Aliases &
Descriptions
for SALL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| sal-like 3 (Drosophila)1 2 | | sal (Drosophila)-like 31 | | ZNF7961 2 3 | | sal-like protein 32 | | Zinc finger protein 7962 3 | | spalt-like zinc finger protein2 | | Zinc finger protein SALL32 3 | | C2H2 zinc finger protein SALL32 | | hSALL32 3 | | |
Export aliases for SALL3 gene to outside databasesPrevious GC identifers: GC18U990052 GC18P076766 GC18P076475 GC18P074839 GC18P074841 |
Summaries
for SALL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9Function: Probable transcription factor
|
Genomic Views
for SALL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SALL3 gene promoter:
CUTL1 oct-B3 POU2F1 POU2F2 Oct-B1 POU2F2 (Oct-2.1) POU2F2B POU2F2C oct-B2 FOXO1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SALL3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SALL3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q23 Ensembl cytogenetic band: 18q23 HGNC cytogenetic band: 18q23SALL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P073383: view genomic region
(about GC identifiers)
Start:
|
73,383,851 bp from pter |
End:
|
73,390,108 bp from pter |
Size:
|
6,258 bases |
Orientation:
|
plus strand |
2 alternative locations:
| Chr18+,PATCHES 76,737,558-76,755,478 | Chr18+ 76,740,275-76,757,397 |
RefSeq DNA sequence:- NC_000018.9 NT_025028.14
|
Proteins
for SALL3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9 (See
protein sequence)Recommended Name: Sal-like protein 3 Size: 1300 amino acids; 135346 Da
Subcellular location: Nucleus (Probable)
Developmental stage: In fetal brain of the 24th gestational week
Secondary accessions: Q9UGH1Alternative splicing: 4 isoforms: Q9BXA9-1 Q9BXA9-2 Q9BXA9-3 Q9BXA9-4 Explore the universe of human proteins at neXtProt for SALL3: NX_Q9BXA9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_741996.2
ENSEMBL proteins: ENSP00000340501 ENSP00000299466
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SALL3 for ontologies About GeneDecksing
Antibodies for SALL3:
Assays for SALL3: |
Protein
Domains/
Families
for SALL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SALL3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BXA9ProtoNet protein and cluster: Q9BXA9 UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9Similarity: Belongs to the sal C2H2-type zinc-finger protein familySimilarity: Contains 9 C2H2-type zinc fingers |
Gene Function
for SALL3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9Function: Probable transcription factor
Genatlas biochemistry entry for SALL3:spalt (sal)-like,Drosophila SAL like gene 3,expressed in fetal brain and in several adult tissues,haploinsufficency inthe 18q deletion syndrome and may be contributing to the phenotype3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
SALL3 for ontologies About GeneDecksing
Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sall3):
SALL3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SALL3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SALL3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SALL3
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0021891 | olfactory bulb interneuron development |
IEA | -- | | GO:0045449 | regulation of transcription |
IEA | -- |
About this table
SALL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for SALL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SALL3
|
Transcripts
for SALL3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SALL3 gene: NM_171999.2 Additional cDNA sequence: BC148296.2 4 DOTS entries: DT.436404 DT.436647 DT.121091407 DT.95290774 24/26 AceView cDNA sequences (see all 26): AI480087 AI871434 AI656975 AI634411 AI637836 AA649850 BF432623 BE220771 BE501147 AW450071 NM_171999 BF739956 AW137217 AI015631 R42871 AI668981 AA429109 AI475090 AW027492 T07317 AI949558 R37086 R21486 H92108
 highest scoring ESTs for SALL3:AI055828 AI564778 AI566552 AI869498 AI871129 AW269333 BE222946 H23192 Z40278 AI480087 Unigene Cluster for SALL3: Sal-like 3 (Drosophila) Hs.700557 [show with all ESTs]Unigene Representative Sequence: NM_171999
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339709(uc010dra.2) ENST00000299466(uc002lmt.2)
|
Expression
for SALL3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SALL3 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching SALL3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 72559_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
0.85 |
0.49 |
AI857524 |
0.40 |
1.00 |
0.76 |
1 |
| 80288_at2, 3
|
U95-E |
1 |
0.81 |
1.00 |
0.84 |
1.52 |
AI871434 |
0.60 |
1.00 |
0.82 |
1 |
| 1553411_s_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SALL3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTTTTCGTGT
SOURCE GeneReport for Unigene cluster: Hs.700557
UniProtKB/Swiss-Prot: SALL3_HUMAN, Q9BXA9Tissue specificity: Widely expressed in adult with highest levels in heart. Expressed in fetal brain (in neurons ofhippocampus, cortex, mediodorsal and ventrolateral thalamic nuclei, putamen, cerebellum and brainstem)
SABiosciences Custom PCR Arrays for SALL3
|
Orthologs
for SALL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SALL3 gene from 5/7 species (see all 7)
About this table Species with no ortholog for SALL3
ENSEMBL Gene Tree for SALL3 (if available) |
Paralogs
for SALL3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SALL3 gene
- ZNF2362 SALL22 SALL42 SALL12
SALL3 for paralogs About GeneDecksing
|
Genomic Variants
for SALL3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 18 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SALL3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SALL3
2 CNVs: 73211 35601 | | QIAGEN SeqTarget long-range PCR primers for resequencing SALL3 |
|
Disorders & Mutations
for SALL3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SALL3 for disorders About GeneDecksing
OMIM: 605079
Human Genome Epidemiology (HuGE) Navigator: SALL3 (1 document)
Export disorders and mutations for SALL3 gene to outside databases
|
Medical News
for SALL3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SALL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for SALL3 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with SALL3)- SALL3, a new member of the human spalt-like gene family, maps to 18q23. (PubMed id 10610715)1, 2, 3 Kohlhase J.... Engel W. (1999)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- Regulation and function of Spalt proteins during anim al development. (PubMed id 19247946)1 de Celis J.F. and Barrio R. (2009)
- SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma. (PubMed id 19139273)1 Shikauchi Y....Yoshikawa H. (2009)
- Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility. (PubMed id 18668548)1 Julia A....Marsal S. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The vertebrate spalt genes in development and disease. (PubMed id 16545361)1 Sweetman D. and Munsterberg A. (2006)
- DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)2 Nusbaum C.... Lander E.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SALL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SALL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SALL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SALL3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SALL3 gene:
Search GeneIP for patents involving SALL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SALL3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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