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SNAP25 Gene

protein-coding GIFtS: 68

GC20P010151

synaptosomal-associated protein, 25kDa
(Previous names: synaptosomal-associated protein, 25kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SNAP)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
synaptosomal-associated protein, 25kDa¹ ²		Synaptosomal-associated 25 kDa protein² ³
SNAP-25¹ ² ³		SNAP² ³
RIC-4¹ ²		SUP² ³
dJ1068F16.2¹ ²		synaptosomal-associated protein, 25kD¹
RIC4¹ ²		resistance to inhibitors of cholinesterase 4 homolog²
SEC9¹ ²		FLJ23079²
bA416N4.2¹ ²		synaptosomal-associated protein 25²
Super protein² ³

External Ids:	HGNC: 11132¹	Entrez Gene: 6616²	Ensembl: ENSG00000132639⁷	UniProtKB: P60880³

Export aliases for SNAP25 gene to outside databases

Previous GC identifers: GC20P010187 GC20P010194 GC20P010147 GC20P010199

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SNAP25:

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor

attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The

assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the

other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein

encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein

involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein

isoforms have been described for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880

Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the

synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane

fusion. Regulates plasma membrane recycling through its interaction with CENPF

Gene Wiki entry for SNAP25 (SNAP-25)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SNAP25 gene promoter:
         AP-1   STAT5A   NF-kappaB1   p53   STAT3   NF-kappaB   NRSF form 2   NRSF form 1   c-Fos   c-Jun
         Other transcription factors

Search SABiosciences Chromatin IP Primers for SNAP25

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12-p11.2 Ensembl cytogenetic band: 20p12.2 HGNC cytogenetic band: 20p12-p11.2

SNAP25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNAP25 gene location

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P010151: view genomic region (about GC identifiers)

Start:	10,151,237 bp from pter
End:	10,288,066 bp from pter
Size:	136,830 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.10 NT_011387.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880 (See protein sequence)

Recommended Name: Synaptosomal-associated protein 25

Size: 206 amino acids; 23315 Da

Subunit: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with

CENPF, TRIM9, RIMS1, SNAPIN, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a

complex containing SYT1, SV2B and syntaxin-1 (By similarity)

Subcellular location: Cytoplasm, perinuclear region (By similarity). Cell membrane; Lipid-anchor. Cell junction,

synapse, synaptosome. Note=Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating

at the perinuclear region (By similarity)

Miscellaneous: When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85,

Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead

PDB structure from and Proteopedia :

1KIL (3D)

1XTG (3D)

Secondary accessions: B2RAU4 P13795 P36974 P70557 P70558 Q53EM2 Q5U0B5 Q8IXK3 Q96FM2 Q9BR45

Alternative splicing: 2 isoforms: P60880-1, P13795-1 P60880-2, P13795-2 (Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which encode for positions 56 to 94 and differ only in 9 positions out of 39)

Explore the universe of human proteins at neXtProt for SNAP25: NX_P60880

Post-translational modifications:

Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association (By

similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003072.2 NP_570824.1

ENSEMBL proteins:

ENSP00000254976 ENSP00000400720 ENSP00000307341

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SNAP25 OriGene Protein Over-expression Lysate: SNAP25
	GenScript Custom Purified and Recombinant Proteins Services for SNAP25
	Novus Biologicals Proteins for SNAP25
	Novus Biologicals Lysates for SNAP25
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for SNAP25

5/16 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 16):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005768	endosome	IEA	--
GO:0005802	trans-Golgi network	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0008076	voltage-gated potassium channel complex	IEA	--

About this table

SNAP25 for ontologies About GeneDecksing

Antibodies for SNAP25:

	Millipore Mono- and Polyclonal Antibodies for the study of SNAP25
	Sigma-Aldrich Antibody Arrays and Antibodies for SNAP25
	R&D Systems Antibodies for SNAP25
	Cell Signaling Technology (CST) Antibodies for SNAP25
	OriGene Antibodies (see all 3): SNAP25
	GenScript Superior Antibodies for SNAP25
	Novus Biologicals Antibodies for SNAP25
	Epitomics antibodies for SNAP25

Assays for SNAP25:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SNAP25
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SNAP25

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SNAP25 for domains About GeneDecksing

2 InterPro domains/families:

IPR000928 SNAP-25

IPR000727 T_SNARE_dom

Graphical View of Domain Structure for InterPro Entry P60880

ProtoNet protein and cluster: P60880

1 Blocks protein family: IPB000928 SNAP-25 family

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880

Similarity: Belongs to the SNAP-25 family

Similarity: Contains 2 t-SNARE coiled-coil homology domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880

