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SART1 Gene

protein-coding   GIFtS: 59

GC11P062055
squamous cell carcinoma antigen recognized by T cells
(Previous name: squamous cell carcinoma antigen recognised by T cells )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
squamous cell carcinoma antigen recognized by T cells1 2     U4/U6.U5 tri-snRNP-associated 110 kDa protein2 3
Snu661 2     HOMS12 5
SNRNP1101 2     SART1(800) protein2
squamous cell carcinoma antigen recognised by T cells1 2     U4/U6.U5 tri-snRNP-associated protein 12
Ara11 2     small nuclear ribonucleoprotein 110kDa (U4/U6.U5)2
Squamous cell carcinoma antigen recognized by T cells 12 3     IgE autoantigen2
SNU66 homolog2 3     MGC20382
hSnu662 3     SART12592
SART-12 3     SART1(259) protein2
hSART-12 3     Allergen Hom s 13

External Ids:    HGNC: 105381   Entrez Gene: 90922   Ensembl: ENSG000001754677   UniProtKB: O432903   

Export aliases for SART1 gene to outside databases

Previous GC identifers: GC11P068263 GC11P067410 GC11P065979 GC11P065504 GC11P065485 GC11P065730


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SART1:
This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells,
and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the
mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet.
The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have
tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted
cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer
patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259)
protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome
assembly pathway. (provided by RefSeq)

UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
Function: May play a role in mRNA splicing. May also bind to DNA

Gene Wiki entry for SART1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SART1 gene promoter:
         CUTL1   AP-4   E47   Pax-5   AhR   Arnt   GCNF-1   GCNF-2   AP-2rep   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SART1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SART1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

SART1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SART1 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062055:  view genomic region     (about GC identifiers)

Start:
62,055,564 bp from pter
End:
62,073,712 bp from pter
Size:
18,149 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 65,729,160-65,747,607     
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290 (See protein sequence)
Recommended Name: U4/U6.U5 tri-snRNP-associated protein 1  
Size: 800 amino acids; 90255 Da
Subunit: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1,
DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF,
HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1,
PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3,
SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP,
TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Part of a tri-snRNP complex
Subcellular location: Nucleus. Note=Found in the nucleus of mitogen-activated peripheral blood mononuclear cells
(PBMCs), tumor cells, or normal cell lines, but not in normal tissues except testis and fetal liver or in unstimulated
PBMCs, suggesting preferential expression in proliferating cells
Allergen: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE
autoantigen in atopic dermatitis (AD) patients with severe skin manifestations
Secondary accessions: A6NDN1 Q53GB5
Alternative splicing: 1 isoform:  O43290-1   (A number of isoforms may be produced)

Explore the universe of human proteins at neXtProt for SART1: NX_O43290 

Post-translational modifications:

  • Sumoylated by SUMO21
  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005137.1  

    ENSEMBL proteins: 
    ENSP00000310448 ENSP00000402014 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SART1
    GenScript Custom Purified and Recombinant Proteins Services for SART1 
    Novus Biologicals Proteins for SART1
    Novus Biologicals Lysate for SART1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005654 nucleoplasm IDA16687569
    GO:0005681 spliceosomal complex IEA--
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm TAS9856836
    About this table

    SART1 for ontologies           About GeneDecksing



    Antibodies for SART1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SART1
    Browse R&D Systems for Antibodies
    OriGene Antibodies: SART1
    GenScript Custom Superior Antibodies Services for SART1 
    Novus Biologicals Antibodies for SART1
    Epitomics antibodies for SART1

    Assays for SART1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SART1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SART1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SART1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005011 SART_1

    Graphical View of Domain Structure for InterPro Entry O43290

    ProtoNet protein and cluster: O43290

    UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
    Similarity: Belongs to the SNU66/SART1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
    Function: May play a role in mRNA splicing. May also bind to DNA

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SART1
    Sigma-Aldrich shRNA Panels and shRNA for SART1
    OriGene 29mer shRNA kits in GFP-retroviral vector: SART1
    OriGene shRNA RFP: SART1
    OriGene basic RS shRNA: SART1
    OriGene siRNA: SART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SART1 
    miRNA:Sigma-Aldrich microRNA Mimics for SART1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SART1 
    Search SABiosciences for Assays for microRNAs that regulate SART1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SART1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SART1
    OriGene untagged cDNA clones in CMV expression vector: SART1
    OriGene 3'-UTR clone: SART1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SART1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SART1 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    About this table

    SART1 for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Sart1):

    no phenotypic analysis

    SART1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SART1 for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for SART1):
        hsa03040 Spliceosome

        SABiosciences Pathway-Focused PCR Array including SART1: PAHS-3012A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SART1

