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SATB1 Gene

protein-coding   GIFtS: 59

GC03M018364
SATB homeobox 1
(Previous name: special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
SATB homeobox 11 2
Special AT-rich sequence-binding protein 12 3
special AT-rich sequence binding protein 1 (binds to nuclear
matrix/scaffold-associating DNA's)1
DNA-binding protein SATB12
OTTHUMP000002076892

External Ids:    HGNC: 105411   Entrez Gene: 63042   Ensembl: ENSG000001825687   UniProtKB: Q018263   

Export aliases for SATB1 gene to outside databases

Previous GC identifers: GC03U990069 GC03M018050 GC03M018264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SATB1:
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear
architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene
expression. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq)

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs
during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus
SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the
sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene
expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs)
of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes
(e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters
and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.
Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid
differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the
unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin
context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome
SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1.
Delineates specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated genes
while downregulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of
breast tumors to promote growth and metastasis

Gene Wiki entry for SATB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SATB1 gene promoter:
         CUTL1   GR-alpha   GR-beta   p300   IRF-1   FOXC1   POU2F1   Pax-6   FOXD1   POU3F2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SATB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SATB1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p23   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.3

SATB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SATB1 gene location

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M018364:  view genomic region     (about GC identifiers)

Start:
18,323,828 bp from pter
End:
18,487,080 bp from pter
Size:
163,253 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826 (See protein sequence)
Recommended Name: DNA-binding protein SATB1  
Size: 763 amino acids; 85957 Da
Subunit: Interacts (via DNA-binding domains) with CUX1; leading to inhibit the attachment to DNA (By similarity).
Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed
at least by SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes
transcription repression. Interacts with PCAF. Interacts with sumoylated PML, HDAC1 and HIV-1 Tat via the PDZ-like
dimerization domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300
Subcellular location: Nucleus matrix. Nucleus, PML body. Note=Organized into a cage-like network anchoring loops of
heterochromatin and tethering specialized DNA sequences. When sumoylated, localized in promyelocytic leukemia nuclear
bodies (PML NBs)
Sequence caution: Sequence=BAD92998.1; Type=Erroneous initiation;
PDB structures from and Proteopedia :
1YSE (3D)    2O49 (3D)    2O4A (3D)    3NZL (3D)    
Secondary accessions: B3KXF1 C9JTR6 Q59EQ0
Alternative splicing: 2 isoforms:  Q01826-1   Q01826-2   

Explore the universe of human proteins at neXtProt for SATB1: NX_Q01826 

Post-translational modifications:

  • Sumoylated. Sumoylation promotes cleavage by caspases1
  • Phosphorylated by PKC. Acetylated by PCAF. Phosphorylated form interacts with HDAC1, but unphosphorylated form
  • interacts with PCAF. DNA binding properties are activated by phosphorylation and inactivated by acetylation. In
    opposition, gene expression is down-regulated by phosphorylation but up-regulated by acetylation1
  • Cleaved at Asp-254 by caspase-3 and caspase-6 during T-cell apoptosis in thymus and during B-cell stimulation. The
  • cleaved forms can not dimerize and lose transcription regulation function because of impaired DNA and chromatin
    association1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001124482.1  NP_001182399.1  NP_002962.1  


    ENSEMBL proteins: 
    ENSP00000333367 ENSP00000341024 ENSP00000399708 ENSP00000394520 ENSP00000390529 ENSP00000399518 
    ENSP00000391344 ENSP00000406727 ENSP00000398072 ENSP00000402982 ENSP00000408871 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SATB1
    OriGene Protein Over-expression Lysate: SATB1
    GenScript Custom Purified and Recombinant Proteins Services for SATB1 
    Novus Biologicals Lysate for SATB1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785 chromatin IEA--
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm EXP11463840
    GO:0005720 nuclear heterochromatin IEA--
    GO:0016363 nuclear matrix IEA--
    About this table

    SATB1 for ontologies           About GeneDecksing



    Antibodies for SATB1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SATB1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for SATB1 
    OriGene Antibodies (see all 9): SATB1
    GenScript Custom Superior Antibodies Services for SATB1 
    Novus Biologicals Antibodies for SATB1
    Epitomics antibodies for SATB1

