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SLC16A12 Gene

protein-coding   GIFtS: 44

GC10M084824
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
(Previous names: solute carrier family 16 (monocarboxylic acid transporters), member 12 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)1 2     DKFZp686E1882
MCT121 2 3 5     monocarboxylate transporter 122
CJMG2 5     Solute carrier family 16 member 123
solute carrier family 16 (monocarboxylic acid transporters), member 121     MCT 123

External Ids:    HGNC: 230941   Entrez Gene: 3877002   Ensembl: ENSG000001527797   UniProtKB: Q6ZSM33   

Export aliases for SLC16A12 gene to outside databases

Previous GC identifers: GC00U913090 GC10M090857 GC10U900559 GC10M091181


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC16A12:
This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in
this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. (provided by RefSeq)

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
monocarboxylates (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC16A12 gene promoter:
         E4BP4   Meis-1   HOXA9B   Chx10   Hlf   Sox9   MEF-2A   STAT5A   ATF-2   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLC16A12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC16A12 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.31   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23.32

SLC16A12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC16A12 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M084824:  view genomic region     (about GC identifiers)

Start:
84,824,228 bp from pter
End:
84,929,593 bp from pter
Size:
105,366 bases
Orientation:
minus strand

1 alternative location:
Chr10- 91,190,056-91,316,398     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3 (See protein sequence)
Recommended Name: Monocarboxylate transporter 12  
Size: 486 amino acids; 53075 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Sequence caution: Sequence=BAC85987.1; Type=Erroneous initiation;
Secondary accessions: Q5M9M9 Q5T7J2 Q6ZV76

Explore the universe of human proteins at neXtProt for SLC16A12: NX_Q6ZSM3 

REFSEQ proteins: NP_998771.3  

ENSEMBL proteins: 
ENSP00000360855 ENSP00000343022 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane IEA--
About this table

SLC16A12 for ontologies           About GeneDecksing



Antibodies for SLC16A12: 
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Uscn ELISAs and CLIAs for SLC16A12 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC16A12 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR011701 MFS_1
 IPR020846 Major_facilitator_SF
 IPR016196 MFS_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q6ZSM3

ProtoNet protein and cluster: Q6ZSM3

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3
Similarity: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many
monocarboxylates (By similarity)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC16A12
OriGene shRNA RFP (see all 2): SLC16A12
OriGene basic RS shRNA (see all 2): SLC16A12
OriGene siRNA: SLC16A12
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC16A12 
miRNA:Sigma-Aldrich microRNA Mimics for SLC16A12
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC16A12 
2 SABiosciences Assays for microRNAs that regulate SLC16A12:
hsa-miR-576-5p hsa-miR-9

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: SLC16A12
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLC16A12
OriGene untagged cDNA clones in CMV expression vector: SLC16A12
OriGene 3'-UTR clone: SLC16A12 
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Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for SLC16A12 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0015293 symporter activity IEA--
About this table

SLC16A12 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for SLC16A12 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC16A12

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0055085 transmembrane transport IEA--
About this table

SLC16A12 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC16A12


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC16A12
Sigma-Aldrich shRNA for SLC16A12
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC16A12
OriGene shRNA RFP (see all 2): SLC16A12
OriGene basic RS shRNA (see all 2): SLC16A12
OriGene siRNA: SLC16A12
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC16A12 
miRNA: Sigma-Aldrich microRNA Mimics for SLC16A12
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC16A12 
2 SABiosciences Assays for microRNAs that regulate SLC16A12:
hsa-miR-576-5p hsa-miR-9
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: SLC16A12
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLC16A12
OriGene untagged cDNA clones in CMV expression vector: SLC16A12
OriGene 3'-UTR Clone: SLC16A12 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for SLC16A12 
Primers: OriGene genome-wide validated SYBR primer pairs: SLC16A12
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for SLC16A12: PPH58278A

REFSEQ mRNAs for SLC16A12 gene: 

NM_213606.3  

Additional cDNA sequence: 

AK124901.1 AK127303.1 BC086873.1 CR614627.1 

4 DOTS entries:

DT.101964142  DT.121248685  DT.40192811  DT.70103483 

24/27 AceView cDNA sequences (see all 27):

CR614627 AW118671 CA842760 BF195954 AI811653 CB068043 BQ269565 BX102238 
CD000588 AI264674 CF553043 BQ417484 NM_213606 BM055162 BQ288035 AI733820 
BM054923 BQ286201 CA848698 AK124901 BX439794 AK127303 BG433490 AI792642 

highest scoring ESTs for SLC16A12:

AK127303 AI264674 AJ706758 AK124901 BF195954 BG433490 CF553043 CK826025 CK826026 CR936657 

Unigene Cluster for SLC16A12:

Solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
Hs.530338  [show with all ESTs]
Unigene Representative Sequence: NM_213606


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000371790 ENST00000475682 ENST00000341233(uc001kgl.2 uc001kgm.2)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SLC16A12 expression in normal and diseased human tissues

