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SLCO1B3 Gene

protein-coding   GIFtS: 49

GC12P020736
solute carrier organic anion transporter family, member 1B3
(Previous names: solute carrier family 21 (organic anion transporter), member 8 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SLC21A8)
Products    

Aliases &
Descriptions
for SLCO1B3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
solute carrier organic anion transporter family, member 1B31 2     OATP-82 3
OATP1B31 2 3     liver-specific organic anion transporter 3TM132
solute carrier family 21 (organic anion transporter), member 81 2     SLC21A82
OATP81 2     organic anion transporter LST-3c2
Organic anion-transporting polypeptide 82 3     LST32
Organic anion transporter 82 3     solute carrier organic anion transporter family member 1B32
Liver-specific organic anion transporter 22 3     LST-3TM132
Solute carrier family 21 member 82 3     OATP8,SLC21A83
LST-22 3     LST23

External Ids:    HGNC: 109611   Entrez Gene: 282342   Ensembl: ENSG000001117007   UniProtKB: Q9NPD53   

Export aliases for SLCO1B3 gene to outside databases

Previous GC identifers: GC12P020859 GC12P020963


Summaries
for SLCO1B3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLCO1B3:
SLCO1B3 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile
acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et
al., 2004 (PubMed 14993604)).(supplied by OMIM)

UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
Function: Mediates the Na(+)-independent transport of organic anions such as 17-beta-glucuronosyl estradiol,
taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
sulfobromophthalein (BSP)

Gene Wiki entry for SLCO1B3

Genomic Views
for SLCO1B3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLCO1B3 gene promoter:
         HNF-4alpha2   COUP-TF1   STAT5A   PPAR-gamma2   PPAR-gamma1   Pbx1a   CUTL1   C/EBPalpha   HNF-1A   C/EBPbeta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLCO1B3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12   Ensembl cytogenetic band:  12p12.2   HGNC cytogenetic band: 12p12

SLCO1B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLCO1B3 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P020736:  view genomic region     (about GC identifiers)

Start:
 20,736,680 bp from pter
End:
 20,842,657 bp from pter
Size:
 105,978 bases
Orientation:
 plus strand

1 alternative location:
Chr12+ 20,963,638-21,069,658     
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  

Proteins
for SLCO1B3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5 (See protein sequence)
Recommended Name: Solute carrier organic anion transporter family member 1B3  
Size: 702 amino acids; 77403 Da
Subcellular location: Basal cell membrane; Multi-pass membrane protein. Lateral cell membrane; Multi-pass membrane
protein. Note=Detected in basal and lateral plasma membranes of hepatocytes

Explore the universe of human proteins at neXtProt for SLCO1B3: NX_Q9NPD5 

Post-translational modifications:

  • N-glycosylated1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_062818.1  

    ENSEMBL proteins: 
    ENSP00000392763 ENSP00000370956 ENSP00000261196 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SLCO1B3
    GenScript Custom Purified and Recombinant Proteins Services for SLCO1B3 
    Novus Biologicals Lysate for SLCO1B3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005886 plasma membrane EXP11159893
    GO:0005887 integral to plasma membrane TAS10779507
    GO:0009925 basal plasma membrane IEA--
    GO:0016020 membrane ----
    About this table

    SLCO1B3 for ontologies           About GeneDecksing



    Antibodies for SLCO1B3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SLCO1B3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SLCO1B3 
    Novus Biologicals Antibodies for SLCO1B3
    Browse antibodies at Epitomics

    Assays for SLCO1B3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLCO1B3 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for SLCO1B3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLCO1B3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR004156 OA_transporter
     IPR020846 Major_facilitator_SF
     IPR016196 MFS_general_subst_transpt
     IPR011497 Prot_Inh_Kazal_2

    Graphical View of Domain Structure for InterPro Entry Q9NPD5

    ProtoNet protein and cluster: Q9NPD5

    2 Blocks protein families:
    IPB004156 Organic anion transporter polypeptide (OATP)
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Similarity: Belongs to the organo anion transporter (TC 2.A.60) family
    Similarity: Contains 1 Kazal-like domain