    Assays for SATB1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SATB1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SATB1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SATB1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR010982 Lambda_DNA-bd
     IPR012287 Homeodomain-rel
     IPR003350 Hmoeo_CUT
     IPR001356 Homeobox
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q01826

    ProtoNet protein and cluster: Q01826

    1 Blocks protein family: IPB003350 Homeodomain protein CUT

    UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
    Similarity: Belongs to the CUT homeobox family
    Similarity: Contains 2 CUT DNA-binding domains
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
    Function: Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs
    during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus
    SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the
    sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene
    expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs)
    of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes
    (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters
    and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.
    Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid
    differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the
    unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin
    context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome
    SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1.
    Delineates specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated genes
    while downregulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of
    breast tumors to promote growth and metastasis

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SATB1
    Sigma-Aldrich shRNA for SATB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SATB1
    OriGene shRNA RFP (see all 2): SATB1
    OriGene basic RS shRNA (see all 2): SATB1
    OriGene siRNA (see all 2): SATB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SATB1 
    miRNA:Sigma-Aldrich microRNA Mimics for SATB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SATB1 
    8/21 SABiosciences Assays for microRNAs that regulate SATB1 (see all 21):
    hsa-miR-448 hsa-miR-495 hsa-miR-944 hsa-miR-508-3p hsa-miR-483-3p hsa-miR-501-5p hsa-miR-23a hsa-miR-1283

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SATB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SATB1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SATB1
    OriGene 3'-UTR clone (see all 2): SATB1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SATB1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SATB1 

    Genatlas biochemistry entry for SATB1:
    special A-T rich binding protein 1,binding selectively to nuclear matrix/scaffold associated regions of DNA,i.e.
    MARbeta,upstream of the T cell receptor beta gene,with five or more CAG repeats

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding ----
    GO:0003690 double-stranded DNA binding TAS1505028
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0016564 transcription repressor activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    SATB1 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Satb1):

    behavior/neurologicalgrowth/sizehematopoietic systemimmune systemlethality-postnatal
    vision/eye

    SATB1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for SATB1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SATB1

    2 Interacting proteins for SATB1 (Q018262 ENSP000003333673) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP6ENSP000002651643STRING: ENSP00000265164
    --Q7KZS02MINT-66384
    About this table

    5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP15851481
    GO:0006325 chromatin organization TAS1505028
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006915 apoptosis TAS--
    GO:0006921 cellular component disassembly involved in apoptosis TAS--
    About this table

    SATB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SATB1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SATB1
    Sigma-Aldrich shRNA for SATB1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SATB1
    OriGene shRNA RFP (see all 2): SATB1
    OriGene basic RS shRNA (see all 2): SATB1
    OriGene siRNA (see all 2): SATB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SATB1 
    miRNA: Sigma-Aldrich microRNA Mimics for SATB1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SATB1 
    8/21 SABiosciences Assays for microRNAs that regulate SATB1 (see all 21):
    hsa-miR-448 hsa-miR-495 hsa-miR-944 hsa-miR-508-3p hsa-miR-483-3p hsa-miR-501-5p hsa-miR-23a hsa-miR-1283
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SATB1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SATB1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SATB1
    OriGene 3'-UTR Clone (see all 2): SATB1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SATB1 
    Primers: OriGene genome-wide validated SYBR primer pairs: SATB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SATB1: PPH19752A

    REFSEQ mRNAs for SATB1 gene (3 alternative transcripts): 

    NM_001131010.2  NM_001195470.1  NM_002971.4  

    Additional cDNA sequence: 

    AB209761.1 AK127242.1 BC001744.1 BX648762.1 M97287.1 U92993.1 

    17 DOTS entries:

    DT.99977308  DT.95241924  DT.317164  DT.120849565  DT.100817927  DT.100817924  DT.40115556  DT.100817922 
    DT.120849544  DT.91752834  DT.100817925  DT.120849542  DT.120849547  DT.120849622  DT.95200698  DT.95241927 
    DT.91760706 

    24/57 AceView cDNA sequences (see all 57):

    AW086483 CK905940 BE222083 BQ272258 BE218845 BE242509 BE696486 AI801288 
    BE773817 AA403100 AI393942 BE773822 BE773765 N71153 BE242198 AI381176 
    BF511877 AA193295 BE773759 AA403099 AA648794 BE773646 AI291575 BE773894 

    highest scoring ESTs for SATB1:

