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SLC38A4 Gene

protein-coding   GIFtS: 48

GC12M044189
solute carrier family 38, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
solute carrier family 38, member 41 2     FLJ101912
ATA31 2 3 5     MGC1268762
NAT31 2 3 5     N amino acid transporter 32
PAAT1 2     sodium-coupled neutral amino acid transporter 42
System N amino acid transporter 32 3     amino acid transporter system A32
Amino acid transporter A32 3     Solute carrier family 38 member 43
System A amino acid transporter 32 3     SNAT43
Na(+)-coupled neutral amino acid transporter 42 3     

External Ids:    HGNC: 146791   Entrez Gene: 550892   Ensembl: ENSG000001392097   UniProtKB: Q969I63   

Export aliases for SLC38A4 gene to outside databases

Previous GC identifers: GC12M047138 GC12M046875 GC12M045444


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC38A4:
SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic
amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH
dependent (Hatanaka et al., 2001 (PubMed 11342143)).(supplied by OMIM)

UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.
May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC38A4 gene promoter:
         MEF-2A   c-Myb   FOXD1   POU2F1   E2F   E2F-1   RSRFC4   AP-2rep   RFX1   POU3F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLC38A4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

SLC38A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC38A4 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M044189:  view genomic region     (about GC identifiers)

Start:
44,189,482 bp from pter
End:
44,250,721 bp from pter
Size:
61,240 bases
Orientation:
minus strand

1 alternative location:
Chr12- 47,158,546-47,219,780     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6 (See protein sequence)
Recommended Name: Sodium-coupled neutral amino acid transporter 4  
Size: 547 amino acids; 60764 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: A8K553

Explore the universe of human proteins at neXtProt for SLC38A4: NX_Q969I6 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001137296.1  NP_060488.2  


    ENSEMBL proteins: 
    ENSP00000389843 ENSP00000378816 ENSP00000266579 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for SLC38A4 
    Novus Biologicals Proteins for SLC38A4
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular ----
    GO:0005840 ribosome ----
    GO:0005886 plasma membrane EXP11342143
    GO:0016021 integral to membrane IEA--
    About this table

    SLC38A4 for ontologies           About GeneDecksing



    Antibodies for SLC38A4: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SLC38A4
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SLC38A4 
    Browse antibodies at Epitomics

    Assays for SLC38A4: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC38A4 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC38A4 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC38A4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q969I6

    ProtoNet protein and cluster: Q969I6

    1 Blocks protein family: IPB000517 Ribosomal protein L30

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Function: Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium
    ions. Has a broad specificity, with a preference for Ala, followed by His, Cys, Asn, Ser, Gly, Val, Thr, Gln and Met.
    May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is
    pH-dependent, with low transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5
    Biophysicochemical properties: pH dependence: Optimum pH is 7.5-8.5;

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC38A4
    Sigma-Aldrich shRNA for SLC38A4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC38A4
    OriGene shRNA RFP (see all 2): SLC38A4
    OriGene basic RS shRNA (see all 2): SLC38A4
    OriGene siRNA (see all 2): SLC38A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC38A4 
    miRNA:Sigma-Aldrich microRNA Mimics for SLC38A4
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC38A4 
    5 SABiosciences Assays for microRNAs that regulate SLC38A4:
    hsa-miR-579 hsa-miR-9 hsa-miR-1271 hsa-miR-96 hsa-miR-548c-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC38A4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC38A4
    OriGene untagged cDNA clones in CMV expression vector: SLC38A4
    OriGene 3'-UTR clone (see all 2): SLC38A4 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SLC38A4 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SLC38A4 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735 structural constituent of ribosome ----
    GO:0015171 amino acid transmembrane transporter activity EXP11342143
    GO:0015293 symporter activity IEA--
    About this table

    SLC38A4 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for SLC38A4 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC38A4

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412 translation ----
    GO:0006811 ion transport TAS--
    GO:0006814 sodium ion transport IEA--
    GO:0006865 amino acid transport EXP18195088
    GO:0055085 transmembrane transport TAS--
    About this table