    Gene Function
    for SLCO1B3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Function: Mediates the Na(+)-independent transport of organic anions such as 17-beta-glucuronosyl estradiol,
    taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and
    sulfobromophthalein (BSP)

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLCO1B3
    Sigma-Aldrich shRNA for SLCO1B3
    OriGene 29mer shRNA kits in GFP-retroviral vector: SLCO1B3
    OriGene shRNA RFP: SLCO1B3
    OriGene basic RS shRNA: SLCO1B3
    OriGene siRNA: SLCO1B3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLCO1B3 
    miRNA:Sigma-Aldrich microRNA Mimics for SLCO1B3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLCO1B3 
    Search SABiosciences for Assays for microRNAs that regulate SLCO1B3

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene untagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene 3'-UTR clone: SLCO1B3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SLCO1B3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for SLCO1B3 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215 transporter activity IEA--
    GO:0005515 protein binding IEA--
    GO:0008514 organic anion transmembrane transporter activity TAS10779507
    GO:0015125 bile acid transmembrane transporter activity EXP11159893
    About this table

    SLCO1B3 for ontologies           About GeneDecksing

    Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slco1b2):

    homeostasis/metabolismlife span-post-weaning/agingliver/biliary system

    SLCO1B3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLCO1B3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SLCO1B3 for pathways           About GeneDecksing

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  SLCO1B3
        FXR/RXR Activation
    Hepatic Cholestasis
    PXR/RXR Activation
    LPS/IL-1 Mediated Inhibition of RXR Function

        SABiosciences Pathway-Focused PCR Array including SLCO1B3: PAHS-070A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLCO1B3
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLCO1B3

    4 Interacting proteins for SLCO1B3 (ENSP000003709563) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCB11ENSP000002638173STRING: ENSP00000263817
    ABCC3ENSP000002852383STRING: ENSP00000285238
    ALBENSP000003702903STRING: ENSP00000370290
    FABP6ENSP000003122833STRING: ENSP00000312283
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810 transport ----
    GO:0006811 ion transport IEA--
    GO:0008206 bile acid metabolic process TAS--
    GO:0015711 organic anion transport TAS10779507
    GO:0015721 bile acid and bile salt transport TAS--
    About this table

    SLCO1B3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLCO1B3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SLCO1B3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLCO1B3
    8 Novoseek chemical compound relationships for SLCO1B3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oatp 88.7 3 17823233 (1), 19074973 (1)
    bromosulfophthalein 79.8 3 19881253 (1), 18314419 (1), 15226676 (1)
    taurocholate 76 3 15841457 (1), 19074973 (1)
    estrone sulfate 64.9 1 15159445 (1)
    chenodeoxycholic acid 62 2 16741617 (1), 16534140 (1)
    deoxycholic acid 47.3 2 16741617 (1), 16534140 (1)
    rifampicin 22.5 1 16837569 (1)
    cyclosporin a 1.33 1 15665139 (1)
    About this table



    Transcripts
    for SLCO1B3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLCO1B3
    Sigma-Aldrich shRNA for SLCO1B3
    OriGene 29mer shRNA kits in GFP-retroviral vector: SLCO1B3
    OriGene shRNA RFP: SLCO1B3
    OriGene basic RS shRNA: SLCO1B3
    OriGene siRNA: SLCO1B3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLCO1B3 
    miRNA: Sigma-Aldrich microRNA Mimics for SLCO1B3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLCO1B3 
    Search SABiosciences for Assays for microRNAs that regulate SLCO1B3
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene untagged cDNA clones in CMV expression vector: SLCO1B3
    OriGene 3'-UTR Clone: SLCO1B3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SLCO1B3 
    Primers: OriGene genome-wide validated SYBR primer pairs: SLCO1B3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLCO1B3: PPH19926A

    REFSEQ mRNAs for SLCO1B3 gene: 

