Aliases &
Descriptions
for SLC2A9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| solute carrier family 2 (facilitated glucose transporter), member 91 2 | | UAQTL22 5 | | GLUT92 3 5 | | Glut91 | | URATv11 2 | | OTTHUMP000001156322 | | GLUTX1 2 | | urate voltage-driven efflux transporter 12 | | Glucose transporter type 92 3 | | solute carrier family 2, facilitated glucose transporter member 92 | | GLUT-92 3 | | human glucose transporter-like protein-92 |
Export aliases for SLC2A9 gene to outside databasesPrevious GC identifers: GC04M009497 GC04M009778 GC04M009578 GC04M009504 GC04M009827 GC04M009772 |
Summaries
for SLC2A9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC2A9:
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play asignificant role in maintaining glucose homeostasis. The encoded protein may play a role in the development andsurvival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have beenidentified for this gene. (provided by RefSeq)
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transportsglucose at low rate
Gene Wiki entry for SLC2A9 |
Genomic Views
for SLC2A9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC2A9 gene promoter:
Pax-2 LUN-1 Pax-5 Pax-6 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC2A9
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC2A9  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1SLC2A9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M009162: view genomic region
(about GC identifiers)
Start:
|
9,162,269 bp from pter |
End:
|
9,375,568 bp from pter |
Size:
|
213,300 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr4- 9,772,777-10,056,560 |
RefSeq DNA sequence:- NC_000004.11 NT_006316.16
|
Proteins
for SLC2A9 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0 (See
protein sequence)Recommended Name: Solute carrier family 2, facilitated glucose transporter member 9 Size: 540 amino acids; 58702 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q0VGC4 Q4W5D1 Q8WV30 Q96P00Alternative splicing: 2 isoforms: Q9NRM0-1 Q9NRM0-2 Explore the universe of human proteins at neXtProt for SLC2A9: NX_Q9NRM0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001001290.1 NP_064425.2
ENSEMBL proteins: ENSP00000311383 ENSP00000426800 ENSP00000264784 ENSP00000422209
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SLC2A9 for ontologies About GeneDecksing
Antibodies for SLC2A9:
Assays for SLC2A9: |
Protein
Domains/
Families
for SLC2A9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC2A9 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NRM0ProtoNet protein and cluster: Q9NRM0 2 Blocks protein families: IPB003663 Sugar transporter signature IPB005829 Sugar transporter superfamily
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transportersubfamily |
Gene Function
for SLC2A9 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transportsglucose at low rate
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
-- | -- | | GO:0005351 | sugar:hydrogen symporter activity |
NAS | 10860667 | | GO:0005355 | glucose transmembrane transporter activity |
IEA | -- | | GO:0022857 | transmembrane transporter activity |
TAS | -- | | GO:0022891 | substrate-specific transmembrane transporter activity |
IEA | -- |
About this table
SLC2A9 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Slc2a9):
SLC2A9 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC2A9 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SLC2A9
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A9
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
SLC2A9 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC2A9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
SLC2A9 for compounds About GeneDecksing
 Browse Tocris compounds for SLC2A9
4  Novoseek chemical compound relationships for SLC2A9 gene
About this table
|
Transcripts
for SLC2A9 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLC2A9 gene (2 alternative transcripts): NM_001001290.1 NM_020041.2 Additional cDNA sequence: AF210317.1 AF421859.1 AK096819.1 AK310895.1 BC018897.2 BC110414.1 9 DOTS entries: DT.110094 DT.100745107 DT.75100908 DT.439537 DT.307960 DT.65286643 DT.75194662 DT.40113861 DT.91907721 10 AceView cDNA sequences: AA228138 BE326892 AA227974 AW451509 AI863532 AK025887 W48668 BX111149 W51903 BE326912
 highest scoring ESTs for SLC2A9:AI766064 AK096819 BC018897 BE741795 BE745805 AA059043 AA918717 AA918718 AA918939 AF210317 Unigene Cluster for SLC2A9: Solute carrier family 2 (facilitated glucose transporter), member 9 Hs.656895 [show with all ESTs]Unigene Representative Sequence: AK096819
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SLC2A9
13 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000508585 ENST00000309065(uc003gmd.2) ENST00000505506 ENST00000503280
ENST00000506839 ENST00000481042(uc003gme.1) ENST00000505104 ENST00000513129
ENST00000509214 ENST00000264784(uc003gmc.2) ENST00000503803 ENST00000506583
ENST00000512342
|
Expression
for SLC2A9 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLC2A9 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching SLC2A9 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 63024_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AI766064 |
0.80 |
1.00 |
0.91 |
1 |
| 219991_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_020041 |
0.60 |
1.00 |
0.82 |
1 |
| 240223_at2, 3
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
AI671983 |
0.60 |
1.00 |
0.82 |
1 |
| 219991_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 240223_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLC2A9 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.656895
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver andplacenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage.Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 andisoform 2 are detected in kidney membrane (at protein level)
SABiosciences Custom PCR Arrays for SLC2A9
|
Orthologs
for SLC2A9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC2A9 gene from 5/9 species (see all 9)
About this table Species with no ortholog for SLC2A9
ENSEMBL Gene Tree for SLC2A9 (if available) |
Paralogs
for SLC2A9 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLC2A9 gene
- ENSG000002513572 SLC2A72 SLC2A52 SLC2A112
SLC2A9 for paralogs About GeneDecksing
|
Genomic Variants
for SLC2A9 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0Polymorphism: Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations [MIM:612076].Excess serum accumulation of uric acid can lead to the development of gout
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 4 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SLC2A9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 17 variations for SLC2A9
6 CNVs: 63747 51496 31164 2070 8443 3479
11 Indels: 41763 12404 40601 98624 63748 40602 12405 46721 12406 98625 46720 | | QIAGEN SeqTarget long-range PCR primers for resequencing SLC2A9 |
|
Disorders & Mutations
for SLC2A9 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC2A9 for disorders About GeneDecksing
OMIM: 606142 disorders: 612076 Human Gene Mutation Database (HGMD): SLC2A9
Human Genome Epidemiology (HuGE) Navigator: SLC2A9 (26 documents)
Export disorders and mutations for SLC2A9 gene to outside databases
|
Medical News
for SLC2A9 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for SLC2A9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/51 PubMed articles for SLC2A9 gene, integrated from 7 sources (see all 51):
(articles sorted by number of sources associating them with SLC2A9)- Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PubMed id 10860667)1, 2, 3, 7 Phay J.E.... Moley J.F. (2000)
- Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. (PubMed id 14739288)1, 2, 7 Augustin R....Moley K.H. (2004)
- Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. (PubMed id 11991658)1, 2, 7 Mobasheri A.... Carter S.D. (2002)
- SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PubMed id 18327257)1, 2 Vitart V....Wright A.F. (2008)
- SLC2A9 influences uric acid concentrations with pronounced sex- specific effects. (PubMed id 18327256)1, 2 Doering A.... Meisinger C. (2008)
- A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. (PubMed id 17710649)1, 3 Manolescu A.R....Cheeseman C. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. (PubMed id 19026395)1, 7 Matsuo H....Shinomiya N. (2008)
- Association of nephrolithiasis and gene for glucose t ransporter type 9 (SLC2A9): study of 145 patients. (PubMed id 20162745)1, 7 Polasek O....Lauc G. (2010)
- Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. (PubMed id 18701466)1, 7 Anzai N....Sakurai H. (2008)
|
External Searches for SLC2A9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC2A9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC2A9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC2A9 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC2A9 gene:
Search GeneIP for patents involving SLC2A9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC2A9 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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