SRMS Gene
protein-coding GIFtS: 45
GC20M058902
|
|
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
(Previous name: chromosome 20 open reading frame 148 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf148)
|
Aliases &
Descriptions
for SRMS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| src-related kinase lacking C-terminal regulatory tyrosine and N-terminalmyristylation sites1 2 | | chromosome 20 open reading frame 1481 | | SRM1 2 | | tyrosine-protein kinase Srms2 | | dJ697K14.11 2 | | EC 2.7.10.23 | | C20orf1482 3 | | |
Export aliases for SRMS gene to outside databasesPrevious GC identifers: GC00U990353 GC20M062009 GC20M062851 GC20M062899 GC20M062900 GC20M061642 GC20M062172 |
Summaries
for SRMS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)
|
Genomic Views
for SRMS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRMS gene promoter:
STAT5B c-Fos AP-1 c-Jun p53 CUTL1 SREBP-1a SREBP-1c SREBP-1b PPAR-gamma1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRMS
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SRMS  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33SRMS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M058902: view genomic region
(about GC identifiers)
Start:
|
58,902,368 bp from pter |
End:
|
58,909,062 bp from pter |
Size:
|
6,695 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr20- 62,172,163-62,178,857 |
RefSeq DNA sequence:- NC_000020.10 NT_011333.6
|
Proteins
for SRMS gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6 (See
protein sequence)Recommended Name: Tyrosine-protein kinase Srms Size: 488 amino acids; 54507 DaExplore the universe of human proteins at neXtProt for SRMS: NX_Q9H3Y6
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_543013.1
ENSEMBL proteins: ENSP00000217188
Human Recombinant Proteins
Antibodies for SRMS:
Assays for SRMS: |
Protein
Domains/
Families
for SRMS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRMS for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q9H3Y6ProtoNet protein and cluster: Q9H3Y6 2 Blocks protein families: IPB000980 SH2 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Gene Function
for SRMS gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SRMS_HUMAN, Q9H3Y6Function: May be involved in proliferation or differentiation of keratinocytes in the skin (By similarity)Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme Number (IUBMB): EC 2.7.10.2
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
-- | -- | | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- |
About this table
SRMS for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Srms):
SRMS for phenotypes About GeneDecksing
|
Pathways & Interactions
for SRMS gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for SRMS
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRMS
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein phosphorylation |
IEA | -- |
About this table
SRMS for ontologies About GeneDecksing
|
Drugs & Compounds
for SRMS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SRMS
|
Transcripts
for SRMS gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SRMS gene: NM_080823.2 5 DOTS entries: DT.92044841 DT.95341160 DT.120833226 DT.99947617 DT.99981520 10 AceView cDNA sequences: NM_080823 BM784153 BI835187 BF330815 BF762532 BE066428 BE075993 BM742718 BF330886 BE075953
 highest scoring ESTs for SRMS:NM_080823 BE066428 BE075953 BE075993 BF330815 BF330886 BF762532 BI224647 BI835187 BM742718 Unigene Cluster for SRMS: Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Hs.411061 [show with all ESTs]Unigene Representative Sequence: NM_080823
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SRMS
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SRMS
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217188(uc002yfi.1)
|
Expression
for SRMS gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SRMS expression in normal and diseased human tissues
1 / 2 2 probe-sets matching SRMS gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 234514_at2
|
U133-B |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 234514_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGGAGTGCT
SOURCE GeneReport for Unigene cluster: Hs.411061
SABiosciences Custom PCR Arrays for SRMS
|
Orthologs
for SRMS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SRMS gene from 5/7 species (see all 7)
About this table Species with no ortholog for SRMS
ENSEMBL Gene Tree for SRMS (if available) |
Paralogs
for SRMS gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SRMS gene
- ABL12 TEC2 BMX2 ABL22 ITK2 PTK62 TXK2 BTK2
SRMS for paralogs About GeneDecksing
|
Genomic Variants
for SRMS gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SRMS (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for SRMS
13 CNVs: 30136 31044 50713 30137 50714 5149 5150 53244 4107 53251 50712 10590 30135 | | QIAGEN SeqTarget long-range PCR primers for resequencing SRMS |
|
Disorders & Mutations
for SRMS gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for SRMS gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SRMS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
4 PubMed articles for SRMS gene integrated from 7 sources:
(articles sorted by number of sources associating them with SRMS)- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. (PubMed id 7935409)1, 3 Kohmura N....Aizawa S. (1994)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- RAKing in AKT: a tumor suppressor function for the in tracellular tyrosine kinase FRK. (PubMed id 19652529)7 Brauer P.M. and Tyner A.L. (2009)
|
External Searches for SRMS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRMS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRMS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRMS gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SRMS gene:
Search GeneIP for patents involving SRMS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRMS gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for SRMS |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for SRMS |
| |
|
|
