SLK Gene
protein-coding GIFtS: 56
GC10P099381
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STE20-like kinase
(Previous names: SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase (yeast), STE20-like kinase (yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for SLK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| STE20-like kinase1 2 3 | | STE20-like kinase (yeast)1 | | KIAA02041 2 3 | | LOSK2 | | STK21 2 3 | | bA16H23.12 | | se20-91 2 | | SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrosenonfermenting like kinase2 | | Serine/threonine-protein kinase 22 3 | | Ste20-related serine/threonine kinase2 | | hSLK2 3 | | Long Ste20-like Kinase2 | | CTCL tumor antigen se20-92 3 | | MGC1330672 | | STE20-related kinase2 3 | | SNF1 sucrose nonfermenting like kinase2 | | STE20-related serine/threonine-protein kinase2 3 | | STE20-like serine/threonine-protein kinase2 | | SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrosenonfermenting like kinase (yeast)1 | | EC 2.7.11.13 |
Export aliases for SLK gene to outside databasesPrevious GC identifers: GC10P104620 GC00U905130 GC10P105392 GC10P105716 |
Summaries
for SLK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)
Gene Wiki entry for SLK |
Genomic Views
for SLK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLK gene promoter:
AP-1 c-Fos c-Jun MEF-2A FOXO4 POU3F1 HNF-4alpha2 GATA-1 Chx10 Egr-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLK
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLK  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q24.33 Ensembl cytogenetic band: 10q24.33 HGNC cytogenetic band: 10q25.1SLK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P099381: view genomic region
(about GC identifiers)
Start:
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99,381,490 bp from pter |
End:
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99,418,394 bp from pter |
Size:
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36,905 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr10+ 105,726,959-105,788,991 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
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Proteins
for SLK gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2 (See
protein sequence)Recommended Name: STE20-like serine/threonine-protein kinase Size: 1235 amino acids; 142695 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous discrepancy;Note=Contaminating sequence. Potential poly-A sequence starting in position 614; Sequence=BAA13195.2; Type=Frameshift;Positions=1172;
PDB structures from  and Proteopedia  :2J51 (3D)
2JFL (3D)
2JFM (3D)
2UV2 (3D)
Secondary accessions: O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9NQL0 Q9NQL1Alternative splicing: 2 isoforms: Q9H2G2-1 Q9H2G2-2 Explore the universe of human proteins at neXtProt for SLK: NX_Q9H2G2
Post-translational modifications:
Proteolytically cleaved by caspase-31
Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055535.2
ENSEMBL proteins: ENSP00000336824 ENSP00000358770
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SLK for ontologies About GeneDecksing
Antibodies for SLK:
Assays for SLK: |
Protein
Domains/
Families
for SLK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLK for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9H2G2ProtoNet protein and cluster: Q9H2G2 UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 UVR domain |
Gene Function
for SLK gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
SLK for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Slk (no phenotypes)
SLK for phenotypes About GeneDecksing
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Pathways & Interactions
for SLK gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SLK for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SLK
1  Kegg Pathway (Kegg details for SLK):
SABiosciences Pathway-Focused PCR Array including SLK: PAHS-042A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLK
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLK
1 Interacting protein for SLK (ENSP000003587703) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
SLK for ontologies About GeneDecksing
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Drugs & Compounds
for SLK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
SLK for compounds About GeneDecksing
 Browse Tocris compounds for SLK
2  Novoseek chemical compound relationships for SLK gene
About this table
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Transcripts
for SLK gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SLK gene: NM_014720.2 Additional cDNA sequence: AF273048.1 AK302855.1 AK307389.1 BC008697.1 BC036736.1 BC047762.1 BC047885.1 BC064804.1 BC111565.1 BX648375.1 D86959.1 EF139853.1 5 DOTS entries: DT.92433300 DT.417305 DT.40193723 DT.100792601 DT.75180494 24/330 AceView cDNA sequences (see all 330): BI962634 BC047885 CB122039 AI188477 Z41573 AI335569 BI793331 BU608402 AA688032 CB242557 AI682543 BM968564 AA782186 AL120836 BE859091 BC047762 BE328630 NM_014720 BU632420 AI375419 BE888211 BM981260 AI478214 BF222802
 highest scoring ESTs for SLK:AA128460 AA131682 AA131987 AA147494 AA155670 AA191499 AA292145 AA323083 AA347410 AA362323 Unigene Cluster for SLK: STE20-like kinase Hs.591922 [show with all ESTs]Unigene Representative Sequence: D86959
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SLK
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SLK
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335753 ENST00000369755(uc001kxo.1 uc001kxp.1) ENST00000474260
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Expression
for SLK gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SLK expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching SLK gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 38669_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
1.00 |
1.00 |
AB002804 |
0.80 |
1.00 |
0.91 |
1 |
| 206875_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_014720 |
0.60 |
1.00 |
0.82 |
1 |
| 206874_s_at2
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206875_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 206874_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SLK for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGGGTCCTG
SOURCE GeneReport for Unigene cluster: Hs.591922
Expression variation in blood from EXPOLDB for SLK UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including SLK: PAHS-042A
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Orthologs
for SLK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLK gene from 5/11 species (see all 11)
About this table Species with no ortholog for SLK
ENSEMBL Gene Tree for SLK (if available) |
Paralogs
for SLK gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SLK gene
- MAP4K12 MAP4K52 MAP4K32 STK102 MAP4K22
SLK for paralogs About GeneDecksing
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Genomic Variants
for SLK gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing SLK |
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Disorders & Mutations
for SLK gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLK for disorders About GeneDecksing
1 Novoseek disease relationship for SLK gene
About this table
1 PharmGKB disease relationship for SLK geneAbout this table
Human Genome Epidemiology (HuGE) Navigator: SLK (18 documents)
Export disorders and mutations for SLK gene to outside databases
|
Medical News
for SLK gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SLK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/36 PubMed articles for SLK gene, integrated from 7 sources (see all 36):
(articles sorted by number of sources associating them with SLK)- Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PubMed id 10699464)1, 2, 7 Yamada E.... Yamamoto H. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (2001)
- Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
- A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PubMed id 3526554)1, 3 Celenza J.L. and Carlson M. (1986)
- Ste20-related Protein Kinase LOSK (SLK) Controls Microtubule Radial Array in Interphase. (PubMed id 18287541)1, 7 Burakov A.V....Nadezhdina E.S. (2008)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
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External Searches for SLK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SLK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLK gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SLK gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for SLK gene:
Search GeneIP for patents involving SLK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLK gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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| |  | Search Tocris compounds for SLK |
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 | | | ELISAs and CLIAs for SLK |
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