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SPHK1 Gene

protein-coding   GIFtS: 63

GC17P069809
sphingosine kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
sphingosine kinase 11 2
SPHK1 2 3
SPK 12 3
SK 12 3
SPK3
EC 2.7.1.913

External Ids:    HGNC: 112401   Entrez Gene: 88772   Ensembl: ENSG000001761707   UniProtKB: Q9NYA13   

Export aliases for SPHK1 gene to outside databases

Previous GC identifers: GC17U990140 GC17P077371 GC17P074843 GC17P074977 GC17P071890 GC17P074380


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPHK1:
Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions.
Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974).
Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes
the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit
cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430)
and serum.(supplied by OMIM)

UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with
both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but
not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or
phosphatidylinositol

Gene Wiki entry for SPHK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPHK1 gene promoter:
         NF-kappaB1   AP-1   c-Jun   c-Fos   Sp1   STAT5A   NF-kappaB   NF-E2   NF-E2 p45   E2F-2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SPHK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SPHK1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.2   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

SPHK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPHK1 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P069809:  view genomic region     (about GC identifiers)

Start:
69,809,173 bp from pter
End:
69,812,424 bp from pter
Size:
3,252 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 74,380,690-74,383,941     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1 (See protein sequence)
Recommended Name: Sphingosine kinase 1  
Size: 384 amino acids; 42518 Da
Cofactor: Magnesium
Subunit: Interacts with ACY1 (By similarity). Binds to calmodulin. Interacts with SPHKAP
Miscellaneous: Sphingosine 1-phosphate stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of
NF-kappa-B in response to TNF signaling
Secondary accessions: Q8N632 Q9HD92 Q9NY70 Q9NYL3
Alternative splicing: 2 isoforms:  Q9NYA1-1   Q9NYA1-2   

Explore the universe of human proteins at neXtProt for SPHK1: NX_Q9NYA1 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001136073.1  NP_001136074.1  NP_068807.2  NP_892010.2  


    ENSEMBL proteins: 
    ENSP00000313681 ENSP00000376285 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for SPHK1
    R&D Systems Recombinant & Natural Proteins for SPHK1 (Sphingosine Kinase 1/SPHK1)
    Enzo Life Sciences proteins for SPHK1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SPHK1
    GenScript Custom Purified and Recombinant Proteins Services for SPHK1 
    Novus Biologicals Proteins for SPHK1
    Novus Biologicals Lysate for SPHK1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction TAS10863092
    GO:0005625 soluble fraction IDA15623571
    GO:0005737 cytoplasm IDA15623571
    GO:0005829 cytosol TAS10863092
    GO:0005886 plasma membrane IEA--
    About this table

    SPHK1 for ontologies           About GeneDecksing



    Antibodies for SPHK1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SPHK1
    R&D Systems Antibodies for SPHK1 (Sphingosine Kinase 1/SPHK1)
    Cell Signaling Technology (CST) Antibodies for SPHK1 
    OriGene Antibodies: SPHK1
    GenScript Custom Superior Antibodies Services for SPHK1 
    Novus Biologicals Antibodies for SPHK1
    Epitomics antibodies for SPHK1

    Assays for SPHK1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPHK1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SPHK1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPHK1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001206 Diacylglycerol_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NYA1

    ProtoNet protein and cluster: Q9NYA1

    UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
    Similarity: Contains 1 DAGKc domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
    Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with
    both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but
    not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or
    phosphatidylinositol
    Catalytic activity: ATP + sphinganine = ADP + sphinganine 1-phosphate
    Catalytic activity: ATP + sphingosine = ADP + sphingosine 1-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=14 uM for sphingosine; KM=20 uM for dihydrosphingosine; KM=77 uM
    for ATP; pH dependence: Optimum pH is 7.4;
    Enzyme Number (IUBMB): EC 2.7.1.91 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SPHK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SPHK1
    Sigma-Aldrich shRNA Panels and shRNA for SPHK1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SPHK1
    OriGene shRNA RFP (see all 4): SPHK1
    OriGene basic RS shRNA (see all 4): SPHK1
    OriGene siRNA (see all 4): SPHK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SPHK1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SPHK1 
    2 SABiosciences Assays for microRNAs that regulate SPHK1:
    hsa-miR-124 hsa-miR-506

