Aliases &
Descriptions
for SSH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| slingshot homolog 1 (Drosophila)1 2 | | protein phosphatase Slingshot homolog 12 | | KIAA12981 2 3 5 | | FLJ381022 | | SSH1L2 3 | | slingshot 12 | | SSH-1L2 3 | | FLJ219282 | | SSH-like protein 12 3 | | EC 3.1.3.163 | | hSSH-1L2 3 | | EC 3.1.3.483 |
Export aliases for SSH1 gene to outside databasesPrevious GC identifers: GC12M108286 GC12M109057 GC12M109111 GC12M107681 GC12M107683 GC12M107705 GC12M109180 |
Summaries
for SSH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SSH1:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators ofactin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). TheSSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002(PubMed 11832213)).(supplied by OMIM)
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actinbinding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by thisprotein
Gene Wiki entry for SSH1 |
Genomic Views
for SSH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SSH1 gene promoter:
c-Myc Max1 GR-alpha GR-beta oct-B2 oct-B3 POU2F1 POU2F2C Oct-B1 POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for SSH1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SSH1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12SSH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M106241: view genomic region
(about GC identifiers)
Start:
|
106,241,529 bp from pter |
End:
|
106,316,009 bp from pter |
Size:
|
74,481 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 109,180,971-109,251,351 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for SSH1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5 (See
protein sequence)Recommended Name: Protein phosphatase Slingshot homolog 1 Size: 1049 amino acids; 115511 Da
Subunit: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and alsoblocks recruitment to lamellipodia and stimulation by actin
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Alsorecruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics atsites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=BAA92536.1; Type=Erroneous initiation;
Secondary accessions: Q6P6C0 Q8N9A7 Q8WYL3 Q8WYL4 Q9P2P8Alternative splicing: 5 isoforms: Q8WYL5-1 Q8WYL5-2 Q8WYL5-3 Q8WYL5-4 Q8WYL5-5 Explore the universe of human proteins at neXtProt for SSH1: NX_Q8WYL5
Post-translational modifications:
Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreasedby stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated byPPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001154802.1 NP_001154803.1 NP_061857.3
ENSEMBL proteins: ENSP00000315713 ENSP00000353374 ENSP00000326107 ENSP00000307610
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
SSH1 for ontologies About GeneDecksing
Antibodies for SSH1:
Assays for SSH1: |
Protein
Domains/
Families
for SSH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SSH1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WYL5ProtoNet protein and cluster: Q8WYL5 1 Blocks protein family: IPB000340 Dual specificity protein phosphatase
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5Similarity: Belongs to the protein-tyrosine phosphatase familySimilarity: Contains 1 tyrosine-protein phosphatase domain |
Gene Function
for SSH1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actinbinding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by thisproteinCatalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphateCatalytic activity: A phosphoprotein + H(2)O = a protein + phosphateEnzyme Numbers (IUBMB): EC 3.1.3.16 EC 3.1.3.48
5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
SSH1 for ontologies About GeneDecksing
|
Pathways & Interactions
for SSH1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SSH1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for SSH1
1  Kegg Pathway (Kegg details for SSH1):  | hsa04810 Regulation of actin cytoskeleton |
SABiosciences Pathway-Focused PCR Arrays including SSH1: PAHS-045A PAHS-088A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SSH1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSH1
5/13 Interacting proteins for SSH1 (ENSP000003157133 Q8WYL51, 2) via UniProtKB, MINT, and/or STRING (see all 13)About this table
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): About this table
SSH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SSH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for SSH1
|
Transcripts
