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SNAP25 Gene

protein-coding   GIFtS: 68

GC20P010151
synaptosomal-associated protein, 25kDa
(Previous names: synaptosomal-associated protein, 25kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SNAP)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
synaptosomal-associated protein, 25kDa1 2     Synaptosomal-associated 25 kDa protein2 3
SNAP-251 2 3     SNAP2 3
RIC-41 2     SUP2 3
dJ1068F16.21 2     synaptosomal-associated protein, 25kD1
RIC41 2     resistance to inhibitors of cholinesterase 4 homolog2
SEC91 2     FLJ230792
bA416N4.21 2     synaptosomal-associated protein 252
Super protein2 3     

External Ids:    HGNC: 111321   Entrez Gene: 66162   Ensembl: ENSG000001326397   UniProtKB: P608803   

Export aliases for SNAP25 gene to outside databases

Previous GC identifers: GC20P010187 GC20P010194 GC20P010147 GC20P010199


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNAP25:
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor
attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The
assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the
other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein
encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein
involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein
isoforms have been described for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880
Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the
synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane
fusion. Regulates plasma membrane recycling through its interaction with CENPF

Gene Wiki entry for SNAP25 (SNAP-25)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNAP25 gene promoter:
         AP-1   STAT5A   NF-kappaB1   p53   STAT3   NF-kappaB   NRSF form 2   NRSF form 1   c-Fos   c-Jun   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SNAP25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12-p11.2   Ensembl cytogenetic band:  20p12.2   HGNC cytogenetic band: 20p12-p11.2

SNAP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP25 gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P010151:  view genomic region     (about GC identifiers)

Start:
10,151,237 bp from pter
End:
10,288,066 bp from pter
Size:
136,830 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880 (See protein sequence)
Recommended Name: Synaptosomal-associated protein 25  
Size: 206 amino acids; 23315 Da
Subunit: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with
CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a
complex containing SYT1, SV2B and syntaxin-1 (By similarity)
Subcellular location: Cytoplasm, perinuclear region (By similarity). Cell membrane; Lipid-anchor. Cell junction,
synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating
at the perinuclear region (By similarity)
Miscellaneous: When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85,
Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead
PDB structure from and Proteopedia :
1KIL (3D)    1XTG (3D)    
Secondary accessions: B2RAU4 P13795 P36974 P70557 P70558 Q53EM2 Q5U0B5 Q8IXK3 Q96FM2 Q9BR45
Alternative splicing: 2 isoforms:  P60880-1, P13795-1   P60880-2, P13795-2   (Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which encode for positions 56 to 94 and differ only in 9 positions out of 39)

Explore the universe of human proteins at neXtProt for SNAP25: NX_P60880 

Post-translational modifications:

  • Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By
  • similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_003072.2  NP_570824.1  


    ENSEMBL proteins: 
    ENSP00000254976 ENSP00000400720 ENSP00000307341 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SNAP25
    OriGene Protein Over-expression Lysate: SNAP25
    GenScript Custom Purified and Recombinant Proteins Services for SNAP25 
    Novus Biologicals Proteins for SNAP25
    Novus Biologicals Lysates for SNAP25
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SNAP25

    5/16 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005768 endosome IEA--
    GO:0005802 trans-Golgi network IEA--
    GO:0005886 plasma membrane TAS--
    GO:0008076 voltage-gated potassium channel complex IEA--
    About this table

    SNAP25 for ontologies           About GeneDecksing



    Antibodies for SNAP25: 
    Millipore Mono- and Polyclonal Antibodies for the study of SNAP25
    Sigma-Aldrich Antibody Arrays and Antibodies for SNAP25
    R&D Systems Antibodies for SNAP25
    Cell Signaling Technology (CST) Antibodies for SNAP25 
    OriGene Antibodies (see all 3): SNAP25
    GenScript Superior Antibodies for SNAP25 
    Novus Biologicals Antibodies for SNAP25
    Epitomics antibodies for SNAP25

    Assays for SNAP25: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SNAP25 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SNAP25 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SNAP25 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000928 SNAP-25
     IPR000727 T_SNARE_dom

    Graphical View of Domain Structure for InterPro Entry P60880

    ProtoNet protein and cluster: P60880

    1 Blocks protein family: IPB000928 SNAP-25 family

    UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880
    Similarity: Belongs to the SNAP-25 family
    Similarity: Contains 2 t-SNARE coiled-coil homology domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880
    Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the
    synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane
    fusion. Regulates plasma membrane recycling through its interaction with CENPF

