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SEPT8 Gene

protein-coding GIFtS: 52

GC05M127279

septin 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
septin 8¹ ²		OTTHUMP00000211755²
KIAA0202¹ ² ³ ⁵		OTTHUMP00000066076²
SEP2¹ ²		OTTHUMP00000066080²
septin-8²

External Ids:	HGNC: 16511¹	Entrez Gene: 23176²	Ensembl: ENSG00000164402⁷	UniProtKB: Q92599³

Export aliases for SEPT8 gene to outside databases

Previous GC identifers: GC05M131608 GC05M132533 GC05M132117 GC05M132162 GC05M132114

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SEPT8:

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous

scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle

trafficking (Blaser et al., 2003 (PubMed 12909369)).(supplied by OMIM)

UniProtKB/Swiss-Prot: SEPT8_HUMAN, Q92599

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a

role in platelet secretion

Gene Wiki entry for SEPT8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SEPT8
Other transcription factors

Search SABiosciences Chromatin IP Primers for SEPT8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SEPT8

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31

SEPT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SEPT8 gene location

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M127279: view genomic region (about GC identifiers)

Start:	127,279,118 bp from pter
End:	127,306,224 bp from pter
Size:	27,107 bases
Orientation:	minus strand

1 alternative location:

Chr5- 132,086,509-132,142,933

RefSeq DNA sequence:

NC_000005.9 NT_034772.6

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SEPT8_HUMAN, Q92599 (See protein sequence)

Recommended Name: Septin-8

Size: 483 amino acids; 55756 Da

Subunit: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with

cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By

similarity). Interacts with CDK14, SEPT4, SEPT5 and SEPT7 (By similarity)

Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=In platelets, found in

areas surrounding alpha-granules

Sequence caution: Sequence=AAG09407.1; Type=Erroneous initiation; Sequence=AAH01329.1; Type=Erroneous initiation;

Sequence=AAO13878.1; Type=Erroneous initiation; Sequence=AAO13879.1; Type=Erroneous initiation; Sequence=AAO13880.1;

Type=Erroneous initiation; Sequence=BAA13193.1; Type=Erroneous initiation;

Secondary accessions: A6NC65 A6NKP6 Q8IX36 Q8IX37 Q9BVB3

Alternative splicing: 3 isoforms: Q92599-1 Q92599-2 Q92599-3

Explore the universe of human proteins at neXtProt for SEPT8: NX_Q92599

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001092281.1 NP_001092282.1 NP_001092283.1 NP_055961.1

ENSEMBL proteins:

ENSP00000367971 ENSP00000360548 ENSP00000367978 ENSP00000391926 ENSP00000296873 ENSP00000399840

ENSP00000367993 ENSP00000367991 ENSP00000411823 ENSP00000407421 ENSP00000394766 ENSP00000367973

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for SEPT8
	Novus Biologicals Protein for SEPT8
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0031105	septin complex	IEA	--

About this table

SEPT8 for ontologies About GeneDecksing

Antibodies for SEPT8:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for SEPT8
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for SEPT8
	Novus Biologicals Antibody for SEPT8
	Browse antibodies at Epitomics

Assays for SEPT8:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SEPT8
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SEPT8 for domains About GeneDecksing

2 InterPro domains/families:

IPR016491 Septin

IPR000038 Cell_Div_GTP-bd

Graphical View of Domain Structure for InterPro Entry Q92599

ProtoNet protein and cluster: Q92599

1 Blocks protein family: IPB000038 Cell division/GTP binding protein

UniProtKB/Swiss-Prot: SEPT8_HUMAN, Q92599

Similarity: Belongs to the septin family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SEPT8_HUMAN, Q92599

Function: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a

role in platelet secretion

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SEPT8 Sigma-Aldrich shRNA for SEPT8
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): SEPT8 OriGene shRNA RFP (see all 8): SEPT8 OriGene basic RS shRNA (see all 8): SEPT8 OriGene siRNA (see all 8): SEPT8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SEPT8

miRNA:		Sigma-Aldrich microRNA Mimics for SEPT8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SEPT8
		8/16 SABiosciences Assays for microRNAs that regulate SEPT8 (see all 16):
		hsa-miR-520d-5p hsa-miR-181c hsa-miR-27a hsa-miR-1225-3p hsa-miR-200a hsa-miR-181a hsa-miR-181d hsa-miR-132

