Aliases &
Descriptions
for SH2D4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| SH2 domain containing 4B1 2 | | FLJ419842 | | novel SH2 domain-containing protein2 | | SH2 domain-containing protein 4B2 |
Export aliases for SH2D4B gene to outside databasesPrevious GC identifers: GC10P081962 GC10P082287 |
Summaries
for SH2D4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SH2D4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SH2D4B gene promoter:
POU3F1 IRF-1 TFIID TBP E4BP4 AP-2rep C/EBPbeta FAC1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b)
Other transcription factors
Search SABiosciences Chromatin IP Primers for SH2D4B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SH2D4B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q23.1 Ensembl cytogenetic band: 10q23.1 HGNC cytogenetic band: 10q23.1SH2D4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P076140: view genomic region
(about GC identifiers)
Start:
|
76,140,484 bp from pter |
End:
|
76,250,465 bp from pter |
Size:
|
109,982 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 82,297,658-82,406,316 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for SH2D4B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7 (See
protein sequence)Recommended Name: SH2 domain-containing protein 4B Size: 431 amino acids; 51232 Da
Secondary accessions: Q5SQS5 Q6ZVW9 Q6ZVZ3Alternative splicing: 3 isoforms: Q5SQS7-1 Q5SQS7-2 Q5SQS7-3 Explore the universe of human proteins at neXtProt for SH2D4B: NX_Q5SQS7
REFSEQ proteins (2 alternative transcripts):
NP_001139191.1 NP_997255.2
ENSEMBL proteins: ENSP00000361220 ENSP00000345295 ENSP00000417953 ENSP00000314242
Human Recombinant Proteins
Antibodies for SH2D4B:
Assays for SH2D4B: |
Protein
Domains/
Families
for SH2D4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SH2D4B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5SQS7ProtoNet protein and cluster: Q5SQS7 1 Blocks protein family: IPB000980 SH2 domain signature
UniProtKB/Swiss-Prot: SH24B_HUMAN, Q5SQS7Similarity: Contains 1 SH2 domain |
Gene Function
for SH2D4B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- |
About this table
SH2D4B for ontologies About GeneDecksing
|
Pathways & Interactions
for SH2D4B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SH2D4B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SH2D4B
|
Drugs & Compounds
for SH2D4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
SH2D4B for compounds About GeneDecksing
 Browse Tocris compounds for SH2D4B
6  Novoseek chemical compound relationships for SH2D4B gene
About this table
|
Transcripts
for SH2D4B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SH2D4B gene (2 alternative transcripts): NM_001145719.1 NM_207372.2 Additional cDNA sequence: AK091518.1 AK123885.1 AK123978.1 3 DOTS entries: DT.101977821 DT.99938567 DT.101966547 6 AceView cDNA sequences: AK123885 NM_207372 AK123978 AX747036 AK091518 AX776201
 highest scoring ESTs for SH2D4B:AK091518 AK123885 AK123978 NM_207372 AX747036 AX776201 DA180313 DA504390 DB088096 DB316020 Unigene Cluster for SH2D4B: SH2 domain containing 4B Hs.147643 [show with all ESTs]Unigene Representative Sequence: AK123885
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372147 ENST00000481537(uc001kcn.1) ENST00000339284(uc001kck.1)
ENST00000470604 ENST00000313455(uc001kcl.1 uc001kcm.1) ENST00000372150
|
Expression
for SH2D4B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SH2D4B expression in normal and diseased human tissues
1 / 2 1 probe-set matching SH2D4B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1563849_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCTCATATAT
SOURCE GeneReport for Unigene cluster: Hs.147643
SABiosciences Custom PCR Arrays for SH2D4B
|
Orthologs
for SH2D4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SH2D4B gene from 5/7 species (see all 7)
About this table Species with no ortholog for SH2D4B
ENSEMBL Gene Tree for SH2D4B (if available) |
Paralogs
for SH2D4B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SH2D4B gene
- SH2D4A2 SH2D2A2 HSH2D2
SH2D4B for paralogs About GeneDecksing
|
Genomic Variants
for SH2D4B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SH2D4B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SH2D4B
3 CNVs: 2161 0762 2160 | | QIAGEN SeqTarget long-range PCR primers for resequencing SH2D4B |
|
Disorders & Mutations
for SH2D4B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SH2D4B for disorders About GeneDecksing
1 Novoseek disease relationship for SH2D4B gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemia |
0 |
1 |
16636677 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: SH2D4B (1 document)
Export disorders and mutations for SH2D4B gene to outside databases
|
Medical News
for SH2D4B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SH2D4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/78 PubMed articles for SH2D4B gene, integrated from 7 sources (see all 78):
(articles sorted by number of sources associating them with SH2D4B)- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Molecular recognition by SH2 domains. (PubMed id 12461824)7 Bradshaw J.M. and Waksman G. (2002)
- Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains. (PubMed id 8628292)7 Northrop J.P....Grove J.R. (1996)
- X-linked lymphoproliferative disease: genetics and biochemistry. (PubMed id 11258422)7 Nichols K.E. (2000)
- Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP. (PubMed id 9367831)7 Pesesse X.... Erneux C. (1997)
- Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. (PubMed id 7760813)7 Neumeister E.N....Shaw A.S. (1995)
- Identification of key cytosolic kinases containing ev olutionarily conserved kinase tyrosine-based inhibitory motifs (KTIMs). (PubMed id 20043942)7 Abu-Dayyeh I....Olivier M. (2010)
- O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding m otifs. (PubMed id 19671924)7 Klein A.L....Ball L.E. (2009)
|
External Searches for SH2D4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SH2D4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SH2D4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SH2D4B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SH2D4B gene:
Search GeneIP for patents involving SH2D4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SH2D4B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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