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SRMS Gene

protein-coding   GIFtS: 45

GC20M058902
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
(Previous name: chromosome 20 open reading frame 148 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf148)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal
myristylation sites1 2
     chromosome 20 open reading frame 1481
SRM1 2     tyrosine-protein kinase Srms2
dJ697K14.11 2     EC 2.7.10.23
C20orf1482 3     

External Ids:    HGNC: 112981   Entrez Gene: 67252   Ensembl: ENSG000001255087   UniProtKB: Q9H3Y63   

Export aliases for SRMS gene to outside databases

Previous GC identifers: GC00U990353 GC20M062009 GC20M062851 GC20M062899 GC20M062900 GC20M061642 GC20M062172


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SRMS gene promoter:
         STAT5B   c-Fos   AP-1   c-Jun   p53   CUTL1   SREBP-1a   SREBP-1c   SREBP-1b   PPAR-gamma1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SRMS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SRMS 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

SRMS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SRMS gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M058902:  view genomic region     (about GC identifiers)

Start:
58,902,368 bp from pter
End:
58,909,062 bp from pter
Size:
6,695 bases
Orientation:
minus strand

1 alternative location:
Chr20- 62,172,163-62,178,857     
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6 (See protein sequence)
Recommended Name: Tyrosine-protein kinase Srms  
Size: 488 amino acids; 54507 Da

Explore the universe of human proteins at neXtProt for SRMS: NX_Q9H3Y6 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_543013.1  

    ENSEMBL proteins: 
    ENSP00000217188 


    Human Recombinant Proteins 
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    Uscn ELISAs and CLIAs for SRMS 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SRMS for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR020685 Tyr_prot_kinase
     IPR001245 Ser-Thr/Tyr-Pkinase
     IPR011009 Kinase-like_dom
     IPR000980 SH2

    Graphical View of Domain Structure for InterPro Entry Q9H3Y6

    ProtoNet protein and cluster: Q9H3Y6

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6
    Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SRMS
    Sigma-Aldrich siRNA Panels and siRNA for SRMS
    Sigma-Aldrich shRNA Panels and shRNA for SRMS
    OriGene 29mer shRNA kits in GFP-retroviral vector: SRMS
    OriGene shRNA RFP: SRMS
    OriGene basic RS shRNA: SRMS
    OriGene siRNA: SRMS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SRMS 
    miRNA:Sigma-Aldrich microRNA Mimics for SRMS
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SRMS 
    Search SABiosciences for Assays for microRNAs that regulate SRMS

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SRMS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SRMS
    OriGene untagged cDNA clones in CMV expression vector: SRMS
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SRMS 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SRMS 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515 protein binding IEA--
    About this table

    SRMS for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Srms):

    normal

    SRMS for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for SRMS 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRMS

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    About this table

    SRMS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SRMS


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for SRMS
    Sigma-Aldrich siRNA Panels and siRNA for SRMS
    Sigma-Aldrich shRNA Panels and shRNA for SRMS
    OriGene 29mer shRNA kits in GFP-retroviral vector: SRMS
    OriGene shRNA RFP: SRMS
    OriGene basic RS shRNA: SRMS
    OriGene siRNA: SRMS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SRMS 
    miRNA: Sigma-Aldrich microRNA Mimics for SRMS
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SRMS 
    Search SABiosciences for Assays for microRNAs that regulate SRMS
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: SRMS
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: SRMS
    OriGene untagged cDNA clones in CMV expression vector: SRMS
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: SRMS 
    Primers: OriGene genome-wide validated SYBR primer pairs: SRMS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SRMS: PPH05789A

    REFSEQ mRNAs for SRMS gene: 

    NM_080823.2  

    5 DOTS entries:

    DT.92044841  DT.95341160  DT.120833226  DT.99947617  DT.99981520 

    10 AceView cDNA sequences:

    NM_080823 BM784153 BI835187 BF330815 BF762532 BE066428 BE075993 BM742718 
    BF330886 BE075953 

    highest scoring ESTs for SRMS:

    NM_080823 BE066428 BE075953 BE075993 BF330815 BF330886 BF762532 BI224647 BI835187 BM742718 

    Unigene Cluster for SRMS:

    Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
    Hs.411061  [show with all ESTs]
    Unigene Representative Sequence: NM_080823


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SRMS

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
    SP1:              -                       -         
    SP2:                                                
    SP3:              -                                 

    About this scheme

    ECgene alternative splicing isoforms for SRMS
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217188(uc002yfi.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SRMS expression in normal and diseased human tissues

    1  / 2

    2 probe-sets matching SRMS gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    234514_at2 U133-B 1 0.27 1.00 -- -- -- -- -- -- --
    234514_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SRMS gene expression
    SRMS gene electronic northern expression
    SRMS gene sage expression
    About these images