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SNAP25
    Sigma-Aldrich shRNA for SNAP25
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SNAP25
    OriGene shRNA RFP (see all 2): SNAP25
    OriGene basic RS shRNA (see all 2): SNAP25
    OriGene siRNA (see all 2): SNAP25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SNAP25 
    miRNA:Sigma-Aldrich microRNA Mimics for SNAP25
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SNAP25 
    8/18 SABiosciences Assays for microRNAs that regulate SNAP25 (see all 18):
    hsa-miR-495 hsa-miR-128 hsa-miR-301a hsa-miR-34b hsa-miR-613 hsa-miR-130b hsa-miR-301b hsa-miR-1298

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SNAP25
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SNAP25
    OriGene untagged cDNA clones in CMV expression vector (see all 3): SNAP25
    OriGene 3'-UTR clone (see all 2): SNAP25 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SNAP25 
    Sino Biological Human cDNA Clone for SNAP25

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SNAP25 

    Genatlas biochemistry entry for SNAP25:
    synaptosomal-associated protein 1,25kDa,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE
    protein,palmitoylated in vivo for the binding to syntaxin

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149 SNARE binding IEA--
    GO:0005249 voltage-gated potassium channel activity IEA--
    GO:0005515 protein binding IPI8692999
    GO:0017022 myosin binding IEA--
    GO:0017075 syntaxin-1 binding IEA--
    About this table

    SNAP25 for ontologies           About GeneDecksing

    Animal Models: 15/17 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Snap25) (see all 17):

    behavior/neurologicalcardiovascular systemembryogenesisgrowth/sizehearing/vestibular/ear
    lethality-postnatallethality-prenatal/perinatallife span-post-weaning/aginglimbs/digits/tailmuscle
    nervous systemreproductive systemrespiratory systemskeletonskin/coat/nails

    SNAP25 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SNAP25 for pathways           About GeneDecksing

    1 Millipore Pathway for SNAP25
        Clathrin-dependent protein traffic

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  SNAP25
        Huntington's Disease Signaling

    1 Kegg Pathway  (Kegg details for SNAP25):
        hsa04130 SNARE interactions in vesicular transport

        SABiosciences Pathway-Focused PCR Array including SNAP25: PAHS-023A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SNAP25
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SNAP25

    5/31 Interacting proteins for SNAP25 (P608801, 2 ENSP000002549763) via UniProtKB, MINT, and/or STRING (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITSN1Q158112, ENSP000003707193MINT-2843882 MINT-2844026 STRING: ENSP00000370719
    STX1AQ166232, ENSP000002228123MINT-63924 STRING: ENSP00000222812
    STX11O755581, 2EBI-524785,EBI-714135 MINT-63923 MINT-66857
    ZDHHC17Q8IUH51EBI-524785,EBI-524753
    PRRT2Q7Z6L02MINT-63925
    About this table

    5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001504 neurotransmitter uptake NAS8760387
    GO:0006112 energy reserve metabolic process TAS--
    GO:0007268 synaptic transmission TAS--
    GO:0007269 neurotransmitter secretion TAS--
    GO:0007409 axonogenesis IEA--
    About this table

    SNAP25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SNAP25 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNAP25
    10/27 Novoseek chemical compound relationships for SNAP25 gene (see all 27)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    toxin-s 48.4 2 17112344 (1), 19253949 (1)
    calcium 48.2 75 14980208 (4), 11830673 (3), 19004828 (3), 8861939 (2) (see all 42)
    mastoparan 45.8 4 9243624 (2), 11741293 (1)
    n-ethylmaleimide 38 1 19748891 (1)
    catecholamine 37.3 7 16445859 (3), 7556639 (2), 8611567 (1)
    toxin a 35.7 1 7588600 (1)
    mgatp 30.3 1 11861772 (1)
    acetylcholine 29.3 7 9243624 (3), 8900203 (1), 10564353 (1), 10783705 (1)
    atp 22.5 7 8702751 (3), 7957884 (1), 17886343 (1), 12914955 (1) (see all 5)
    palmitate 20.8 7 11916915 (1), 15355980 (1), 8641455 (1), 9349529 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SNAP25
    Sigma-Aldrich shRNA for SNAP25
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SNAP25
    OriGene shRNA RFP (see all 2): SNAP25
    OriGene basic RS shRNA (see all 2): SNAP25
    OriGene siRNA (see all 2): SNAP25
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SNAP25 
    miRNA: Sigma-Aldrich microRNA Mimics for SNAP25
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SNAP25 
    8/18 SABiosciences Assays for microRNAs that regulate SNAP25 (see all 18):
    hsa-miR-495 hsa-miR-128 hsa-miR-301a hsa-miR-34b hsa-miR-613 hsa-miR-130b hsa-miR-301b hsa-miR-1298
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SNAP25
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SNAP25
    OriGene untagged cDNA clones in CMV expression vector (see all 3): SNAP25
    OriGene 3'-UTR Clone (see all 2): SNAP25 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SNAP25 
    Primers: OriGene genome-wide validated SYBR primer pairs: SNAP25
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SNAP25: PPH01881A

