Aliases &
Descriptions
for SRR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| serine racemase1 2 | | ILV11 2 | | ISO11 2 | | EC 5.1.1.183 |
Export aliases for SRR gene to outside databasesPrevious GC identifers: GC17P002513 GC17P002158 GC17P002413 GC17P002153 |
Summaries
for SRR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4Function: Catalyzes the synthesis of D-serine from L-serine
|
Genomic Views
for SRR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SRR gene promoter:
YY1 CUTL1 Lmo2 E2F E2F-1 deltaCREB CREB GATA-1 Bach2 Bach1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SRR
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SRR  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13SRR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P002102: view genomic region
(about GC identifiers)
Start:
|
2,102,020 bp from pter |
End:
|
2,123,254 bp from pter |
Size:
|
21,235 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr17+ 2,207,248-2,228,554 |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
|
Proteins
for SRR gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4 (See
protein sequence)Recommended Name: Serine racemase Size: 340 amino acids; 36566 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subunit: Homodimer (By similarity)
PDB structure from  and Proteopedia  :3L6B (3D)
3L6R (3D)
Secondary accessions: Q6IA55Explore the universe of human proteins at neXtProt for SRR: NX_Q9GZT4
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_068766.1
ENSEMBL proteins: ENSP00000339435
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
SRR for ontologies About GeneDecksing
Antibodies for SRR:
Assays for SRR: |
Protein
Domains/
Families
for SRR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SRR for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9GZT4ProtoNet protein and cluster: Q9GZT4 2 Blocks protein families: IPB000634 Serine/threonine dehydratase IPB001926 Pyridoxal-5'-phosphate-dependent enzyme
UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4Similarity: Belongs to the serine/threonine dehydratase family |
Gene Function
for SRR gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4Function: Catalyzes the synthesis of D-serine from L-serineCatalytic activity: L-serine = D-serineEnzyme regulation: Activated by divalent cations like calcium, magnesium and manganese, as well as by nucleotides likeATP, ADP or GTPEnzyme Number (IUBMB): EC 5.1.1.18
5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12): About this table
SRR for ontologies About GeneDecksing
Animal Models: 5 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Srr):
SRR for phenotypes About GeneDecksing
|
Pathways & Interactions
for SRR gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SRR for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for SRR):  | hsa00260 Glycine, serine and threonine metabolism |
SABiosciences Custom Pathway-Focused PCR Arrays for SRR
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SRR
5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12): About this table
SRR for ontologies About GeneDecksing
|
Drugs & Compounds
for SRR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
SRR for compounds About GeneDecksing
 Browse Tocris compounds for SRR
8  Novoseek chemical compound relationships for SRR gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nmda |
79 |
23 |
11309496 (2), 12176074 (2), 17067558 (2), 12393813 (1) (see all 13) |
| serine |
78.6 |
235 |
17880399 (8), 20091774 (7), 15193426 (6), 15536068 (6) (see all 44) |
| glutamate |
67 |
5 |
17006901 (1), 18812225 (1), 20106978 (1), 12176074 (1) (see all 5) |
| pyridoxal 5-phosphate |
58.8 |
1 |
19791805 (1) |
| pyruvate |
36 |
4 |
20091774 (2), 11309496 (1), 15681805 (1) |
| valine |
25.8 |
1 |
12393813 (1) |
| nitric oxide |
12.3 |
7 |
16182447 (3), 16298487 (1), 20021361 (1) |
| calcium |
0 |
3 |
12021263 (2), 17172010 (1) |
About this table
|
Transcripts
for SRR gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SRR gene: NM_021947.1 Additional cDNA sequence: AF169974.1 AK023169.1 AK223120.1 AL834378.1 AY034081.1 AY743705.1 AY743706.1 AY743707.1 AY743708.1 BC010266.1 BC057234.1 BC074728.2 CR457300.1 CR619119.1 13 DOTS entries: DT.99974731 DT.99953799 DT.446103 DT.454995 DT.100817839 DT.95352513 DT.121010804 DT.121010872 DT.121010997 DT.91711597 DT.100044581 DT.121010845 DT.121010822 24/88 AceView cDNA sequences (see all 88): AV649514 AY034081 BM713885 AK023169 Z39268 CB129474 BU625449 BU738738 BU739679 BI259607 AL834378 AI952697 AF169974 AI291087 NM_021947 AI500493 H88365 CR457300 AU131397 AA446793 BG152669 AI342735 BM676503 N74185
