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SOD2 Gene

protein-coding   GIFtS: 74

GC06M157570
superoxide dismutase 2, mitochondrial
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
superoxide dismutase 2, mitochondrial1 2     indophenoloxidase B2
MNSOD2 5     superoxide dismutase [Mn], mitochondrial2
MVCD62 5     manganese-containing superoxide dismutase2
IPOB2     mangano-superoxide dismutase2
Mn superoxide dismutase2     EC 1.15.1.13

External Ids:    HGNC: 111801   Entrez Gene: 66482   Ensembl: ENSG000001120967   UniProtKB: P041793   

Export aliases for SOD2 gene to outside databases

Previous GC identifers: GC06M159539 GC06M159973 GC06M160009 GC06M160012 GC06M160070 GC06M160020 GC06M160102


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SOD2:
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms
a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative
phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been
associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate
transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq)

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Gene Wiki entry for SOD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SOD2 gene promoter:
         STAT1alpha   STAT1beta   STAT1   AP-1   FOXO1a   c-Fos   c-Jun   IRF-1   p53   AP-2alphaA   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SOD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SOD2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25

SOD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SOD2 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M157570:  view genomic region     (about GC identifiers)

Start:
157,570,584 bp from pter
End:
157,584,704 bp from pter
Size:
14,121 bases
Orientation:
minus strand

1 alternative location:
Chr6- 160,100,148-160,114,353     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SODM_HUMAN, P04179 (See protein sequence)
Recommended Name: Superoxide dismutase [Mn], mitochondrial precursor  
Size: 222 amino acids; 24722 Da
Cofactor: Binds 1 manganese ion per subunit
Subunit: Homotetramer
Subcellular location: Mitochondrion matrix
PDB structures from and Proteopedia :
1AP5 (3D)    1AP6 (3D)    1EM1 (3D)    1JA8 (3D)    1LUV (3D)    1LUW (3D)    1MSD (3D)    1N0J (3D)    
1N0N (3D)    1PL4 (3D)    1PM9 (3D)    1QNM (3D)    1SZX (3D)    1VAR (3D)    1XDC (3D)    1XIL (3D)    
1ZSP (3D)    1ZTE (3D)    1ZUQ (3D)    2ADP (3D)    2ADQ (3D)    2GDS (3D)    2P4K (3D)    2QKA (3D)    
2QKC (3D)    3C3S (3D)    3C3T (3D)    
Secondary accessions: B2R7R1 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3

Explore the universe of human proteins at neXtProt for SOD2: NX_P04179 

Post-translational modifications:

  • Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_000627.2  NP_001019636.1  NP_001019637.1  


    ENSEMBL proteins: 
    ENSP00000337127 ENSP00000404804 ENSP00000406713 ENSP00000356022 ENSP00000356021 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for SOD2
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for SOD2
    OriGene Purified Proteins (see all 2): SOD2
    OriGene Protein Over-expression Lysate (see all 2): SOD2
    GenScript Custom Purified and Recombinant Proteins Services for SOD2 
    Novus Biologicals Proteins for SOD2
    Novus Biologicals Lysates for SOD2
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SOD2

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625 soluble fraction IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IDA12551919
    GO:0005743 mitochondrial inner membrane IEA--
    GO:0005759 mitochondrial matrix TAS10511315
    About this table

    SOD2 for ontologies           About GeneDecksing



    Antibodies for SOD2: 
    Millipore Mono- and Polyclonal Antibodies for the study of SOD2
    Sigma-Aldrich Antibodies for SOD2
    R&D Systems Antibodies for SOD2 (SOD2/Mn-SOD)
    OriGene Antibodies: SOD2
    GenScript Custom Superior Antibodies Services for SOD2 
    Novus Biologicals Antibodies for SOD2
    Epitomics antibodies for SOD2

    Assays for SOD2: 
    Millipore Kits and Assays for the Analysis of SOD2
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    R&D Systems ELISAs for SOD2 (SOD2/Mn-SOD)
    GenScript Custom Assay Services for SOD2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SOD2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SOD2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019831 Mn/Fe_SOD_N
     IPR001189 Mn/Fe_SOD
     IPR019833 Mn/Fe_SOD_BS
     IPR019832 Mn/Fe_SOD_C