Function: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the

synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane

fusion. Regulates plasma membrane recycling through its interaction with CENPF

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for SNAP25 Sigma-Aldrich shRNA for SNAP25
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SNAP25 OriGene shRNA RFP (see all 2): SNAP25 OriGene basic RS shRNA (see all 2): SNAP25 OriGene siRNA (see all 2): SNAP25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SNAP25

miRNA:		Sigma-Aldrich microRNA Mimics for SNAP25 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SNAP25
		8/18 SABiosciences Assays for microRNAs that regulate SNAP25 (see all 18):
		hsa-miR-495 hsa-miR-128 hsa-miR-301a hsa-miR-34b hsa-miR-613 hsa-miR-130b hsa-miR-301b hsa-miR-1298

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SNAP25 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SNAP25 OriGene untagged cDNA clones in CMV expression vector (see all 3): SNAP25 OriGene 3'-UTR clone (see all 2): SNAP25 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SNAP25
		Sino Biological Human cDNA Clone for SNAP25

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for SNAP25

Genatlas biochemistry entry for SNAP25:

synaptosomal-associated protein 1,25kDa,soluble N ethylmaleimide-sensitive factor-attachment protein receptor,SNARE

protein,palmitoylated in vivo for the binding to syntaxin

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000149	SNARE binding	IEA	--
GO:0005249	voltage-gated potassium channel activity	IEA	--
GO:0005515	protein binding	IPI	8692999
GO:0017022	myosin binding	IEA	--
GO:0017075	syntaxin-1 binding	IEA	--

About this table

SNAP25 for ontologies About GeneDecksing

Animal Models: 15/17 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Snap25) (see all 17):

behavior/neurological	cardiovascular system	embryogenesis	growth/size	hearing/vestibular/ear
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle
nervous system	reproductive system	respiratory system	skeleton	skin/coat/nails

SNAP25 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SNAP25 for pathways About GeneDecksing

1 Millipore Pathway for SNAP25

Clathrin-dependent protein traffic

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SNAP25

Huntington's Disease Signaling

1 Kegg Pathway (Kegg details for SNAP25):

hsa04130 SNARE interactions in vesicular transport

SABiosciences Pathway-Focused PCR Array including SNAP25: PAHS-023A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SNAP25

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SNAP25

5/31 Interacting proteins for SNAP25 (P60880^{1, 2} ENSP00000254976³) via UniProtKB, MINT, and/or STRING (see all 31)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITSN1	Q15811², ENSP00000370719³	MINT-2843882 MINT-2844026 STRING: ENSP00000370719
STX1A	Q16623², ENSP00000222812³	MINT-63924 STRING: ENSP00000222812
STX11	O75558¹^,²	EBI-524785,EBI-714135 MINT-63923 MINT-66857
ZDHHC17	Q8IUH5¹	EBI-524785,EBI-524753
PRRT2	Q7Z6L0²	MINT-63925

About this table

5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001504	neurotransmitter uptake	NAS	8760387
GO:0006112	energy reserve metabolic process	TAS	--
GO:0007268	synaptic transmission	TAS	--
GO:0007269	neurotransmitter secretion	TAS	--
GO:0007409	axonogenesis	IEA	--

About this table

SNAP25 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

SNAP25 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SNAP25
10/27 Novoseek chemical compound relationships for SNAP25 gene (see all 27)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
toxin-s	48.4	2	17112344 (1), 19253949 (1)
calcium	48.2	75	14980208 (4), 11830673 (3), 19004828 (3), 8861939 (2) (see all 42)
mastoparan	45.8	4	9243624 (2), 11741293 (1)
n-ethylmaleimide	38	1	19748891 (1)
catecholamine	37.3	7	16445859 (3), 7556639 (2), 8611567 (1)
toxin a	35.7	1	7588600 (1)
mgatp	30.3	1	11861772 (1)
acetylcholine	29.3	7	9243624 (3), 8900203 (1), 10564353 (1), 10783705 (1)
atp	22.5	7	8702751 (3), 7957884 (1), 17886343 (1), 12914955 (1) (see all 5)
palmitate	20.8	7	11916915 (1), 15355980 (1), 8641455 (1), 9349529 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for SNAP25 Sigma-Aldrich shRNA for SNAP25
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): SNAP25 OriGene shRNA RFP (see all 2): SNAP25 OriGene basic RS shRNA (see all 2): SNAP25 OriGene siRNA (see all 2): SNAP25
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SNAP25

miRNA:		Sigma-Aldrich microRNA Mimics for SNAP25 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SNAP25
		8/18 SABiosciences Assays for microRNAs that regulate SNAP25 (see all 18):
		hsa-miR-495 hsa-miR-128 hsa-miR-301a hsa-miR-34b hsa-miR-613 hsa-miR-130b hsa-miR-301b hsa-miR-1298

