Aliases &
Descriptions
for SLC5A11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| solute carrier family 5 (sodium/glucose cotransporter), member 111 2 | | Na(+)/myo-inositol cotransporter 22 3 | | SMIT21 2 3 | | putative sodium-coupled cotransporter RKST12 | | KST11 2 3 | | RKST12 | | SGLT61 2 | | na+/myo-inositol cotransporter 22 | | Sodium/glucose cotransporter KST12 3 | | sodium/myo-inositol cotransporter 22 | | Solute carrier family 5 member 112 3 | | homolog of rabbit KST12 | | Sodium-dependent glucose cotransporter2 3 | | SLGTX3 |
Export aliases for SLC5A11 gene to outside databasesPrevious GC identifers: GC16P024825 GC16P024765 |
Summaries
for SLC5A11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC5A11:
Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive activetransport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002)(PubMed 12039040).(supplied by OMIM)
UniProtKB/Swiss-Prot: SC5AB_HUMAN, Q8WWX8Function: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1.Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI)but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis throughthe TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorptionin at least the proximal tubule of the kidney
|
Genomic Views
for SLC5A11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A11 gene promoter:
NRSF form 1 NRSF form 2 Lmo2 COUP-TF1 HNF-4alpha2 GATA-1 PPAR-gamma1 PPAR-gamma2 AREB6 HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A11
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16pter-p11 Ensembl cytogenetic band: 16p12.1 HGNC cytogenetic band: 16p12-p11SLC5A11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P022948: view genomic region
(about GC identifiers)
Start:
|
22,948,142 bp from pter |
End:
|
23,016,331 bp from pter |
Size:
|
68,190 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 24,857,162-24,922,947 |
RefSeq DNA sequence:- NC_000016.9 NT_010393.16
|
Proteins
for SLC5A11 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SC5AB_HUMAN, Q8WWX8 (See
protein sequence)Recommended Name: Sodium/myo-inositol cotransporter 2 Size: 675 amino acids; 74036 Da
Subcellular location: Membrane; Multi-pass membrane protein (By similarity)
Miscellaneous: Acts as an autoimmune modifier in systemic lupus erythematosus (SLE) as it is significantly associatedwith low complement component 4 (C4), anti-Smith antibody, serositis, and alopecia
Secondary accessions: Q6PF02 Q6ZUW3 Q86Y55 Q96PP5Alternative splicing: 4 isoforms: Q8WWX8-1 Q8WWX8-2 Q8WWX8-3 Q8WWX8-4 Explore the universe of human proteins at neXtProt for SLC5A11: NX_Q8WWX8
REFSEQ proteins: NP_443176.2
ENSEMBL proteins: ENSP00000389606 ENSP00000416782 ENSP00000289932
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SLC5A11 for ontologies About GeneDecksing
Antibodies for SLC5A11:
Assays for SLC5A11: |
Protein
Domains/
Families
for SLC5A11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WWX8ProtoNet protein and cluster: Q8WWX8 1 Blocks protein family: IPB001734 Na+/solute symporter
UniProtKB/Swiss-Prot: SC5AB_HUMAN, Q8WWX8Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Gene Function
for SLC5A11 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SC5AB_HUMAN, Q8WWX8Function: Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1.Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI)but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis throughthe TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorptionin at least the proximal tubule of the kidney
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- | | GO:0015166 | polyol transmembrane transporter activity |
TAS | -- | | GO:0015293 | symporter activity |
IEA | -- |
About this table
SLC5A11 for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Slc5a11 (no phenotypes)
SLC5A11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC5A11 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SLC5A11
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A11
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
SLC5A11 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC5A11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SLC5A11
|
Transcripts