    NM_019844.2  

    Additional cDNA sequence: 

    AF187815.1 AJ251506.1 AK055874.1 AY257471.1 AY342017.1 AY442326.1 BC022843.1 BC058006.1 
    BC070264.1 BC105597.1 CR594924.1 

    6 DOTS entries:

    DT.101981096  DT.75197718  DT.91655560  DT.70104685  DT.92431202  DT.92431206 

    24/49 AceView cDNA sequences (see all 49):

    CR594924 BG616856 BM968322 AI270220 BC022843 AF187815 CA311212 BG567966 
    AK055874 BC070264 BX094205 NM_019844 BC058006 BX497794 BX410159 CB161997 
    BG563594 BU633737 AY342017 CB162237 BG563836 AV681834 AJ251506 BG569268 

    highest scoring ESTs for SLCO1B3:

    AF187815 AI270220 AJ251506 AK055874 AV656155 AV684392 AV687698 AV720291 AY342017 BE047219 

    Unigene Cluster for SLCO1B3:

    Solute carrier organic anion transporter family, member 1B3
    Hs.504966  [show with all ESTs]
    Unigene Representative Sequence: NM_019844


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000451344 ENST00000381545 ENST00000261196(uc001rek.2 uc001rel.2 uc010sil.1 uc001reo.2)


    Expression
    for SLCO1B3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SLCO1B3 expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching SLCO1B3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    206354_at2, 3 U133-A 1 0.82 1.00 -- -- NM_019844 0.60 0.78 0.69 1
    206354_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SLCO1B3 gene expression
    SLCO1B3 gene electronic northern expression
    SLCO1B3 gene sage expression
    About these images

    CGAP SAGE TAG: TTAAGTTGTA

    SOURCE GeneReport for Unigene cluster: Hs.504966

    UniProtKB/Swiss-Prot: SO1B3_HUMAN, Q9NPD5
    Tissue specificity: Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the
    central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas,
    liver and gall bladder

    Primers: OriGene genome-wide validated SYBR primer pairs: SLCO1B3
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLCO1B3: PPH19926A
        SABiosciences Expression via Pathway-Focused PCR Array including SLCO1B3: PAHS-070A 


    Orthologs
    for SLCO1B3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for SLCO1B3 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 SLCO1B31   -- solute carrier organic anion transporter family, member more 83(n)
    74.41(a)    		 403519  XM_534873.2  XP_534873.2 
    cow
    (Bos taurus)    		 SLCO1B31   -- solute carrier organic anion transporter family, member more 80.9(n)
    71.49(a)    		 404160  NM_205804.1  NP_991373.1 
    rat
    (Rattus norvegicus)    		 Slco1b21   -- solute carrier organic anion transporter family, member more 75.67(n)
    66.02(a)    		 58978  NM_031650.1  NP_113838.1 
    mouse
    (Mus musculus)    		 Slco1b21 , 5 6 (72.57 cM)5
    		 solute carrier organic anion transporter family, member more1, 5 75.88(n)1
    67.11(a)1    		 282531  NM_020495.11  NP_065241.11 
     AA2426885  AA2666625  (see all 25)
    chicken
    (Gallus gallus)    		 SLCO1B31   -- solute carrier organic anion transporter family, member more 60.76(n)
    52.23(a)    		 418187  XM_416418.2  XP_416418.2 
    About this table        Species with no ortholog for SLCO1B3

    ENSEMBL Gene Tree for SLCO1B3 (if available)

    Paralogs
    for SLCO1B3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SLCO1B3 gene
    SLCO3A12  SLCO5A12  SLCO1B12  LST-3TM122  SLCO1A22  SLCO1C12  