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): SNAP25 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): SNAP25 OriGene untagged cDNA clones in CMV expression vector (see all 3): SNAP25 OriGene 3'-UTR Clone (see all 2): SNAP25 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): SNAP25

Primers:		OriGene genome-wide validated SYBR primer pairs: SNAP25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SNAP25: PPH01881A

REFSEQ mRNAs for SNAP25 gene (2 alternative transcripts):

NM_003081.2 NM_130811.1

Additional cDNA sequence:

AK090857.1 AK091322.1 AK094560.1 AK098347.1 AK098767.1 AK124279.1 AK223617.1 AK289647.1

AK314359.1 BC010647.1 BC047512.1 BT019684.1 BX647443.1 CR593483.1 CR595223.1 CR603170.1

CR605011.1 CR606156.1 CR607483.1 CR609324.1 CR610237.1 CR614022.1 CR619486.1 CR619659.1

CR624018.1 CR624370.1 D21267.1 L19760.1 L19761.1

24/55 DOTS entries (see all 55):

DT.452947 DT.95090568 DT.99937938 DT.91961969 DT.100880485 DT.120816230 DT.100880478 DT.95090569

DT.100880489 DT.95317053 DT.120816140 DT.120816273 DT.120816130 DT.92460503 DT.100880491 DT.100880474

DT.120816066 DT.409111 DT.120816214 DT.120816248 DT.120816149 DT.120816098 DT.120816257 DT.120816071

24/634 AceView cDNA sequences (see all 634):

BP361775 BM675372 CD107216 AA350200 BQ778272 BM666216 F02132 AA326483

BP361110 BX444377 AK094560 AA322536 CA942488 AA321762 BX459476 BU743010

CR603170 BM684515 AA894766 BX463624 BP360297 BP360011 CR595223 BP361673

highest scoring ESTs for SNAP25:

D21267 AA017039 AA081771 AA084617 AA093447 AA166848 AA169277 AA321761 AA321828 AA322529

Unigene Cluster for SNAP25:

Synaptosomal-associated protein, 25kDa

Hs.167317 [show with all ESTs]

Unigene Representative Sequence: AK090857

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SNAP25 (see all 11)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:											-		-		-										-								-		-
SP2:											-		-		-										-		-						-		-
SP3:											-		-		-										-				-		-		-		-
SP4:													-		-										-				-		-		-		-
SP5:											-		-		-										-		-

About this scheme

ECgene alternative splicing isoforms for SNAP25
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495883 ENST00000254976(uc002wnq.1 uc002wns.1 uc010gcb.1 uc010gcc.1)

ENST00000492814 ENST00000430336 ENST00000304886(uc002wnr.1 uc010gca.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

SNAP25 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching SNAP25 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38484_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.23	D21267	1.00	1.00	1.00	1
71882_at*²^{, 3}	U95-E	1	0.50	1.00	0.61	0.86	AI806346	0.60	1.00	0.82	1
202507_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L19760	0.80	1.00	0.91	1
202508_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003081	0.60	1.00	0.82	1
202507_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202508_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

SNAP25 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

SNAP25 gene electronic northern expression

About these images

CGAP SAGE TAG: TAATATTAAA

SOURCE GeneReport for Unigene cluster: Hs.167317

Expression variation in blood from EXPOLDB for SNAP25

UniProtKB/Swiss-Prot: SNP25_HUMAN, P60880

Tissue specificity: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei,

and granule cells of the cerebellum

Primers:		OriGene genome-wide validated SYBR primer pairs: SNAP25 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for SNAP25: PPH01881A

SABiosciences Expression via Pathway-Focused PCR Array including SNAP25: PAHS-023A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SNAP25 gene from 5/13 species (see all 13)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SNAP25¹	--	synaptosomal-associated protein, 25kDa	97.25(n) 100(a)	477158 XM_844584.1 XP_849677.1
chimpanzee (Pan troglodytes)	SNAP25¹	--	synaptosomal-associated protein, 25kDa	94.66(n) 95.63(a)	458096 NM_001009094.1 NP_001009094.1
cow (Bos taurus)	SNAP25¹	--	synaptosomal-associated protein, 25kDa	91.59(n) 95.63(a)	540853 NM_001076246.1 NP_001069714.1
rat (Rattus norvegicus)	Snap25¹	--	synaptosomal-associated protein 25	89.64(n) 95.63(a)	25012 NM_030991.1 NP_112253.1
mouse (Mus musculus)	Snap25^{1 , 5}	2 (67.56 cM)⁵	synaptosomal-associated protein 25^{1, 5}	90.13(n)¹ 95.63(a)¹	20614¹ NM_011428.3¹ NP_035558.1¹ AF483516⁵ AF483517⁵ (see all 12)