    CGAP SAGE TAG: CTGGAGTGCT

    SOURCE GeneReport for Unigene cluster: Hs.411061
    Primers: OriGene genome-wide validated SYBR primer pairs: SRMS
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SRMS: PPH05789A
        SABiosciences Custom PCR Arrays for SRMS 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SRMS gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SRMS1   -- src-related kinase lacking C-terminal regulatory tyrosine more 84.13(n)
    80(a)
    477286  XM_534478.2  XP_534478.2 
    chimpanzee
    (Pan troglodytes)
    SRMS1   -- src-related kinase lacking C-terminal regulatory tyrosine more 99.18(n)
    99.59(a)
    470000  XM_525384.2  XP_525384.2 
    cow
    (Bos taurus)
    SRMS1   -- src-related kinase lacking C-terminal regulatory tyrosine more 82.33(n)
    79.5(a)
    521816  XM_600086.3  XP_600086.3 
    rat
    (Rattus norvegicus)
    Srms1   -- src-related kinase lacking C-terminal regulatory tyrosine more 80.58(n)
    80.17(a)
    296472  NM_001011961.1  NP_001011961.1 
    mouse
    (Mus musculus)
    Srms1 , 5 2 (103.62 cM)5
    src-related kinase lacking C-terminal regulatory tyrosine more1, 5 80.51(n)1
    79.34(a)1
    208111  NM_011481.31  NP_035611.31 
     AK0495825  BB1962455  (see all 9)
    About this table        Species with no ortholog for SRMS

    ENSEMBL Gene Tree for SRMS (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SRMS gene
    ABL12  TEC2  BMX2  ABL22  ITK2  PTK62  TXK2  BTK2  

    SRMS for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/131 NCBI SNPs in SRMS are shown (see all 131)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs3106541,2
    C,F,A,62172269(+) GAGCAC/AGTAGA 2 /V /L ref1 mis1 ese310Minor allele frequency- A:0.25NS EA NA WA 674
    rs3106551,2
    C,F,A,62172281(+) CTCCGC/TCGGGC 2 T A mis1 ref1 ese38Minor allele frequency- T:0.18NS EA NA WA 612
    rs3106561,2
    C,62173029(-) GACGCC/TGGCCT 1 -- int14Minor allele frequency- T:0.00NA WA 8
    rs3106571,2
    C,F,A,H,62173561(+) CGTGAC/GGATGT 2 L V mis1 ref1 ese38Minor allele frequency- G:0.15MN NA NS EA 734
    rs3106581,2
    C,F,A,H,62173741(+) TGAGGG/ATTGGA 1 -- int15Minor allele frequency- A:0.21NA WA 260
    rs3106591,2
    C,A,62177836(+) CTGCCC/TTCACC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs3106601,2
    F,A62177962(+) ctgccC/Ttcacc 1 -- int11Minor allele frequency- T:0.50NA 4
    rs3106611,2
    --62177973(+) cagagC/Ttcctg 1 -- int10--------
    rs3106621,2
    --62177983(+) ggagcA/Gtgggc 1 -- int10--------
    rs3660191,2
    C,F,A,62178105(-) ATGGAT/GCGGTC 1 -- int12Minor allele frequency- G:0.03NA EA 160
    About this table

    HapMap Linkage Disequilibrium images for SRMS (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for SRMS
         13 CNVs: 30136 31044 50713 30137 50714 5149 5150 53244 4107 53251 50712 10590 30135

    QIAGEN SeqTarget long-range PCR primers for resequencing SRMS 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    4 PubMed articles for SRMS gene integrated from 7 sources:
    (articles sorted by number of sources associating them with SRMS)
    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    2. A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PubMed id 7935409)1, 3 Kohmura N....Aizawa S. (1994)
    3. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    4. RAKing in AKT: a tumor suppressor function for the in tracellular tyrosine kinase FRK. (PubMed id 19652529)7 Brauer P.M. and Tyner A.L. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6725 HGNC: 11298 AceView: SRMS Ensembl:ENSG00000125508 euGenes: HUgn6725
    ECgene: SRMS H-InvDB: SRMS

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SRMS gene:
    Search GeneIP for patents involving SRMS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     SeqTarget long-range PCR primers for resequencing SRMS
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SRMS
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SRMS
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     Regulatory tfbs in SRMS promoter
     Search Chromatin IP Primers for SRMS
     RT2 qPCR Primer Assay for SRMS
     Search GNC Networks for SRMS
     Search for Assays for microRNAs that regulate SRMS
     SABiosciences Custom PCR Arrays for SRMS
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     ELISAs and CLIAs for SRMS
           

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