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SDC3 Gene

protein-coding GIFtS: 59

GC01M029448

syndecan 3
(Previous name: syndecan 3 (N-syndecan) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
syndecan 3¹ ²		syndecan neural type²
SYND3¹ ² ³ ⁵		syndecan proteoglycan 3²
N-syndecan¹ ²		syndecan-3²
SDCN² ⁵		KIAA0468³
syndecan 3 (N-syndecan)¹

External Ids:	HGNC: 10660¹	Entrez Gene: 9672²	Ensembl: ENSG00000162512⁷	UniProtKB: O75056³

Export aliases for SDC3 gene to outside databases

Previous GC identifers: GC01M031136 GC01M030326 GC01M030768 GC01M030844 GC01M031011 GC01M031342

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SDC3:

The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of

cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a

sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. (provided by RefSeq)

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056

Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization

of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a

sugar-dependent mechanism

Gene Wiki entry for SDC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SDC3 gene promoter:
         MyoD   HNF-1A   MEF-2A   Cdc5   Nkx6-1   SRF   E47   POU3F2   Pbx1a   TFIID
         Other transcription factors

Search SABiosciences Chromatin IP Primers for SDC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SDC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1pter-p22.3 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1pter-p22.3

SDC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SDC3 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M029448: view genomic region (about GC identifiers)

Start:	29,448,414 bp from pter
End:	29,487,314 bp from pter
Size:	38,901 bases
Orientation:	minus strand

1 alternative location:

Chr1- 31,342,313-31,381,608

RefSeq DNA sequence:

NC_000001.10 NT_032977.9

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056 (See protein sequence)

Recommended Name: Syndecan-3

Size: 442 amino acids; 45497 Da

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=BAA32313.2; Type=Miscellaneous discrepancy; Note=Intron retention;

Secondary accessions: Q5T1Z6 Q5T1Z7 Q96CT3 Q96PR8

Explore the universe of human proteins at neXtProt for SDC3: NX_O75056

Post-translational modifications:

O-glycosylated within the Thr/Ser-rich region which could interact with lectin domains on other molecules (Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055469.3

ENSEMBL proteins:

ENSP00000344468 ENSP00000351199 ENSP00000338346

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for SDC3 (Syndecan-3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for SDC3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0019717	synaptosome	IEA	--
GO:0030424	axon	IEA	--
GO:0043234	protein complex	IEA	--

About this table

SDC3 for ontologies About GeneDecksing

Antibodies for SDC3:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SDC3
	R&D Systems Antibodies for SDC3 (Syndecan-3)
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	GenScript Custom Superior Antibodies Services for SDC3
	Browse antibodies at Epitomics

Assays for SDC3:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SDC3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SDC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SDC3 for domains About GeneDecksing

2 InterPro domains/families:

IPR001050 Syndecan

IPR003585 Neurexin-like

Graphical View of Domain Structure for InterPro Entry O75056

ProtoNet protein and cluster: O75056

2 Blocks protein families:

IPB001050 Syndecan

IPB003585 Neurexin/syndecan/glycophorin C

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056

Similarity: Belongs to the syndecan proteoglycan family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056

Function: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization

of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a

sugar-dependent mechanism

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SDC3 Sigma-Aldrich shRNA for SDC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): SDC3 OriGene shRNA RFP (see all 5): SDC3 OriGene basic RS shRNA (see all 5): SDC3 OriGene siRNA (see all 4): SDC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SDC3

miRNA:		Sigma-Aldrich microRNA Mimics for SDC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SDC3
		Search SABiosciences for Assays for microRNAs that regulate SDC3

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: SDC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SDC3 OriGene untagged cDNA clones in CMV expression vector (see all 2): SDC3 OriGene 3'-UTR clone: SDC3 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SDC3
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for SDC3

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008092	cytoskeletal protein binding	IEA	--

About this table

SDC3 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Sdc3):

adipose tissue

behavior/neurological

growth/size

homeostasis/metabolism

SDC3 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SDC3 for pathways About GeneDecksing

1 Millipore Pathway for SDC3

Neurophysiological process Receptor-mediated axon growth repulsion

3 Kegg Pathways (Kegg details for SDC3):

	hsa04512 ECM-receptor interaction
	hsa04514 Cell adhesion molecules (CAMs)
	hsa05144 Malaria

SABiosciences Custom Pathway-Focused PCR Arrays for SDC3

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SDC3

5/49 Interacting proteins for SDC3 (ENSP00000344468³) via UniProtKB, MINT, and/or STRING (see all 49)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AGRP	ENSP00000290953³	STRING: ENSP00000290953
APH1B	ENSP00000261879³	STRING: ENSP00000261879
EGFR	ENSP00000275493³	STRING: ENSP00000275493
IL8	ENSP00000306512³	STRING: ENSP00000306512
MC4R	ENSP00000299766³	STRING: ENSP00000299766

