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SPHK2 Gene

protein-coding   GIFtS: 55

GC19P045501
sphingosine kinase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
sphingosine kinase 21 2
SPK 22 3
SK 22 3
sphingosine kinase type 2 isoform2
EC 2.7.1.913

External Ids:    HGNC: 188591   Entrez Gene: 568482   Ensembl: ENSG000000631767   UniProtKB: Q9NRA03   

Export aliases for SPHK2 gene to outside databases

Previous GC identifers: GC19P049767 GC19P049490 GC19P053798 GC19P053814 GC19P049122


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPHK2_HUMAN, Q9NRA0
Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with
both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and
L-threo-dihydrosphingosine. Binds phosphoinositides


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPHK2 gene promoter:
         AP-1   c-Jun   c-Fos   COUP-TF1   HNF-4alpha2   p53   STAT5A   PPAR-gamma2   PPAR-gamma1   c-Myc   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SPHK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SPHK2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.2

SPHK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPHK2 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045501:  view genomic region     (about GC identifiers)

Start:
45,501,739 bp from pter
End:
45,513,198 bp from pter
Size:
11,460 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 49,122,548-49,133,973     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SPHK2_HUMAN, Q9NRA0 (See protein sequence)
Recommended Name: Sphingosine kinase 2  
Size: 654 amino acids; 69217 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Isoform 1: Cytoplasm. Membrane
Subcellular location: Isoform 2: Lysosome membrane
Secondary accessions: Q9BRN1 Q9H0Q2 Q9NWU7
Alternative splicing: 3 isoforms:  Q9NRA0-1   Q9NRA0-2   Q9NRA0-3   (Experimental confirmation may be lacking for some isoforms)

Explore the universe of human proteins at neXtProt for SPHK2: NX_Q9NRA0 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_064511.2  

    ENSEMBL proteins: 
    ENSP00000385562 ENSP00000341091 ENSP00000245222 ENSP00000413369 ENSP00000410044 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for SPHK2
    R&D Systems Recombinant & Natural Proteins for SPHK2 (Sphingosine Kinase 2/SPHK2)
    Enzo Life Sciences proteins for SPHK2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for SPHK2 
    Novus Biologicals Proteins for SPHK2
    Novus Biologicals Lysate for SPHK2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624 membrane fraction IDA10751414
    GO:0005737 cytoplasm IEA--
    GO:0005765 lysosomal membrane IEA--
    GO:0005829 cytosol TAS--
    GO:0016020 membrane IEA--
    About this table

    SPHK2 for ontologies           About GeneDecksing



    Antibodies for SPHK2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SPHK2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SPHK2 
    Novus Biologicals Antibodies for SPHK2
    Epitomics antibodies for SPHK2

    Assays for SPHK2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPHK2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SPHK2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPHK2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001206 Diacylglycerol_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9NRA0

    ProtoNet protein and cluster: Q9NRA0

    UniProtKB/Swiss-Prot: SPHK2_HUMAN, Q9NRA0
    Similarity: Contains 1 DAGKc domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SPHK2_HUMAN, Q9NRA0
    Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with
    both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and
    L-threo-dihydrosphingosine. Binds phosphoinositides
    Catalytic activity: ATP + sphinganine = ADP + sphinganine 1-phosphate
    Catalytic activity: ATP + sphingosine = ADP + sphingosine 1-phosphate
    Enzyme regulation: Inhibited by sulfatide
    Biophysicochemical properties: Kinetic parameters: KM=3.4 uM for sphingosine; pH dependence: Optimum pH is 7.5;
    Enzyme Number (IUBMB): EC 2.7.1.91 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SPHK2
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SPHK2
    Sigma-Aldrich shRNA Panels and shRNA for SPHK2
    OriGene 29mer shRNA kits in GFP-retroviral vector: SPHK2
    OriGene shRNA RFP: SPHK2
    OriGene basic RS shRNA: SPHK2
    OriGene siRNA: SPHK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SPHK2 
    miRNA:Sigma-Aldrich microRNA Mimics for SPHK2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SPHK2 
    7 SABiosciences Assays for microRNAs that regulate SPHK2:
    hsa-miR-153 hsa-miR-301b hsa-miR-454 hsa-miR-130a hsa-miR-301a hsa-miR-650 hsa-miR-130b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SPHK2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SPHK2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SPHK2
    OriGene 3'-UTR clone: SPHK2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SPHK2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SPHK2 

    5/9 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003824 catalytic activity ----
    GO:0004143 diacylglycerol kinase activity IEA--
    GO:0005515 protein binding IPI16316995
    GO:0005524 ATP binding IEA--
    About this table

    SPHK2 for ontologies           About GeneDecksing

    Animal Models: 9 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Sphk2):

    cardiovascular systemembryogenesishematopoietic systemhomeostasis/metabolismimmune system
    lethality-prenatal/perinatalmusclenervous systemnormal