    5/758 Interacting proteins for SART1 (O432902) via UniProtKB, MINT, and/or STRING (see all 758)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    ACTBP607092MINT-7945693 MINT-7947479
    ACTL6AO960192MINT-7945693 MINT-7947479
    ACTR1AP611632MINT-7945693 MINT-7947479
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387 spliceosomal snRNP assembly TAS16687569
    GO:0006397 mRNA processing IEA--
    GO:0007050 cell cycle arrest NAS16158934
    GO:0008380 RNA splicing IEA--
    GO:0008629 induction of apoptosis by intracellular signals NAS16158934
    About this table

    SART1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SART1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SART1
    1 Novoseek chemical compound relationship for SART1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 31.8 2 9765622 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SART1
    Sigma-Aldrich shRNA Panels and shRNA for SART1
    OriGene 29mer shRNA kits in GFP-retroviral vector: SART1
    OriGene shRNA RFP: SART1
    OriGene basic RS shRNA: SART1
    OriGene siRNA: SART1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SART1 
    miRNA: Sigma-Aldrich microRNA Mimics for SART1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SART1 
    Search SABiosciences for Assays for microRNAs that regulate SART1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SART1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SART1
    OriGene untagged cDNA clones in CMV expression vector: SART1
    OriGene 3'-UTR Clone: SART1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SART1 
    Primers: OriGene genome-wide validated SYBR primer pairs: SART1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SART1: PPH20140A

    REFSEQ mRNAs for SART1 gene: 

    NM_005146.4  

    Additional cDNA sequence: 

    AB006198.1 AF353625.1 AK223016.1 AK293200.1 AK297589.1 AK298184.1 AK309104.1 BC001058.2 
    BC018607.1 BT006637.1 BX648500.1 CR611735.1 CR626621.1 Y14314.1 

    12 DOTS entries:

    DT.444262  DT.95125833  DT.203630  DT.95163945  DT.102831545  DT.100781489  DT.100892166  DT.120694154 
    DT.95163785  DT.97854769  DT.100892145  DT.95253152 

    24/303 AceView cDNA sequences (see all 303):

    BQ879021 BG257275 NM_005146 AA599522 CR626621 BU845294 BQ669005 BC001058 
    BU191480 BU539509 BQ650376 AF353625 C04465 BQ877227 BQ687380 BQ897701 
    BC018607 BU727129 AU122629 BE295074 BU176234 CA422671 BE252565 BE253792 

    highest scoring ESTs for SART1:

    AA424068 AB006198 AA074222 AA150708 AA524379 AA535861 AA599522 AA719206 AA719303 AA738331 

    Unigene Cluster for SART1:

    Squamous cell carcinoma antigen recognized by T cells
    Hs.502883  [show with all ESTs]
    Unigene Representative Sequence: NM_005146


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SART1 (see all 8)

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
    SP1:              -           -           -                                                                                                           -         
    SP2:                                                                                            -                                                               
    SP3:              -           -                                                                                                                                 
    SP4:                                                                                      -     -     -                                                         
    SP5:                          -           -                                                                                                                     

    ExUns: 20a · 20b ^ 21
    SP1:        -         
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  

    About this scheme

    ECgene alternative splicing isoforms for SART1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312397(uc010rot.1 uc001ogl.2) ENST00000417603(uc009yqy.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SART1 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching SART1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33706_at2, 3 U95-A 1 1.00 1.00 0.45 1.27 AB006198 1.00 1.00 1.00 1
    50455_at2, 3 U95-B 1 0.44 1.00 0.68 0.74 AA424068 1.00 1.00 1.00 1
    200051_at2, 3 U133-B 1 1.00 1.00 -- -- NM_005146 0.60 1.00 0.82 1
    200051_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    SART1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SART1 gene expression
    SART1 gene electronic northern expression
    SART1 gene sage expression
    About these images

    CGAP SAGE TAG: AACGCGAACA

    SOURCE GeneReport for Unigene cluster: Hs.502883

    Expression variation in blood from EXPOLDB for SART1

    UniProtKB/Swiss-Prot: SNUT1_HUMAN, O43290
    Tissue specificity: Ubiquitously expressed