    Graphical View of Domain Structure for InterPro Entry P04179

    ProtoNet protein and cluster: P04179

    1 Blocks protein family: IPB001189 Manganese and iron superoxide dismutase

    UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
    Similarity: Belongs to the iron/manganese superoxide dismutase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SODM_HUMAN, P04179
    Function: Destroys radicals which are normally produced within the cells and which are toxic to biological systems
    Catalytic activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)
    Enzyme Number (IUBMB): EC 1.15.1.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SOD2
    Sigma-Aldrich shRNA Panels and shRNA for SOD2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SOD2
    OriGene shRNA RFP (see all 4): SOD2
    OriGene basic RS shRNA (see all 4): SOD2
    OriGene siRNA (see all 4): SOD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SOD2 
    miRNA:Sigma-Aldrich microRNA Mimics for SOD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SOD2 
    Search SABiosciences for Assays for microRNAs that regulate SOD2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): SOD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): SOD2
    OriGene untagged cDNA clones in CMV expression vector (see all 5): SOD2
    OriGene 3'-UTR clone (see all 3): SOD2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): SOD2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SOD2 

    Genatlas biochemistry entry for SOD2:
    manganese superoxide dismutase 2,mitochondrial,catabolic pathway of activated oxygen species,free radical
    detoxification,susceptibility factor for non familial idiopathy dilated cardiomyopathy in Japanese

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004784 superoxide dismutase activity IMP12551919
    GO:0005515 protein binding IPI17353931
    GO:0016491 oxidoreductase activity IEA--
    GO:0019825 oxygen binding IEA--
    GO:0030145 manganese ion binding TAS10511315
    About this table

    SOD2 for ontologies           About GeneDecksing

    Animal Models: 15/22 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Sod2) (see all 22):

    adipose tissuebehavior/neurologicalcardiovascular systemcellulargrowth/size
    hearing/vestibular/earhematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatal
    lethality-prenatal/perinatallife span-post-weaning/agingliver/biliary systemmusclenervous system

    SOD2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SOD2 for pathways           About GeneDecksing

    1 Millipore Pathway for SOD2
        Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR2

    3 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  SOD2
        Mitochondrial Dysfunction
    NRF2-mediated Oxidative Stress Response
    Acute Phase Response Signaling

    2 Kegg Pathways  (Kegg details for SOD2):
        hsa04146 Peroxisome
    hsa05016 Huntington's disease

        SABiosciences Pathway-Focused PCR Arrays including SOD2 (see all 8): PAHS-003A PAHS-050A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SOD2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SOD2

    5/11 Interacting proteins for SOD2 (ENSP000003371273 P041791) via UniProtKB, MINT, and/or STRING (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKAO149651EBI-716989,EBI-448680
    ATP5JENSP000002849713STRING: ENSP00000284971
    CATENSP000002410523STRING: ENSP00000241052
    FOXO1ENSP000003688803STRING: ENSP00000368880
    FOXO3ENSP000003395273STRING: ENSP00000339527
    About this table

    5/50 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 50):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000302 response to reactive oxygen species ----
    GO:0000303 response to superoxide IMP16179351
    GO:0001306 age-dependent response to oxidative stress ----
    GO:0001315 age-dependent response to reactive oxygen species IMP14980699
    GO:0001666 response to hypoxia IEA--
    About this table

    SOD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SOD2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SOD2
    10/144 Novoseek chemical compound relationships for SOD2 gene (see all 144)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    manganese superoxide 99.1 2165 7856748 (7), 11207049 (7), 16365243 (6), 9081096 (5) (see all 99)
    superoxide 91.8 911 18247479 (4), 2230537 (4), 7969912 (4), 10529750 (3) (see all 99)
    zinc superoxide 84.7 77 7856748 (6), 9989524 (2), 10692109 (2), 15258423 (2) (see all 44)
    oxygen 79.1 274 11536448 (4), 1385428 (3), 7914182 (2), 11159050 (2) (see all 99)
    manganese 76.3 184 1550052 (6), 10521117 (6), 12950012 (4), 12215453 (3) (see all 90)
    h2o2 73.6 158 16114557 (5), 9535218 (3), 10919671 (3), 19306099 (3) (see all 84)
    copper 64.4 150 7856748 (6), 14531733 (4), 1793616 (3), 9989524 (2) (see all 85)
    peroxynitrite 63.9 44 11152462 (5), 9603906 (4), 9425011 (2), 19917352 (2) (see all 20)
    n acetylcysteine 60.1 27 11709424 (2), 18829485 (2), 9518260 (1), 18281048 (1) (see all 16)
    3-nitrotyrosine 56.4 10 16895800 (3), 14656937 (2), 9848095 (1), 16765071 (1) (see all 5)
    About this table

