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SSH1 Gene

protein-coding   GIFtS: 60

GC12M106241
slingshot homolog 1 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
slingshot homolog 1 (Drosophila)1 2     protein phosphatase Slingshot homolog 12
KIAA12981 2 3 5     FLJ381022
SSH1L2 3     slingshot 12
SSH-1L2 3     FLJ219282
SSH-like protein 12 3     EC 3.1.3.163
hSSH-1L2 3     EC 3.1.3.483

External Ids:    HGNC: 305791   Entrez Gene: 544342   Ensembl: ENSG000000841127   UniProtKB: Q8WYL53   

Export aliases for SSH1 gene to outside databases

Previous GC identifers: GC12M108286 GC12M109057 GC12M109111 GC12M107681 GC12M107683 GC12M107705 GC12M109180


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SSH1:
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of
actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The
SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002
(PubMed 11832213)).(supplied by OMIM)

UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.
Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this
protein

Gene Wiki entry for SSH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SSH1 gene promoter:
         c-Myc   Max1   GR-alpha   GR-beta   oct-B2   oct-B3   POU2F1   POU2F2C   Oct-B1   POU2F2B   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for SSH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for SSH1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.12

SSH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SSH1 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M106241:  view genomic region     (about GC identifiers)

Start:
106,241,529 bp from pter
End:
106,316,009 bp from pter
Size:
74,481 bases
Orientation:
minus strand

1 alternative location:
Chr12- 109,180,971-109,251,351     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5 (See protein sequence)
Recommended Name: Protein phosphatase Slingshot homolog 1  
Size: 1049 amino acids; 115511 Da
Subunit: Interacts with actin and this stimulates phosphatase activity. Also interacts with LIMK1 and with the 14-3-3
proteins YWHAB, YWHAG, YWHAQ, and YWHAZ. Interaction with 14-3-3 proteins inhibits phosphatase activity and also
blocks recruitment to lamellipodia and stimulation by actin
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also
recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at
sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis
Miscellaneous: Tyrosine phosphatase activity has not been demonstrated for this protein to date
Sequence caution: Sequence=BAA92536.1; Type=Erroneous initiation;
Secondary accessions: Q6P6C0 Q8N9A7 Q8WYL3 Q8WYL4 Q9P2P8
Alternative splicing: 5 isoforms:  Q8WYL5-1   Q8WYL5-2   Q8WYL5-3   Q8WYL5-4   Q8WYL5-5   

Explore the universe of human proteins at neXtProt for SSH1: NX_Q8WYL5 

Post-translational modifications:

  • Phosphorylated. Inhibitory phosphorylation by PAK4 promotes binding to YWHAZ. Phosphorylation at Ser-978 is decreased
  • by stimuli which promote actin reorganization and lamellipodia formation. Can be dephosphorylated and activated by
    PPP3CA/calcineurin A. Phosphorylation decreases immediately prior to telophase1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001154802.1  NP_001154803.1  NP_061857.3  


    ENSEMBL proteins: 
    ENSP00000315713 ENSP00000353374 ENSP00000326107 ENSP00000307610 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SSH1
    GenScript Custom Purified and Recombinant Proteins Services for SSH1 
    Novus Biologicals Proteins for SSH1
    Novus Biologicals Lysates for SSH1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA14645219
    GO:0005856 cytoskeleton IEA--
    GO:0005886 plasma membrane IDA14645219
    GO:0030027 lamellipodium IEA--
    GO:0030496 midbody IEA--
    About this table

    SSH1 for ontologies           About GeneDecksing



    Antibodies for SSH1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for SSH1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for SSH1 
    Novus Biologicals Antibodies for SSH1
    Browse antibodies at Epitomics

    Assays for SSH1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SSH1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SSH1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SSH1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000387 Dual-sp/Tyr_phosphatase
     IPR020422 Dual-sp_phosphatase_subgr_cat
     IPR014876 DEK_C
     IPR016130 Tyr_Pase_AS
     IPR000340 Dual-sp_phosphatase_cat-dom

