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SIX2 Gene

protein-coding GIFtS: 52

GC02M044969

SIX homeobox 2
(Previous names: sine oculis homeobox (Drosophila) homolog 2, sine oculis homeobox homolog 2 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
SIX homeobox 2¹ ²
Sine oculis homeobox homolog 2² ³
sine oculis homeobox homolog 2 (Drosophila)¹
sine oculis homeobox (Drosophila) homolog 2¹
homeobox protein SIX2²

External Ids:	HGNC: 10888¹	Entrez Gene: 10736²	Ensembl: ENSG00000170577⁷	UniProtKB: Q9NPC8³

Export aliases for SIX2 gene to outside databases

Previous GC identifers: GC02M045231 GC02M045401 GC02M045206 GC02M045143 GC02M045232

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIX2:

This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis'

homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be

involved in limb or eye development. (provided by RefSeq)

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8

Function: May be involved in limb tendon and ligament development (By similarity)

Gene Wiki entry for SIX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SIX2 gene promoter:
         FAC1   SRF   CUTL1   POU2F1   USF1   GCNF-1   GCNF-2   PPAR-gamma1   PPAR-gamma2   GATA-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for SIX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SIX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p21 HGNC cytogenetic band: 2p21

SIX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIX2 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M044969: view genomic region (about GC identifiers)

Start:	44,969,941 bp from pter
End:	44,974,159 bp from pter
Size:	4,219 bases
Orientation:	minus strand

1 alternative location:

Chr2- 45,232,343-45,236,543

RefSeq DNA sequence:

NC_000002.11 NT_022184.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8 (See protein sequence)

Recommended Name: Homeobox protein SIX2

Size: 291 amino acids; 32286 Da

Subcellular location: Nucleus

Secondary accessions: Q9BXH7

Explore the universe of human proteins at neXtProt for SIX2: NX_Q9NPC8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_058628.3

ENSEMBL proteins:

ENSP00000304502

Human Recombinant Proteins

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1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

SIX2 for ontologies About GeneDecksing

Antibodies for SIX2:

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Assays for SIX2:

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	GenScript Custom Assay Services for SIX2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SIX2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SIX2 for domains About GeneDecksing

4 InterPro domains/families:

IPR012287 Homeodomain-rel

IPR001356 Homeobox

IPR017970 Homeobox_CS

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9NPC8

ProtoNet protein and cluster: Q9NPC8

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8

Similarity: Belongs to the SIX/Sine oculis homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8

Function: May be involved in limb tendon and ligament development (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for SIX2 Sigma-Aldrich shRNA for SIX2
		OriGene 29mer shRNA kits in GFP-retroviral vector: SIX2 OriGene shRNA RFP: SIX2 OriGene basic RS shRNA: SIX2 OriGene siRNA: SIX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2

miRNA:		Sigma-Aldrich microRNA Mimics for SIX2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2
		1 SABiosciences Assays for microRNA that regulate SIX2:
		hsa-miR-576-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: SIX2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SIX2 OriGene untagged cDNA clones in CMV expression vector: SIX2 OriGene 3'-UTR clone: SIX2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SIX2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for SIX2

Genatlas biochemistry entry for SIX2:

Drosophila sine oculis homolog SIX2 homeo box encoding gene,expressed in mesenchyme in mouse

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

SIX2 for ontologies About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Six2):

lethality-prenatal/perinatal

normal

renal/urinary system

SIX2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including SIX2: PAHS-083A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SIX2

5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001656	metanephros development	IEA	--
GO:0001822	kidney development	IMP	18305125
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006606	protein import into nucleus	IEA	--

About this table

SIX2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SIX2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for SIX2 Sigma-Aldrich shRNA for SIX2
		OriGene 29mer shRNA kits in GFP-retroviral vector: SIX2 OriGene shRNA RFP: SIX2 OriGene basic RS shRNA: SIX2 OriGene siRNA: SIX2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2

miRNA:		Sigma-Aldrich microRNA Mimics for SIX2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2
		1 SABiosciences Assays for microRNA that regulate SIX2:
		hsa-miR-576-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: SIX2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SIX2 OriGene untagged cDNA clones in CMV expression vector: SIX2 OriGene 3'-UTR Clone: SIX2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SIX2

Primers:		OriGene genome-wide validated SYBR primer pairs: SIX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SIX2: PPH10860A

REFSEQ mRNAs for SIX2 gene:

NM_016932.4

Additional cDNA sequence:

