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SLC2A9 Gene

protein-coding   GIFtS: 53

GC04M009162
solute carrier family 2 (facilitated glucose transporter), member 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
solute carrier family 2 (facilitated glucose transporter), member 91 2     UAQTL22 5
GLUT92 3 5     Glut91
URATv11 2     OTTHUMP000001156322
GLUTX1 2     urate voltage-driven efflux transporter 12
Glucose transporter type 92 3     solute carrier family 2, facilitated glucose transporter member 92
GLUT-92 3     human glucose transporter-like protein-92

External Ids:    HGNC: 134461   Entrez Gene: 566062   Ensembl: ENSG000001096677   UniProtKB: Q9NRM03   

Export aliases for SLC2A9 gene to outside databases

Previous GC identifers: GC04M009497 GC04M009778 GC04M009578 GC04M009504 GC04M009827 GC04M009772


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC2A9:
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a
significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and
survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports
glucose at low rate

Gene Wiki entry for SLC2A9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A9 gene promoter:
         Pax-2   LUN-1   Pax-5   Pax-6   POU2F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLC2A9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC2A9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

SLC2A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A9 gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M009162:  view genomic region     (about GC identifiers)

Start:
9,162,269 bp from pter
End:
9,375,568 bp from pter
Size:
213,300 bases
Orientation:
minus strand

1 alternative location:
Chr4- 9,772,777-10,056,560     
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 9  
Size: 540 amino acids; 58702 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q0VGC4 Q4W5D1 Q8WV30 Q96P00
Alternative splicing: 2 isoforms:  Q9NRM0-1   Q9NRM0-2   

Explore the universe of human proteins at neXtProt for SLC2A9: NX_Q9NRM0 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001001290.1  NP_064425.2  


    ENSEMBL proteins: 
    ENSP00000311383 ENSP00000426800 ENSP00000264784 ENSP00000422209 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): SLC2A9
    GenScript Custom Purified and Recombinant Proteins Services for SLC2A9 
    Novus Biologicals Proteins for SLC2A9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635 nuclear envelope IEA--
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane IEA--
    GO:0016020 membrane ----
    GO:0016021 integral to membrane NAS10860667
    About this table

    SLC2A9 for ontologies           About GeneDecksing



    Antibodies for SLC2A9: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SLC2A9
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SLC2A9 
    Novus Biologicals Antibodies for SLC2A9
    Browse antibodies at Epitomics

    Assays for SLC2A9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC2A9 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC2A9 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 Major_facilitator_SF
     IPR016196 MFS_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NRM0

    ProtoNet protein and cluster: Q9NRM0

    2 Blocks protein families:
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter
    subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports
    glucose at low rate

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A9
    Sigma-Aldrich shRNA for SLC2A9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC2A9
    OriGene shRNA RFP (see all 2): SLC2A9
    OriGene basic RS shRNA (see all 2): SLC2A9
    OriGene siRNA (see all 2): SLC2A9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A9 
    miRNA:Sigma-Aldrich microRNA Mimics for SLC2A9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A9 
    Search SABiosciences for Assays for microRNAs that regulate SLC2A9

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene 3'-UTR clone (see all 2): SLC2A9 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SLC2A9 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SLC2A9 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215 transporter activity ----
    GO:0005351 sugar:hydrogen symporter activity NAS10860667
    GO:0005355 glucose transmembrane transporter activity IEA--
    GO:0022857 transmembrane transporter activity TAS--
    GO:0022891 substrate-specific transmembrane transporter activity IEA--
    About this table

    SLC2A9 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a9):

    behavior/neurologicalgrowth/sizehomeostasis/metabolismimmune systemlethality-prenatal/perinatal
    renal/urinary system

    SLC2A9 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for SLC2A9 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A9

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport ----
    GO:0008643 carbohydrate transport IEA--
    GO:0015758 glucose transport NAS10860667
    GO:0046415 urate metabolic process IMP19503597
    GO:0055085 transmembrane transport TAS--
    About this table