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for SPHK1 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): SPHK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): SPHK1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): SPHK1
    OriGene 3'-UTR clone (see all 4): SPHK1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SPHK1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SPHK1 

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding ISS--
    GO:0003677 DNA binding IDA12393916
    GO:0004143 diacylglycerol kinase activity IEA--
    GO:0005515 protein binding IPI12080051
    About this table

    SPHK1 for ontologies           About GeneDecksing

    Animal Models: 10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sphk1):

    cardiovascular systemembryogenesishematopoietic systemhomeostasis/metabolismimmune system
    lethality-prenatal/perinatallife span-post-weaning/agingmusclenervous systemnormal

    SPHK1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SPHK1 for pathways           About GeneDecksing

    2 Millipore Pathways for SPHK1
        Development VEGF signaling and activation
    Development VEGF signaling via VEGFR2 - generic cascades

    5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  SPHK1 (see all 8)
        Sphingolipid Metabolism
    Human Embryonic Stem Cell Pluripotency
    Sphingosine-1-phosphate Signaling
    Glycerophospholipid Metabolism
    Glycerolipid Metabolism

    5 Kegg Pathways  (Kegg details for SPHK1):
        hsa00600 Sphingolipid metabolism
    hsa01100 Metabolic pathways
    hsa04020 Calcium signaling pathway
    hsa04370 VEGF signaling pathway
    hsa04666 Fc gamma R-mediated phagocytosis

        SABiosciences Pathway-Focused PCR Arrays including SPHK1 (see all 5): PAHS-015A PAHS-024A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SPHK1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPHK1

    5/36 Interacting proteins for SPHK1 (Q9NYA11, 2 ENSP000003136813) via UniProtKB, MINT, and/or STRING (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTSBP078582, ENSP000003456723MINT-3974266 MINT-3974278 MINT-3974294 MINT-3974318 STRING: ENSP00000345672
    FHL2Q141921EBI-985303,EBI-701903
    FYNP062411EBI-985303,EBI-515315
    SPHKAPQ2M3C71EBI-985303,EBI-1803914
    TRAF6Q9Y4K32MINT-4050292 MINT-4050310
    About this table

    5/36 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 36):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934 positive regulation of protein phosphorylation IEA--
    GO:0001956 positive regulation of neurotransmitter secretion IEA--
    GO:0006457 protein folding TAS--
    GO:0006665 sphingolipid metabolic process TAS--
    GO:0006670 sphingosine metabolic process IDA--
    About this table

    SPHK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SPHK1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SPHK1 available from Tocris Bioscience
    CompoundAction CAS number
    SKI IISelective non-lipid inhibitor of sphingosine kinase; antitumor[312636-16-1]
    About this table


    10/25 Novoseek chemical compound relationships for SPHK1 gene (see all 25)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 97.7 499 16281067 (6), 18620522 (6), 17643421 (6), 14532121 (4) (see all 99)
    n,n-dimethylsphingosine 93.7 32 15302883 (2), 11418646 (2), 15848761 (1), 15265705 (1) (see all 14)
    ceramide 83.9 68 16357178 (5), 16281067 (4), 19240026 (4), 19765607 (3) (see all 22)
    sphinganine 1-phosphate 80.4 5 18644793 (1), 16278291 (1), 16529909 (1)
    ceramides 55.1 1 18283525 (1)
    lipid 50.8 35 19782042 (2), 18638570 (1), 12954646 (1), 15265705 (1) (see all 20)
    phosphatidylserine 35.9 4 10751414 (1), 19782042 (1)
    camptothecin 32.8 7 16357178 (3), 16516161 (3)
    phosphatidylinositol 31.4 2 19325137 (1), 11418646 (1)
    phorbol 28.5 1 20236935 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SPHK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SPHK1
    Sigma-Aldrich shRNA Panels and shRNA for SPHK1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SPHK1
    OriGene shRNA RFP (see all 4): SPHK1
    OriGene basic RS shRNA (see all 4): SPHK1
    OriGene siRNA (see all 4): SPHK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SPHK1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SPHK1 
    2 SABiosciences Assays for microRNAs that regulate SPHK1:
    hsa-miR-124 hsa-miR-506
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): SPHK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): SPHK1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): SPHK1
    OriGene 3'-UTR Clone (see all 4): SPHK1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SPHK1 
    Primers: OriGene genome-wide validated SYBR primer pairs: SPHK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SPHK1: PPH02491A