    3 PharmGKB drug compound relationships for SOD2 gene
    Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
    epirubicinFA  9569045
    estradiolFA  14514655
    tamoxifenFA  14514655
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for SOD2
    Sigma-Aldrich shRNA Panels and shRNA for SOD2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SOD2
    OriGene shRNA RFP (see all 4): SOD2
    OriGene basic RS shRNA (see all 4): SOD2
    OriGene siRNA (see all 4): SOD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SOD2 
    miRNA: Sigma-Aldrich microRNA Mimics for SOD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SOD2 
    Search SABiosciences for Assays for microRNAs that regulate SOD2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): SOD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): SOD2
    OriGene untagged cDNA clones in CMV expression vector (see all 5): SOD2
    OriGene 3'-UTR Clone (see all 3): SOD2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): SOD2 
    Primers: OriGene genome-wide validated SYBR primer pairs: SOD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SOD2: PPH01716A

    REFSEQ mRNAs for SOD2 gene (3 alternative transcripts): 

    NM_000636.2  NM_001024465.1  NM_001024466.1  

    Additional cDNA sequence: 

    AK296809.1 AK304766.1 AK313082.1 AL050388.1 AY280718.1 AY280719.1 AY280720.1 AY280721.1 
    BC012423.1 BC016015.1 BC016934.1 BC035422.1 BC041951.1 BT006967.1 CR626136.1 DQ003134.1 
    M31163.1 M36693.1 X07834.1 X14322.1 X15132.1 X59445.1 Y00472.1 Y00985.1 

    24/56 DOTS entries (see all 56):

    DT.101985421  DT.95350909  DT.420015  DT.97856570  DT.91763736  DT.95189349  DT.100828782  DT.100828766 
    DT.100828787  DT.121326891  DT.121326878  DT.121327136  DT.121327061  DT.121326777  DT.86851629  DT.100692392 
    DT.100828778  DT.121327128  DT.87001758  DT.100828790  DT.100688162  DT.100828793  DT.99947916  DT.121327054 

    24/538 AceView cDNA sequences (see all 538):

    AA343663 AW794755 AA977637 AU077038 AU280001 AI473383 BF060664 BQ691900 
    BM768463 BQ719652 BP350474 CA446393 BU682373 F04037 AI459858 BQ009368 
    BQ950610 AI288966 AA363542 CA306232 AL135472 BU621731 AA602843 BU195882 

    highest scoring ESTs for SOD2:

    X07834 AA011434 AA317108 AA343610 AA363542 AA370060 AA370365 AA370378 AA370601 AA370844 

    Unigene Cluster for SOD2:

    Superoxide dismutase 2, mitochondrial
    Hs.487046  [show with all ESTs]
    Unigene Representative Sequence: BC041951


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SOD2 (see all 8)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9
    SP1:                                -     -     -                                   -     -     -         
    SP2:                                -     -     -                                                         
    SP3:                                -     -     -                                                         
    SP4:                                -     -     -     -                             -     -     -         
    SP5:                                      -     -                                                         

    About this scheme

    ECgene alternative splicing isoforms for SOD2
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337404(uc003qsi.1 uc011efu.1 uc011efv.1) ENST00000444946
    ENST00000452684(uc003qsj.2) ENST00000367055(uc003qsf.3 uc003qsg.2)
    ENST00000367054(uc003qsh.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SOD2 expression in normal and diseased human tissues