1  / 2  / 3

1 probe-set matching SLC16A12 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
80010_at2, 3 U95-D 1 0.94 1.00 1.00 1.00 AI264674 0.60 1.00 0.82 1
About this table

SLC16A12 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
SLC16A12 gene expression
SLC16A12 gene electronic northern expression
SLC16A12 gene sage expression
About these images

CGAP SAGE TAG: GGAATGATGT

SOURCE GeneReport for Unigene cluster: Hs.530338

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3
Tissue specificity: Most highly expressed in kidney, followed by retina, lung, and testis. Very weakly expressed in
brain and liver. Also detected in lens

Primers: OriGene genome-wide validated SYBR primer pairs: SLC16A12
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for SLC16A12: PPH58278A
    SABiosciences Custom PCR Arrays for SLC16A12 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC16A12 gene from 5/13 species (see all 13)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
SLC16A121   -- solute carrier family 16, member 12 (monocarboxylic more 91.25(n)
93.12(a)
486789  XM_543918.1  XP_543918.1 
chimpanzee
(Pan troglodytes)
SLC16A121   -- solute carrier family 16, member 12 (monocarboxylic more 99.59(n)
99.18(a)
450588  XM_507905.2  XP_507905.2 
cow
(Bos taurus)
SLC16A121   -- solute carrier family 16, member 12 (monocarboxylic more 90.67(n)
91.36(a)
538469  XM_580537.3  XP_580537.2 
rat
(Rattus norvegicus)
Slc16a121   -- solute carrier family 16, member 12 (monocarboxylic more 84.57(n)
86.42(a)
309525  XM_220057.4  XP_220057.4 
mouse
(Mus musculus)
Slc16a121 , 5 19 (29.79 cM)5
solute carrier family 16 (monocarboxylic acid transporters), more1, 5 84.5(n)1
86.83(a)1
2406381  NM_172838.21  NP_766426.11 
 AK0282845  AK0290765  (see all 9)
About this table        Species with no ortholog for SLC16A12

ENSEMBL Gene Tree for SLC16A12 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for SLC16A12 gene
SLC16A72  LOC4404592  SLC16A12  SLC16A32  SLC16A52  SLC16A82  SLC16A62  

SLC16A12 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/24 NCBI SNPs in SLC16A12 are shown (see all 24)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 10 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs37400301,2
C,F,91222287(+) CAGCCA/CAGTTA 1 -- ut5124Minor allele frequency- C:0.13NA NS EA 2058
rs73421211,2
C,F,91191759(+) TGACTC/GCCTCC 1 -- ut315Minor allele frequency- G:0.02NS EA WA 468
rs79204921,2
C,F,91190068(+) CAATAA/GATTCA 1 -- ut316Minor allele frequency- G:0.08NS EA WA 468
rs111857451,2
--91294396(+) cctgtA/Ttctgc 1 -- ut51 ese30--------
rs113148481,2
C91192239(+) AAAAA-/ATAAGA 1 -- ut31 trp31Minor allele frequency- A:0.50NA 2
rs171214271,2
C,F,91191280(+) GGAGCA/GTACAC 1 -- ut319Minor allele frequency- G:0.04NA NS EA 722
rs347980901,2
C91190772(+) TTTTT-/TGAGAT 1 -- ut312Minor allele frequency- T:0.25NA 4
rs412849541,2
--91190560(+) ATACTC/TCACAG 1 -- ut310--------
rs618551731,2
--91190739(+) CTTTGA/GCATTT 1 -- ut310--------
rs618551741,2
--91190759(+) CTTCCA/TATTTT 1 -- ut310--------
About this table

HapMap Linkage Disequilibrium images for SLC16A12 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLC16A12: --

QIAGEN SeqTarget long-range PCR primers for resequencing SLC16A12 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC16A12 for disorders           About GeneDecksing

OMIM: 611910   disorders: 612018  

UniProtKB/Swiss-Prot: MOT12_HUMAN, Q6ZSM3

  • Defects in SLC16A12 are a cause of cataract juvenile with microcornea and glucosuria (CJMG) [MIM:612018].
  • Renal glucosuria is defined by elevated glucose level in the urine without hyperglycemia and without evidence of
    morphological renal anomalies

    Human Gene Mutation Database (HGMD): SLC16A12
    Human Genome Epidemiology (HuGE) Navigator: SLC16A12 (2 documents)

    Export disorders and mutations for SLC16A12 gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    8 PubMed articles for SLC16A12 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with SLC16A12)
    1. Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria. (PubMed id 18304496)1, 2 Kloeckener-Gruissem B.... Berger W. (2008)
    2. Alterations of the 5'untranslated leader region of SL C16A12 lead to age-related cataract. (PubMed id 20181839)1 Zuercher J....Kloeckener-Gruissem B. (2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    5. The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. (PubMed id 12739169)1 Halestrap A.P. and Meredith D. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387700 HGNC: 23094 AceView: LOC387700 Ensembl:ENSG00000152779 euGenes: HUgn387700
    ECgene: SLC16A12 H-InvDB: SLC16A12

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SLC16A12 gene:
    Search GeneIP for patents involving SLC16A12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Novus Biologicals
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    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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