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SLC2A5 Gene

protein-coding GIFtS: 56

GC01M008246

solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUT5)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
solute carrier family 2 (facilitated glucose/fructose transporter), member 5¹ ²		GLUT-5² ³
GLUT5² ³ ⁵		solute carrier family 2, facilitated glucose transporter member 5²
Glucose transporter type 5, small intestine² ³		solute carrier family 2 (facilitated glucose transporter), member 5²
Fructose transporter² ³		glucose transporter-like protein 5²

External Ids:	HGNC: 11010¹	Entrez Gene: 6518²	Ensembl: ENSG00000142583⁷	UniProtKB: P22732³

Export aliases for SLC2A5 gene to outside databases

Previous GC identifers: GC01M008717 GC01M008908 GC01M008772 GC01M009031 GC01M009019 GC01M009095

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732

Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC2A5 gene promoter:
         PPAR-gamma2   PPAR-gamma1   E47   GCNF-2   GCNF-1   RORalpha2   Lmo2   SREBP-1c   SREBP-1b   SREBP-1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for SLC2A5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC2A5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.2

SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A5 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M008246: view genomic region (about GC identifiers)

Start:	8,246,781 bp from pter
End:	8,298,698 bp from pter
Size:	51,918 bases
Orientation:	minus strand

1 alternative location:

Chr1- 9,095,166-9,148,537

RefSeq DNA sequence:

NC_000001.10 NT_021937.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732 (See protein sequence)

Recommended Name: Solute carrier family 2, facilitated glucose transporter member 5

Size: 501 amino acids; 54974 Da

Subcellular location: Membrane; Multi-pass membrane protein

Mass spectrometry: Mass=54973.98; Method=MALDI; Range=1-501; Source=PubMed:11840567;

Sequence caution: Sequence=AAB60641.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1YG1 (3D)

Secondary accessions: Q14770 Q5T977

Explore the universe of human proteins at neXtProt for SLC2A5: NX_P22732

REFSEQ proteins (2 alternative transcripts):

NP_001129057.1 NP_003030.1

ENSEMBL proteins:

ENSP00000366641 ENSP00000366631 ENSP00000388106

Human Recombinant Proteins

	Millipore Purified and/or Recombinant SLC2A5 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SLC2A5 OriGene Protein Over-expression Lysate: SLC2A5
	GenScript Custom Purified and Recombinant Proteins Services for SLC2A5
	Novus Biologicals Protein for SLC2A5
	Novus Biologicals Lysates for SLC2A5
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	EXP	1634504
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	IEA	--

About this table

SLC2A5 for ontologies About GeneDecksing

Antibodies for SLC2A5:

	Millipore Mono- and Polyclonal Antibodies for the study of SLC2A5
	Sigma-Aldrich Antibodies for SLC2A5
	R&D Systems Antibodies for SLC2A5 (Glut5)
	OriGene Antibodies (see all 10): SLC2A5
	GenScript Custom Superior Antibodies Services for SLC2A5
	Novus Biologicals Antibodies for SLC2A5
	Browse antibodies at Epitomics

Assays for SLC2A5:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC2A5
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC2A5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR005829 Sugar_transporter_CS

IPR005828 Sub_transporter

IPR003663 Sugar/inositol_transpt

IPR002442 Fru_transpt_5

IPR020846 Major_facilitator_SF

Graphical View of Domain Structure for InterPro Entry P22732

ProtoNet protein and cluster: P22732

4 Blocks protein families:

IPB000803 Mammalian facilitated glucose transporter family signature

IPB002442 Fructose transporter (GLUT5) signature

IPB003663 Sugar transporter signature

IPB005829 Sugar transporter superfamily

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter

subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732

Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter

Induction: By forskolin in Caco-2 cells

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A5 Sigma-Aldrich shRNA for SLC2A5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): SLC2A5 OriGene shRNA RFP (see all 3): SLC2A5 OriGene basic RS shRNA (see all 3): SLC2A5 OriGene siRNA (see all 3): SLC2A5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A5

miRNA:		Sigma-Aldrich microRNA Mimics for SLC2A5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A5
		Search SABiosciences for Assays for microRNAs that regulate SLC2A5

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A5 OriGene untagged cDNA clones in CMV expression vector: SLC2A5 OriGene 3'-UTR clone (see all 2): SLC2A5 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SLC2A5
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for SLC2A5

Genatlas biochemistry entry for SLC2A5:

solute carrier family 2,member A5,facilitated glucose transporter

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	IEA	--
GO:0005353	fructose transmembrane transporter activity	EXP	1634504
GO:0005355	glucose transmembrane transporter activity	TAS	1695905
GO:0022891	substrate-specific transmembrane transporter activity	IEA	--

About this table

SLC2A5 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Slc2a5):

hearing/vestibular/ear

no phenotypic analysis

SLC2A5 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SLC2A5 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SLC2A5

