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Aliases & Descriptionsfor SLC35C2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions solute carrier family 35, member C21 2 FLJ464342 ovarian cancer overexpressed 11 2 FLJ370392 CGI-151 2 MGC320792 Ovarian cancer-overexpressed gene 1 protein2 3 BA394O2.12 C20orf52 3 OTTHUMP000000316942 OVCOV12 3 MGC391832 bA394O2.11 MGC206332 solute carrier family 35 member C22
Export aliases for SLC35C2 gene to outside databases Previous GC identifers: GC20M045616 GC20M045663 GC20M044411 GC20M044978
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Summariesfor SLC35C2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for SLC35C2 : Oxygenation levels play an important role in the regulation of cellular invasiveness which occurs during early implantation when the trophoblast cells invade the uterus as well as during tumour progression and metastasis. This gene, which is regulated by oxygen tension, is induced in hypoxic trophoblast cells and is overexpressed in ovarian cancer. Two protein isoforms are encoded by transcript variants of this gene. (provided by RefSeq) UniProtKB/Swiss-Prot: S35C2_HUMAN, Q9NQQ7 Function : May play an important role in the cellular response to tissue hypoxiaGene Wiki entry for SLC35C2
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Genomic Viewsfor SLC35C2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC35C2 gene promoter: ATF6 CHOP-10 C/EBPalpha Bach1 PPAR-gamma2 PPAR-gamma1 MEF-2A CUTL1 Elk-1 AREB6 Other transcription factors Search SABiosciences Chromatin IP Primers for SLC35C2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLC35C2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q11.21-q13.11 SLC35C2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure
GeneLoc location for GC20M041719: view genomic region
(about GC identifiers )
Start:
41,719,094 bp from pter
End:
41,733,960 bp from pter
Size:
14,867 bases
Orientation:
minus strand
1 alternative location : Chr 20- 44,978,167-44,993,043
RefSeq DNA sequence: NC_000020.10 NT_011362.10
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Proteinsfor SLC35C2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: S35C2_HUMAN, Q9NQQ7 (See
protein sequence )Recommended Name: Solute carrier family 35 member C2 Size : 365 amino acids; 40432 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=AAD27724.1; Type=Frameshift; Positions=168, 211, 305;
Secondary accessions : Q5JW05 Q96CJ8 Q9Y304Alternative splicing : 2 isoforms : Q9NQQ7-1 Q9NQQ7-2 Explore the universe of human proteins at neXtProt for SLC35C2: NX_Q9NQQ7 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_057029.8 NP_775096.1 NP_775271.1 ENSEMBL proteins: ENSP00000415736 ENSP00000397142 ENSP00000361297 ENSP00000361299 ENSP00000361303 ENSP00000361304 ENSP00000318960 ENSP00000361301 ENSP00000243896 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table
SLC35C2 for ontologies About GeneDecksing Antibodies for SLC35C2: Assays for SLC35C2:
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Protein
Domains/ Familiesfor SLC35C2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC35C2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9NQQ7 ProtoNet protein and cluster: Q9NQQ7
1 Blocks protein family : IPB002198 Short-chain dehydrogenase/reductase SDR UniProtKB/Swiss-Prot: S35C2_HUMAN, Q9NQQ7 Similarity : Belongs to the TPT transporter family. SLC35C subfamily
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Gene Functionfor SLC35C2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: S35C2_HUMAN, Q9NQQ7 Function : May play an important role in the cellular response to tissue hypoxiaInduction : In hypoxic trophoblast cells
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Pathways & Interactionsfor SLC35C2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
SLC35C2 for pathways About GeneDecksing 1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SLC35C2 SABiosciences Custom Pathway-Focused PCR Arrays for SLC35C2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLC35C2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35C2 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006810 transport
IEA -- GO:0055085 transmembrane transport
-- --
About this table
SLC35C2 for ontologies About GeneDecksing
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Drugs & Compoundsfor SLC35C2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for SLC35C2
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Transcriptsfor SLC35C2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for SLC35C2 gene (3 alternative transcripts): NM_015945.10 NM_173073.2 NM_173179.2
Additional cDNA sequence: AF455052.1 AK092830.1 AK128842.1 AK222928.1 AK300207.1 AK300798.1 AK301022.1 AK315726.1 BC014191.2 BC021138.1 BC025277.1 CR590584.1 CR593672.1 CR596090.1 CR598943.1 CR605819.1 CR609774.1 CR610991.1 CR612071.1 CR612094.1 CR616219.1
24/32 DOTS entries (see all 32 ): DT.86838315 DT.100667213 DT.100030813 DT.100667205 DT.452614 DT.101956033 DT.100030810 DT.100667209
DT.105931 DT.100809371 DT.91676318 DT.95264048 DT.97850424 DT.100667208 DT.120808757 DT.120808760 DT.120808772 DT.95264056 DT.100667210 DT.95264053 DT.95264057 DT.100667211 DT.100770858 DT.101984761 24/391 AceView cDNA sequences (see all 391 ):