    SLCO1B3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLCO1B3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1445 NCBI SNPs in SLCO1B3 are shown (see all 1445)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs9756531,2
    		C,F,A,H,20998860(+) aatctT/Cttttt 1 -- int111Minor allele frequency- C:0.34NS EA NA WA 634
    rs9756541,2
    		C,F,A,H,20998980(+) tcttaT/Catcag 1 -- int17Minor allele frequency- C:0.12NA 84
    rs9756551,2
    		C,F,A,H,20999068(+) acttcT/Ctttgg 1 -- int110Minor allele frequency- C:0.39NS EA NA WA 478
    rs9756561,2
    		C,F,A,H,20999081(+) acattC/Tactat 1 -- int16Minor allele frequency- T:0.37NA WA 60
    rs9756571,2
    		C,F,A,20999345(+) ACTTCG/ATTGAC 1 -- int19Minor allele frequency- A:0.47NS EA NA 584
    rs9757061,2
    		C,F,A,20991681(+) ccactG/Atcata 1 -- int110Minor allele frequency- A:0.34NS NA EA WA 456
    rs9800841,2
    		C,F,A,21046875(+) AGTGGC/GTTAGC 1 -- int118Minor allele frequency- G:0.36NS EA NA WA 1266
    rs9800851,2
    		C,F,A,21046894(+) ATTTGG/TCTCAT 1 -- int110Minor allele frequency- T:0.32MN NA EA WA 540
    rs10173851,2
    		C,F,A,21015139(+) TGATCT/GTCTGT 1 -- int112Minor allele frequency- G:0.29MN NS EA NA WA 810
    rs10173861,2
    		C,F,A,21015205(+) TCAAAA/CTTTGT 1 -- int19Minor allele frequency- C:0.34MN NS EA NA 610
    About this table

    HapMap Linkage Disequilibrium images for SLCO1B3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SLCO1B3
         5 CNVs: 49020 3878 31863 0162 71474
         1 Indel: 33251

    QIAGEN SeqTarget long-range PCR primers for resequencing SLCO1B3 

    Disorders & Mutations
    for SLCO1B3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLCO1B3 for disorders           About GeneDecksing

    OMIM: 605495

    3 Novoseek disease relationships for SLCO1B3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatocellular carcinoma 1 6 14739090 (2), 12695556 (2)
    tumors 0 1 17308056 (1)
    cancer 0 3 20130966 (2), 17186002 (1)
    About this table

    Human Gene Mutation Database (HGMD): SLCO1B3
    Human Genome Epidemiology (HuGE) Navigator: SLCO1B3 (22 documents)

    Export disorders and mutations for SLCO1B3 gene to outside databases

    Medical News
    for SLCO1B3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for SLCO1B3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/81 PubMed articles for SLCO1B3 gene, integrated from 7 sources (see all 81):
    (articles sorted by number of sources associating them with SLCO1B3)
    1. LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. (PubMed id 11375950)1, 2, 7 Abe T.... Matsuno S. (2001)
    2. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. (PubMed id 10779507)1, 2 Koenig J.... Keppler D. (2000)
    3. Overexpression of OATP1B3 confers apoptotic resistance in colon cancer. (PubMed id 19074900)1, 7 Lee W....El-Rifai W. (2008)
    4. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). (PubMed id 15226676)1, 7 Letschert K....Konig J. (2004)
    5. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. (PubMed id 14739090)1, 7 Vavricka S.R....Kullak-Ublick G.A. (2004)
    6. Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. (PubMed id 15159445)1, 7 Hirano M....Sugiyama Y. (2004)
    7. Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. (PubMed id 12695556)1, 7 Cui Y....Keppler D. (2003)
    8. Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport. (PubMed id 18690707)1, 7 Gui C. and Hagenbuch B. (2008)
    9. Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene. (PubMed id 16741617)1, 7 Ohtsuka H....Unno M. (2006)
    10. Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. (PubMed id 16534140)1, 7 Yamaguchi H....Goto J. (2006)

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    Genome Databases showing SLCO1B3 gene

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    Entrez Gene: 28234 HGNC: 10961 AceView: SLCO1B3 Ensembl:ENSG00000111700 euGenes: HUgn28234
    ECgene: SLCO1B3 H-InvDB: SLCO1B3

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    Intellectual Property
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