HIF1α Signaling

1 Kegg Pathway (Kegg details for SLC2A5):

hsa04973 Carbohydrate digestion and absorption

SABiosciences Custom Pathway-Focused PCR Arrays for SLC2A5

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLC2A5

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC2A5

5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006810	transport	--	--
GO:0008643	carbohydrate transport	IEA	--
GO:0008645	hexose transport	TAS	--
GO:0015755	fructose transport	TAS	1634504

About this table

SLC2A5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

SLC2A5 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC2A5
10 Novoseek chemical compound relationships for SLC2A5 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose	89	155	7980458 (8), 17947353 (6), 8404647 (5), 12820898 (5) (see all 49)
cytochalasin b	73.1	5	1634504 (1), 1397712 (1), 7980458 (1), 11718673 (1) (see all 5)
glucose	62.4	72	8764205 (3), 1695905 (3), 8554516 (3), 7980458 (3) (see all 31)
galactose	38.4	4	7980458 (2), 11718673 (1), 11341798 (1)
monosaccharide	34.5	1	11804845 (1)
glyceraldehyde 3-phosphate	20.8	4	11877642 (1), 11341798 (1)
sodium	5.49	14	9073126 (2), 11877642 (1), 9073127 (1), 11341798 (1)
cyclic amp	4.52	10	8037665 (4), 8554516 (2)
oligonucleotide	0	2	8245960 (1), 7980458 (1)
lipid	0	1	17079126 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A5 Sigma-Aldrich shRNA for SLC2A5
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): SLC2A5 OriGene shRNA RFP (see all 3): SLC2A5 OriGene basic RS shRNA (see all 3): SLC2A5 OriGene siRNA (see all 3): SLC2A5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A5

miRNA:		Sigma-Aldrich microRNA Mimics for SLC2A5 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A5
		Search SABiosciences for Assays for microRNAs that regulate SLC2A5

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A5 OriGene untagged cDNA clones in CMV expression vector: SLC2A5 OriGene 3'-UTR Clone (see all 2): SLC2A5 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for SLC2A5

Primers:		OriGene genome-wide validated SYBR primer pairs: SLC2A5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SLC2A5: PPH08987A

REFSEQ mRNAs for SLC2A5 gene (2 alternative transcripts):

NM_001135585.1 NM_003039.2

Additional cDNA sequence:

AF451839.1 AF479408.1 AK289849.1 AK290398.1 AK294368.1 AK295785.1 AK300091.1 AK300477.1

AK302047.1 AK302057.1 AK302137.1 BC001692.2 BC001820.2 BC035878.1 M55531.1

11 DOTS entries:

DT.448954 DT.310883 DT.121388622 DT.92429282 DT.91956199 DT.92429281 DT.121388633 DT.100022645

DT.86853866 DT.101978310 DT.121388630

24/160 AceView cDNA sequences (see all 160):

BG207571 BX096261 T28018 BX644129 BP344468 BE218165 AA416861 BE267513

AI309058 AA481400 AI796342 BC001820 AI538194 BM673646 CA309754 AI125358

AI360190 CB153237 BC035878 AW950275 BQ010925 BI830826 AA194382 F34598

highest scoring ESTs for SLC2A5:

M55531 AA233480 AI198627 AI802333 AI823806 AW028145 BC001692 BC001820 BC035878 BE267513

Unigene Cluster for SLC2A5:

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5

Hs.530003 [show with all ESTs]

Unigene Representative Sequence: NM_003039

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14
SP1:															-
SP2:															-
SP3:			-		-
SP4:											-		-

About this scheme

ECgene alternative splicing isoforms for SLC2A5
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377424(uc010nzy.1 uc010nzz.1 uc001apo.2 uc010oaa.1 uc010oab.1)

ENST00000473209 ENST00000484798 ENST00000486632 ENST00000487492 ENST00000479813

ENST00000377414(uc010oac.1 uc001app.3) ENST00000464985 ENST00000461296

ENST00000487835 ENST00000456780 ENST00000474145

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SLC2A5 expression in normal and diseased human tissues

¹ / ² / ³

9 probe-sets matching SLC2A5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34362_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.25	M55531	1.00	1.00	1.00	1
48410_at²^{, 3}	U95-B	1	0.38	1.00	-0.27	1.24	AI823806	0.80	1.00	0.91	1
84397_at²^{, 3}	U95-D	1	0.31	1.00	0.78	0.61	AA747436	0.20	1.00	0.72	1
204429_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE560461	0.40	1.00	0.76	1
204430_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003039	0.60	1.00	0.82	1
230705_at²^{, 3}	U133-B	1	0.27	1.00	--	--	AI823806	0.80	1.00	0.91	1
204429_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204430_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230705_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

About this table

SLC2A5 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

SLC2A5 gene electronic northern expression

About these images

CGAP SAGE TAG: GGCATTTGTT

SOURCE GeneReport for Unigene cluster: Hs.530003

Expression variation in blood from EXPOLDB for SLC2A5

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732

Tissue specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose

tissue

Primers:		OriGene genome-wide validated SYBR primer pairs: SLC2A5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SLC2A5: PPH08987A