    SLC2A9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SLC2A9 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A9
    4 Novoseek chemical compound relationships for SLC2A9 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochalasin b 59.5 9 14739288 (1)
    2-deoxyglucose 54.5 5 14739288 (2)
    glucose 47.7 16 20162745 (2), 15943951 (2), 10860667 (2), 11780753 (1) (see all 7)
    fructose 47.3 1 11780753 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC2A9
    Sigma-Aldrich shRNA for SLC2A9
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC2A9
    OriGene shRNA RFP (see all 2): SLC2A9
    OriGene basic RS shRNA (see all 2): SLC2A9
    OriGene siRNA (see all 2): SLC2A9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC2A9 
    miRNA: Sigma-Aldrich microRNA Mimics for SLC2A9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC2A9 
    Search SABiosciences for Assays for microRNAs that regulate SLC2A9
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SLC2A9
    OriGene 3'-UTR Clone (see all 2): SLC2A9 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SLC2A9 
    Primers: OriGene genome-wide validated SYBR primer pairs: SLC2A9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLC2A9: PPH10576A

    REFSEQ mRNAs for SLC2A9 gene (2 alternative transcripts): 

    NM_001001290.1  NM_020041.2  

    Additional cDNA sequence: 

    AF210317.1 AF421859.1 AK096819.1 AK310895.1 BC018897.2 BC110414.1 

    9 DOTS entries:

    DT.110094  DT.100745107  DT.75100908  DT.439537  DT.307960  DT.65286643  DT.75194662  DT.40113861 
    DT.91907721 

    10 AceView cDNA sequences:

    AA228138 BE326892 AA227974 AW451509 AI863532 AK025887 W48668 BX111149 
    W51903 BE326912 

    highest scoring ESTs for SLC2A9:

    AI766064 AK096819 BC018897 BE741795 BE745805 AA059043 AA918717 AA918718 AA918939 AF210317 

    Unigene Cluster for SLC2A9:

    Solute carrier family 2 (facilitated glucose transporter), member 9
    Hs.656895  [show with all ESTs]
    Unigene Representative Sequence: AK096819


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:              -     -                             -     -                                                   
    SP2:                    -                             -     -                                                   
    SP3:                                                                                                            
    SP4:                                -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for SLC2A9
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508585 ENST00000309065(uc003gmd.2) ENST00000505506 ENST00000503280
    ENST00000506839 ENST00000481042(uc003gme.1) ENST00000505104 ENST00000513129
    ENST00000509214 ENST00000264784(uc003gmc.2) ENST00000503803 ENST00000506583
    ENST00000512342

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SLC2A9 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching SLC2A9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    63024_at2, 3 U95-C 1 0.94 1.00 1.00 1.00 AI766064 0.80 1.00 0.91 1
    219991_at2, 3 U133-A 1 1.00 1.00 -- -- NM_020041 0.60 1.00 0.82 1
    240223_at2, 3 U133-B 1 0.27 1.00 -- -- AI671983 0.60 1.00 0.82 1
    219991_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    240223_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    SLC2A9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SLC2A9 gene expression
    SLC2A9 gene electronic northern expression
    SLC2A9 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.656895

    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and
    placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage.
    Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and
    isoform 2 are detected in kidney membrane (at protein level)

    Primers: OriGene genome-wide validated SYBR primer pairs: SLC2A9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLC2A9: PPH10576A
        SABiosciences Custom PCR Arrays for SLC2A9 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SLC2A9 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SLC2A91   -- solute carrier family 2 (facilitated glucose transporter), more 88.03(n)
    88.57(a)
    479093  XM_536240.2  XP_536240.2 
    chimpanzee
    (Pan troglodytes)
    SLC2A91   -- solute carrier family 2 (facilitated glucose transporter), more 99.11(n)
    98.89(a)
    465225  XM_520688.2  XP_520688.2 
    rat
    (Rattus norvegicus)
    Slc2a91   -- solute carrier family 2 (facilitated glucose transporter), more 82.94(n)
    85.38(a)
    501925  XM_577349.2  XP_577349.2 
    mouse
    (Mus musculus)
    Slc2a91 , 5 5 (20.43 cM)5
    solute carrier family 2 (facilitated glucose transporter), more1, 5 82.77(n)1
    85.74(a)1
    1175911  NM_001012363.11  NP_001012363.11 
     AF4694805  AF4904635  (see all 14)
    chicken
    (Gallus gallus)
    SLC2A91   -- solute carrier family 2 (facilitated glucose transporter), more 69.17(n)
    75.83(a)
    422843  XM_420789.2  XP_420789.2 
    About this table        Species with no ortholog for SLC2A9