for SLC5A11 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLC5A11 gene: NM_052944.2 Additional cDNA sequence: AF292385.1 AJ305237.1 AK125267.1 AK295427.1 AK298373.1 AK303691.1 AY044906.1 BC049385.1 BC057780.1 U41898.1 8 DOTS entries: DT.40219384 DT.101981529 DT.97769784 DT.120710650 DT.91645282 DT.91998278 DT.95227298 DT.421529 24/48 AceView cDNA sequences (see all 48): BC049385 BX113343 AW779714 AJ305237 AU076740 AY044906 AI569837 NM_052944 BI603332 CD635400 AI433352 BG204516 CD635402 AK125267 BQ067646 BG200456 CD635395 BC057780 CD635405 CD635404 BP383448 AF292385 CD635398 AW016514
 highest scoring ESTs for SLC5A11:AA772233 AF292385 AI433352 AI569837 AJ305237 AK125267 AW016514 AW243037 AW612332 AW779714 Unigene Cluster for SLC5A11: Solute carrier family 5 (sodium/glucose cotransporter), member 11 Hs.164118 [show with all ESTs]Unigene Representative Sequence: AK125267
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC5A11
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SLC5A11
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000449109 ENST00000488922(uc010bxt.2) ENST00000424767 ENST00000347898(uc002dms.2 uc010vcd.1 uc002dmt.2 uc010vce.1 uc002dmu.2 uc002dmv.2)
|
Expression
for SLC5A11 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLC5A11 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching SLC5A11 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 82293_at2, 3
|
U95-D |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
AA772233 |
1.00 |
1.00 |
1.00 |
1 |
| 237254_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AA772233 |
1.00 |
1.00 |
1.00 |
1 |
| 237254_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLC5A11 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACCCCAAAGC
SOURCE GeneReport for Unigene cluster: Hs.164118
UniProtKB/Swiss-Prot: SC5AB_HUMAN, Q8WWX8Tissue specificity: Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression inbrain, colon, spleen, lung and peripheral blood leukocytes
SABiosciences Custom PCR Arrays for SLC5A11
|
Orthologs
for SLC5A11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC5A11 gene from 5/7 species (see all 7)
About this table Species with no ortholog for SLC5A11
ENSEMBL Gene Tree for SLC5A11 (if available) |
Paralogs
for SLC5A11 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLC5A11 gene
- SLC5A32 SLC5A102 SLC5A22 SLC5A12 SLC5A42 SLC5A92
SLC5A11 for paralogs About GeneDecksing
|
Genomic Variants
for SLC5A11 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC5A11
1 Indel: 45412 | | QIAGEN SeqTarget long-range PCR primers for resequencing SLC5A11 |
|
Disorders & Mutations
for SLC5A11 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC5A11 for disorders About GeneDecksing
OMIM: 610238
Human Gene Mutation Database (HGMD): SLC5A11
Human Genome Epidemiology (HuGE) Navigator: SLC5A11 (3 documents)
Export disorders and mutations for SLC5A11 gene to outside databases
|
Medical News
for SLC5A11 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SLC5A11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for SLC5A11 gene integrated from 7 sources:
(articles sorted by number of sources associating them with SLC5A11)- New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families. (PubMed id 12039040)1, 2, 3 Roll P....Szepetowski P. (2002)
- The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE. (PubMed id 18069935)1, 2 Tsai L.-J.... Lan J.-L. (2008)
- Identification of a novel Na+/myo-inositol cotranspor ter. (PubMed id 12133831)1, 3 Coady M.J....Lapointe J.Y. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010 Dec 10)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Spina bifida and genetic factors related to myo-inositol, glucose, and zinc. (PubMed id 15172003)2 Groenen P.M.W.... Steegers-Theunissen R.P.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The pore of plant K(+) channels is involved in voltage and pH sensing: domain-swapping between different K(+) channel alpha-subunits. (PubMed id 11283347)7 Hoth S....Hedrich R. (2001)
|
External Searches for SLC5A11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A11 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC5A11 gene:
Search GeneIP for patents involving SLC5A11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A11 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for SLC5A11 |
| |  |  |  |  | | | | |
 | | |
|
|