SABiosciences Custom PCR Arrays for SLC2A5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC2A5 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SLC2A5¹	--	solute carrier family 2 (facilitated glucose/fructose more	83.9(n) 85.03(a)	489640 XM_546760.2 XP_546760.2
chimpanzee (Pan troglodytes)	SLC2A5¹	--	solute carrier family 2 (facilitated glucose/fructose more	99.4(n) 99.6(a)	457916 XM_001160154.1 XP_001160154.1
cow (Bos taurus)	SLC2A5¹	--	solute carrier family 2 (facilitated glucose/fructose more	80.9(n) 80.24(a)	282868 XM_583977.3 XP_583977.2
rat (Rattus norvegicus)	Slc2a5¹	--	solute carrier family 2 (facilitated glucose/fructose more	80.27(n) 81.8(a)	65197 NM_031741.1 NP_113929.1
mouse (Mus musculus)	Slc2a5^{1 , 5}	4 (80.97 cM)⁵	solute carrier family 2 (facilitated glucose transporter), more^{1, 5}	79.53(n)¹ 83(a)¹	56485¹ NM_019741.3¹ NP_062715.2¹ AF161071⁵ AI526984⁵ (see all 9)

About this table Species with no ortholog for SLC2A5

ENSEMBL Gene Tree for SLC2A5 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SLC2A5 gene

ENSG00000251357² SLC2A9² SLC2A7² SLC2A11²

SLC2A5 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs5438^1,2	C,F,O,A,	9129620(-)	`TGAGCG/AGCACT`	2	--	ut5¹ ese³		13		MN EA EU NA NS WA	3111
rs5840^1,2	C,F,A,	9097241(+)	`CCTGTT/CGGGGC`	1	--	ut3¹ ese³		12		MN NS EA NA WA	992
rs762605^1,2	--	9097851(-)	`TCCCGC/TAGGAG`	1	--	int¹		0	--	--	--	--
rs765615^1,2	C,F,	9121687(-)	`GAATTG/AGAAAA`	2	--	int¹		5		NA WA	10
rs765616^1,2	C,	9121679(-)	`AAAGAT/ATTTTT`	2	--	int¹		1		NA	2
rs765617^1,2	C,F,O,A,	9121782(-)	`CAAACC/TTTAGG`	2	--	int¹		24		NA EA NS MN WA	1497
rs765618^1,2	C	9121623(-)	`cagtgA/Gtacaa`	2	--	int¹		0	--	--	--	--
rs769897^1,2	C,F,	9099727(-)	`TTGCCT/CTGCAG`	1	--	int¹		2		MN WA	234
rs770022^1,2		9114714(+)	`cgtagC/Tggttc`	2	--	int¹		0	--	--	--	--
rs770023^1,2	C,A,	9115234(+)	`gatctT/Cgggta`	2	--	int¹		6		NS EA NA WA	518

About this table

HapMap Linkage Disequilibrium images for SLC2A5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC2A5: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for SLC2A5

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC2A5 for disorders About GeneDecksing

OMIM: 138230

5 Novoseek disease relationships for SLC2A5 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
malabsorption	22.9	2	8941659 (2)
cancer	4.01	1	16523487 (1), 18398011 (1)
colon cancer	0	2	8037665 (1)
breast cancer	0	2	8700847 (1), 16523487 (1)
tumors	0	3	16523487 (2), 10622535 (1)

About this table

1 PharmGKB disease relationship for SLC2A5 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872 12730115

About this table

Human Genome Epidemiology (HuGE) Navigator: SLC2A5 (5 documents)

Export disorders and mutations for SLC2A5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/99 PubMed articles for SLC2A5 gene, integrated from 7 sources (see all 99):
(articles sorted by number of sources associating them with SLC2A5)

Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PubMed id 8037665)^{1, 2, 7} Mahraoui L.... Brot-Laroche E. (1994)
Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)^{1, 3, 7} White P.S....Brodeur G.M. (1998)
Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PubMed id 1695905)^{1, 2, 7} Kayano T.... Bell G.I. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)^{1, 2} Harris R.A....Zvelebil M.J. (2002)
Fructose transporter in human spermatozoa and small intestine is GLUT5. (PubMed id 1634504)^{1, 7} Burant C.F....Davidson N.O. (1992)
Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone. (PubMed id 17251278)^{1, 7} Stuart C.A....Yin D. (2007)
Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PubMed id 12820898)^{1, 7} Gouyon F....Brot-Laroche E. (2003)
Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. (PubMed id 16803853)^{1, 7} Stuart C.A....Ferrando A.A. (2006)
Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. (PubMed id 18439419)^{1, 7} Mochizuki K....Goda T. (2008)

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Entrez Gene: 6518	HGNC: 11010	AceView: SLC2A5	Ensembl:ENSG00000142583	euGenes: HUgn6518
ECgene: SLC2A5	Kegg: 6518	H-InvDB: SLC2A5

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