    AA001621 AA193295 AK127242 AU184901 AW837055 BC001744 BE218845 BE222083 BE266904 BI018721 

    Unigene Cluster for SATB1:

    SATB homeobox 1
    Hs.517717  [show with all ESTs]
    Unigene Representative Sequence: NM_001195470


    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SATB1 (see all 15)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13 ^ 14a ·
    SP1:                                                              -     -                 -     -     -     -                                                   
    SP2:                                                              -     -                 -     -     -     -                                                   
    SP3:                    -     -     -     -     -     -     -     -     -                 -     -     -     -                                                   
    SP4:                                                                                                        -                                                   
    SP5:                                      -     -     -     -     -     -                 -     -     -     -                                                   

    ExUns: 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b
    SP1:                                -                     
    SP2:                                -     -               
    SP3:                                -     -               
    SP4:                                                      
    SP5:                                                      

    About this scheme

    ECgene alternative splicing isoforms for SATB1
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000482788 ENST00000332610(uc003cbi.2) ENST00000338745(uc003cbh.2 uc003cbj.2)
    ENST00000476178 ENST00000475083 ENST00000454909 ENST00000450898 ENST00000415069
    ENST00000482122 ENST00000417717 ENST00000444341 ENST00000491519 ENST00000452260
    ENST00000493952 ENST00000457005 ENST00000440737 ENST00000467628 ENST00000487699


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SATB1 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching SATB1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36899_at2, 3 U95-A 1 1.00 1.00 0.93 1.05 M97287 0.60 0.75 0.68 1
    87288_at2, 3 U95-E 1 1.00 1.00 0.82 1.50 AA001621 0.60 1.00 0.82 1
    35667_at2, 3 U95-A 2 0.69 0.67 0.03 0.29 U33920 0.20 0.10 0.16 2
    53365_f_at2 U95-B 1 0.56 1.00 0.98 0.74 -- -- -- -- --
    73870_at2 U95-E 1 0.56 1.00 0.96 1.07 -- -- -- -- --
    46768_r_at2 U95-B 1 0.44 1.00 0.91 0.66 -- -- -- -- --
    203408_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002971 0.20 0.50 0.38 1
    241365_at2 U133-B 1 0.27 1.00 -- -- -- -- -- -- --
    203408_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    241365_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    SATB1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SATB1 gene expression
    SATB1 gene electronic northern expression
    SATB1 gene sage expression
    About these images

    CGAP SAGE TAG: CAAATAAGCT

    SOURCE GeneReport for Unigene cluster: Hs.517717

    Expression variation in blood from EXPOLDB for SATB1

    UniProtKB/Swiss-Prot: SATB1_HUMAN, Q01826
    Tissue specificity: Expressed predominantly in thymus

    Primers: OriGene genome-wide validated SYBR primer pairs: SATB1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SATB1: PPH19752A
        SABiosciences Custom PCR Arrays for SATB1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SATB1 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SATB11   -- SATB homeobox 1 94.44(n)
    97.84(a)
    485650  XM_542770.2  XP_542770.2 
    chimpanzee
    (Pan troglodytes)
    SATB11   -- SATB homeobox 1 99.78(n)
    100(a)
    460213  XM_516316.2  XP_516316.2 
    cow
    (Bos taurus)
    SATB11   -- SATB homeobox 1 86.54(n)
    91.35(a)
    516952  XM_864906.2  XP_869999.1 
    rat
    (Rattus norvegicus)
    Satb11   -- SATB homeobox 1 90.52(n)
    98.3(a)
    316164  NM_001012129.1  NP_001012129.1 
    mouse
    (Mus musculus)
    Satb11 , 5 17 (26.81 cM)5
    special AT-rich sequence binding protein 11, 5 91.18(n)1
    98.17(a)1
    202301  NM_009122.11  NP_033148.11 
     AI1219935  AI5285215  (see all 25)
    About this table        Species with no ortholog for SATB1

    ENSEMBL Gene Tree for SATB1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SATB1 gene
    SATB22  