    REFSEQ mRNAs for SPHK1 gene (4 alternative transcripts): 

    NM_001142601.1  NM_001142602.1  NM_021972.3  NM_182965.2  

    Additional cDNA sequence: 

    AF200328.1 AF238083.1 AF266756.1 AJ245504.1 AK022402.1 AK023393.1 AK095578.1 AK122781.1 
    AK225250.1 AK225258.1 AK292294.1 AK292614.1 BC004112.2 BC008040.2 BC009419.1 BC014439.1 
    BC030553.1 

    12 DOTS entries:

    DT.97787241  DT.121009204  DT.100818143  DT.100818135  DT.100036081  DT.100818141  DT.121009321  DT.95274954 
    DT.100722931  DT.100818142  DT.100698066  DT.91708490 

    24/113 AceView cDNA sequences (see all 113):

    BU626812 AI074186 AK022402 BC030553 BM916526 BM471470 CA307119 BM810136 
    CD369198 NM_182965 BX106465 CD366097 AA026251 BM709951 AI042283 BU630558 
    BC004112 BU728196 BQ027486 BE904632 BU736749 BU617770 CD676171 NM_021972 

    highest scoring ESTs for SPHK1:

    AI769914 AA026479 AA081127 AA081152 AA232646 AA232791 AA372241 AA372249 AA639414 AF200328 

    Unigene Cluster for SPHK1:

    Sphingosine kinase 1
    Hs.68061  [show with all ESTs]
    Unigene Representative Sequence: AK095578


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for SPHK1 (see all 11)

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b
    SP1:        -     -     -     -     -     -     -     -     -           -     -                                               -               
    SP2:                                                  -     -           -     -                                               -               
    SP3:                                                  -     -           -                                                     -               
    SP4:                                                        -           -     -                                               -               
    SP5:              -     -     -     -     -     -     -     -           -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for SPHK1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000323374(uc002jrf.1 uc002jrg.1 uc010wtc.1 uc002jrh.2 uc002jrj.2 uc002jri.2)
    ENST00000392496(uc002jrk.3)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SPHK1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching SPHK1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    51923_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI769914 1.00 1.00 1.00 1
    219257_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_021972 0.60 1.00 0.82 1
    219257_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    SPHK1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SPHK1 gene expression
    SPHK1 gene electronic northern expression
    SPHK1 gene sage expression
    About these images

    CGAP SAGE TAG: GAGAAGGGCA

    SOURCE GeneReport for Unigene cluster: Hs.68061

    UniProtKB/Swiss-Prot: SPHK1_HUMAN, Q9NYA1
    Tissue specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: SPHK1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SPHK1: PPH02491A
        SABiosciences Expression via Pathway-Focused PCR Arrays including SPHK1 (see all 5): PAHS-015A PAHS-024A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SPHK1 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SPHK11   -- sphingosine kinase 1 85.46(n)
    86.99(a)
    483329  XM_540448.2  XP_540448.2 
    cow
    (Bos taurus)
    SPHK11   -- sphingosine kinase 1 83.08(n)
    81.7(a)
    618605  XM_870939.2  XP_876032.2 
    rat
    (Rattus norvegicus)
    Sphk11   -- sphingosine kinase 1 79.2(n)
    78.59(a)
    170897  NM_133386.2  NP_596877.2 
    mouse
    (Mus musculus)
    Sphk11 , 5 11 (81.42 cM)5
    sphingosine kinase 11, 5 79.93(n)1
    81.15(a)1
    206981  NM_025367.51  NP_079643.21 
     AA0117255  AF0687485  (see all 15)
    chicken
    (Gallus gallus)
    SPHK11   -- sphingosine kinase 1 65.14(n)
    57.8(a)
    427803  XM_425374.2  XP_425374.2 
    About this table        Species with no ortholog for SPHK1

    ENSEMBL Gene Tree for SPHK1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SPHK1 gene
    AGK2  SPHK22  