for SSH1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for SSH1 gene (3 alternative transcripts): NM_001161330.1 NM_001161331.1 NM_018984.3 Additional cDNA sequence: AB037719.1 AB072355.1 AB072356.1 AB072357.1 AK025581.1 AK095421.1 BC005101.1 BC013792.1 BC020243.1 BC062341.1 CR623842.1 12 DOTS entries: DT.455121 DT.100736574 DT.40192573 DT.97791344 DT.99936175 DT.100762767 DT.91685765 DT.121191769 DT.91882424 DT.95253954 DT.121191815 DT.97763549 24/231 AceView cDNA sequences (see all 231): AI917378 BQ431836 AA399626 AI962661 AW449167 AI952731 AA588758 CD515032 AI907357 BU156035 AI799390 BC013792 AI394133 BU617420 BM354012 AA424975 BM701229 BU172934 BM989371 BC062341 AI288068 AI659758 BQ929507 BX643818
 highest scoring ESTs for SSH1:AI651213 AL121364 W28356 AB072355 AB072356 BC062341 BE244945 AA010349 AA296414 AA345259 Unigene Cluster for SSH1: Slingshot homolog 1 (Drosophila) Hs.199763 [show with all ESTs]Unigene Representative Sequence: NM_018984
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 (see all 8)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for SSH1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000326495(uc001tnm.2) ENST00000360239 ENST00000326470(uc010sxg.1 uc001tnn.3)
ENST00000303438(uc001tnl.2 uc001tno.1)
|
Expression
for SSH1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| SSH1 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching SSH1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 80528_at2, 3
|
U95-E |
1 |
0.94 |
1.00 |
-0.27 |
0.78 |
AL121364 |
0.80 |
1.00 |
0.91 |
1 |
| 57654_s_at2, 3
|
U95-C |
1 |
0.69 |
1.00 |
0.63 |
1.29 |
AI651213 |
0.80 |
1.00 |
0.91 |
1 |
| 34082_at2, 3
|
U95-A |
1 |
0.50 |
1.00 |
0.53 |
0.83 |
W28356 |
0.80 |
1.00 |
0.91 |
1 |
| 48756_at2, 3
|
U95-C |
1 |
0.31 |
1.00 |
0.67 |
1.13 |
AL041728 |
0.40 |
1.00 |
0.76 |
1 |
| 221752_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AL041728 |
0.40 |
1.00 |
0.76 |
1 |
| 221753_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AI651213 |
0.80 |
1.00 |
0.91 |
1 |
| 221752_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1555624_a_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1554274_a_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 221753_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
SSH1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGTTGTTTGG
SOURCE GeneReport for Unigene cluster: Hs.199763
Expression variation in blood from EXPOLDB for SSH1 SABiosciences Expression via Pathway-Focused PCR Arrays including SSH1: PAHS-045A PAHS-088A
|
Orthologs
for SSH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SSH1 gene from 5/9 species (see all 9)
About this table Species with no ortholog for SSH1
ENSEMBL Gene Tree for SSH1 (if available) |
Paralogs
for SSH1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for SSH1 gene
- DUSP142 DUSP282 DUSP212 SSH22 SSH32 DUSP182 STYX2
SSH1 for paralogs About GeneDecksing
|
Genomic Variants
for SSH1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for SSH1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SSH1
1 CNV: 5312
4 Indels: 71575 76146 86560 76147 | | QIAGEN SeqTarget long-range PCR primers for resequencing SSH1 |
|
Disorders & Mutations
for SSH1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SSH1 for disorders About GeneDecksing
OMIM: 606778
Human Gene Mutation Database (HGMD): SSH1
Human Genome Epidemiology (HuGE) Navigator: SSH1 (1 document)
Export disorders and mutations for SSH1 gene to outside databases
|
Medical News
for SSH1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for SSH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/32 PubMed articles for SSH1 gene, integrated from 7 sources (see all 32):
(articles sorted by number of sources associating them with SSH1)- Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2, 7 Nagata-Ohashi K.... Mizuno K. (2004)
- Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2, 7 Wang Y.... Mizuno K. (2005)
- Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PubMed id 12684437)1, 2, 7 Endo M....Mizuno K. (2003)
- Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PubMed id 12807904)1, 2, 7 Kaji N.... Mizuno K. (2003)
- Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 7 Soosairajah J.... Bernard O. (2005)
- Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PubMed id 16230460)1, 2, 7 Nishita M.... Mizuno K. (2005)
- Efficient Salmonella entry requires activity cycles of host ADF and cofilin. (PubMed id 15056216)1, 2 Dai S.... Zhou D. (2004)
- Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. (PubMed id 14645219)1, 2 Nishita M....Mizuno K. (2004)
|
External Searches for SSH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SSH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SSH1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SSH1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SSH1 gene:
Search GeneIP for patents involving SSH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SSH1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for SSH1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for SSH1 |
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