    SLC38A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC38A4


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLC38A4
    Sigma-Aldrich shRNA for SLC38A4
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SLC38A4
    OriGene shRNA RFP (see all 2): SLC38A4
    OriGene basic RS shRNA (see all 2): SLC38A4
    OriGene siRNA (see all 2): SLC38A4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLC38A4 
    miRNA: Sigma-Aldrich microRNA Mimics for SLC38A4
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLC38A4 
    5 SABiosciences Assays for microRNAs that regulate SLC38A4:
    hsa-miR-579 hsa-miR-9 hsa-miR-1271 hsa-miR-96 hsa-miR-548c-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SLC38A4
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SLC38A4
    OriGene untagged cDNA clones in CMV expression vector: SLC38A4
    OriGene 3'-UTR Clone (see all 2): SLC38A4 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SLC38A4 
    Primers: OriGene genome-wide validated SYBR primer pairs: SLC38A4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLC38A4: PPH13316A

    REFSEQ mRNAs for SLC38A4 gene (2 alternative transcripts): 

    NM_001143824.1  NM_018018.4  

    Additional cDNA sequence: 

    AB055003.1 AF193836.1 AF305814.1 AK291168.1 BC069819.1 BC101827.1 BC104913.1 

    4 DOTS entries:

    DT.92424569  DT.100787327  DT.100787325  DT.100787326 

    24/62 AceView cDNA sequences (see all 62):

    AB055003 AW204828 AA680367 CB068274 CA778351 AW772290 CB164010 AF193836 
    BG568069 CB162716 CB154705 AU118969 CA778277 CA777992 BC069819 BE463522 
    BG618784 CA950937 BX283789 CD652538 BG290858 BG618592 AA705032 BG533486 

    highest scoring ESTs for SLC38A4:

    AF193836 AF305814 AI434618 BX472148 AA366947 AA995080 AB055003 AI207547 AI276746 AI536648 

    Unigene Cluster for SLC38A4:

    Solute carrier family 38, member 4
    Hs.446077  [show with all ESTs]
    Unigene Representative Sequence: NM_018018


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC38A4

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:                    -                                                                                                                     
    SP2:                    -     -                                                                                                               
    SP3:                          -                                                                                                               
    SP4:                                                                                                                    -                     

    About this scheme

    ECgene alternative splicing isoforms for SLC38A4
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447411 ENST00000395426 ENST00000266579(uc001rpi.2 uc001rpj.2 uc009zkl.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SLC38A4 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching SLC38A4 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    77426_at2, 3 U95-E 1 0.88 1.00 1.00 1.00 AI434618 0.80 1.00 0.91 1
    220786_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018018 0.60 1.00 0.82 1
    1555345_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    220786_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    SLC38A4 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SLC38A4 gene expression
    SLC38A4 gene electronic northern expression
    SLC38A4 gene sage expression
    About these images

    CGAP SAGE TAG: TAACAATCAT

    SOURCE GeneReport for Unigene cluster: Hs.446077

    UniProtKB/Swiss-Prot: S38A4_HUMAN, Q969I6
    Tissue specificity: Detected in embryonic and adult liver, and at lower levels in adult muscle, kidney and pancreas.
    Detected in placenta syncytiotrophoblasts throughout gestation. Detected in fetal blood vessels

    Primers: OriGene genome-wide validated SYBR primer pairs: SLC38A4
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLC38A4: PPH13316A
        SABiosciences Custom PCR Arrays for SLC38A4 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SLC38A4 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SLC38A41   -- solute carrier family 38, member 4 92.61(n)
    94.94(a)
    486595  XM_858893.1  XP_863986.1 
    chimpanzee
    (Pan troglodytes)
    SLC38A41   -- solute carrier family 38, member 4 99.54(n)
    99.21(a)
    451853  XM_001163431.1  XP_001163431.1 
    cow
    (Bos taurus)
    SLC38A41   -- solute carrier family 38, member 4 91.53(n)
    93.6(a)
    527476  XM_605868.3  XP_605868.3 
    rat
    (Rattus norvegicus)
    Slc38a41   -- solute carrier family 38, member 4 83.24(n)
    88.12(a)
    170573  NM_130748.1  NP_570104.1 
    mouse
    (Mus musculus)
    Slc38a41 , 5 15 (52.77 cM)5
    solute carrier family 38, member 41, 5 82.51(n)1
    87.02(a)1
    693541  NM_027052.31  NP_081328.21 
     AA7955415  AB0550045  (see all 19)
    About this table        Species with no ortholog for SLC38A4