AF136940.1 AF332196.1 AF332197.1 BC024033.2 BT020100.1 CR595397.1

2 DOTS entries:

DT.92417765 DT.92417764

24/35 AceView cDNA sequences (see all 35):

BQ071675 BX280822 NM_016932 BC024033 AF332196 AI630789 AF332197 AI697859

AF136940 AA808542 AI697804 CR595397 BG829041 BX347429 BM999458 BM017907

CA413774 AI811914 BX400894 BX341976 BQ944758 AW078611 BU543706 CF619326

highest scoring ESTs for SIX2:

AF136940 AF332196 AF332197 BC024033 BE298099 BE547717 BG829041 BQ071675 BX280822 AI697804

Unigene Cluster for SIX2:

SIX homeobox 2

Hs.101937 [show with all ESTs]

Unigene Representative Sequence: NM_016932

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000303077(uc002ruo.2 uc002rup.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SIX2 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching SIX2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89148_at²^{, 3}	U95-E	1	0.75	1.00	1.00	1.00	AI697804	0.60	1.00	0.82	1
206511_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_016932	0.60	1.00	0.82	1
206510_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AF332197	0.80	1.00	0.91	1
206511_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
206510_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

SIX2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

SIX2 gene electronic northern expression

About these images

CGAP SAGE TAG: TGAATGTTCT

SOURCE GeneReport for Unigene cluster: Hs.101937

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8

Tissue specificity: Strongly expressed in skeletal muscle

Primers:		OriGene genome-wide validated SYBR primer pairs: SIX2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SIX2: PPH10860A

SABiosciences Expression via Pathway-Focused PCR Array including SIX2: PAHS-083A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SIX2 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SIX2¹	--	SIX homeobox 2	94.73(n) 98.97(a)	481357 XM_538478.2 XP_538478.2
chimpanzee (Pan troglodytes)	SIX2¹	--	SIX homeobox 2	99.89(n) 99.66(a)	459197 XM_515444.2 XP_515444.2
cow (Bos taurus)	SIX2¹	--	SIX homeobox 2	94.73(n) 99.31(a)	539492 XM_587683.3 XP_587683.2
rat (Rattus norvegicus)	Six2¹	--	SIX homeobox 2	92.67(n) 98.63(a)	366542 XM_345630.3 XP_345631.3
mouse (Mus musculus)	Six2^{1 , 5}	17 (55.72 cM)⁵	sine oculis-related homeobox 2 homolog (Drosophila)^{1, 5}	93.13(n)¹ 98.63(a)¹	20472¹ NM_011380.1¹ NP_035510.1¹ AK142139⁵ BC068021⁵ (see all 7)

About this table Species with no ortholog for SIX2

ENSEMBL Gene Tree for SIX2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SIX2 gene

SIX4² SIX5² SIX6² SIX3² SIX1²

SIX2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs895631^1,2	C,A,	45235010(-)	`TCCTTG/AGGCCC`	1	--	int¹		10		NA EA WA	337
rs921117^1,2	C,F,A,	45238211(-)	`GCAAAA/GCCAAA`	1	--	ng5¹		15		NA EA NS WA	876
rs921118^1,2	C,A,	45238173(-)	`TTCCGC/TGCTCC`	1	--	ng5¹ tfbs³		8		NA EA WA	220
rs1118180^1,2	--	45235602(-)	`GAGGCA/CTAAAC`	1	--	int¹		0	--	--	--	--
rs1529973^1,2	C,O,	45234061(+)	`GCTAGG/CAGGTT`	1	--	int¹		8		MN NA EA WA	402
rs2164705^1,2	A	45234083(+)	`GATCCC/GAGGTC`	1	--	int¹		0	--	--	--	--
rs2290029^1,2	C,F,	45232828(-)	`TTCTCT/CCCTGC`	1	--	ut3¹		2		EA	1554
rs2290030^1,2	C,F,A,H,	45232686(-)	`GAAAAG/TACAGG`	1	--	ut3¹ ese³		22		EA NS NA WA	2786
rs2342412^1,2	C,A,	45237996(+)	`CCTCCT/GCTTCC`	1	--	ng5¹ trp³		6		NA EA WA	216
rs2959228^1,2	C,	45236803(-)	`CCCTCC/AGTTCT`	1	--	ng5¹		2		EA NA	90

About this table

HapMap Linkage Disequilibrium images for SIX2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SIX2: --

QIAGEN SeqTarget long-range PCR primers for resequencing SIX2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SIX2 for disorders About GeneDecksing