    SPHK2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SPHK2 for pathways           About GeneDecksing

    5/6 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  SPHK2 (see all 6)
        Sphingolipid Metabolism
    Glycerolipid Metabolism
    Ceramide Signaling
    Glycerophospholipid Metabolism
    Phospholipid Degradation

    5 Kegg Pathways  (Kegg details for SPHK2):
        hsa00600 Sphingolipid metabolism
    hsa01100 Metabolic pathways
    hsa04020 Calcium signaling pathway
    hsa04370 VEGF signaling pathway
    hsa04666 Fc gamma R-mediated phagocytosis

        SABiosciences Pathway-Focused PCR Arrays including SPHK2: PAHS-037A PAHS-091A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SPHK2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPHK2

    5/26 Interacting proteins for SPHK2 (Q9NRA01 ENSP000002452223) via UniProtKB, MINT, and/or STRING (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL2Q141921EBI-985324,EBI-701903
    FYNP062411EBI-985324,EBI-515315
    LYNP079481EBI-985324,EBI-79452
    IL12AENSP000003032313STRING: ENSP00000303231
    IL12BENSP000002312283STRING: ENSP00000231228
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001568 blood vessel development ----
    GO:0006665 sphingolipid metabolic process TAS--
    GO:0006669 sphinganine-1-phosphate biosynthetic process NAS10751414
    GO:0006670 sphingosine metabolic process ----
    GO:0006916 anti-apoptosis NAS10751414
    About this table

    SPHK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    SPHK2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for SPHK2 available from Tocris Bioscience
    CompoundAction CAS number
    SKI IISelective non-lipid inhibitor of sphingosine kinase; antitumor[312636-16-1]
    About this table


    2 Novoseek chemical compound relationships for SPHK2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sphingosine 94.2 58 13129923 (2), 15951439 (2), 19618460 (2), 17311928 (2) (see all 39)
    ceramide 72 7 16118219 (3), 19765607 (1), 19842132 (1), 19240026 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SPHK2
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SPHK2
    Sigma-Aldrich shRNA Panels and shRNA for SPHK2
    OriGene 29mer shRNA kits in GFP-retroviral vector: SPHK2
    OriGene shRNA RFP: SPHK2
    OriGene basic RS shRNA: SPHK2
    OriGene siRNA: SPHK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SPHK2 
    miRNA: Sigma-Aldrich microRNA Mimics for SPHK2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SPHK2 
    7 SABiosciences Assays for microRNAs that regulate SPHK2:
    hsa-miR-153 hsa-miR-301b hsa-miR-454 hsa-miR-130a hsa-miR-301a hsa-miR-650 hsa-miR-130b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SPHK2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SPHK2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): SPHK2
    OriGene 3'-UTR Clone: SPHK2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SPHK2 
    Primers: OriGene genome-wide validated SYBR primer pairs: SPHK2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SPHK2: PPH21192A

    REFSEQ mRNAs for SPHK2 gene: 

    NM_020126.3  

    11 AceView cDNA sequences:

    BC006161 NM_020126 AK122735 AL136701 CR614720 BC010671 AK000599 AF245447 
    AB100373 AK074601 CO246179 

    highest scoring ESTs for SPHK2:

    AB100373 AL580072 BM793811 AA907391 AK125560 AL583449 AW196191 BG171363 BM803297 BQ337947 


    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for SPHK2 (see all 20)

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b · 13c ^
    SP1:                                      -     -     -                 -     -     -     -     -     -                 -     -                 -               
    SP2:                                      -     -     -                 -     -     -     -     -     -                                         -               
    SP3:                                                                                                                                            -               
    SP4:        -     -     -     -     -     -     -     -                 -     -     -     -     -     -                                         -               
    SP5:                                      -     -     -                 -     -     -     -     -     -     -     -     -     -     -     -     -               

    ExUns: 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18
    SP1:                          -                                 
    SP2:                          -                                 
    SP3:                          -                                 
    SP4:                                                            
    SP5:                          -                                 

    About this scheme

    ECgene alternative splicing isoforms for SPHK2
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406269(uc002pjt.2) ENST00000340932(uc010xzu.1) ENST00000245222(uc002pjr.2 uc010xzt.1 uc002pjs.2 uc002pjv.2)
    ENST00000443164(uc002pju.2 uc002pjw.2) ENST00000426514

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SPHK2 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching SPHK2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40273_at2, 3 U133-A 1 0.94 1.00 0.82 1.03 AA485440 0.60 0.75 0.68 1
    88521_at2, 3 U95-E 1 0.38 1.00 0.78 0.97 AA702497 0.20 0.50 0.38 1
    209857_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF245447 0.60 0.75 0.68 1
    40273_at2, 3 U133-A 1 0.94 1.00 -- -- AA485440 0.60 0.75 0.68 1
    209857_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    40273_at2 U133Plus2 1 0.94 1.00 -- -- -- -- -- -- --
    About this table

