387 DT.95378808 DT.98081977 DT.92469637 DT.100060125 DT.100739925 DT.92469644 DT.100638918 DT.92469626 DT.92469622 DT.121021573 DT.100739953 DT.100739968 DT.121021874 DT.100739938 DT.91869254 DT.100876268 DT.91651851 DT.100868623 DT.95252543 DT.121022024 DT.100739912 DT.121021789 DT.100739963 24/2925 AceView cDNA sequences (see all 2925): BQ961732 BE277510 BQ689486 AA100259 BE259635 AW327844 AW197160 BM841531 BQ682440 BE018962 BU845076 BE407190 AI424764 BG291467 AA371531 BQ949434 BM918016 AI818016 CR618357 BQ959691 BG164256 BG754205 BG770424 BM551200
 highest scoring ESTs for RPS17:BG766552 M13932 AA071281 AA094178 AA094742 AA095622 AA147118 AA186422 AA225295 AA228991 Unigene Cluster for RPS17: Ribosomal protein S17 Hs.433427 [show with all ESTs]Unigene Representative Sequence: BM918752
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330339(uc002bhq.1 uc002bhr.1)
|
Expression
for RPS17 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| RPS17 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching RPS17 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 34592_at2, 3
|
U95-A |
7 |
0.94 |
0.57 |
0.99 |
1.00 |
M13932 |
1.00 |
0.77 |
0.89 |
1 |
| 34593_g_at2, 3
|
U95-A |
7 |
0.81 |
0.48 |
0.99 |
1.00 |
M13932 |
1.00 |
0.77 |
0.89 |
1 |
| 201665_x_at2, 3
|
U133-A |
5 |
0.91 |
0.65 |
-- |
-- |
NM_001021 |
0.60 |
0.83 |
0.73 |
1 |
| 211487_x_at2
|
U133-A |
5 |
0.82 |
0.57 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212578_x_at2, 3
|
U133-A |
5 |
0.82 |
0.55 |
-- |
-- |
BF026595 |
0.20 |
0.50 |
0.38 |
1 |
| 201665_x_at2
|
U133Plus2 |
5 |
0.91 |
0.65 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 211487_x_at2
|
U133Plus2 |
5 |
0.82 |
0.57 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212578_x_at2
|
U133Plus2 |
5 |
0.82 |
0.55 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
RPS17 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCCGCGTTC
SOURCE GeneReport for Unigene cluster: Hs.433427
Expression variation in blood from EXPOLDB for RPS17 SABiosciences Custom PCR Arrays for RPS17
|
Orthologs
for RPS17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RPS17 gene from 5/16 species (see all 16)
About this table Species with no ortholog for RPS17
ENSEMBL Gene Tree for RPS17 (if available) |
Paralogs
for RPS17 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for RPS17 gene
- LOC1005055032
RPS17 for paralogs About GeneDecksing
|
Genomic Variants
for RPS17 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for RPS17 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for RPS17
8 CNVs: 0190 30716 3972 72314 72323 2197 7074 0788 |
Disorders & Mutations
for RPS17 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RPS17 for disorders About GeneDecksing
OMIM: 180472 disorders: 612527 UniProtKB/Swiss-Prot: RS17_HUMAN, P08708
Defects in RPS17 are the cause of Diamond-Blackfan anemia type 4 (DBA4) [MIM:612527]. DBA4 is a form ofDiamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy.Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and anincreased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenitalanomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenitalanomaliesGeneTests: RPS17
Diamond-Blackfan Anemia
Locus Specific Mutation Databases (LSDB): RPS17
Human Gene Mutation Database (HGMD): RPS17
Human Genome Epidemiology (HuGE) Navigator: RPS17 (2 documents)
Export disorders and mutations for RPS17 gene to outside databases
|
Medical News
for RPS17 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for RPS17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/31 PubMed articles for RPS17 gene, integrated from 7 sources (see all 31):
(articles sorted by number of sources associating them with RPS17)- [Mapping the genes for ribosomal proteins S14 and S17 on human chromosomes using cDNA from a panel of hybrid cells] (PubMed id 7661859)1, 3, 7 Filipenko M.L....Mertvetsov N.P. (1995)
- Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. (PubMed id 19061985)1, 2 Gazda H.T....Beggs A.H. (2008)
- Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia. (PubMed id 17647292)1, 2 Cmejla R....Pospisilova D. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)1, 2 Vladimirov S.N.... Otto A. (1996)
- The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. (PubMed id 1577483)1, 3 Feo S....Fried M. (1992)
- The transcriptionally active human ribosomal protein S17 gene. (PubMed id 3240863)1, 2 Chen I.-T. and Roufa D.J. (1988)
- Homologous ribosomal proteins in bacteria, yeast, and humans. (PubMed id 3529092)1, 2 Chen I.-T.... Roufa D.J. (1986)
- Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase. (PubMed id 8878544)1, 7 Patel H.R....Gelfand E.W. (1996)
|
External Searches for RPS17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing RPS17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RPS17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RPS17 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| Diamond-Blackfan Anemia mutation database | http://www.dbagenes.unito.it/home.php?select_db=RPS17 |
|
| | |
About This Section
| Patent Information for RPS17 gene:
Search GeneIP for patents involving RPS17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RPS17 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for RPS17 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for RPS17 |
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