    1  / 2  / 3

    12 probe-sets matching SOD2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    73312_s_at2, 3 U95-E 2 1.00 0.91 0.96 1.44 AI984828 0.60 1.00 0.82 1
    34666_at2, 3 U95-A 1 0.81 1.00 0.97 0.79 X07834 1.00 1.00 1.00 1
    45237_at2, 3 U95-B 1 0.56 1.00 0.97 1.29 AA142976 0.60 1.00 0.82 1
    86491_at2, 3 U95-D 2 0.50 0.62 0.41 0.49 AW007472 0.40 1.00 0.76 1
    215223_s_at2, 3 U133-A 1 1.00 1.00 -- -- W46388 0.60 1.00 0.82 1
    216841_s_at2, 3 U133-A 1 1.00 1.00 -- -- X15132 0.80 1.00 0.91 1
    221477_s_at2, 3 U133-A 1 0.64 1.00 -- -- BF575213 0.20 1.00 0.72 1
    215078_at2, 3 U133-A 1 0.46 1.00 -- -- AL050388 0.80 1.00 0.91 1
    215223_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    216841_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    221477_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    215078_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    SOD2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SOD2 gene expression
    SOD2 gene electronic northern expression
    SOD2 gene sage expression
    About these images

    CGAP SAGE TAG: GTCTTAAAGT

    SOURCE GeneReport for Unigene cluster: Hs.487046

    Expression variation in blood from EXPOLDB for SOD2

    Primers: OriGene genome-wide validated SYBR primer pairs: SOD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SOD2: PPH01716A
        SABiosciences Expression via Pathway-Focused PCR Arrays including SOD2 (see all 8): PAHS-003A PAHS-050A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SOD2 gene from 5/25 species (see all 25)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SOD21   -- superoxide dismutase 2, mitochondrial 88.44(n)
    90.99(a)
    476258  XM_533463.2  XP_533463.2 
    chimpanzee
    (Pan troglodytes)
    SOD21   -- superoxide dismutase 2, mitochondrial 99.83(n)
    100(a)
    449634  NM_001009022.1  NP_001009022.1 
    cow
    (Bos taurus)
    SOD21   -- superoxide dismutase 2, mitochondrial 88.29(n)
    91.44(a)
    281496  NM_201527.2  NP_963285.2 
    rat
    (Rattus norvegicus)
    Sod21   -- superoxide dismutase 2, mitochondrial 86.04(n)
    87.84(a)
    24787  NM_017051.2  NP_058747.1 
    mouse
    (Mus musculus)
    Sod21 , 5 17 (8.75 cM)5
    superoxide dismutase 2, mitochondrial1, 5 86.94(n)1
    90.09(a)1
    206561  NM_013671.31  NP_038699.21 
     AA4144455  AI8514705  (see all 26)
    About this table        Species with no ortholog for SOD2

    ENSEMBL Gene Tree for SOD2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/241 NCBI SNPs in SOD2 are shown (see all 241)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs48801,2
    C,F,160113872(-) TCCGGT/CTTTGG 6 /A /V mis1 ref127Minor allele frequency- C:0.34MN NS EA NA WA 2094
    rs78551,2
    C,F160100302(+) AGGACA/GTTATC 2 -- ut3110Minor allele frequency- G:0.03MN NS EA NA 1032
    rs80311,2
    C,F,O,A,H,160100640(-) AATACT/AGTTTT 2 -- int123Minor allele frequency- A:0.21MN EA NS NA WA 3058
    rs103701,2
    C,F,A,H,160101532(-) AAAAAA/CATTTA 2 -- int112Minor allele frequency- C:0.28NS MN NA EA WA 1238
    rs118541,2
    --160101336(+) AAGCAG/ATAATC 2 -- int11Minor allele frequency- A:0.00MN 184
    rs149231,2
    --160100231(+) TCAAAA/CAAAAA 2 -- ut310--------
    rs10645631,2
    C160103418(-) TGATGT/CTGCTT 3 -- int1 ut311Minor allele frequency- C:0.00MN 184
    rs11417181,2
    C160109256(-) CCAGAT/CAGCTY 5 /T /I int1 mis1 ref15Minor allele frequency- C:0.00MN 392
    rs15703181,2
    C,160111473(-) attCTA/GTCTAA 3 -- int16Minor allele frequency- G:0.29NA EA WA 216
    rs18006651,2
    C,F,160107091(-) CAGTCG/ATAGAG 3 -- int15Minor allele frequency- A:0.02NS NA 388
    About this table

    HapMap Linkage Disequilibrium images for SOD2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SOD2
         1 CNV: 3647
         1 Indel: 11272

    QIAGEN SeqTarget long-range PCR primers for resequencing SOD2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SOD2 for disorders           About GeneDecksing

