Aliases &
Descriptions
for SLC5A10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| solute carrier family 5 (sodium/glucose cotransporter), member 101 2 | | FLJ252172 | | SGLT51 2 3 | | OTTHUMP000000657322 | | Solute carrier family 5 member 102 3 | | OTTHUMP000000657312 | | Na(+)/glucose cotransporter 52 3 | | sodium/glucose cotransporter 52 |
Export aliases for SLC5A10 gene to outside databasesPrevious GC identifers: GC17P019062 GC17P019054 GC17P018794 GC17P018796 GC17P018853 |
Summaries
for SLC5A10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC5A10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A10 gene promoter:
CUTL1 p53 AREB6 AP-4 POU3F2 (N-Oct-5a) POU3F2 POU3F2 (N-Oct-5b) FOXJ2 (long isoform) HNF-1A POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2SLC5A10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P018422: view genomic region
(about GC identifiers)
Start:
|
18,421,401 bp from pter |
End:
|
18,491,305 bp from pter |
Size:
|
69,905 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 18,853,989-18,924,004 |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
|
Proteins
for SLC5A10 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1 (See
protein sequence)Recommended Name: Sodium/glucose cotransporter 5 Size: 596 amino acids; 64342 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAB71619.1; Type=Frameshift; Positions=156;
Secondary accessions: A8MUC9 B7WPR4 Q6P5X0 Q8IXM4 Q96LQ1Alternative splicing: 4 isoforms: A0PJK1-1 A0PJK1-2 A0PJK1-3 A0PJK1-4 (Named isoforms)Explore the universe of human proteins at neXtProt for SLC5A10: NX_A0PJK1
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001035915.1 NP_689564.3
ENSEMBL proteins: ENSP00000324346 ENSP00000401875 ENSP00000379007 ENSP00000379005 ENSP00000284168 ENSP00000379008 ENSP00000379004
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
SLC5A10 for ontologies About GeneDecksing
Antibodies for SLC5A10:
Assays for SLC5A10: |
Protein
Domains/
Families
for SLC5A10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A0PJK1ProtoNet protein and cluster: A0PJK1 UniProtKB/Swiss-Prot: SC5AA_HUMAN, A0PJK1Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Gene Function
for SLC5A10 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- |
About this table
SLC5A10 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC5A10 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SLC5A10
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A10
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
SLC5A10 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC5A10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SLC5A10
|
Transcripts
for SLC5A10 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLC5A10 gene (2 alternative transcripts): NM_001042450.1 NM_152351.3 Additional cDNA sequence: AK057946.1 AK298345.1 BC034380.1 BC039868.1 BC062617.1 BC112347.1 5 DOTS entries: DT.100734993 DT.421598 DT.40127220 DT.95262511 DT.75143620 24/39 AceView cDNA sequences (see all 39): AA970307 BC034380 AJ230824 BX119120 BC062617 AI347280 AI733311 AJ230787 AW577412 AK057946 BX377205 BX402941 BC039868 AJ230822 BI762467 BI765329 NM_152351 AI793336 BX401443 AA983237 AJ230788 BX106391 BX105612 BX448481
 highest scoring ESTs for SLC5A10:BG991378 AK057946 BC034380 BC039868 BC062617 AA745934 AJ230822 AW270922 BF510408 BI762273 Unigene Cluster for SLC5A10: Solute carrier family 5 (sodium/glucose cotransporter), member 10 Hs.462418 [show with all ESTs]Unigene Representative Sequence: BC039868
GeneLoc Exon Structure
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317977(uc002gur.1 uc002gux.1) ENST00000417251(uc010vyl.1)
ENST00000395645 ENST00000395643 ENST00000284168 ENST00000395647(uc002guu.1 uc002gut.1)
ENST00000395642(uc002guv.1)
|
Expression
for SLC5A10 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLC5A10 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching SLC5A10 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 83416_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI936410 |
0.20 |
0.25 |
0.23 |
2 |
| 239707_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BF510408 |
0.40 |
0.67 |
0.55 |
1 |
| 239707_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLC5A10 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.462418
SABiosciences Custom PCR Arrays for SLC5A10
|
Orthologs
for SLC5A10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC5A10 gene from 5 species
About this table Species with no ortholog for SLC5A10
ENSEMBL Gene Tree for SLC5A10 (if available) |
Paralogs
for SLC5A10 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLC5A10 gene
- SLC5A32 SLC5A22 SLC5A12 SLC5A42 SLC5A92 SLC5A112
SLC5A10 for paralogs About GeneDecksing
|
Genomic Variants
for SLC5A10 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SLC5A10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for SLC5A10
6 CNVs: 88374 7145 30808 23520 4025 77543 | | QIAGEN SeqTarget long-range PCR primers for resequencing SLC5A10 |
|
Disorders & Mutations
for SLC5A10 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC5A10 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: SLC5A10 (2 documents)
Export disorders and mutations for SLC5A10 gene to outside databases
|
Medical News
for SLC5A10 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SLC5A10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
9 PubMed articles for SLC5A10 gene integrated from 7 sources:
(articles sorted by number of sources associating them with SLC5A10)- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Cloning and expression of bovine sodium/glucose cotransporters. (PubMed id 15591382)7 Zhao F.Q....McFadden T.B. (2005)
|
External Searches for SLC5A10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A10 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC5A10 gene:
Search GeneIP for patents involving SLC5A10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A10 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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