Aliases &
Descriptions
for SLC5A4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| solute carrier family 5 (low affinity glucose cotransporter), member 41 2 | | Na(+)/glucose cotransporter 32 3 | | SAAT11 2 3 | | sodium transporter2 | | SGLT31 2 | | solute carrier family 5 (neutral amino acid transporters, system A), member 42 | | DJ90G24.41 2 | | low affinity sodium-glucose cotransporter2 | | Sodium/glucose cotransporter 32 3 | | low affinity sodium glucose cotransporter2 | | Solute carrier family 5 member 42 3 | | SGLT23 |
Export aliases for SLC5A4 gene to outside databasesPrevious GC identifers: GC22M029310 GC22M030939 GC22M032614 |
Summaries
for SLC5A4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91Function: Sodium-dependent glucose transporter (By similarity)
|
Genomic Views
for SLC5A4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC5A4 gene promoter:
HNF-1A CUTL1 LUN-1 c-Myc Max1 MRF-2 CREB deltaCREB USF1 Max
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC5A4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2-q12.3 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q12.1-q12.3SLC5A4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M015572: view genomic region
(about GC identifiers)
Start:
|
15,572,136 bp from pter |
End:
|
15,608,952 bp from pter |
Size:
|
36,817 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr22- 32,614,465-32,651,328 |
RefSeq DNA sequence:- NC_000022.10 NT_011520.12
|
Proteins
for SLC5A4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91 (See
protein sequence)Recommended Name: Low affinity sodium-glucose cotransporter Size: 659 amino acids; 72456 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: O15279Explore the universe of human proteins at neXtProt for SLC5A4: NX_Q9NY91
REFSEQ proteins: NP_055042.1
ENSEMBL proteins: ENSP00000266086
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
SLC5A4 for ontologies About GeneDecksing
Antibodies for SLC5A4:
Assays for SLC5A4: |
Protein
Domains/
Families
for SLC5A4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC5A4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NY91ProtoNet protein and cluster: Q9NY91 1 Blocks protein family: IPB001734 Na+/solute symporter
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
Gene Function
for SLC5A4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SC5A4_HUMAN, Q9NY91Function: Sodium-dependent glucose transporter (By similarity)
Genatlas biochemistry entry for SLC5A4:solute carrier family 5,neutral amino acid transporters,system A,member 4,expressed in kidney,smallintestine,spleen,liver,muscle2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- | | GO:0015293 | symporter activity |
IEA | -- |
About this table
SLC5A4 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC5A4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SLC5A4 for pathways About GeneDecksing
1  Millipore Pathway for SLC5A4
SABiosciences Pathway-Focused PCR Array including SLC5A4: PAHS-070A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC5A4
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
SLC5A4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC5A4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
SLC5A4 for compounds About GeneDecksing
 Browse Tocris compounds for SLC5A4
3  Novoseek chemical compound relationships for SLC5A4 gene
About this table
|
Transcripts
for SLC5A4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLC5A4 gene: NM_014227.2 Additional cDNA sequence: AJ133127.1 GQ292716.1 U41897.1 2 DOTS entries: DT.40271884 DT.421760 5 AceView cDNA sequences: H55471 NM_014227 AJ133127 BU157483 U41897
 highest scoring ESTs for SLC5A4:AJ133127 H55471 NM_014227 U41897 BU157483 AL008723 BF895438 BX280314 DA876270 H55533 Unigene Cluster for SLC5A4: Solute carrier family 5 (low affinity glucose cotransporter), member 4 Hs.130101 [show with all ESTs]Unigene Representative Sequence: AJ133127
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000266086(uc003ami.2)
|
Expression
for SLC5A4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLC5A4 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching SLC5A4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 33010_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AL008723 |
0.20 |
1.00 |
0.72 |
1 |
| 215960_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
AJ133127 |
0.80 |
1.00 |
0.91 |
1 |
| 215960_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLC5A4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGCTCCCTGA
SOURCE GeneReport for Unigene cluster: Hs.130101
SABiosciences Expression via Pathway-Focused PCR Array including SLC5A4: PAHS-070A
|
Orthologs
for SLC5A4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC5A4 gene from 4 species
About this table Species with no ortholog for SLC5A4
ENSEMBL Gene Tree for SLC5A4 (if available) |
Paralogs
for SLC5A4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLC5A4 gene
- SLC5A32 SLC5A102 SLC5A22 SLC5A12 SLC5A92 SLC5A112
SLC5A4 for paralogs About GeneDecksing
|
Genomic Variants
for SLC5A4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 22 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SLC5A4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC5A4
1 CNV: 5358 | | QIAGEN SeqTarget long-range PCR primers for resequencing SLC5A4 |
|
Disorders & Mutations
for SLC5A4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC5A4 for disorders About GeneDecksing
Genetic Association Database (GAD): SLC5A4
Human Genome Epidemiology (HuGE) Navigator: SLC5A4 (2 documents)
Export disorders and mutations for SLC5A4 gene to outside databases
|
Medical News
for SLC5A4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SLC5A4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for SLC5A4 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with SLC5A4)- Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. (PubMed id 16319503)1, 4 Munafo M.R....Johnstone E.C. (2006)
- The sodium/substrate symporter family: structural and functional features. (PubMed id 12354616)1, 3 Jung H. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1. (PubMed id 9501190)1, 3 Veyhl M....Koepsell H. (1998)
- Protection of muscle membrane excitability during cycling in humans: a role for SGLT3? (PubMed id 18198291)1 Fairchild T.J. (2008)
- Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. (PubMed id 17705872)1 Blaya C....Manfro G.G. (2007)
- Imino sugars are potent agonists of the human glucose sensor SGLT3. (PubMed id 17110502)1 Voss A.A....Wright E.M. (2007)
- A glucose sensor hiding in a family of transporters. (PubMed id 13130073)1 Diez-Sampedro A....Koepsell H. (2003)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney. (PubMed id 7493971)7 You G....Hediger M.A. (1995)
|
External Searches for SLC5A4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC5A4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC5A4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC5A4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC5A4 gene:
Search GeneIP for patents involving SLC5A4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC5A4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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