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

About this table

SDC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SDC3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SDC3 Sigma-Aldrich shRNA for SDC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): SDC3 OriGene shRNA RFP (see all 5): SDC3 OriGene basic RS shRNA (see all 5): SDC3 OriGene siRNA (see all 4): SDC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SDC3

miRNA:		Sigma-Aldrich microRNA Mimics for SDC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SDC3
		Search SABiosciences for Assays for microRNAs that regulate SDC3

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: SDC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SDC3 OriGene untagged cDNA clones in CMV expression vector (see all 2): SDC3 OriGene 3'-UTR Clone: SDC3 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SDC3

Primers:		OriGene genome-wide validated SYBR primer pairs: SDC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SDC3: PPH13085A

REFSEQ mRNAs for SDC3 gene:

NM_014654.3

Additional cDNA sequence:

AF248634.1 AK295698.1 AL049426.1 CR610672.1 CR619177.1

12 DOTS entries:

DT.97822059 DT.95239940 DT.444173 DT.121338024 DT.75147740 DT.92457868 DT.95239945 DT.100723844

DT.100800280 DT.100821837 DT.121338008 DT.97815964

24/240 AceView cDNA sequences (see all 240):

F11324 AA349753 BI333107 BQ677150 AW117922 AA054013 Z38336 BM685271

BM676907 AI950871 BQ015777 BX643294 BQ221140 BF725896 BE874804 BM712824

CR619177 BQ185272 BX095994 AI884533 BM714004 CR610672 AW016338 BM720804

highest scoring ESTs for SDC3:

AB007937 AF248634 AA054013 AA333597 AA348680 AA349753 AA558579 AA707252 AI022456 AI146353

Unigene Cluster for SDC3:

Syndecan 3

Hs.158287 [show with all ESTs]

Unigene Representative Sequence: NM_014654

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SDC3 (see all 6)

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	·	9c
SP1:			-		-		-		-												-
SP2:					-		-		-
SP3:
SP4:																					-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for SDC3
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000471567 ENST00000339394 ENST00000358423 ENST00000336798(uc001bsd.2 uc001bse.2)

ENST00000487984

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SDC3 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching SDC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32092_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB007937	0.80	1.00	0.91	1
202898_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014654	0.60	1.00	0.82	1
1554864_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202898_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

SDC3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

SDC3 gene electronic northern expression

About these images

CGAP SAGE TAG: GCCAAAACCT

SOURCE GeneReport for Unigene cluster: Hs.158287

Expression variation in blood from EXPOLDB for SDC3

UniProtKB/Swiss-Prot: SDC3_HUMAN, O75056

Tissue specificity: Expressed in the nervous system, the adrenal gland, and the spleen

Primers:		OriGene genome-wide validated SYBR primer pairs: SDC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SDC3: PPH13085A

SABiosciences Custom PCR Arrays for SDC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SDC3 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SDC3¹	--	syndecan 3	83.87(n) 85.62(a)	487323 XM_544449.2 XP_544449.2
chimpanzee (Pan troglodytes)	SDC3¹	--	syndecan 3	99.24(n) 98.99(a)	744364 XM_001149044.1 XP_001149044.1
cow (Bos taurus)	SDC3¹	--	syndecan 3	90.72(n) 92.99(a)	618198 XM_870523.2 XP_875616.2
rat (Rattus norvegicus)	Sdc3¹	--	syndecan 3	83.14(n) 84.74(a)	116673 NM_053893.2 NP_446345.2
mouse (Mus musculus)	Sdc3^{1 , 5}	4 (63.63 cM)⁵	syndecan 3^{1, 5}	82.69(n)¹ 83.83(a)¹	20970¹ NM_011520.3¹ NP_035650.2¹ AK087492⁵ AK129153⁵ (see all 30)

About this table Species with no ortholog for SDC3

ENSEMBL Gene Tree for SDC3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SDC3 gene

SDC4² SDC2² SDC1²

SDC3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs6943^1,2	C,F,	31342590(-)	`CCAGGC/ACTTCC`	1	--	ut3¹ ese³		5		MN NA WA	448
rs870325^1,2	C,F,	31360447(+)	`CAATCG/ACTTAC`	1	--	int¹		11		NA EA NS WA	727
rs870326^1,2	H	31360448(+)	`AATCGC/GTTACC`	1	--	int¹		7		EA NA NS	454
rs947647^1,2	C,F,O,A,H,	31374481(+)	`GGCCCA/TTGGTC`	1	--	int¹		28		NA EA MN NS WA	1782
rs947648^1,2	C,F,A,	31363409(+)	`ctaaaT/Attagt`	1	--	int¹		16		NS EA NA WA	1230
rs947649^1,2	C,F,A,H,	31367970(-)	`CCCCAT/ACTGCT`	1	--	int¹		11		NA EA MN WA	772
rs947650^1,2	C,F,O,A,H,	31367929(-)	`TACCCC/GCAACA`	1	--	int¹		15		EA NA NS WA	732
rs1057249^1,2	--	31343292(-)	`CCTGTA/GATGGA`	1	--	ut3¹ ese³		0	--	--	--	--
rs1141367^1,2	F	31342397(-)	`TTTTTT/GTTTTT`	1	--	ut3¹		1		MN	184
rs1539360^1,2	C,A,H,	31346199(-)	`GTGGGC/TGCCCT`	2	G	ref¹ syn¹		5		EA NA	222

