Aliases &
Descriptions
for SLC38A4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| solute carrier family 38, member 41 2 | | FLJ101912 | | ATA31 2 3 5 | | MGC1268762 | | NAT31 2 3 5 | | N amino acid transporter 32 | | PAAT1 2 | | sodium-coupled neutral amino acid transporter 42 | | System N amino acid transporter 32 3 | | amino acid transporter system A32 | | Amino acid transporter A32 3 | | Solute carrier family 38 member 43 | | System A amino acid transporter 32 3 | | SNAT43 | | Na(+)-coupled neutral amino acid transporter 42 3 | | |
Export aliases for SLC38A4 gene to outside databasesPrevious GC identifers: GC12M047138 GC12M046875 GC12M045444 |
Summaries
for SLC38A4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC38A4:
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationicamino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pHdependent (Hatanaka et al., 2001 (PubMed 11342143)).(supplied by OMIM)
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodiumions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake ispH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
|
Genomic Views
for SLC38A4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC38A4 gene promoter:
MEF-2A c-Myb FOXD1 POU2F1 E2F E2F-1 RSRFC4 AP-2rep RFX1 POU3F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC38A4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13SLC38A4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M044189: view genomic region
(about GC identifiers)
Start:
|
44,189,482 bp from pter |
End:
|
44,250,721 bp from pter |
Size:
|
61,240 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 47,158,546-47,219,780 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for SLC38A4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6 (See
protein sequence)Recommended Name: Sodium-coupled neutral amino acid transporter 4 Size: 547 amino acids; 60764 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K553Explore the universe of human proteins at neXtProt for SLC38A4: NX_Q969I6
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001137296.1 NP_060488.2
ENSEMBL proteins: ENSP00000389843 ENSP00000378816 ENSP00000266579
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SLC38A4 for ontologies About GeneDecksing
Antibodies for SLC38A4:
Assays for SLC38A4: |
Protein
Domains/
Families
for SLC38A4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC38A4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969I6ProtoNet protein and cluster: Q969I6 1 Blocks protein family: IPB000517 Ribosomal protein L30
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6Similarity: Belongs to the amino acid/polyamine transporter 2 family |
Gene Function
for SLC38A4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodiumions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake ispH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5Biophysicochemical properties: pH dependence: Optimum pH is 7.5-8.5;
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
-- | -- | | GO:0015171 | amino acid transmembrane transporter activity |
EXP | 11342143 | | GO:0015293 | symporter activity |
IEA | -- |
About this table
SLC38A4 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC38A4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SLC38A4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A4
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
SLC38A4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC38A4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SLC38A4
|
Transcripts
for SLC38A4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLC38A4 gene (2 alternative transcripts): NM_001143824.1 NM_018018.4 Additional cDNA sequence: AB055003.1 AF193836.1 AF305814.1 AK291168.1 BC069819.1 BC101827.1 BC104913.1 4 DOTS entries: DT.92424569 DT.100787327 DT.100787325 DT.100787326 24/62 AceView cDNA sequences (see all 62): AB055003 AW204828 AA680367 CB068274 CA778351 AW772290 CB164010 AF193836 BG568069 CB162716 CB154705 AU118969 CA778277 CA777992 BC069819 BE463522 BG618784 CA950937 BX283789 CD652538 BG290858 BG618592 AA705032 BG533486
 highest scoring ESTs for SLC38A4:AF193836 AF305814 AI434618 BX472148 AA366947 AA995080 AB055003 AI207547 AI276746 AI536648 Unigene Cluster for SLC38A4: Solute carrier family 38, member 4 Hs.446077 [show with all ESTs]Unigene Representative Sequence: NM_018018
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A4
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c | · | 18d |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SLC38A4
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447411 ENST00000395426 ENST00000266579(uc001rpi.2 uc001rpj.2 uc009zkl.2)
|
Expression
for SLC38A4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLC38A4 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching SLC38A4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 77426_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
AI434618 |
0.80 |
1.00 |
0.91 |
1 |
| 220786_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018018 |
0.60 |
1.00 |
0.82 |
1 |
| 1555345_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 220786_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLC38A4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TAACAATCAT
SOURCE GeneReport for Unigene cluster: Hs.446077
UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas.Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels
SABiosciences Custom PCR Arrays for SLC38A4
|
Orthologs
for SLC38A4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC38A4 gene from 5/9 species (see all 9)
About this table Species with no ortholog for SLC38A4
ENSEMBL Gene Tree for SLC38A4 (if available) |
Paralogs
for SLC38A4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLC38A4 gene
- SLC38A12 SLC38A62 SLC38A52 SLC38A22 SLC38A112 SLC38A102
SLC38A4 for paralogs About GeneDecksing
|
Genomic Variants
for SLC38A4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SLC38A4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC38A4
2 CNVs: 22994 101508 | | QIAGEN SeqTarget long-range PCR primers for resequencing SLC38A4 |
|
Disorders & Mutations
for SLC38A4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC38A4 for disorders About GeneDecksing
OMIM: 608065
Export disorders and mutations for SLC38A4 gene to outside databases
|
Medical News
for SLC38A4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SLC38A4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for SLC38A4 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with SLC38A4)- A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. (PubMed id 11414754)1, 2, 3 Gu S.... Jiang J.X. (2001)
- Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (PubMed id 11342143)1, 2, 7 Hatanaka T.... Ganapathy V. (2001)
- SNAT4 isoform of system A amino acid transporter is expressed in human placenta. (PubMed id 16148032)1, 2 Desforges M.... Sibley C.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. (PubMed id 12845534)1, 2 Mackenzie B. and Erickson J.D. (2004)
- Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. (PubMed id 18703994)1 Iruloh C.G....Glazier J.D. (2009)
- The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. (PubMed id 19015196)1 Desforges M....Glazier J.D. (2009)
- Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (2008)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
|
External Searches for SLC38A4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC38A4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC38A4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC38A4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC38A4 gene:
Search GeneIP for patents involving SLC38A4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC38A4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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