    REFSEQ mRNAs for SNAP25 gene (2 alternative transcripts): 

    NM_003081.2  NM_130811.1  

    Additional cDNA sequence: 

    AK090857.1 AK091322.1 AK094560.1 AK098347.1 AK098767.1 AK124279.1 AK223617.1 AK289647.1 
    AK314359.1 BC010647.1 BC047512.1 BT019684.1 BX647443.1 CR593483.1 CR595223.1 CR603170.1 
    CR605011.1 CR606156.1 CR607483.1 CR609324.1 CR610237.1 CR614022.1 CR619486.1 CR619659.1 
    CR624018.1 CR624370.1 D21267.1 L19760.1 L19761.1 

    24/55 DOTS entries (see all 55):

    DT.452947  DT.95090568  DT.99937938  DT.91961969  DT.100880485  DT.120816230  DT.100880478  DT.95090569 
    DT.100880489  DT.95317053  DT.120816140  DT.120816273  DT.120816130  DT.92460503  DT.100880491  DT.100880474 
    DT.120816066  DT.409111  DT.120816214  DT.120816248  DT.120816149  DT.120816098  DT.120816257  DT.120816071 

    24/634 AceView cDNA sequences (see all 634):

    BP361775 BM675372 CD107216 AA350200 BQ778272 BM666216 F02132 AA326483 
    BP361110 BX444377 AK094560 AA322536 CA942488 AA321762 BX459476 BU743010 
    CR603170 BM684515 AA894766 BX463624 BP360297 BP360011 CR595223 BP361673 

    highest scoring ESTs for SNAP25:

    D21267 AA017039 AA081771 AA084617 AA093447 AA166848 AA169277 AA321761 AA321828 AA322529 

    Unigene Cluster for SNAP25:

    Synaptosomal-associated protein, 25kDa
    Hs.167317  [show with all ESTs]
    Unigene Representative Sequence: AK090857


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP25 (see all 11)

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                -     -     -                             -                       -     -                                                   
    SP2:                                -     -     -                             -     -                 -     -                                                   
    SP3:                                -     -     -                             -           -     -     -     -                                                   
    SP4:                                      -     -                             -           -     -     -     -                                                   
    SP5:                                -     -     -                             -     -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for SNAP25
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495883 ENST00000254976(uc002wnq.1 uc002wns.1 uc010gcb.1 uc010gcc.1)
    ENST00000492814 ENST00000430336 ENST00000304886(uc002wnr.1 uc010gca.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SNAP25 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching SNAP25 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38484_at2, 3 U95-A 1 1.00 1.00 0.97 1.23 D21267 1.00 1.00 1.00 1
    71882_at*2, 3 U95-E 1 0.50 1.00 0.61 0.86 AI806346 0.60 1.00 0.82 1
    202507_s_at2, 3 U133-A 1 1.00 1.00 -- -- L19760 0.80 1.00 0.91 1
    202508_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003081 0.60 1.00 0.82 1
    202507_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    202508_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    SNAP25 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SNAP25 gene expression
    SNAP25 gene electronic northern expression
    SNAP25 gene sage expression
    About these images

    CGAP SAGE TAG: TAATATTAAA

    SOURCE GeneReport for Unigene cluster: Hs.167317

    Expression variation in blood from EXPOLDB for SNAP25

    UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880
    Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei,
    and granule cells of the cerebellum

    Primers: OriGene genome-wide validated SYBR primer pairs: SNAP25
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SNAP25: PPH01881A
        SABiosciences Expression via Pathway-Focused PCR Array including SNAP25: PAHS-023A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SNAP25 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SNAP251   -- synaptosomal-associated protein, 25kDa 97.25(n)
    100(a)
    477158  XM_844584.1  XP_849677.1 
    chimpanzee
    (Pan troglodytes)
    SNAP251   -- synaptosomal-associated protein, 25kDa 94.66(n)
    95.63(a)
    458096  NM_001009094.1  NP_001009094.1 
    cow
    (Bos taurus)
    SNAP251   -- synaptosomal-associated protein, 25kDa 91.59(n)
    95.63(a)
    540853  NM_001076246.1  NP_001069714.1 
    rat
    (Rattus norvegicus)
    Snap251   -- synaptosomal-associated protein 25 89.64(n)
    95.63(a)
    25012  NM_030991.1  NP_112253.1 
    mouse
    (Mus musculus)
    Snap251 , 5 2 (67.56 cM)5
    synaptosomal-associated protein 251, 5 90.13(n)1
    95.63(a)1
    206141  NM_011428.31  NP_035558.11 
     AF4835165  AF4835175  (see all 12)
    About this table        Species with no ortholog for SNAP25