    SATB1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/803 NCBI SNPs in SATB1 are shown (see all 803)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs120221,2
    --18466172(-) GAGCTT/CGGCGA 2 -- ut51 int11Minor allele frequency- C:0.00MN 184
    rs9135101,2
    --18476265(+) AGTTCA/TCTTGA 1 -- int10--------
    rs11403441,2
    --18465158(-) ATCTCC/TTTTTT 2 -- int1 ut510--------
    rs11403461,2
    --18465148(-) TTTTTG/TTTTTT 2 -- ut51 int10--------
    rs13285401,2
    C,A,18451197(+) TTAATT/GTTAAA 2 -- int16Minor allele frequency- G:0.28NA EA WA 216
    rs13285411,2
    H18451465(+) GGCTAT/GTAGCA 2 -- int14Minor allele frequency- G:0.00NS EA 418
    rs13599941,2
    C,F,18468771(-) AAACAT/CGTCAG 2 -- int1 ng516Minor allele frequency- C:0.13NS EA WA 556
    rs13599951,2
    C,F,A,H,18451687(+) CCAAAA/GCACGG 2 -- int114Minor allele frequency- G:0.11NS EA NA WA 822
    rs13599961,2
    C,F,O,18451858(+) AAAGGC/TTACTT 2 -- int124Minor allele frequency- T:0.38MN NS EA NA WA 1884
    rs13599971,2
    C,F,A,18451883(+) GCTCTG/CGGTAT 2 -- int114Minor allele frequency- C:0.28NS EA NA WA 968
    About this table

    HapMap Linkage Disequilibrium images for SATB1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SATB1
         2 CNVs: 91220 79702

    QIAGEN SeqTarget long-range PCR primers for resequencing SATB1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SATB1 for disorders           About GeneDecksing

    OMIM: 602075

    3 Novoseek disease relationships for SATB1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 62.9 2 17343824 (1)
    breast cancer 8.99 14 19072498 (5), 19642980 (3), 19860849 (2), 9548713 (1) (see all 5)
    necrosis 0 3 11455567 (1), 10800076 (1)
    About this table

    1 PharmGKB disease relationship for SATB1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology (HuGE) Navigator: SATB1 (1 document)

    Export disorders and mutations for SATB1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/87 PubMed articles for SATB1 gene, integrated from 7 sources (see all 87):
    (articles sorted by number of sources associating them with SATB1)
    1. A tissue-specific MAR/SAR DNA-binding protein with unusual binding site recognition. (PubMed id 1505028)1, 2, 3, 7 Dickinson L.A.... Kohwi-Shigematsu T. (1992)
    2. SATB1 targets chromatin remodelling to regulate genes over long distances. (PubMed id 12374985)1, 2, 7 Yasui D.... Kohwi-Shigematsu T. (2002)
    3. Phosphorylation of SATB1, a global gene regulator, acts as a molecular switch regulating its transcriptional activity in vivo. (PubMed id 16630892)1, 2, 7 Kumar P.P.... Galande S. (2006)
    4. Acetylation-dependent interaction of SATB1 and CtBP1 mediates transcriptional repression by SATB1. (PubMed id 19103759)1, 2, 7 Purbey P.K.... Galande S. (2009)
    5. SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis. (PubMed id 11463840)1, 2, 7 Galande S....Kohwi-Shigematsu T. (2001)
    6. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. (PubMed id 18337816)1, 2, 7 Han H.-J.... Kohwi-Shigematsu T. (2008)
    7. SATB1 regulates beta-like globin genes through matrix related nuclear relocation of the cluster. (PubMed id 19332023)1, 2, 7 Gong H....Liang C.-C. (2009)
    8. The behavior of SATB1, a MAR-binding protein, in response to apoptosis stimulation. (PubMed id 16377216)1, 2, 7 Sun Y.... Han X. (2006)
    9. A nuclear targeting determinant for SATB1, a genome organizer in the T cell lineage. (PubMed id 15970696)1, 2, 7 Nakayama Y.... Ogawa T. (2005)
    10. Tissue-specific nuclear architecture and gene expression regulated by SATB1. (PubMed id 12692553)1, 2, 7 Cai S.... Kohwi-Shigematsu T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6304 HGNC: 10541 AceView: SATB1.1 Ensembl:ENSG00000182568 euGenes: HUgn6304
    ECgene: SATB1 H-InvDB: SATB1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SATB1 gene:
    Search GeneIP for patents involving SATB1

    GeneCards and IP:
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     Regulatory tfbs in SATB1 promoter
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     ELISAs and CLIAs for SATB1
           

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