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SIX2 Gene

protein-coding   GIFtS: 52

GC02M044969
SIX homeobox 2
(Previous names: sine oculis homeobox (Drosophila) homolog 2, sine oculis homeobox homolog 2 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
SIX homeobox 21 2
Sine oculis homeobox homolog 22 3
sine oculis homeobox homolog 2 (Drosophila)1
sine oculis homeobox (Drosophila) homolog 21
homeobox protein SIX22

External Ids:    HGNC: 108881   Entrez Gene: 107362   Ensembl: ENSG000001705777   UniProtKB: Q9NPC83   

Export aliases for SIX2 gene to outside databases

Previous GC identifers: GC02M045231 GC02M045401 GC02M045206 GC02M045143 GC02M045232


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SIX2:
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis'
homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be
involved in limb or eye development. (provided by RefSeq)

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
Function: May be involved in limb tendon and ligament development (By similarity)

Gene Wiki entry for SIX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SIX2 gene promoter:
         FAC1   SRF   CUTL1   POU2F1   USF1   GCNF-1   GCNF-2   PPAR-gamma1   PPAR-gamma2   GATA-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SIX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SIX2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p21   Ensembl cytogenetic band:  2p21   HGNC cytogenetic band: 2p21

SIX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SIX2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M044969:  view genomic region     (about GC identifiers)

Start:
44,969,941 bp from pter
End:
44,974,159 bp from pter
Size:
4,219 bases
Orientation:
minus strand

1 alternative location:
Chr2- 45,232,343-45,236,543     
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8 (See protein sequence)
Recommended Name: Homeobox protein SIX2  
Size: 291 amino acids; 32286 Da
Subcellular location: Nucleus
Secondary accessions: Q9BXH7

Explore the universe of human proteins at neXtProt for SIX2: NX_Q9NPC8 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_058628.3  

    ENSEMBL proteins: 
    ENSP00000304502 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
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    OriGene Purified Protein: SIX2
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    Novus Biologicals Protein for SIX2
    Novus Biologicals Lysate for SIX2
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    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    SIX2 for ontologies           About GeneDecksing



    Antibodies for SIX2: 
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    Uscn ELISAs and CLIAs for SIX2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SIX2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR012287 Homeodomain-rel
     IPR001356 Homeobox
     IPR017970 Homeobox_CS
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9NPC8

    ProtoNet protein and cluster: Q9NPC8

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
    Similarity: Belongs to the SIX/Sine oculis homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
    Function: May be involved in limb tendon and ligament development (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SIX2
    Sigma-Aldrich shRNA for SIX2
    OriGene 29mer shRNA kits in GFP-retroviral vector: SIX2
    OriGene shRNA RFP: SIX2
    OriGene basic RS shRNA: SIX2
    OriGene siRNA: SIX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2 
    miRNA:Sigma-Aldrich microRNA Mimics for SIX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2 
    1 SABiosciences Assays for microRNA that regulate SIX2:
    hsa-miR-576-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SIX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SIX2
    OriGene untagged cDNA clones in CMV expression vector: SIX2
    OriGene 3'-UTR clone: SIX2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SIX2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SIX2 

    Genatlas biochemistry entry for SIX2:
    Drosophila sine oculis homolog SIX2 homeo box encoding gene,expressed in mesenchyme in mouse

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515 protein binding IEA--
    GO:0030528 transcription regulator activity IEA--
    GO:0043565 sequence-specific DNA binding IEA--
    About this table

    SIX2 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Six2):

    lethality-prenatal/perinatalnormalrenal/urinary system

    SIX2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including SIX2: PAHS-083A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SIX2

    5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656 metanephros development IEA--
    GO:0001822 kidney development IMP18305125
    GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis IEA--
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0006606 protein import into nucleus IEA--
    About this table