    SPHK2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SPHK2 gene expression
    SPHK2 gene electronic northern expression
    SPHK2 gene sage expression
    About these images

    CGAP SAGE TAG: --

    Expression variation in blood from EXPOLDB for SPHK2

    Primers: OriGene genome-wide validated SYBR primer pairs: SPHK2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SPHK2: PPH21192A
        SABiosciences Expression via Pathway-Focused PCR Arrays including SPHK2: PAHS-037A PAHS-091A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SPHK2 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SPHK21   -- sphingosine kinase 2 88.38(n)
    92.05(a)
    484401  XM_541516.2  XP_541516.2 
    chimpanzee
    (Pan troglodytes)
    SPHK21   -- sphingosine kinase 2 97.87(n)
    97.34(a)
    468943  XM_001171404.1  XP_001171404.1 
    cow
    (Bos taurus)
    SPHK21   -- sphingosine kinase 2 87.37(n)
    91.1(a)
    533103  XM_612394.3  XP_612394.2 
    rat
    (Rattus norvegicus)
    Sphk21   -- sphingosine kinase 2 80.71(n)
    84.59(a)
    308589  NM_001012066.1  NP_001012066.1 
    mouse
    (Mus musculus)
    Sphk21 , 5 7 (29.45 cM)5
    sphingosine kinase 21, 5 80.96(n)1
    83.96(a)1
    566321  NM_020011.41  NP_064395.21 
     AF2454485  AF4152145  (see all 23)
    About this table        Species with no ortholog for SPHK2

    ENSEMBL Gene Tree for SPHK2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SPHK2 gene
    SPHK12  AGK2  

    SPHK2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/92 NCBI SNPs in SPHK2 are shown (see all 92)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs2814101,2
    --49129845(+) ggcggG/Ttggat 1 -- int10--------
    rs2814111,2
    C49129859(+) ctgagG/Atcagg 1 -- int12Minor allele frequency- A:0.50NA WA 4
    rs3862431,2
    C,F,A,49127490(+) CCCAGC/TTCTCG 1 -- int18Minor allele frequency- T:0.26EA NA WA 154
    rs5100661,2
    C,49126587(+) ccgccG/Tcggcc 1 -- int10--------
    rs5613951,2
    C49125308(+) GAGATC/TGAGAC 1 -- int12Minor allele frequency- T:0.50NA WA 4
    rs16453311,2
    C,A,H,49126012(+) TGTCtG/Ctcttt 1 -- int1 trp31Minor allele frequency- C:0.50WA 2
    rs18034831,2
    --49133393(-) CAGTAA/CATTCC 1 -- ut310--------
    rs23011391,2
    C,F,H,49133761(-) CCGTGG/AGCAGC 1 -- ng319Minor allele frequency- A:0.16EA MN NA WA 1794
    rs37457321,2
    --49132552(+) CCCATC/TCTCTG 2 S F ref1 mis1 ese30--------
    rs37457331,2
    C,F,49132634(+) CCGCTG/AGGCAC 2 /L syn1 ref1 ese38Minor allele frequency- A:0.07EA NS NA 2080
    About this table

    HapMap Linkage Disequilibrium images for SPHK2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SPHK2
         1 CNV: 32261
         1 Indel: 40287

    QIAGEN SeqTarget long-range PCR primers for resequencing SPHK2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPHK2 for disorders           About GeneDecksing

    OMIM: 607092

    1 Novoseek disease relationship for SPHK2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 19.1 4 15951439 (1), 17311928 (1), 20110355 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: SPHK2 (1 document)

    Export disorders and mutations for SPHK2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/63 PubMed articles for SPHK2 gene, integrated from 7 sources (see all 63):
    (articles sorted by number of sources associating them with SPHK2)
    1. Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. (PubMed id 10751414)1, 2, 3, 7 Liu H.... Spiegel S. (2000)
    2. A lipid binding domain in sphingosine kinase 2. (PubMed id 19168031)1, 2, 7 Don A.S. and Rosen H. (2009)
    3. Recycling of sphingosine is regulated by the concerte d actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. (PubMed id 17895250)1, 3 Le Stunff H....Spiegel S. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    7. Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. (PubMed id 15951439)1, 7 Hait N.C....Spiegel S. (2005)
    8. Expression of sphingosine kinase 2 in synovial fibrob lasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analog ue, FTY720. (PubMed id 19490468)1, 7 Kamada K....Nose M. (2009)
    9. Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. (PubMed id 17635916)1, 7 Ding G....Nakamura S. (2007)
    10. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. (PubMed id 17311928)1, 7 Hait N.C....Spiegel S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56848 HGNC: 18859 AceView: SPHK2 Ensembl:ENSG00000063176 euGenes: HUgn56848
    ECgene: SPHK2 Kegg: 56848 H-InvDB: SPHK2

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for SPHK2 gene:
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