    ENSEMBL Gene Tree for SLC38A4 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SLC38A4 gene
    SLC38A12  SLC38A62  SLC38A52  SLC38A22  SLC38A112  SLC38A102  

    SLC38A4 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/584 NCBI SNPs in SLC38A4 are shown (see all 584)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1804031,2
    C,F,A,47163306(+) CTTTCT/CTTTTC 1 -- int1 trp312Minor allele frequency- C:0.44NS EA NA WA 632
    rs1804041,2
    C,F,H,47163817(+) TTGGCG/CTATTT 1 -- int111Minor allele frequency- C:0.19NS EA NA WA 568
    rs1804051,2
    C,F,A,47164118(-) AAACAT/CAAAAA 1 -- int111Minor allele frequency- C:0.44NS EA NA WA 636
    rs1804061,2
    C,H,47165042(+) CTTACA/GAATAA 1 -- int111Minor allele frequency- G:0.00NS EA NA WA 432
    rs1804071,2
    C,F,A,47165168(+) TAGTCG/ACTTGT 1 -- int113Minor allele frequency- A:0.36NA EA WA 542
    rs1804081,2
    C,F,O,A,47165323(+) TATGGC/GAATAA 1 -- int122Minor allele frequency- N:0.00NS EA NA WA 2454
    rs1804091,2
    C,F,O,47165429(+) ATTCCT/CGAAGA 1 -- int1100Minor allele frequency- C:0.42EA NA NS PA EU CA WA 6338
    rs1804101,2
    C,F,O,A,H,47166894(+) TCACCA/TTCTCT 1 -- int117Minor allele frequency- T:0.44NA NS EA WA 782
    rs1804111,2
    C,H,47167036(+) GACAAG/AGCAAG 1 -- int111Minor allele frequency- A:0.00NS EA NA WA 434
    rs1804121,2
    C,F,A,H,47167078(+) ACGACG/AGAGCT 1 -- int112Minor allele frequency- A:0.44EA NS NA WA 510
    About this table

    HapMap Linkage Disequilibrium images for SLC38A4 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SLC38A4
         2 CNVs: 22994 101508

    QIAGEN SeqTarget long-range PCR primers for resequencing SLC38A4 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC38A4 for disorders           About GeneDecksing

    OMIM: 608065


    Export disorders and mutations for SLC38A4 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/12 PubMed articles for SLC38A4 gene, integrated from 7 sources (see all 12):
    (articles sorted by number of sources associating them with SLC38A4)
    1. A novel human amino acid transporter, hNAT3: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. (PubMed id 11414754)1, 2, 3 Gu S.... Jiang J.X. (2001)
    2. Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A. (PubMed id 11342143)1, 2, 7 Hatanaka T.... Ganapathy V. (2001)
    3. SNAT4 isoform of system A amino acid transporter is expressed in human placenta. (PubMed id 16148032)1, 2 Desforges M.... Sibley C.P. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family. (PubMed id 12845534)1, 2 Mackenzie B. and Erickson J.D. (2004)
    7. Amino acid transport systems beta and A in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. (PubMed id 18703994)1 Iruloh C.G....Glazier J.D. (2009)
    8. The SNAT4 isoform of the system A amino acid transporter is functional in human placental microvillous plasma membrane. (PubMed id 19015196)1 Desforges M....Glazier J.D. (2009)
    9. Amino acid transport across mammalian intestinal and renal epithelia. (PubMed id 18195088)1 BrAPer S. (2008)
    10. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55089 HGNC: 14679 AceView: SLC38A4 Ensembl:ENSG00000139209 euGenes: HUgn55089
    ECgene: SLC38A4 H-InvDB: SLC38A4

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SLC38A4 gene:
    Search GeneIP for patents involving SLC38A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in SLC38A4 promoter
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     ELISAs and CLIAs for SLC38A4
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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