    SIX2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SIX2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SIX2
    Sigma-Aldrich shRNA for SIX2
    OriGene 29mer shRNA kits in GFP-retroviral vector: SIX2
    OriGene shRNA RFP: SIX2
    OriGene basic RS shRNA: SIX2
    OriGene siRNA: SIX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2 
    miRNA: Sigma-Aldrich microRNA Mimics for SIX2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2 
    1 SABiosciences Assays for microRNA that regulate SIX2:
    hsa-miR-576-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SIX2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SIX2
    OriGene untagged cDNA clones in CMV expression vector: SIX2
    OriGene 3'-UTR Clone: SIX2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SIX2 
    Primers: OriGene genome-wide validated SYBR primer pairs: SIX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SIX2: PPH10860A

    REFSEQ mRNAs for SIX2 gene: 

    NM_016932.4  

    Additional cDNA sequence: 

    AF136940.1 AF332196.1 AF332197.1 BC024033.2 BT020100.1 CR595397.1 

    2 DOTS entries:

    DT.92417765  DT.92417764 

    24/35 AceView cDNA sequences (see all 35):

    BQ071675 BX280822 NM_016932 BC024033 AF332196 AI630789 AF332197 AI697859 
    AF136940 AA808542 AI697804 CR595397 BG829041 BX347429 BM999458 BM017907 
    CA413774 AI811914 BX400894 BX341976 BQ944758 AW078611 BU543706 CF619326 

    highest scoring ESTs for SIX2:

    AF136940 AF332196 AF332197 BC024033 BE298099 BE547717 BG829041 BQ071675 BX280822 AI697804 

    Unigene Cluster for SIX2:

    SIX homeobox 2
    Hs.101937  [show with all ESTs]
    Unigene Representative Sequence: NM_016932


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303077(uc002ruo.2 uc002rup.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SIX2 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching SIX2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    89148_at2, 3 U95-E 1 0.75 1.00 1.00 1.00 AI697804 0.60 1.00 0.82 1
    206511_s_at2, 3 U133-A 1 0.73 1.00 -- -- NM_016932 0.60 1.00 0.82 1
    206510_at2, 3 U133-A 1 0.64 1.00 -- -- AF332197 0.80 1.00 0.91 1
    206511_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    206510_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    SIX2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SIX2 gene expression
    SIX2 gene electronic northern expression
    SIX2 gene sage expression
    About these images

    CGAP SAGE TAG: TGAATGTTCT

    SOURCE GeneReport for Unigene cluster: Hs.101937

    UniProtKB/Swiss-Prot: SIX2_HUMAN, Q9NPC8
    Tissue specificity: Strongly expressed in skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: SIX2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SIX2: PPH10860A
        SABiosciences Expression via Pathway-Focused PCR Array including SIX2: PAHS-083A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SIX2 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SIX21   -- SIX homeobox 2 94.73(n)
    98.97(a)
    481357  XM_538478.2  XP_538478.2 
    chimpanzee
    (Pan troglodytes)
    SIX21   -- SIX homeobox 2 99.89(n)
    99.66(a)
    459197  XM_515444.2  XP_515444.2 
    cow
    (Bos taurus)
    SIX21   -- SIX homeobox 2 94.73(n)
    99.31(a)
    539492  XM_587683.3  XP_587683.2 
    rat
    (Rattus norvegicus)
    Six21   -- SIX homeobox 2 92.67(n)
    98.63(a)
    366542  XM_345630.3  XP_345631.3 
    mouse
    (Mus musculus)
    Six21 , 5 17 (55.72 cM)5
    sine oculis-related homeobox 2 homolog (Drosophila)1, 5 93.13(n)1
    98.63(a)1
    204721  NM_011380.11  NP_035510.11 
     AK1421395  BC0680215  (see all 7)
    About this table        Species with no ortholog for SIX2

    ENSEMBL Gene Tree for SIX2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SIX2 gene
    SIX42  SIX52  SIX62  SIX32  SIX12  