About this table Species with no ortholog for SNAP25

ENSEMBL Gene Tree for SNAP25 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for SNAP25 gene

SNAP23²

SNAP25 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3223^1,2	C,A,	10278372(-)	`AGGGGC/TTACAG`	1	--	int¹		6		MN NA EA WA	350
rs8636^1,2	C,F,O,A,H,	10287742(+)	`GGCTAC/TGTTTT`	1	--	ut3¹		32		MN NS EA NA WA	3238
rs362547^1,2	C,F,O,A,H,	10245139(+)	`TTCTTC/TAGCCA`	1	--	int¹		21		NS EA NA WA	1454
rs362548^1,2	C,F,A,	10246815(+)	`TTCTGA/GTGATT`	1	--	int¹		15		NS EA NA WA	780
rs362549^1,2	C,F,O,A,H,	10269890(+)	`CCTGGA/GACTTT`	1	--	int¹		18		EA NS NA WA	2270
rs362550^1,2	C,F,	10275015(+)	`AAATTC/TTGCTT`	1	--	int¹		6		MN NA EA WA	398
rs362562^1,2	C,F,	10243186(+)	`CAGTGG/ATTTGT`	1	--	int¹		15		NS EA NA WA	1062
rs362563^1,2	C,F,	10243251(+)	`GCTCAT/CAAACA`	1	--	int¹		12		NS EA NA WA	938
rs362564^1,2	C,F,O,A,H,	10244626(+)	`GGAACT/CGTTGC`	1	--	int¹		18		NS EA NA WA	1186
rs362565^1,2	C	10245780(+)	`TTTAAC/GTAGGA`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for SNAP25 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SNAP25: --

QIAGEN SeqTarget long-range PCR primers for resequencing SNAP25

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SNAP25 for disorders About GeneDecksing

OMIM: 600322

10/17 Novoseek disease relationships for SNAP25 gene (see all 17)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tetanus	74.3	11	7588600 (1), 15900706 (1), 9013335 (1), 7591680 (1) (see all 11)
botulism	71.6	2	10601242 (1), 8243676 (1)
attention-deficit hyperactivity disorder	42.8	6	10889551 (2), 19099826 (2), 17979583 (1), 18194215 (1)
paralysis	37.5	5	17976638 (1), 12381720 (1), 16195243 (1), 19176217 (1)
schizophrenia	32.6	26	19132710 (5), 18512733 (3), 18347838 (3), 11287790 (1) (see all 12)
insulinoma	29.6	4	11978639 (2), 9658409 (1), 11502551 (1)
coloboma	22.4	2	12759129 (1), 10889551 (1)
alzheimers disease	22.4	5	18194215 (1), 2075860 (1), 10344268 (1), 10343324 (1)
bipolar disorder	13.2	2	18726138 (1), 16542183 (1)
intoxication	9.89	1	15486565 (1)

About this table

Genetic Association Database (GAD): SNAP25
Human Genome Epidemiology (HuGE) Navigator: SNAP25 (42 documents)

Export disorders and mutations for SNAP25 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/401 PubMed articles for SNAP25 gene, integrated from 7 sources (see all 401):
(articles sorted by number of sources associating them with SNAP25)

The C terminus of SNAP25 is essential for Ca(2+)-depe ndent binding of synaptotagmin to SNARE complexes. (PubMed id 10692432)^{1, 3, 7} Gerona R.R....Martin T.F. (2000)
The SNAP-25 gene may be associated with clinical response and weight gain in antipsychotic treatment of schizophrenia. (PubMed id 15823421)^{1, 4, 7} Muller D.J....Kennedy J.L. (2005)
Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2. (PubMed id 8760387)^{1, 2, 7} Jagadish M.N....Ward C.W. (1996)
Support for association between ADHD and two candidate genes: NET1 and DRD1. (PubMed id 15717291)^{1, 4} Bobb A.J....Rapoport J.L. (2005)
The SNAP25 gene as a susceptibility gene contributing to attention-deficit hyperactivity disorder. (PubMed id 16088329)^{1, 4} Feng Y....Barr C.L. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Haplotype analysis of SNAP-25 suggests a role in the aetiology of ADHD. (PubMed id 15007392)^{1, 4} Mill J....Asherson P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder. (PubMed id 12660803)^{1, 4} Kustanovich V....Nelson S.F. (2003)
Association study of a SNAP-25 microsatellite and attention deficit hyperactivity disorder. (PubMed id 11920846)^{1, 4} Mill J....Asherson P. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6616	HGNC: 11132	AceView: SNAP25	Ensembl:ENSG00000132639	euGenes: HUgn6616
ECgene: SNAP25	Kegg: 6616	H-InvDB: SNAP25

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for SNAP25 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for SNAP25 gene:
Search GeneIP for patents involving SNAP25

GeneCards and IP:
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