    SPHK1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/47 NCBI SNPs in SPHK1 are shown (see all 47)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915201,2
    --74384407(-) aacttC/Ttgggc 4 -- ng310--------
    rs3467971,2
    C,F,A,74378901(+) CCAGTC/ACCCTC 3 -- ng5119Minor allele frequency- A:0.15NA NS EA WA 2496
    rs3467991,2
    C,F,74384123(-) AGAGGC/TCCCCC 4 -- ng318Minor allele frequency- T:0.10MN EA NA WA 630
    rs3468001,2
    C,F,74384072(-) CAGAAT/CGACTA 4 -- ng313Minor allele frequency- C:0.02MN NA WA 306
    rs3468011,2
    C,F,74383678(-) CAGCGC/TGGCCC 4 -- ut31 ese311Minor allele frequency- T:0.06NS EA NA WA 3780
    rs3468021,2
    C,F,A,74383601(-) CAACCG/ACTGAC 8 /S ref1 syn1 ese34Minor allele frequency- A:0.07EA NA WA 1704
    rs3468031,2
    C,F,A,H,74381567(-) GGCTGT/CAGGAG 5 /T /A ut51 mis1 ref15Minor allele frequency- C:0.20NA 10
    rs9087211,2
    C,F,A,74380786(-) GACTGG/AAGCGC 4 -- ut51 ng514Minor allele frequency- A:0.09MN EA WA 1486
    rs22478561,2
    C,A,H,74381555(-) ACCGGC/TGTCAT 5 T A mis1 ref1 ut51 ese35Minor allele frequency- T:0.23NA EA 166
    rs37440371,2
    C,F,A,H,74383475(+) GTATAT/CGTGCC 8 /Y syn1 ref115Minor allele frequency- C:0.37EA NS NA 2555
    About this table

    HapMap Linkage Disequilibrium images for SPHK1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SPHK1
         2 CNVs: 73036 5032

    QIAGEN SeqTarget long-range PCR primers for resequencing SPHK1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPHK1 for disorders           About GeneDecksing

    OMIM: 603730

    10/17 Novoseek disease relationships for SPHK1 gene (see all 17)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 44.4 15 19074142 (5), 16106218 (3), 19723667 (2), 17855624 (1) (see all 5)
    glioblastoma multiforme 35.6 4 16106218 (2), 19074142 (1), 19723667 (1)
    renal fibrosis 27 2 19789541 (1), 19657322 (1)
    cancer 25.9 40 18691013 (4), 18638570 (3), 18701480 (3), 18620522 (3) (see all 14)
    tumors 22.4 32 18058224 (5), 20508814 (2), 17699730 (1), 18638570 (1) (see all 11)
    inflammation 18.8 6 17913601 (1), 15191888 (1), 15743396 (1), 19665772 (1) (see all 5)
    necrosis 17.8 6 17699730 (1), 15710602 (1), 20053797 (1), 16269668 (1) (see all 5)
    breast cancer 17.6 15 16194537 (4), 12881510 (2), 18701480 (1), 20110355 (1) (see all 9)
    glioma 9.67 9 19147534 (2), 18055454 (2), 17855624 (2), 17376432 (1)
    colon cancer 8.18 14 18824518 (3), 19240026 (3), 18701480 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: SPHK1 (1 document)

    Export disorders and mutations for SPHK1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/237 PubMed articles for SPHK1 gene, integrated from 7 sources (see all 237):
    (articles sorted by number of sources associating them with SPHK1)
    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity. (PubMed id 12080051)1, 2 Lacana E.... Spiegel S. (2002)
    3. Functional characterization of human sphingosine kinase-1. (PubMed id 10802064)1, 2 Nava V.E.... Spiegel S. (2000)
    4. Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. (PubMed id 10947957)1, 2 Pitson S.M.... Wattenberg B.W. (2000)
    5. Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution. (PubMed id 10863092)1, 2 Melendez A.J.... Takacs L. (2000)
    6. Molecular cloning and functional characterization of murine sphingosine kinase. (PubMed id 9726979)1, 3 Kohama T....Spiegel S. (1998)
    7. Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival. (PubMed id 18980995)1, 7 Li J....Li M. (2008)
    8. Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells. (PubMed id 17482291)1, 7 Francy J.M....Yun J.K. (2007)
    9. Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. (PubMed id 19782042)1, 7 Hengst J.A....Yun J.K. (2009)
    10. Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells. (PubMed id 19074142)1, 7 Paugh B.S....Kordula T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8877 HGNC: 11240 AceView: SPHK1 Ensembl:ENSG00000176170 euGenes: HUgn8877
    ECgene: SPHK1 Kegg: 8877 H-InvDB: SPHK1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SPHK1 gene:
    Search GeneIP for patents involving SPHK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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