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SLC2A5 Gene

protein-coding   GIFtS: 56

GC01M008246
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLUT5)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
solute carrier family 2 (facilitated glucose/fructose transporter), member 51 2     GLUT-52 3
GLUT52 3 5     solute carrier family 2, facilitated glucose transporter member 52
Glucose transporter type 5, small intestine2 3     solute carrier family 2 (facilitated glucose transporter), member 52
Fructose transporter2 3     glucose transporter-like protein 52

External Ids:    HGNC: 110101   Entrez Gene: 65182   Ensembl: ENSG000001425837   UniProtKB: P227323   

Export aliases for SLC2A5 gene to outside databases

Previous GC identifers: GC01M008717 GC01M008908 GC01M008772 GC01M009031 GC01M009019 GC01M009095


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A5 gene promoter:
         PPAR-gamma2   PPAR-gamma1   E47   GCNF-2   GCNF-1   RORalpha2   Lmo2   SREBP-1c   SREBP-1b   SREBP-1a   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLC2A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC2A5 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A5 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M008246:  view genomic region     (about GC identifiers)

Start:
8,246,781 bp from pter
End:
8,298,698 bp from pter
Size:
51,918 bases
Orientation:
minus strand

1 alternative location:
Chr1- 9,095,166-9,148,537     
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 5  
Size: 501 amino acids; 54974 Da
Subcellular location: Membrane; Multi-pass membrane protein
Mass spectrometry: Mass=54973.98; Method=MALDI; Range=1-501; Source=PubMed:11840567;
Sequence caution: Sequence=AAB60641.1; Type=Erroneous gene model prediction;
PDB structures from and Proteopedia :
1YG1 (3D)    
Secondary accessions: Q14770 Q5T977

Explore the universe of human proteins at neXtProt for SLC2A5: NX_P22732 

REFSEQ proteins (2 alternative transcripts): 
NP_001129057.1  NP_003030.1  


ENSEMBL proteins: 
ENSP00000366641 ENSP00000366631 ENSP00000388106 


Human Recombinant Proteins 
Millipore Purified and/or Recombinant SLC2A5 Protein
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: SLC2A5
OriGene Protein Over-expression Lysate: SLC2A5
GenScript Custom Purified and Recombinant Proteins Services for SLC2A5 
Novus Biologicals Protein for SLC2A5
Novus Biologicals Lysates for SLC2A5
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane EXP1634504
GO:0016020 membrane ----
GO:0016021 integral to membrane IEA--
About this table

SLC2A5 for ontologies           About GeneDecksing



Antibodies for SLC2A5: 
Millipore Mono- and Polyclonal Antibodies for the study of SLC2A5
Sigma-Aldrich Antibodies for SLC2A5
R&D Systems Antibodies for SLC2A5 (Glut5)
OriGene Antibodies (see all 10): SLC2A5
GenScript Custom Superior Antibodies Services for SLC2A5 
Novus Biologicals Antibodies for SLC2A5
Browse antibodies at Epitomics

Assays for SLC2A5: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SLC2A5 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC2A5 for domains           About GeneDecksing

5/6 InterPro domains/families (see all 6):
 IPR005829 Sugar_transporter_CS
 IPR005828 Sub_transporter
 IPR003663 Sugar/inositol_transpt
 IPR002442 Fru_transpt_5
 IPR020846 Major_facilitator_SF

Graphical View of Domain Structure for InterPro Entry P22732

ProtoNet protein and cluster: P22732

4 Blocks protein families:
IPB000803 Mammalian facilitated glucose transporter family signature
IPB002442 Fructose transporter (GLUT5) signature
IPB003663 Sugar transporter signature
IPB005829 Sugar transporter superfamily


UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter
subfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter
Induction: By forskolin in Caco-2 cells

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A5
Sigma-Aldrich shRNA for SLC2A5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): SLC2A5
OriGene shRNA RFP (see all 3): SLC2A5
OriGene basic RS shRNA (see all 3): SLC2A5
OriGene siRNA (see all 3): SLC2A5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A5 
miRNA:Sigma-Aldrich microRNA Mimics for SLC2A5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A5 
Search SABiosciences for Assays for microRNAs that regulate SLC2A5

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A5
OriGene untagged cDNA clones in CMV expression vector: SLC2A5
OriGene 3'-UTR clone (see all 2): SLC2A5 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for SLC2A5 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for SLC2A5 

Genatlas biochemistry entry for SLC2A5:
solute carrier family 2,member A5,facilitated glucose transporter

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
GO:0005353 fructose transmembrane transporter activity EXP1634504
GO:0005355 glucose transmembrane transporter activity TAS1695905
GO:0022891 substrate-specific transmembrane transporter activity IEA--
About this table

SLC2A5 for ontologies           About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a5):

hearing/vestibular/earno phenotypic analysis

SLC2A5 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


SLC2A5 for pathways           About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  SLC2A5
    HIF1α Signaling

1 Kegg Pathway  (Kegg details for SLC2A5):
    hsa04973 Carbohydrate digestion and absorption

    SABiosciences Custom Pathway-Focused PCR Arrays for SLC2A5 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLC2A5
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A5