OMIM: 604994

Human Gene Mutation Database (HGMD): SIX2

Export disorders and mutations for SIX2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/19 PubMed articles for SIX2 gene, integrated from 7 sources (see all 19):
(articles sorted by number of sources associating them with SIX2)

Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. (PubMed id 10773454)^{1, 2, 7} Boucher C.A.... Bailey M.E.S. (2000)
Familial syndromic esophageal atresia maps to 2p23-p24. (PubMed id 10677303)^{1, 2} Celli J....Brunner H.G. (2000)
The six family of homeobox genes in development and cancer. (PubMed id 19055944)¹ Christensen K.L....Ford H.L. (2008)
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. (PubMed id 18989625)¹ Kumar J.P. (2008)
SIX2 and BMP4 mutations associate with anomalous kidney development. (PubMed id 18305125)¹ Weber S.... Burdine R.D. (2008)
Six3 and Six6 activity is modulated by members of the groucho family. (PubMed id 12441302)¹ Lopez-Rios J....Bovolenta P. (2003)
Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. (PubMed id 12215533)¹ Ikeda K....Kawakami K. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. (PubMed id 11734542)¹ Buller C....Xu P.X. (2001)
Identification and expression of six family genes in mouse retina. (PubMed id 8814301)¹ Kawakami K....Saito T. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10736	HGNC: 10888	AceView: SIX2	Ensembl:ENSG00000170577	euGenes: HUgn10736
ECgene: SIX2	H-InvDB: SIX2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for SIX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for SIX2 gene:
Search GeneIP for patents involving SIX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
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	Predesigned and custom siRNAs for SIX2		Antibodies for SIX2
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2
	SeqTarget long-range PCR primers for resequencing SIX2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SIX2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2

	GenScript Custom Purified and Recombinant Proteins Services for SIX2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SIX2
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	Regulatory tfbs in SIX2 promoter
	Search Chromatin IP Primers for SIX2
	RT² qPCR Primer Assay for SIX2
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	SABiosciences PCR Arrays including SIX2

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Antibodies for SIX2

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for SIX2

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

SIX2 gene at Home site.

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SIX2 Gene

protein-coding GIFtS: 52

Aliases &
Descriptions
for SIX2 gene

Summaries
for SIX2 gene

Genomic Views
for SIX2 gene

Proteins
for SIX2 gene

Protein Domains/
Families
for SIX2 gene

Gene Function
for SIX2 gene

Pathways & Interactions
for SIX2 gene

Drugs & Compounds
for SIX2 gene

Transcripts
for SIX2 gene

Expression
for SIX2 gene

Orthologs
for SIX2 gene

Paralogs
for SIX2 gene

Genomic Variants
for SIX2 gene

Disorders & Mutations
for SIX2 gene

Medical News
for SIX2 gene

Publications
for SIX2 gene

External Searches for SIX2 gene

Genome Databases showing SIX2 gene

Other Databases showing SIX2 gene

Specialized Databases showing SIX2 gene

Intellectual Property
for SIX2 gene

Products
for SIX2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SIX2 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor SIX2 gene

Summariesfor SIX2 gene

Genomic Viewsfor SIX2 gene

Proteinsfor SIX2 gene

Protein Domains/Familiesfor SIX2 gene

Gene Functionfor SIX2 gene

Pathways & Interactionsfor SIX2 gene

Drugs & Compoundsfor SIX2 gene

Transcriptsfor SIX2 gene

Expression for SIX2 gene

Orthologsfor SIX2 gene

Paralogsfor SIX2 gene

Genomic Variantsfor SIX2 gene

Disorders & Mutationsfor SIX2 gene

Medical Newsfor SIX2 gene

Publicationsfor SIX2 gene

External Searches for SIX2 gene

Genome Databases showing SIX2 gene

Other Databases showing SIX2 gene

Specialized Databases showing SIX2 gene

Intellectual Propertyfor SIX2 gene

Productsfor SIX2 gene

View Random Gene

Aliases &
Descriptions
for SIX2 gene

Summaries
for SIX2 gene

Genomic Views
for SIX2 gene

Proteins
for SIX2 gene

Protein Domains/
Families
for SIX2 gene

Gene Function
for SIX2 gene

Pathways & Interactions
for SIX2 gene

Drugs & Compounds
for SIX2 gene

Transcripts
for SIX2 gene

Expression
for SIX2 gene

Orthologs
for SIX2 gene

Paralogs
for SIX2 gene

Genomic Variants
for SIX2 gene

Disorders & Mutations
for SIX2 gene

Medical News
for SIX2 gene

Publications
for SIX2 gene

Intellectual Property
for SIX2 gene

Products
for SIX2 gene