    Graphical View of Domain Structure for InterPro Entry Q8WYL5

    ProtoNet protein and cluster: Q8WYL5

    1 Blocks protein family: IPB000340 Dual specificity protein phosphatase

    UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
    Similarity: Belongs to the protein-tyrosine phosphatase family
    Similarity: Contains 1 tyrosine-protein phosphatase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SSH1_HUMAN, Q8WYL5
    Function: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin
    binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.
    Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this
    protein
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
    Catalytic activity: A phosphoprotein + H(2)O = a protein + phosphate
    Enzyme Numbers (IUBMB): EC 3.1.3.16  EC 3.1.3.48 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SSH1
    Sigma-Aldrich shRNA Panels and shRNA for SSH1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SSH1
    OriGene shRNA RFP (see all 4): SSH1
    OriGene basic RS shRNA (see all 4): SSH1
    OriGene siRNA (see all 3): SSH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SSH1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SSH1 
    8/10 SABiosciences Assays for microRNAs that regulate SSH1 (see all 10):
    hsa-miR-31 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): SSH1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): SSH1
    OriGene untagged cDNA clones in CMV expression vector: SSH1
    OriGene 3'-UTR clone (see all 3): SSH1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SSH1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for SSH1 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding IDA11832213
    GO:0004721 phosphoprotein phosphatase activity IMP19000834
    GO:0004725 protein tyrosine phosphatase activity IEA--
    GO:0005515 protein binding IPI17350576
    GO:0008138 protein tyrosine/serine/threonine phosphatase activity IEA--
    About this table

    SSH1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    SSH1 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  SSH1
        Actin Cytoskeleton Signaling

    1 Kegg Pathway  (Kegg details for SSH1):
        hsa04810 Regulation of actin cytoskeleton

        SABiosciences Pathway-Focused PCR Arrays including SSH1: PAHS-045A PAHS-088A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for SSH1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SSH1

    5/13 Interacting proteins for SSH1 (ENSP000003157133 Q8WYL51, 2) via UniProtKB, MINT, and/or STRING (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CORO1BQ9BR761EBI-1222387,EBI-351152
    YWHABP319462MINT-8006699 MINT-8006692 MINT-8008870
    YWHAQP273482MINT-8008916
    YWHAZP631042MINT-8008923
    GRB2ENSP000003390073STRING: ENSP00000339007
    About this table

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902 cell morphogenesis IMP14645219
    GO:0006470 protein dephosphorylation IMP14645219
    GO:0016311 dephosphorylation ----
    GO:0030036 actin cytoskeleton organization IMP11832213
    GO:0032268 regulation of cellular protein metabolic process IDA19000834
    About this table

    SSH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SSH1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for SSH1
    Sigma-Aldrich shRNA Panels and shRNA for SSH1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): SSH1
    OriGene shRNA RFP (see all 4): SSH1
    OriGene basic RS shRNA (see all 4): SSH1
    OriGene siRNA (see all 3): SSH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of SSH1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of SSH1 
    8/10 SABiosciences Assays for microRNAs that regulate SSH1 (see all 10):
    hsa-miR-31 hsa-miR-98 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-let-7b
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): SSH1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): SSH1
    OriGene untagged cDNA clones in CMV expression vector: SSH1
    OriGene 3'-UTR Clone (see all 3): SSH1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for SSH1 
    Primers: OriGene genome-wide validated SYBR primer pairs: SSH1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SSH1: PPH09650A

    REFSEQ mRNAs for SSH1 gene (3 alternative transcripts): 

    NM_001161330.1  NM_001161331.1  NM_018984.3  

    Additional cDNA sequence: 

    AB037719.1 AB072355.1 AB072356.1 AB072357.1 AK025581.1 AK095421.1 BC005101.1 BC013792.1 
    BC020243.1 BC062341.1 CR623842.1 

    12 DOTS entries:

    DT.455121  DT.100736574  DT.40192573  DT.97791344  DT.99936175  DT.100762767  DT.91685765  DT.121191769 
    DT.91882424  DT.95253954  DT.121191815  DT.97763549 

    24/231 AceView cDNA sequences (see all 231):

    AI917378 BQ431836 AA399626 AI962661 AW449167 AI952731 AA588758 CD515032 
    AI907357 BU156035 AI799390 BC013792 AI394133 BU617420 BM354012 AA424975 
    BM701229 BU172934 BM989371 BC062341 AI288068 AI659758 BQ929507 BX643818 

    highest scoring ESTs for SSH1:

    AI651213 AL121364 W28356 AB072355 AB072356 BC062341 BE244945 AA010349 AA296414 AA345259 

    Unigene Cluster for SSH1:

    Slingshot homolog 1 (Drosophila)
    Hs.199763  [show with all ESTs]
    Unigene Representative Sequence: NM_018984


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SSH1 (see all 8)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18
    SP1:                          -     -                 -           -                                   -                                         -     -         
    SP2:                          -     -                 -           -                                   -                                                         
    SP3:                                -                 -           -                                   -                                                         
    SP4:                          -     -     -           -           -                                                                                             
    SP5:                                            -     -           -                                                                                             

