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SLK Gene

protein-coding   GIFtS: 56

GC10P099381
STE20-like kinase
(Previous names: SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase (yeast), STE20-like kinase (yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
STE20-like kinase1 2 3     STE20-like kinase (yeast)1
KIAA02041 2 3     LOSK2
STK21 2 3     bA16H23.12
se20-91 2     SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose
nonfermenting like kinase2
Serine/threonine-protein kinase 22 3     Ste20-related serine/threonine kinase2
hSLK2 3     Long Ste20-like Kinase2
CTCL tumor antigen se20-92 3     MGC1330672
STE20-related kinase2 3     SNF1 sucrose nonfermenting like kinase2
STE20-related serine/threonine-protein kinase2 3     STE20-like serine/threonine-protein kinase2
SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose
nonfermenting like kinase (yeast)1
     EC 2.7.11.13

External Ids:    HGNC: 110881   Entrez Gene: 97482   Ensembl: ENSG000000656137   UniProtKB: Q9H2G23   

Export aliases for SLK gene to outside databases

Previous GC identifers: GC10P104620 GC00U905130 GC10P105392 GC10P105716


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)

Gene Wiki entry for SLK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLK gene promoter:
         AP-1   c-Fos   c-Jun   MEF-2A   FOXO4   POU3F1   HNF-4alpha2   GATA-1   Chx10   Egr-3   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SLK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLK 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.33   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q25.1

SLK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLK gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099381:  view genomic region     (about GC identifiers)

Start:
99,381,490 bp from pter
End:
99,418,394 bp from pter
Size:
36,905 bases
Orientation:
plus strand

1 alternative location:
Chr10+ 105,726,959-105,788,991     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2 (See protein sequence)
Recommended Name: STE20-like serine/threonine-protein kinase  
Size: 1235 amino acids; 142695 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAH47762.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence starting in position 611; Sequence=AAH47885.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence starting in position 422; Sequence=AAH64804.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Potential poly-A sequence starting in position 614; Sequence=BAA13195.2; Type=Frameshift;
Positions=1172;
PDB structures from and Proteopedia :
2J51 (3D)    2JFL (3D)    2JFM (3D)    2UV2 (3D)    
Secondary accessions: O00211 Q6P1Z4 Q86WU7 Q86WW1 Q92603 Q9NQL0 Q9NQL1
Alternative splicing: 2 isoforms:  Q9H2G2-1   Q9H2G2-2   

Explore the universe of human proteins at neXtProt for SLK: NX_Q9H2G2 

Post-translational modifications:

  • Proteolytically cleaved by caspase-31
  • Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055535.2  

    ENSEMBL proteins: 
    ENSP00000336824 ENSP00000358770 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SLK
    GenScript Custom Purified and Recombinant Proteins Services for SLK 
    Novus Biologicals Protein for SLK
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA18029348
    GO:0005886 plasma membrane IDA18029348
    About this table

    SLK for ontologies           About GeneDecksing



    Antibodies for SLK: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SLK
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SLK 
    Novus Biologicals Antibodies for SLK
    Browse antibodies at Epitomics

    Assays for SLK: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLK 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLK 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLK for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2G2

    ProtoNet protein and cluster: Q9H2G2

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UVR domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Function: Mediates apoptosis and actin stress fiber dissolution (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SLK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLK
    Sigma-Aldrich shRNA Panels and shRNA for SLK
    OriGene 29mer shRNA kits in GFP-retroviral vector: SLK
    OriGene shRNA RFP: SLK
    OriGene basic RS shRNA: SLK
    OriGene siRNA: SLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLK 
    miRNA:Sigma-Aldrich microRNA Mimics for SLK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLK 
    2 SABiosciences Assays for microRNAs that regulate SLK:
    hsa-miR-219-5p hsa-miR-340

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SLK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLK
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SLK
    OriGene 3'-UTR clone: SLK 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SLK 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SLK 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003677 DNA binding IEA--
    GO:0004518 nuclease activity IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IEA--
    About this table

    SLK for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Slk (no phenotypes)


    SLK for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SLK for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  SLK
        Mitotic Roles of Polo-Like Kinase

    1 Kegg Pathway  (Kegg details for SLK):
        hsa04114 Oocyte meiosis

        SABiosciences Pathway-Focused PCR Array including SLK: PAHS-042A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SLK
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLK

    1 Interacting protein for SLK (ENSP000003587703) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3ENSP000003110323STRING: ENSP00000311032
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006289 nucleotide-excision repair IEA--
    GO:0006468 protein phosphorylation IEA--
    GO:0006915 apoptosis IEA--
    About this table

    SLK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SLK for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLK
    2 Novoseek chemical compound relationships for SLK gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 44.6 2 9346925 (1), 10699464 (1)
    glucose 10.2 3 16316999 (1), 19640899 (1), 12965890 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SLK
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SLK
    Sigma-Aldrich shRNA Panels and shRNA for SLK
    OriGene 29mer shRNA kits in GFP-retroviral vector: SLK
    OriGene shRNA RFP: SLK
    OriGene basic RS shRNA: SLK
    OriGene siRNA: SLK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLK 
    miRNA: Sigma-Aldrich microRNA Mimics for SLK
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLK 
    2 SABiosciences Assays for microRNAs that regulate SLK:
    hsa-miR-219-5p hsa-miR-340
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SLK
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SLK
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SLK
    OriGene 3'-UTR Clone: SLK 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SLK 
    Primers: OriGene genome-wide validated SYBR primer pairs: SLK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLK: PPH11003A

    REFSEQ mRNAs for SLK gene: 

    NM_014720.2  

    Additional cDNA sequence: 