    OMIM: 147460   disorders: 612634  

    UniProtKB/Swiss-Prot: SODM_HUMAN, P04179

  • Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6
  • (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence
    of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and
    diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is
    characterized by vascular permeability and increased tissue ischemia and angiogenesis

    10/92 Novoseek disease relationships for SOD2 gene (see all 92)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 58.7 129 20514411 (4), 1960995 (3), 2406241 (2), 2222450 (2) (see all 75)
    tumors 54.5 432 12469139 (8), 10919671 (6), 1988135 (6), 7780953 (4) (see all 99)
    amyotrophic lateral sclerosis 49 18 7985495 (2), 9452823 (2), 7699393 (1), 7719145 (1) (see all 12)
    cancer 47.5 158 19074833 (5), 19405048 (4), 19467856 (4), 9926924 (3) (see all 87)
    cell damage 42.9 10 11729237 (3), 7524486 (1), 20107204 (1), 8360707 (1) (see all 7)
    neurodegenerative diseases 42 4 10762167 (1), 8334770 (1), 12618592 (1)
    neurodegeneration 40.1 3 17251466 (1), 16485861 (1), 14681883 (1)
    shock 35.5 46 15128298 (2), 1337859 (2), 7514009 (2), 8144583 (1) (see all 31)
    breast cancer 35.1 148 15386537 (5), 15184255 (5), 16945136 (4), 17965603 (4) (see all 49)
    merrf 34.2 3 11403514 (1), 11907800 (1)
    About this table

    2 PharmGKB disease relationships for SOD2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Breast NeoplasmsFA  14514655
    MesotheliomaFA  9569045
    About this table

    Human Gene Mutation Database (HGMD): SOD2
    Genetic Association Database (GAD): SOD2
    Human Genome Epidemiology (HuGE) Navigator: SOD2 (288 documents)

    Export disorders and mutations for SOD2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/1539 PubMed articles for SOD2 gene, integrated from 7 sources (see all 1539):
    (articles sorted by number of sources associating them with SOD2)
    1. The polymorphism of manganese superoxide dismutase is associated with diabetic nephropathy in Japanese type 2 diabetic patients. (PubMed id 12624725)1, 2, 4, 7 Nomiyama T....Kawamori R. (2003)
    2. Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells. (PubMed id 1988135)1, 2, 7 St Clair D.K. and Holland J.C. (1991)
    3. Polymorphism in the manganese superoxide dismutase (MnSOD) gene and risk of breast cancer in young women. (PubMed id 15883815)1, 4, 7 Bergman M....Wingren S. (2005)
    4. Manganese superoxide dismutase (MnSOD) polymorphism, alpha-tocopherol supplementation and prostate cancer risk in the alpha-tocopherol, beta-carotene cancer prevention study (Finland). (PubMed id 12948282)1, 4, 7 Woodson K....Albanes D. (2003)
    5. Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility. (PubMed id 15386537)1, 4, 7 Kocabas N.A....Karakaya A.E. (2005)
    6. Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. (PubMed id 16157826)1, 4, 7 Stickel F....Schuppan D. (2005)
    7. Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. (PubMed id 11323405)1, 4, 7 Mitrunen K....Hirvonen A. (2001)
    8. Manganese superoxide dismutase gene polymorphism (V16A) is associated with stages of albuminuria in Korean type 2 diabetic patients. (PubMed id 16324912)1, 4, 7 Lee S.J....Kim T.W. (2006)
    9. Oxidative stress-related gene polymorphism and the risk of preeclampsia. (PubMed id 15734083)1, 4, 7 Kim Y.J....Pang M.G. (2005)
    10. Manganese superoxide dismutase polymorphism, plasma antioxidants, cigarette smoking, and risk of breast cancer. (PubMed id 15184255)1, 4, 7 Tamimi R.M....Hunter D.J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6648 HGNC: 11180 AceView: SOD2 Ensembl:ENSG00000112096 euGenes: HUgn6648
    ECgene: SOD2 Kegg: 6648 H-InvDB: SOD2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for SOD2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sod2/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SOD2
    Wikipedia http://en.wikipedia.org/wiki/Superoxide_dismutase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SOD2 gene:
    Search GeneIP for patents involving SOD2

    GeneCards and IP:
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