    ENSEMBL Gene Tree for SLC2A9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SLC2A9 gene
    ENSG000002513572  SLC2A72  SLC2A52  SLC2A112  

    SLC2A9 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Polymorphism: Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations [MIM:612076].
    Excess serum accumulation of uric acid can lead to the development of gout


    10/2777 NCBI SNPs in SLC2A9 are shown (see all 2777)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs41441,2
    C,F,A,H,10016322(+) GCCTGC/TCTCAC 2 -- int18Minor allele frequency- T:0.29NA WA 140
    rs7345531,2
    C,F,O,A,9923004(-) CTTTCA/CGGGAT 2 -- int117Minor allele frequency- C:0.30NA NS EA WA 860
    rs7372671,2
    C,F,A,H,9934744(+) AACTGG/TCTCTG 2 -- int17Minor allele frequency- T:0.23NS EA NA WA 494
    rs7460821,2
    C,F,9913287(+) GTGACA/C/TGCAGG 2 -- int12NA EA 160
    rs7510921,2
    C,F,A,H,10005897(-) TGGCTA/GTGGGA 2 -- int19Minor allele frequency- G:0.27NA EA WA 224
    rs8744321,2
    C,F,O,A,H,9920606(+) GAATTT/AATGAA 2 -- int120Minor allele frequency- A:0.22NS EA NA WA 1530
    rs8819711,2
    C,F,A,9930962(-) TCCCCA/GAGATG 2 -- int19Minor allele frequency- G:0.38NS EA NA WA 630
    rs8822221,2
    C,F,A,H,9981294(+) CCACCG/ACCTCC 2 -- int12Minor allele frequency- A:0.21WA NA 52
    rs8822231,2
    C,F,O,9981625(+) ccttgA/CgttTA 2 -- int114Minor allele frequency- C:0.42EA NA NS WA 780
    rs8830411,2
    C,F,A,H,9868346(+) TTGGAC/TGTACT 2 -- int19Minor allele frequency- T:0.28MN NS EA NA WA 766
    About this table

    HapMap Linkage Disequilibrium images for SLC2A9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 17 variations for SLC2A9
         6 CNVs: 63747 51496 31164 2070 8443 3479
         11 Indels: 41763 12404 40601 98624 63748 40602 12405 46721 12406 98625 46720

    QIAGEN SeqTarget long-range PCR primers for resequencing SLC2A9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC2A9 for disorders           About GeneDecksing

    OMIM: 606142   disorders: 612076  

    Human Gene Mutation Database (HGMD): SLC2A9
    Human Genome Epidemiology (HuGE) Navigator: SLC2A9 (26 documents)

    Export disorders and mutations for SLC2A9 gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/51 PubMed articles for SLC2A9 gene, integrated from 7 sources (see all 51):
    (articles sorted by number of sources associating them with SLC2A9)
    1. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PubMed id 10860667)1, 2, 3, 7 Phay J.E.... Moley J.F. (2000)
    2. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. (PubMed id 14739288)1, 2, 7 Augustin R....Moley K.H. (2004)
    3. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. (PubMed id 11991658)1, 2, 7 Mobasheri A.... Carter S.D. (2002)
    4. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PubMed id 18327257)1, 2 Vitart V....Wright A.F. (2008)
    5. SLC2A9 influences uric acid concentrations with pronounced sex- specific effects. (PubMed id 18327256)1, 2 Doering A.... Meisinger C. (2008)
    6. A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. (PubMed id 17710649)1, 3 Manolescu A.R....Cheeseman C. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. (PubMed id 19026395)1, 7 Matsuo H....Shinomiya N. (2008)
    9. Association of nephrolithiasis and gene for glucose t ransporter type 9 (SLC2A9): study of 145 patients. (PubMed id 20162745)1, 7 Polasek O....Lauc G. (2010)
    10. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. (PubMed id 18701466)1, 7 Anzai N....Sakurai H. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56606 HGNC: 13446 AceView: SLC2A9.1 Ensembl:ENSG00000109667 euGenes: HUgn56606
    ECgene: SLC2A9 H-InvDB: SLC2A9

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    (Patent information from GeneIP,
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