    AF273048.1 AK302855.1 AK307389.1 BC008697.1 BC036736.1 BC047762.1 BC047885.1 BC064804.1 
    BC111565.1 BX648375.1 D86959.1 EF139853.1 

    5 DOTS entries:

    DT.92433300  DT.417305  DT.40193723  DT.100792601  DT.75180494 

    24/330 AceView cDNA sequences (see all 330):

    BI962634 BC047885 CB122039 AI188477 Z41573 AI335569 BI793331 BU608402 
    AA688032 CB242557 AI682543 BM968564 AA782186 AL120836 BE859091 BC047762 
    BE328630 NM_014720 BU632420 AI375419 BE888211 BM981260 AI478214 BF222802 

    highest scoring ESTs for SLK:

    AA128460 AA131682 AA131987 AA147494 AA155670 AA191499 AA292145 AA323083 AA347410 AA362323 

    Unigene Cluster for SLK:

    STE20-like kinase
    Hs.591922  [show with all ESTs]
    Unigene Representative Sequence: D86959


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLK

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                                                                                        -                           
    SP2:                                                                                      -                 -                           
    SP3:                                                                                      -                                             

    About this scheme

    ECgene alternative splicing isoforms for SLK
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000335753 ENST00000369755(uc001kxo.1 uc001kxp.1) ENST00000474260


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SLK expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching SLK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38669_at2, 3 U95-A 1 0.81 1.00 1.00 1.00 AB002804 0.80 1.00 0.91 1
    206875_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_014720 0.60 1.00 0.82 1
    206874_s_at2 U133-A 1 0.82 1.00 -- -- -- -- -- -- --
    206875_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    206874_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    SLK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SLK gene expression
    SLK gene electronic northern expression
    SLK gene sage expression
    About these images

    CGAP SAGE TAG: GTGGGTCCTG

    SOURCE GeneReport for Unigene cluster: Hs.591922

    Expression variation in blood from EXPOLDB for SLK

    UniProtKB/Swiss-Prot: SLK_HUMAN, Q9H2G2
    Tissue specificity: Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: SLK
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SLK: PPH11003A
        SABiosciences Expression via Pathway-Focused PCR Array including SLK: PAHS-042A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SLK gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SLK1   -- STE20-like kinase (yeast) 91.44(n)
    90.69(a)
    486876  XM_544006.2  XP_544006.2 
    cow
    (Bos taurus)
    SLK1   -- STE20-like kinase (yeast) 90.32(n)
    88.65(a)
    535342  XM_615401.3  XP_615401.3 
    rat
    (Rattus norvegicus)
    Slk1   -- STE20-like kinase (yeast) 83.78(n)
    81.9(a)
    54308  NM_019349.1  NP_062222.1 
    mouse
    (Mus musculus)
    Slk1 , 5 19 (39.77 cM)5
    STE20-like kinase (yeast)1, 5 84.54(n)1
    84.65(a)1
    208741  NM_009289.21  NP_033315.11 
     AA1184135  AA8225315  (see all 27)
    chicken
    (Gallus gallus)
    SLK1   -- STE20-like kinase (yeast) 73.83(n)
    73.99(a)
    423878  XM_421743.2  XP_421743.2 
    About this table        Species with no ortholog for SLK

    ENSEMBL Gene Tree for SLK (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SLK gene
    MAP4K12  MAP4K52  MAP4K32  STK102  MAP4K22  

    SLK for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    QIAGEN SeqTarget long-range PCR primers for resequencing SLK 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLK for disorders           About GeneDecksing

    1 Novoseek disease relationship for SLK gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    renal failure acute ischemic 78.3 2 16316999 (1), 17003224 (1)
    About this table

    1 PharmGKB disease relationship for SLK gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12730115
    About this table

    Human Genome Epidemiology (HuGE) Navigator: SLK (18 documents)

    Export disorders and mutations for SLK gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/36 PubMed articles for SLK gene, integrated from 7 sources (see all 36):
    (articles sorted by number of sources associating them with SLK)
    1. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. (PubMed id 10699464)1, 2, 7 Yamada E.... Yamamoto H. (2000)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    5. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PubMed id 11149944)1, 2 Eichmueller S....Schadendorf D. (2001)
    6. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    7. A yeast gene that is essential for release from glucose repression encodes a protein kinase. (PubMed id 3526554)1, 3 Celenza J.L. and Carlson M. (1986)
    8. Ste20-related Protein Kinase LOSK (SLK) Controls Microtubule Radial Array in Interphase. (PubMed id 18287541)1, 7 Burakov A.V....Nadezhdina E.S. (2008)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9748 HGNC: 11088 AceView: SLK Ensembl:ENSG00000065613 euGenes: HUgn9748
    ECgene: SLK Kegg: 9748 H-InvDB: SLK

    (According to HUGE)
    About This Section
    HUGE: KIAA0204

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for SLK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SLK gene:
    Search GeneIP for patents involving SLK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for SLK Antibodies for SLK
     Super-pooled esiRNAs for SLK Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for SLK microRNA Mimics for SLK
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for SLK
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SLK
     SeqTarget long-range PCR primers for resequencing SLK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SLK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SLK
     GenScript Custom Purified and Recombinant Proteins Services for SLK GenScript cDNA clones with any tag delivered in your preferred vector for SLK
     GenScript Custom Assay Services for SLK GenScript Custom Superior Antibodies Services for SLK
     GenScript Custom overexpressing Cell Line Services for SLK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLK promoter
     Search Chromatin IP Primers for SLK
     RT2 qPCR Primer Assay for SLK
     GNC Network for SLK
     Assays for microRNAs that regulate SLK
     SABiosciences PCR Arrays including SLK
     Search Tocris compounds for SLK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for SLK
     Proteins for SLK
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for SLK
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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