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene untagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene 3'-UTR clone (see all 4): SEPT8 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SEPT8
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for SEPT8

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005515	protein binding	IPI	17685441
GO:0005525	GTP binding	IEA	--

About this table

SEPT8 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SEPT8 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SEPT8

RhoA Signaling

SABiosciences Custom Pathway-Focused PCR Arrays for SEPT8

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SEPT8

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SEPT8

2 Interacting proteins for SEPT8 (Q92599¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SEPT2	Q15019¹	EBI-958021,EBI-741220
SEPT5	Q99719¹	EBI-958021,EBI-373345

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--

About this table

SEPT8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SEPT8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SEPT8 Sigma-Aldrich shRNA for SEPT8
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 8): SEPT8 OriGene shRNA RFP (see all 8): SEPT8 OriGene basic RS shRNA (see all 8): SEPT8 OriGene siRNA (see all 8): SEPT8
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SEPT8

miRNA:		Sigma-Aldrich microRNA Mimics for SEPT8 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SEPT8
		8/16 SABiosciences Assays for microRNAs that regulate SEPT8 (see all 16):
		hsa-miR-520d-5p hsa-miR-181c hsa-miR-27a hsa-miR-1225-3p hsa-miR-200a hsa-miR-181a hsa-miR-181d hsa-miR-132

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene untagged cDNA clones in CMV expression vector (see all 4): SEPT8 OriGene 3'-UTR Clone (see all 4): SEPT8 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SEPT8

Primers:		OriGene genome-wide validated SYBR primer pairs: SEPT8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SEPT8: PPH16694A

REFSEQ mRNAs for SEPT8 gene (4 alternative transcripts):

NM_001098811.1 NM_001098812.1 NM_001098813.1 NM_015146.1

Additional cDNA sequence:

AF179995.1 AF440761.1 AF440762.1 AF440763.1 AK057797.1 BC001329.1 BC140759.1 BC171779.1

CR590471.1 CR617026.1 D86957.1

23 DOTS entries:

DT.95309873 DT.91955824 DT.445350 DT.110097 DT.91653311 DT.95309869 DT.95309871 DT.99955875

DT.120876759 DT.95245773 DT.120876757 DT.120876720 DT.100807333 DT.99999349 DT.100807330 DT.100807331

DT.100807332 DT.120876724 DT.120876745 DT.120876755 DT.40303743 DT.92443141 DT.120876765

1 AceView cDNA sequence:

AW752481

highest scoring ESTs for SEPT8:

D86957 AF179995 AF440761 AF440762 AF440763 AI912094 AK057797 AL520957 AL527033 AL532971

Unigene Cluster for SEPT8:

Septin 8

Hs.522057 [show with all ESTs]

Unigene Representative Sequence: AF179995

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SEPT8 (see all 11)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·
SP1:											-		-		-		-		-										-
SP2:																			-										-
SP3:																			-										-																						-
SP4:																			-										-																						-
SP5:																													-										-

ExUns:	13b	^	14
SP1:
SP2:
SP3:	-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for SEPT8
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378699 ENST00000371493 ENST00000378706 ENST00000371478 ENST00000412572

ENST00000492490 ENST00000296873(uc003kxs.1 uc003kxu.2 uc011cxi.1 uc003kxv.2)

ENST00000448933(uc003kxt.2) ENST00000378721 ENST00000378719(uc003kxr.2)

ENST00000414594 ENST00000453480 ENST00000481030 ENST00000458488 ENST00000378701

ENST00000481794

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SEPT8 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching SEPT8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38067_at²^{, 3}	U95-A	1	1.00	1.00	0.41	1.03	D86957	1.00	1.00	1.00	1
62160_at²^{, 3}	U95-C	1	0.31	1.00	0.97	1.00	AI912094	0.80	1.00	0.91	1
208999_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D86957	1.00	1.00	1.00	1
209000_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001329	0.60	1.00	0.82	1
208999_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209000_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

SEPT8 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

SEPT8 gene electronic northern expression

About these images

CGAP SAGE TAG: CTTTTCTAAA

SOURCE GeneReport for Unigene cluster: Hs.522057

Expression variation in blood from EXPOLDB for SEPT8

UniProtKB/Swiss-Prot: SEPT8_HUMAN, Q92599

Tissue specificity: Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is

expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen.

Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and

putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low

levels in prostate, testis and ovary

Primers:		OriGene genome-wide validated SYBR primer pairs: SEPT8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SEPT8: PPH16694A

SABiosciences Custom PCR Arrays for SEPT8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SEPT8 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SEPT8¹	--	septin 8	93.23(n) 98.52(a)	474677 XM_531903.2 XP_531903.2
chimpanzee (Pan troglodytes)	SEPT8¹	--	septin 8	96.93(n) 97.24(a)	462057 XM_517927.2 XP_517927.2
cow (Bos taurus)	SEPT8¹	--	septin 8	92.96(n) 99.07(a)	540614 NM_001076230.1 NP_001069698.1
rat (Rattus norvegicus)	Sept8¹	--	septin 8	91.79(n) 97.72(a)	303135 XM_220423.4 XP_220423.4
mouse (Mus musculus)	Sept8^{1 , 5}	11 (31.96 cM)⁵	septin 8^{1, 5}	91.67(n)¹ 98.36(a)¹	20362¹ NM_033144.1¹ NP_149156.1¹ AB093215⁵ AC005742⁵ (see all 17)

About this table Species with no ortholog for SEPT8

ENSEMBL Gene Tree for SEPT8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SEPT8 gene

SEPT3² SEPT6² SEPT9² SEPT11² SEPT14² SEPT10² SEPT12²

SEPT8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs30506^1,2	C,F,A,	132100472(-)	`GTCCCG/AGGAGG`	4	--	int¹		11	NS EA NA WA	780
rs30507^1,2	C,F,O,	132099999(-)	`ACCTAC/TGACCT`	8	Y	syn¹ ref¹ ese³		17	MN NS EA NA WA	1424
rs30508^1,2	C,F,A,	132099238(-)	`TCTGTC/TCCTCC`	4	--	int¹		13	EA NS NA WA	2246
rs30509^1,2	C,F,A,H,	132098420(-)	`GCATGG/TCTATC`	4	--	int¹		9	EA NS NA WA	1986
rs30510^1,2	C,H,	132098242(-)	`AGCAAC/G/TGGGGT`	12	N K	ref¹ mis¹ syn¹		7	MN NA WA	196
rs30513^1,2	C,F,A,	132115224(-)	`GTCATG/ATTCAA`	1	--	ng5¹		7	MN NS NA EA WA	470
rs30514^1,2	C,F,	132114847(-)	`ATTTCA/GGCATT`	4	--	ng5¹		12	MN NS EA NA WA	994
rs30515^1,2	C,F,A,	132113511(-)	`GAAGGC/ACGCCT`	4	--	ng5¹ ut5¹		3	NA WA	76
rs30516^1,2	C,F,	132112560(-)	`AAGGCT/AAACCC`	4	--	int¹		4	MN EA NA	454
rs30517^1,2	C,F,	132112433(-)	`TTCTTT/CCTGCA`	4	--	int¹		7	MN EA NA WA	578

About this table

HapMap Linkage Disequilibrium images for SEPT8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SEPT8
1 CNV: 69201

QIAGEN SeqTarget long-range PCR primers for resequencing SEPT8

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SEPT8 for disorders About GeneDecksing

OMIM: 608418

1 Novoseek disease relationship for SEPT8 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	18	1	12023038 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: SEPT8 (2 documents)

Export disorders and mutations for SEPT8 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/27 PubMed articles for SEPT8 gene, integrated from 7 sources (see all 27):
(articles sorted by number of sources associating them with SEPT8)

Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)^{1, 2, 3} Nagase T....Nomura N. (1996)
Isolation of new splice isoforms, characterization and expression analysis of the human septin SEPT8 (KIAA0202). (PubMed id 12909369)^{1, 2, 7} Blaeser S....Zieger B. (2003)
The novel human platelet septin SEPT8 is an interaction partner of SEPT4. (PubMed id 15116257)^{1, 2, 7} Blaser S....Zieger B. (2004)
Human septin-septin interaction: CDCrel-1 partners with KIAA0202. (PubMed id 12023038)^{1, 2, 7} Blaeser S.... Zieger B. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mammalian septins nomenclature. (PubMed id 12475938)^{1, 2} Macara I.G.... Zieger B. (2002)
KIAA0202, a human septin family member, interacting with hPFTAIRE1. (PubMed id 12098780)^{1, 2} Yang T.... Chen J.Y. (2002)
Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11. (PubMed id 10704283)^{1, 2} Wenderfer S.E.... Monaco J.J. (2000)
Computational and biological analysis of 680 kb of DNA sequence from the human 5q31 cytokine gene cluster region. (PubMed id 9149945)^{1, 3} Frazer K.A....Rubin E.M. (1997)
Septin expression in proliferative retinal membranes. (PubMed id 17625225)^{1, 7} Xin X....Meyer P. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23176	HGNC: 16511	AceView: SEPT8.1	Ensembl:ENSG00000164402	euGenes: HUgn23176
ECgene: SEPT8	H-InvDB: SEPT8

(According to HUGE)
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HUGE: KIAA0202

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for SEPT8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for SEPT8 gene:
Search GeneIP for patents involving SEPT8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SEPT8		Antibodies for SEPT8
	Super-pooled esiRNAs for SEPT8		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for SEPT8		microRNA Mimics for SEPT8
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SEPT8
	SeqTarget long-range PCR primers for resequencing SEPT8
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SEPT8
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SEPT8

	GenScript Custom Purified and Recombinant Proteins Services for SEPT8		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SEPT8
	GenScript Custom Assay Services for SEPT8		GenScript Custom Superior Antibodies Services for SEPT8
	GenScript Custom overexpressing Cell Line Services for SEPT8		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for SEPT8
	Search Chromatin IP Primers for SEPT8
	RT² qPCR Primer Assay for SEPT8
	GNC Network for SEPT8
	Assays for microRNAs that regulate SEPT8
	SABiosciences Custom PCR Arrays for SEPT8

Search Tocris compounds for SEPT8

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for SEPT8
	Proteins for SEPT8

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

Browse ELISAs and CLIAs at Uscn

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

SEPT8 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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SEPT8 Gene

protein-coding GIFtS: 52

Aliases &
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for SEPT8 gene

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Export list of displayed genes

SEPT8 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor SEPT8 gene

Summariesfor SEPT8 gene

Genomic Viewsfor SEPT8 gene

Proteinsfor SEPT8 gene

Protein Domains/Familiesfor SEPT8 gene

Gene Functionfor SEPT8 gene

Pathways & Interactionsfor SEPT8 gene

Drugs & Compoundsfor SEPT8 gene

Transcriptsfor SEPT8 gene

Expression for SEPT8 gene

Orthologsfor SEPT8 gene

Paralogsfor SEPT8 gene

Genomic Variantsfor SEPT8 gene

Disorders & Mutationsfor SEPT8 gene

Medical Newsfor SEPT8 gene

Publicationsfor SEPT8 gene

External Searches for SEPT8 gene

Genome Databases showing SEPT8 gene

Other Databases showing SEPT8 gene

Specialized Databases showing SEPT8 gene

Intellectual Propertyfor SEPT8 gene

Productsfor SEPT8 gene

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Aliases &
Descriptions
for SEPT8 gene

Summaries
for SEPT8 gene

Genomic Views
for SEPT8 gene

Proteins
for SEPT8 gene

Protein Domains/
Families
for SEPT8 gene

Gene Function
for SEPT8 gene

Pathways & Interactions
for SEPT8 gene

Drugs & Compounds
for SEPT8 gene

Transcripts
for SEPT8 gene

Expression
for SEPT8 gene

Orthologs
for SEPT8 gene

Paralogs
for SEPT8 gene

Genomic Variants
for SEPT8 gene

Disorders & Mutations
for SEPT8 gene

Medical News
for SEPT8 gene

Publications
for SEPT8 gene

Intellectual Property
for SEPT8 gene

Products
for SEPT8 gene