BQ681771 AA451942 BM545876 CA406570 NM_173179 BM924054 AW151233 CR596090 BU625167 BQ888643 CR605819 BX356294 CA448399 BQ679625 BU623063 BM676068 BI962734 BE503792 BI489990 BQ890523 AI356485 BX384115 BI906206 BQ028141
highest scoring ESTs for SLC35C2 :AA018345 AF455052 AI241474 AI741613 AL602183 BC014191 BC021138 BE242648 BG701835 BI821346 Unigene Cluster for SLC35C2:
Solute carrier family 35, member C2 Hs.593344 [show with all ESTs ] Unigene Representative Sequence: AK092830 GeneLoc Exon Structure 5/29 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35C2 (see all 29 ) ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · SP1 :           -   -   -   -   -   -                         -   -       SP2 :                                             -   -       SP3 :           -   -   -   -   -   -                         -   -       SP4 :           -   -   -   -   -   -               -           -   -       SP5 :                                   -           -   -      
ExUns: 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15a · 15b SP1 : -     -   -   -   -           -             -       SP2 : -     -   -               -             -       SP3 : -     -   -               -                   SP4 : -     -   -   -   -                             SP5 : -     -   -   -   -           -                  
About this scheme ECgene alternative splicing isoforms for SLC35C2 15 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000484188 ENST00000424568 ENST00000420518 ENST00000481809 ENST00000372223 ENST00000372225 ENST00000372229 ENST00000493599 ENST00000372230 ENST00000484318 ENST00000480329 ENST00000317734 (uc002xrp.2 uc010zxn.1 ) ENST00000372227 (uc002xro.2 )ENST00000243896 (uc002xrq.2 uc002xrr.2 uc010zxo.1 uc010zxp.1 )ENST00000487729
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Expression for SLC35C2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section SLC35C2 expression in normal and diseased human tissues 1 / 2 / 3
7 probe-sets matching SLC35C2 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
63310_at2 , 3
U95-C
1
1.00
1.00
0.85
1.21
AI741613
0.80
1.00
0.91
1
63309_at2 , 3
U95-C
1
1.00
1.00
0.94
0.91
AI241474
0.80
1.00
0.91
1
55273_at2 , 3
U95-C
1
0.88
1.00
0.95
0.88
AA514688
0.60
1.00
0.82
1
219447_s_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_015945
0.60
1.00
0.82
1
225037_at2 , 3
U133-B
1
1.00
1.00
--
--
AL518563
0.40
1.00
0.76
1
219447_s_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
225037_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
SLC35C2 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACTTTTGCCC SOURCE GeneReport for Unigene cluster: Hs.593344 UniProtKB/Swiss-Prot: S35C2_HUMAN, Q9NQQ7 Tissue specificity : Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed inovarian cancer
SABiosciences Custom PCR Arrays for SLC35C2
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Orthologsfor SLC35C2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for SLC35C2 gene from 5/20 species (see all 20 )
About this table Species with no ortholog for SLC35C2 ENSEMBL Gene Tree for SLC35C2 (if available)
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Paralogsfor SLC35C2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Pseudogenes 1 related pseudogene
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Genomic Variantsfor SLC35C2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 20 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for SLC35C2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC35C2: --
QIAGEN SeqTarget long-range PCR primers for resequencing SLC35C2
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Disorders & Mutationsfor SLC35C2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor SLC35C2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor SLC35C2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/16 PubMed articles for SLC35C2 gene, integrated from 7 sources (see all 16 ): (articles sorted by number of sources associating them with SLC35C2) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093) 1 , 2 , 3 Lai C.H....Lin W. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Identification, molecular characterization, and tissue expression of OVCOV1. (PubMed id 12461647) 1 , 2 Leach R.E.... Krawetz S.A. (2002) The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052) 1 , 2 Deloukas P....Rogers J. (2001) Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band q13.1-->q13.2 by fluorescent in situ hybridization. (PubMed id 11856893) 1 , 2 Leach R.E....Krawetz S.A. (2001) A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316) 1 , 3 Fossey S.C....Bowden D.W. (2001) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330) 2 Gauci S....Mohammed S. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005)
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External Searches for SLC35C2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC35C2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC35C2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SLC35C2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SLC35C2 gene: Search GeneIP for patents involving SLC35C2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC35C2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for SLC35C2
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