    Primers: OriGene genome-wide validated SYBR primer pairs: SART1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SART1: PPH20140A
        SABiosciences Expression via Pathway-Focused PCR Array including SART1: PAHS-3012A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SART1 gene from 5/16 species (see all 16)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SART11   -- squamous cell carcinoma antigen recognized by T cells 89.87(n)
    96.67(a)
    483721  XM_540842.2  XP_540842.2 
    cow
    (Bos taurus)
    SART11   -- squamous cell carcinoma antigen recognized by T cells 90.83(n)
    95.85(a)
    615704  XM_867580.2  XP_872673.2 
    rat
    (Rattus norvegicus)
    Sart11   -- squamous cell carcinoma antigen recognized by T cells 87.36(n)
    95.24(a)
    29678  NM_031596.1  NP_113784.1 
    mouse
    (Mus musculus)
    Sart11 , 5 19 (4.31 cM)5
    squamous cell carcinoma antigen recognized by T-cells more1, 5 88.42(n)1
    95.5(a)1
    202271  NM_016882.31  NP_058578.31 
     AB0147215  AF1053345  (see all 12)
    zebrafish
    (Danio rerio)
    Dr.10882   -- Transcribed sequence with weak similarity to protein more 77.22(n)  57064343 
    About this table        Species with no ortholog for SART1

    ENSEMBL Gene Tree for SART1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/264 NCBI SNPs in SART1 are shown (see all 264)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs4938991,2
    C,65747952(+) AGCCTA/CGGAGG 1 -- ng315Minor allele frequency- C:0.48NA WA 128
    rs5013531,2
    C,F,A,65739549(+) aggggG/Ttacac 1 -- int18Minor allele frequency- T:0.33EA NA WA 390
    rs5423321,2
    C,F,A,65744421(-) CACTGA/GTCACC 1 -- int111Minor allele frequency- G:0.42EA NS NA 1882
    rs5439521,2
    C,F,A,65744275(-) TGAGCG/ACCCCC 1 -- int17Minor allele frequency- A:0.27NA WA 144
    rs5504351,2
    C,F,A,65732651(+) CTGGCA/GGCTGC 2 A syn1 ref1 ese316Minor allele frequency- G:0.44EA NA MN NS 2410
    rs5521301,2
    C,F,A,65732800(-) GGGGAG/AAAAGT 1 -- int1 trp313Minor allele frequency- A:0.28NS EA NA WA 2132
    rs5566431,2
    C,F,65733289(+) TGGTGG/ACCTTG 1 -- int110Minor allele frequency- A:0.47NS EA NA WA 516
    rs5869211,2
    C,F,A,H,65747701(+) CTAGAG/ACTGCG 1 -- ng3110Minor allele frequency- A:0.21MN NS EA NA WA 724
    rs6227791,2
    C,F,65744247(-) CGGCGC/TGGCCC 1 -- int16Minor allele frequency- T:0.13NS EA WA NA 386
    rs6422931,2
    C,65730217(+) aggagG/Agctat 1 -- int16Minor allele frequency- A:0.49NA WA 130
    About this table

    HapMap Linkage Disequilibrium images for SART1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SART1
         1 Indel: 71343

    QIAGEN SeqTarget long-range PCR primers for resequencing SART1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SART1 for disorders           About GeneDecksing

    OMIM: 605941

    3 Novoseek disease relationships for SART1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 20.2 8 11092984 (1), 10853014 (1), 9765622 (1), 10597192 (1) (see all 7)
    cancer 17.5 4 11092984 (1), 9765622 (1), 11182058 (1)
    carcinoma squamous cell 17.4 1 10929426 (1)
    About this table

    Human Gene Mutation Database (HGMD): SART1
    Human Genome Epidemiology (HuGE) Navigator: SART1 (2 documents)

    Export disorders and mutations for SART1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/47 PubMed articles for SART1 gene, integrated from 7 sources (see all 47):
    (articles sorted by number of sources associating them with SART1)
    1. A gene encoding antigenic peptides of human squamous cell carcinoma recognized cytotoxic T lymphocytes. (PubMed id 9449708)1, 2, 3 Shichijo S.... Itoh K. (1998)
    2. Intron loss in the SART1 genes of Fugu rubripes and Tetraodon nigroviridis. (PubMed id 11410364)1, 2, 7 Bolland D.J. and Hewitt J.E. (2001)
    3. A proteomic study of SUMO-2 target proteins. (PubMed id 15175327)1, 2, 7 Vertegaal A.C.O.... Lamond A.I. (2004)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    7. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    8. The 65 and 110 kDa SR-related proteins of the U4/U6*U5 tri-snRNP are essential for the assembly of mature spliceosomes. (PubMed id 11350945)1, 2 Makarova O.V.... Luehrmann R. (2001)
    9. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. (PubMed id 9856836)1, 2 Valenta R....Stingl G. (1998)
    10. Expression of the SART1 tumor rejection antigen in renal cell carcinoma. (PubMed id 10929426)1, 7 Shintaku I....Itoh K. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9092 HGNC: 10538 AceView: SART1 Ensembl:ENSG00000175467 euGenes: HUgn9092
    ECgene: SART1 Kegg: 9092 H-InvDB: SART1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for SART1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for SART1 gene:
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