    SIX2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/53 NCBI SNPs in SIX2 are shown (see all 53)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8956311,2
    C,A,45235010(-) TCCTTG/AGGCCC 1 -- int110Minor allele frequency- A:0.06NA EA WA 337
    rs9211171,2
    C,F,A,45238211(-) GCAAAA/GCCAAA 1 -- ng5115Minor allele frequency- G:0.50NA EA NS WA 876
    rs9211181,2
    C,A,45238173(-) TTCCGC/TGCTCC 1 -- ng51 tfbs38Minor allele frequency- T:0.48NA EA WA 220
    rs11181801,2
    --45235602(-) GAGGCA/CTAAAC 1 -- int10--------
    rs15299731,2
    C,O,45234061(+) GCTAGG/CAGGTT 1 -- int18Minor allele frequency- C:0.32MN NA EA WA 402
    rs21647051,2
    A45234083(+) GATCCC/GAGGTC 1 -- int10--------
    rs22900291,2
    C,F,45232828(-) TTCTCT/CCCTGC 1 -- ut312Minor allele frequency- C:0.06EA 1554
    rs22900301,2
    C,F,A,H,45232686(-) GAAAAG/TACAGG 1 -- ut31 ese322Minor allele frequency- T:0.05EA NS NA WA 2786
    rs23424121,2
    C,A,45237996(+) CCTCCT/GCTTCC 1 -- ng51 trp36Minor allele frequency- G:0.47NA EA WA 216
    rs29592281,2
    C,45236803(-) CCCTCC/AGTTCT 1 -- ng512Minor allele frequency- A:0.03EA NA 90
    About this table

    HapMap Linkage Disequilibrium images for SIX2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SIX2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing SIX2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SIX2 for disorders           About GeneDecksing

    OMIM: 604994

    Human Gene Mutation Database (HGMD): SIX2

    Export disorders and mutations for SIX2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/19 PubMed articles for SIX2 gene, integrated from 7 sources (see all 19):
    (articles sorted by number of sources associating them with SIX2)
    1. Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2. (PubMed id 10773454)1, 2, 7 Boucher C.A.... Bailey M.E.S. (2000)
    2. Familial syndromic esophageal atresia maps to 2p23-p24. (PubMed id 10677303)1, 2 Celli J....Brunner H.G. (2000)
    3. The six family of homeobox genes in development and cancer. (PubMed id 19055944)1 Christensen K.L....Ford H.L. (2008)
    4. The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. (PubMed id 18989625)1 Kumar J.P. (2008)
    5. SIX2 and BMP4 mutations associate with anomalous kidney development. (PubMed id 18305125)1 Weber S.... Burdine R.D. (2008)
    6. Six3 and Six6 activity is modulated by members of the groucho family. (PubMed id 12441302)1 Lopez-Rios J....Bovolenta P. (2003)
    7. Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. (PubMed id 12215533)1 Ikeda K....Kawakami K. (2002)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. (PubMed id 11734542)1 Buller C....Xu P.X. (2001)
    10. Identification and expression of six family genes in mouse retina. (PubMed id 8814301)1 Kawakami K....Saito T. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10736 HGNC: 10888 AceView: SIX2 Ensembl:ENSG00000170577 euGenes: HUgn10736
    ECgene: SIX2 H-InvDB: SIX2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SIX2 gene:
    Search GeneIP for patents involving SIX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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     Predesigned and custom siRNAs for SIX2 Antibodies for SIX2
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     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
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     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SIX2
     SeqTarget long-range PCR primers for resequencing SIX2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SIX2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SIX2
     GenScript Custom Purified and Recombinant Proteins Services for SIX2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SIX2
     GenScript Custom Assay Services for SIX2 GenScript Custom Superior Antibodies Services for SIX2
     GenScript Custom overexpressing Cell Line Services for SIX2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
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     Regulatory tfbs in SIX2 promoter
     Search Chromatin IP Primers for SIX2
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     GNC Network for SIX2
     Assays for microRNAs that regulate SIX2
     SABiosciences PCR Arrays including SIX2
     Search Tocris compounds for SIX2
     Browse Sino Biological Proteins and Antibodies
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     Antibodies for SIX2
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for SIX2
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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