5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0005975 carbohydrate metabolic process TAS--
GO:0006810 transport ----
GO:0008643 carbohydrate transport IEA--
GO:0008645 hexose transport TAS--
GO:0015755 fructose transport TAS1634504
About this table

SLC2A5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

SLC2A5 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC2A5
10 Novoseek chemical compound relationships for SLC2A5 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
fructose 89 155 7980458 (8), 17947353 (6), 8404647 (5), 12820898 (5) (see all 49)
cytochalasin b 73.1 5 1634504 (1), 1397712 (1), 7980458 (1), 11718673 (1) (see all 5)
glucose 62.4 72 8764205 (3), 1695905 (3), 8554516 (3), 7980458 (3) (see all 31)
galactose 38.4 4 7980458 (2), 11718673 (1), 11341798 (1)
monosaccharide 34.5 1 11804845 (1)
glyceraldehyde 3-phosphate 20.8 4 11877642 (1), 11341798 (1)
sodium 5.49 14 9073126 (2), 11877642 (1), 9073127 (1), 11341798 (1)
cyclic amp 4.52 10 8037665 (4), 8554516 (2)
oligonucleotide 0 2 8245960 (1), 7980458 (1)
lipid 0 1 17079126 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A5
Sigma-Aldrich shRNA for SLC2A5
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): SLC2A5
OriGene shRNA RFP (see all 3): SLC2A5
OriGene basic RS shRNA (see all 3): SLC2A5
OriGene siRNA (see all 3): SLC2A5
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A5 
miRNA: Sigma-Aldrich microRNA Mimics for SLC2A5
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A5 
Search SABiosciences for Assays for microRNAs that regulate SLC2A5
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A5
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A5
OriGene untagged cDNA clones in CMV expression vector: SLC2A5
OriGene 3'-UTR Clone (see all 2): SLC2A5 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for SLC2A5 
Primers: OriGene genome-wide validated SYBR primer pairs: SLC2A5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for SLC2A5: PPH08987A

REFSEQ mRNAs for SLC2A5 gene (2 alternative transcripts): 

NM_001135585.1  NM_003039.2  

Additional cDNA sequence: 

AF451839.1 AF479408.1 AK289849.1 AK290398.1 AK294368.1 AK295785.1 AK300091.1 AK300477.1 
AK302047.1 AK302057.1 AK302137.1 BC001692.2 BC001820.2 BC035878.1 M55531.1 

11 DOTS entries:

DT.448954  DT.310883  DT.121388622  DT.92429282  DT.91956199  DT.92429281  DT.121388633  DT.100022645 
DT.86853866  DT.101978310  DT.121388630 

24/160 AceView cDNA sequences (see all 160):

BG207571 BX096261 T28018 BX644129 BP344468 BE218165 AA416861 BE267513 
AI309058 AA481400 AI796342 BC001820 AI538194 BM673646 CA309754 AI125358 
AI360190 CB153237 BC035878 AW950275 BQ010925 BI830826 AA194382 F34598 

highest scoring ESTs for SLC2A5:

M55531 AA233480 AI198627 AI802333 AI823806 AW028145 BC001692 BC001820 BC035878 BE267513 

Unigene Cluster for SLC2A5:

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5
Hs.530003  [show with all ESTs]
Unigene Representative Sequence: NM_003039


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:                                            -                                                               
SP2:                                            -                                                               
SP3:        -     -                                                                                             
SP4:                                -     -                                                                     

About this scheme

ECgene alternative splicing isoforms for SLC2A5
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000377424(uc010nzy.1 uc010nzz.1 uc001apo.2 uc010oaa.1 uc010oab.1)
ENST00000473209 ENST00000484798 ENST00000486632 ENST00000487492 ENST00000479813
ENST00000377414(uc010oac.1 uc001app.3) ENST00000464985 ENST00000461296
ENST00000487835 ENST00000456780 ENST00000474145

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SLC2A5 expression in normal and diseased human tissues

1  / 2  / 3

9 probe-sets matching SLC2A5 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
34362_at2, 3 U95-A 1 1.00 1.00 0.96 1.25 M55531 1.00 1.00 1.00 1
48410_at2, 3 U95-B 1 0.38 1.00 -0.27 1.24 AI823806 0.80 1.00 0.91 1
84397_at2, 3 U95-D 1 0.31 1.00 0.78 0.61 AA747436 0.20 1.00 0.72 1
204429_s_at2, 3 U133-A 1 1.00 1.00 -- -- BE560461 0.40 1.00 0.76 1
204430_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003039 0.60 1.00 0.82 1
230705_at2, 3 U133-B 1 0.27 1.00 -- -- AI823806 0.80 1.00 0.91 1
204429_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
204430_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
230705_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
About this table

SLC2A5 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
SLC2A5 gene expression
SLC2A5 gene electronic northern expression
SLC2A5 gene sage expression
About these images

CGAP SAGE TAG: GGCATTTGTT

SOURCE GeneReport for Unigene cluster: Hs.530003

Expression variation in blood from EXPOLDB for SLC2A5

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Tissue specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose
tissue