 highest scoring ESTs for SRR:AI955087 AA055538 AA432108 AA649607 AL834378 AY034081 BE774682 BF334502 BF693663 BI763753 Unigene Cluster for SRR: Serine racemase Hs.461954 [show with all ESTs]Unigene Representative Sequence: AK023169
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000344595(uc002fue.1 uc002fuh.1 uc002fui.1)
|
Expression
for SRR gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SRR expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching SRR gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 50118_at2, 3
|
U95-B |
1 |
0.50 |
1.00 |
1.00 |
1.00 |
AI955087 |
1.00 |
0.90 |
0.95 |
1 |
| 222844_s_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AF169974 |
0.60 |
1.00 |
0.82 |
1 |
| 219204_s_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_021947 |
0.60 |
0.83 |
0.73 |
1 |
| 219205_at2, 3
|
U133-A |
1 |
0.27 |
1.00 |
-- |
-- |
NM_021947 |
0.60 |
0.83 |
0.73 |
1 |
| 222844_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 219204_s_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 219205_at2
|
U133Plus2 |
1 |
0.27 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SRR for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CAAGAGCCTG
SOURCE GeneReport for Unigene cluster: Hs.461954
Expression variation in blood from EXPOLDB for SRR UniProtKB/Swiss-Prot: SRR_HUMAN, Q9GZT4Tissue specificity: Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels insubstantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart,skeletal muscle, kidney and liver
SABiosciences Custom PCR Arrays for SRR
|
Orthologs
for SRR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SRR gene from 5/10 species (see all 10)
About this table Species with no ortholog for SRR
ENSEMBL Gene Tree for SRR (if available) |
Paralogs
for SRR gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for SRR gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
| | | QIAGEN SeqTarget long-range PCR primers for resequencing SRR |
|
Disorders & Mutations
for SRR gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SRR for disorders About GeneDecksing
OMIM: 606477
5 Novoseek disease relationships for SRR gene
About this table
Human Gene Mutation Database (HGMD): SRR
Human Genome Epidemiology (HuGE) Navigator: SRR (10 documents)
Export disorders and mutations for SRR gene to outside databases
|
Medical News
for SRR gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SRR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/61 PubMed articles for SRR gene, integrated from 7 sources (see all 61):
(articles sorted by number of sources associating them with SRR)- Characterization and localization of a human serine racemase. (PubMed id 15193426)1, 2, 3, 7 Xia M.... Connolly T.M. (2004)
- Identification of multiple serine racemase (SRR) mRNA isoforms and genetic analyses of SRR and DAO in schizophrenia and D-serine levels. (PubMed id 15953485)1, 3, 7 Yamada K....Yoshikawa T. (2005)
- Human serine racemase: molecular cloning, genomic organization and functional expression. (PubMed id 11054547)1, 2, 7 DeMiranda J.... Wolosker H. (2000)
- A genetic variant of the serine racemase gene is associated with schizophrenia. (PubMed id 17067558)1, 3, 7 Morita Y....Kuroda S. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- d-Amino acid oxidase and serine racemase in human brain: normal distribution and altered expression in schizophrenia. (PubMed id 17880399)1, 7 Verrall L....Burnet P.W. (2007)
- Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity. (PubMed id 15536068)1, 7 Foltyn V.N....Wolosker H. (2005)
- Recombinant human serine racemase: enzymologic characterization and comparison with its mouse ortholog. (PubMed id 18812225)1, 7 Hoffman H.E....Konvalinka J. (2009)
- Serine racemase and D-serine transport in human placenta and evidence for a transplacental gradient for D-serine in humans. (PubMed id 15219883)1, 7 Chen Z....Prasad P.D. (2004)
|
External Searches for SRR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SRR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SRR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SRR gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SRR gene:
Search GeneIP for patents involving SRR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SRR gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for SRR |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for SRR |
| |
|
|
