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SNORD73A Gene

RNA gene   GIFtS: 34

GC04P152025
small nucleolar RNA, C/D box 73A
(Previous names: RNA, U73 small nucleolar )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RNU73)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
small nucleolar RNA, C/D box 73A1 2     U732
U73a1 2     v-fos transformation effector protein3
RNU73A1 2     FTE13
RNA, U73 small nucleolar1     MFTL3
RNU732     Fte-13

External Ids:    HGNC: 102351   Entrez Gene: 89442   Ensembl: ENSG000001454257   UniProtKB: P612473   

Export aliases for SNORD73A gene to outside databases

Previous GC identifer: GC04P152244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247
Function: May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SNORD73A gene promoter:
         E47   GR-alpha   GATA-1   CUTL1   GATA-2   Chx10   E2F   E2F-2   E2F-5   E2F-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SNORD73A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.3   HGNC cytogenetic band: 4q31.3

SNORD73A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SNORD73A gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P152025:  view genomic region     (about GC identifiers)

Start:
152,020,725 bp from pter
End:
152,025,804 bp from pter
Size:
5,080 bases
Orientation:
plus strand

1 alternative location:
Chr4+ 147,750,299-147,750,363     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247 (See protein sequence)
Recommended Name: 40S ribosomal protein S3a  
Size: 264 amino acids; 29945 Da
Subunit: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit.
The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49
different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a mRNP granule complex, at least composed
of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2,
ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and
untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3 (By similarity)
Subcellular location: Cytoplasm. Nucleus (By similarity). Note=Localized in cytoplasmic mRNP granules containing
untranslated mRNAs
Secondary accessions: B2R4D4 P33443 P49241

Explore the universe of human proteins at neXtProt for SNORD73A: NX_P61247 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2




  • ENSEMBL proteins: 
    ENSP00000346050 ENSP00000422994 ENSP00000425024 ENSP00000421770 ENSP00000425978 ENSP00000421277 
    ENSP00000423953 ENSP00000421776 ENSP00000421457 ENSP00000424547 ENSP00000425508 ENSP00000426282 
    ENSP00000426466 


    Human Recombinant Proteins 
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    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular ----
    GO:0005634 nucleus ----
    GO:0005730 nucleolus ----
    GO:0005737 cytoplasm ----
    GO:0005829 cytosol ----
    About this table

    SNORD73A for ontologies           About GeneDecksing



    Antibodies for SNORD73A: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SNORD73A for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001593 Ribosomal_S3Ae
     IPR018281 Ribosomal_S3Ae_CS

    Graphical View of Domain Structure for InterPro Entry P61247

    ProtoNet protein and cluster: P61247

    UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247
    Similarity: Belongs to the ribosomal protein S3Ae family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: RS3A_HUMAN, P61247
    Function: May play a role during erythropoiesis through regulation of transcription factor DDIT3 (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    Gene
    Editing:
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SNORD73A 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723 RNA binding ----
    GO:0003735 structural constituent of ribosome ----
    GO:0005515 protein binding ----
    About this table

    SNORD73A for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for SNORD73A 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SNORD73A

    5/277 Interacting proteins for SNORD73A (P612471, 2 ENSP000003460503) via UniProtKB, MINT, and/or STRING (see all 277)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PABPC1P119402, ENSP000003130073MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000313007
    RPL26P612542, ENSP000003507503MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000350750
    RPL29P479142, ENSP000002941893MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000294189
    RPS2P158802, ENSP000003418853MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000341885
    SNORD4AP627502, ENSP000003479693MINT-6488590 MINT-6489355 MINT-6488791 STRING: ENSP00000347969
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412 translation ----
    GO:0006413 translational initiation ----
    GO:0006414 translational elongation ----
    GO:0006917 induction of apoptosis ----
    GO:0030154 cell differentiation ----
    About this table

    SNORD73A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SNORD73A


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for SNORD73A
    Browse shRNA at Sigma-Aldrich
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SNORD73A 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SNORD73A 
    Search SABiosciences for Assays for microRNAs that regulate SNORD73A
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SNORD73A 
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for SNORD73A

    24/6227 AceView cDNA sequences (see all 6227):

    BE728718 BQ957553 BG163401 BX424384 BQ020502 BE293407 BE729074 AI884605 
    BE391504 AI744098 BM801346 AW515902 BE744279 AW593066 BM452018 BQ068538 
    BE378619 BM311094 BU183195 BP373781 BX464760 BG105104 BU839577 BQ056502 

    highest scoring ESTs for SNORD73A:

    AA228479 BQ432548 CN315189 AA078965 AA173726 AA181374 AA197205 AA224924 AA508669 AA599471 


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SNORD73A (see all 7)

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7
    SP1:              -     -                       -           -     -     -                     
    SP2:                    -                       -           -     -     -                     
    SP3:                                            -           -     -     -                     
    SP4:              -     -                       -                                             
    SP5:              -     -                                                                     

    About this scheme

    ECgene alternative splicing isoforms for SNORD73A
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274065(uc003ilz.2) ENST00000509736 ENST00000507485(uc003ima.1 uc011cie.1)
    ENST00000505243 ENST00000514682 ENST00000515818 ENST00000503002 ENST00000512690
    ENST00000508783 ENST00000512797 ENST00000507327 ENST00000515792 ENST00000506126
    ENST00000510993

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SNORD73A expression in normal and diseased human tissues

     / 3 Data from Genenote  (Publications) and GNF BioGPS
        About these images

    SNORD73A gene expression
    SNORD73A gene electronic northern expression
    SNORD73A gene sage expression
    About these images

    CGAP SAGE TAG: --
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for SNORD73A
        SABiosciences Custom PCR Arrays for SNORD73A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SNORD73A gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    baker's yeast
    (Saccharomyces cerevisiae)
    RPS1B(YML063W)4 13(146482-147249) Ribosomal protein 10 (rp10) of the small (40S) subunit; more   -- 854939  NP_013648.1 
    About this table        Species with no ortholog for SNORD73A

    ENSEMBL Gene Tree for SNORD73A (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SNORD73A
         1 CNV: 34438
    Search QIAGEN SeqTarget long-range PCR primers for resequencing for SNORD73A 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SNORD73A for disorders           About GeneDecksing

    OMIM: 603568


    Export disorders and mutations for SNORD73A gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for SNORD73A gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with SNORD73A)
    1. A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes. (PubMed id 9573378)1, 3 Rebane A....Metspalu A. (1998)
    2. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
    4. Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis. (PubMed id 19007248)2 Wang B.... Korner R. (2008)
    5. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)2 Joeson L.... Nielsen F.C. (2007)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
    10. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8944 HGNC: 10235 AceView: RPS3A Ensembl:ENSG00000145425 euGenes: HUgn8944
    ECgene: SNORD73A H-InvDB: SNORD73A

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SNORD73A gene:
    Search GeneIP for patents involving SNORD73A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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    About This Section

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