About this table

HapMap Linkage Disequilibrium images for SDC3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SDC3: --

QIAGEN SeqTarget long-range PCR primers for resequencing SDC3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SDC3 for disorders About GeneDecksing

OMIM: 186357 disorders: 601665

Human Gene Mutation Database (HGMD): SDC3
Human Genome Epidemiology (HuGE) Navigator: SDC3 (3 documents)

Export disorders and mutations for SDC3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/40 PubMed articles for SDC3 gene, integrated from 7 sources (see all 40):
(articles sorted by number of sources associating them with SDC3)

Cloning and characterization of human syndecan-3. (PubMed id 11527150)^{1, 2, 3} Berndt C.... Reina M. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2} Seki N.... Ohara O. (1997)
Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan. (PubMed id 1556152)^{1, 3} Carey D.J....Cizmeci-Smith G. (1992)
Role of syndecan-3 polymorphisms in obesity and femal e hyperandrogenism. (PubMed id 19820907)^{1, 7} SchA1ring A.N....GAPtte M. (2009)
Clock genes and body composition in patients with sch izophrenia under treatment with antipsychotic drugs. (PubMed id 21050724)¹ Moons T....van Winkel R. (2010 Nov 1)
Expression of basic fibroblast growth factor, its rec eptors and syndecans in bladder cancer. (PubMed id 19822079)¹ Marzioni D....Montironi R. (2009)
Pleiotrophin expression in human pancreatic cancer and its correlation with clinicopathological features, perineural invasion, and prognosis. (PubMed id 18716876)¹ Yao J....Zhang M. (2009)
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)² Heibeck T.H.... Qian W.-J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9672	HGNC: 10660	AceView: SDC3	Ensembl:ENSG00000162512	euGenes: HUgn9672
ECgene: SDC3	Kegg: 9672	H-InvDB: SDC3

(According to HUGE)
About This Section

HUGE: KIAA0468

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for SDC3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SDC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for SDC3 gene:
Search GeneIP for patents involving SDC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SDC3		Antibodies for SDC3
	Super-pooled esiRNAs for SDC3		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SDC3		microRNA Mimics for SDC3
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for SDC3 (Syndecan-3)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for SDC3 (Syndecan-3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SDC3
	SeqTarget long-range PCR primers for resequencing SDC3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SDC3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SDC3

	GenScript Custom Purified and Recombinant Proteins Services for SDC3		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SDC3
	GenScript Custom Assay Services for SDC3		GenScript Custom Superior Antibodies Services for SDC3
	GenScript Custom overexpressing Cell Line Services for SDC3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SDC3 promoter
	Search Chromatin IP Primers for SDC3
	RT² qPCR Primer Assay for SDC3
	GNC Network for SDC3
	Search for Assays for microRNAs that regulate SDC3
	SABiosciences Custom PCR Arrays for SDC3

Search Tocris compounds for SDC3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for SDC3

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

SDC3 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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SDC3 Gene

protein-coding GIFtS: 59

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Export list of displayed genes

SDC3 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor SDC3 gene

Summariesfor SDC3 gene

Genomic Viewsfor SDC3 gene

Proteinsfor SDC3 gene

Protein Domains/Familiesfor SDC3 gene

Gene Functionfor SDC3 gene

Pathways & Interactionsfor SDC3 gene

Drugs & Compoundsfor SDC3 gene

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Expression for SDC3 gene

Orthologsfor SDC3 gene

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Genome Databases showing SDC3 gene

Other Databases showing SDC3 gene

Specialized Databases showing SDC3 gene

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Aliases &
Descriptions
for SDC3 gene

Summaries
for SDC3 gene

Genomic Views
for SDC3 gene

Proteins
for SDC3 gene

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Families
for SDC3 gene

Gene Function
for SDC3 gene

Pathways & Interactions
for SDC3 gene

Drugs & Compounds
for SDC3 gene

Transcripts
for SDC3 gene

Expression
for SDC3 gene

Orthologs
for SDC3 gene

Paralogs
for SDC3 gene

Genomic Variants
for SDC3 gene

Disorders & Mutations
for SDC3 gene

Medical News
for SDC3 gene

Publications
for SDC3 gene

Intellectual Property
for SDC3 gene

Products
for SDC3 gene