    ENSEMBL Gene Tree for SNAP25 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SNAP25 gene
    SNAP232  

    SNAP25 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/907 NCBI SNPs in SNAP25 are shown (see all 907)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs32231,2
    C,A,10278372(-) AGGGGC/TTACAG 1 -- int16Minor allele frequency- T:0.18MN NA EA WA 350
    rs86361,2
    C,F,O,A,H,10287742(+) GGCTAC/TGTTTT 1 -- ut3132Minor allele frequency- T:0.31MN NS EA NA WA 3238
    rs3625471,2
    C,F,O,A,H,10245139(+) TTCTTC/TAGCCA 1 -- int121Minor allele frequency- N:0.00NS EA NA WA 1454
    rs3625481,2
    C,F,A,10246815(+) TTCTGA/GTGATT 1 -- int115Minor allele frequency- G:0.26NS EA NA WA 780
    rs3625491,2
    C,F,O,A,H,10269890(+) CCTGGA/GACTTT 1 -- int118Minor allele frequency- G:0.49EA NS NA WA 2270
    rs3625501,2
    C,F,10275015(+) AAATTC/TTGCTT 1 -- int16Minor allele frequency- T:0.07MN NA EA WA 398
    rs3625621,2
    C,F,10243186(+) CAGTGG/ATTTGT 1 -- int115Minor allele frequency- A:0.21NS EA NA WA 1062
    rs3625631,2
    C,F,10243251(+) GCTCAT/CAAACA 1 -- int112Minor allele frequency- C:0.16NS EA NA WA 938
    rs3625641,2
    C,F,O,A,H,10244626(+) GGAACT/CGTTGC 1 -- int118Minor allele frequency- C:0.45NS EA NA WA 1186
    rs3625651,2
    C10245780(+) TTTAAC/GTAGGA 1 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for SNAP25 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SNAP25: --

    QIAGEN SeqTarget long-range PCR primers for resequencing SNAP25 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SNAP25 for disorders           About GeneDecksing

    OMIM: 600322

    10/17 Novoseek disease relationships for SNAP25 gene (see all 17)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tetanus 74.3 11 7588600 (1), 15900706 (1), 9013335 (1), 7591680 (1) (see all 11)
    botulism 71.6 2 10601242 (1), 8243676 (1)
    attention-deficit hyperactivity disorder 42.8 6 10889551 (2), 19099826 (2), 17979583 (1), 18194215 (1)
    paralysis 37.5 5 17976638 (1), 12381720 (1), 16195243 (1), 19176217 (1)
    schizophrenia 32.6 26 19132710 (5), 18512733 (3), 18347838 (3), 11287790 (1) (see all 12)
    insulinoma 29.6 4 11978639 (2), 9658409 (1), 11502551 (1)
    coloboma 22.4 2 12759129 (1), 10889551 (1)
    alzheimers disease 22.4 5 18194215 (1), 2075860 (1), 10344268 (1), 10343324 (1)
    bipolar disorder 13.2 2 18726138 (1), 16542183 (1)
    intoxication 9.89 1 15486565 (1)
    About this table

    Genetic Association Database (GAD): SNAP25
    Human Genome Epidemiology (HuGE) Navigator: SNAP25 (42 documents)

    Export disorders and mutations for SNAP25 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/401 PubMed articles for SNAP25 gene, integrated from 7 sources (see all 401):
    (articles sorted by number of sources associating them with SNAP25)
    1. The C terminus of SNAP25 is essential for Ca(2+)-depe ndent binding of synaptotagmin to SNARE complexes. (PubMed id 10692432)1, 3, 7 Gerona R.R....Martin T.F. (2000)
    2. The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. (PubMed id 15823421)1, 4, 7 Muller D.J....Kennedy J.L. (2005)
    3. Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)1, 2, 7 Jagadish M.N....Ward C.W. (1996)
    4. Support for association between ADHD and two candidate genes: NET1 and DRD1. (PubMed id 15717291)1, 4 Bobb A.J....Rapoport J.L. (2005)
    5. The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder. (PubMed id 16088329)1, 4 Feng Y....Barr C.L. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. (PubMed id 15007392)1, 4 Mill J....Asherson P. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder. (PubMed id 12660803)1, 4 Kustanovich V....Nelson S.F. (2003)
    10. Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. (PubMed id 11920846)1, 4 Mill J....Asherson P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6616 HGNC: 11132 AceView: SNAP25 Ensembl:ENSG00000132639 euGenes: HUgn6616
    ECgene: SNAP25 Kegg: 6616 H-InvDB: SNAP25

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SNAP25 gene:
    Search GeneIP for patents involving SNAP25

    GeneCards and IP:
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