Primers: OriGene genome-wide validated SYBR primer pairs: SLC2A5
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for SLC2A5: PPH08987A
    SABiosciences Custom PCR Arrays for SLC2A5 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SLC2A5 gene from 5/9 species (see all 9)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
SLC2A51   -- solute carrier family 2 (facilitated glucose/fructose more 83.9(n)
85.03(a)
489640  XM_546760.2  XP_546760.2 
chimpanzee
(Pan troglodytes)
SLC2A51   -- solute carrier family 2 (facilitated glucose/fructose more 99.4(n)
99.6(a)
457916  XM_001160154.1  XP_001160154.1 
cow
(Bos taurus)
SLC2A51   -- solute carrier family 2 (facilitated glucose/fructose more 80.9(n)
80.24(a)
282868  XM_583977.3  XP_583977.2 
rat
(Rattus norvegicus)
Slc2a51   -- solute carrier family 2 (facilitated glucose/fructose more 80.27(n)
81.8(a)
65197  NM_031741.1  NP_113929.1 
mouse
(Mus musculus)
Slc2a51 , 5 4 (80.97 cM)5
solute carrier family 2 (facilitated glucose transporter), more1, 5 79.53(n)1
83(a)1
564851  NM_019741.31  NP_062715.21 
 AF1610715  AI5269845  (see all 9)
About this table        Species with no ortholog for SLC2A5

ENSEMBL Gene Tree for SLC2A5 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for SLC2A5 gene
ENSG000002513572  SLC2A92  SLC2A72  SLC2A112  

SLC2A5 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/408 NCBI SNPs in SLC2A5 are shown (see all 408)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs54381,2
C,F,O,A,9129620(-) TGAGCG/AGCACT 2 -- ut51 ese313Minor allele frequency- A:0.07MN EA EU NA NS WA 3111
rs58401,2
C,F,A,9097241(+) CCTGTT/CGGGGC 1 -- ut31 ese312Minor allele frequency- C:0.47MN NS EA NA WA 992
rs7626051,2
--9097851(-) TCCCGC/TAGGAG 1 -- int10--------
rs7656151,2
C,F,9121687(-) GAATTG/AGAAAA 2 -- int15Minor allele frequency- A:0.40NA WA 10
rs7656161,2
C,9121679(-) AAAGAT/ATTTTT 2 -- int11Minor allele frequency- A:0.50NA 2
rs7656171,2
C,F,O,A,9121782(-) CAAACC/TTTAGG 2 -- int124Minor allele frequency- A:0.04NA EA NS MN WA 1497
rs7656181,2
C9121623(-) cagtgA/Gtacaa 2 -- int10--------
rs7698971,2
C,F,9099727(-) TTGCCT/CTGCAG 1 -- int12Minor allele frequency- C:0.03MN WA 234
rs7700221,2
9114714(+) cgtagC/Tggttc 2 -- int10--------
rs7700231,2
C,A,9115234(+) gatctT/Cgggta 2 -- int16Minor allele frequency- C:0.04NS EA NA WA 518
About this table

HapMap Linkage Disequilibrium images for SLC2A5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLC2A5: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for SLC2A5 

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC2A5 for disorders           About GeneDecksing

OMIM: 138230

5 Novoseek disease relationships for SLC2A5 gene

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
malabsorption 22.9 2 8941659 (2)
cancer 4.01 1 16523487 (1), 18398011 (1)
colon cancer 0 2 8037665 (1)
breast cancer 0 2 8700847 (1), 16523487 (1)
tumors 0 3 16523487 (2), 10622535 (1)
About this table

1 PharmGKB disease relationship for SLC2A5 gene
Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
About this table

Human Genome Epidemiology (HuGE) Navigator: SLC2A5 (5 documents)

Export disorders and mutations for SLC2A5 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/99 PubMed articles for SLC2A5 gene, integrated from 7 sources (see all 99):
(articles sorted by number of sources associating them with SLC2A5)
  1. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PubMed id 8037665)1, 2, 7 Mahraoui L.... Brot-Laroche E. (1994)
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 7 White P.S....Brodeur G.M. (1998)
  3. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PubMed id 1695905)1, 2, 7 Kayano T.... Bell G.I. (1990)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
  6. Fructose transporter in human spermatozoa and small intestine is GLUT5. (PubMed id 1634504)1, 7 Burant C.F....Davidson N.O. (1992)
  7. Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone. (PubMed id 17251278)1, 7 Stuart C.A....Yin D. (2007)
  8. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PubMed id 12820898)1, 7 Gouyon F....Brot-Laroche E. (2003)
  9. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. (PubMed id 16803853)1, 7 Stuart C.A....Ferrando A.A. (2006)
  10. Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. (PubMed id 18439419)1, 7 Mochizuki K....Goda T. (2008)

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Entrez Gene: 6518 HGNC: 11010 AceView: SLC2A5 Ensembl:ENSG00000142583 euGenes: HUgn6518
ECgene: SLC2A5 Kegg: 6518 H-InvDB: SLC2A5

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