    About this scheme

    ECgene alternative splicing isoforms for SSH1
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000326495(uc001tnm.2) ENST00000360239 ENST00000326470(uc010sxg.1 uc001tnn.3)
    ENST00000303438(uc001tnl.2 uc001tno.1)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    SSH1 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching SSH1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    80528_at2, 3 U95-E 1 0.94 1.00 -0.27 0.78 AL121364 0.80 1.00 0.91 1
    57654_s_at2, 3 U95-C 1 0.69 1.00 0.63 1.29 AI651213 0.80 1.00 0.91 1
    34082_at2, 3 U95-A 1 0.50 1.00 0.53 0.83 W28356 0.80 1.00 0.91 1
    48756_at2, 3 U95-C 1 0.31 1.00 0.67 1.13 AL041728 0.40 1.00 0.76 1
    221752_at2, 3 U133-A 1 1.00 1.00 -- -- AL041728 0.40 1.00 0.76 1
    221753_at2, 3 U133-A 1 0.82 1.00 -- -- AI651213 0.80 1.00 0.91 1
    221752_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1555624_a_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    1554274_a_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    221753_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    SSH1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    SSH1 gene expression
    SSH1 gene electronic northern expression
    SSH1 gene sage expression
    About these images

    CGAP SAGE TAG: AGTTGTTTGG

    SOURCE GeneReport for Unigene cluster: Hs.199763

    Expression variation in blood from EXPOLDB for SSH1

    Primers: OriGene genome-wide validated SYBR primer pairs: SSH1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for SSH1: PPH09650A
        SABiosciences Expression via Pathway-Focused PCR Arrays including SSH1: PAHS-045A PAHS-088A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for SSH1 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    SSH11   -- slingshot homolog 1 (Drosophila) 86.42(n)
    85.78(a)
    477526  XM_846619.1  XP_851712.1 
    chimpanzee
    (Pan troglodytes)
    SSH11   -- slingshot homolog 1 (Drosophila) 95.61(n)
    94.54(a)
    467124  XM_522524.2  XP_522524.2 
    cow
    (Bos taurus)
    SSH11   -- slingshot homolog 1 (Drosophila) 84.98(n)
    84.95(a)
    538233  XM_618431.3  XP_618431.3 
    rat
    (Rattus norvegicus)
    Ssh11   -- slingshot homolog 1 (Drosophila) 81.97(n)
    83.2(a)
    304580  XM_222275.4  XP_222275.4 
    mouse
    (Mus musculus)
    Ssh11 , 5 5 (55.82 cM)5
    slingshot homolog 1 (Drosophila)1, 5 82.8(n)1
    84.65(a)1
    2316371  NM_198109.31  NP_932777.21 
     AA3997205  AB0992875  (see all 27)
    About this table        Species with no ortholog for SSH1

    ENSEMBL Gene Tree for SSH1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for SSH1 gene
    DUSP142  DUSP282  DUSP212  SSH22  SSH32  DUSP182  STYX2  

    SSH1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/592 NCBI SNPs in SSH1 are shown (see all 592)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7691471,2
    C,F,109217736(-) ATGGCT/CGGGCG 1 -- int13Minor allele frequency- C:0.28NA EA WA 210
    rs8811791,2
    H109178725(+) CTTTCC/TTGTGC 1 -- ut315Minor allele frequency- T:0.00MN NS EA 602
    rs8885311,2
    C,F,O,A,109220389(+) GTCTCT/CGTGAC 1 -- int111Minor allele frequency- C:0.23MN NA NS EA 900
    rs9336311,2
    --109183084(+) AACATA/GAGGGT 1 -- int10--------
    rs9870441,2
    C,F,A,109250356(+) CGTGAG/AACACA 1 -- int112Minor allele frequency- A:0.39NS EA NA WA 1236
    rs10353171,2
    C,F,A,H,109195024(+) TATGAG/ATATAC 1 -- int110Minor allele frequency- A:0.46NS EA NA WA 632
    rs11069111,2
    C,F,H,109200798(+) TGTCCT/CGGAGG 1 -- int111Minor allele frequency- C:0.30NA EA NS WA 742
    rs14772211,2
    C,F,A,109213309(+) CTGTAG/AAGATG 1 -- int110Minor allele frequency- A:0.34NA EA NS WA 634
    rs15490871,2
    C,F,109201326(+) GCAGGT/CTCAGG 1 -- int17Minor allele frequency- C:0.18EA NS NA 510
    rs18619951,2
    C,H,109193613(+) GGCCCG/AGGAGA 1 -- int112Minor allele frequency- A:0.00MN NS EA NA WA 612
    About this table

    HapMap Linkage Disequilibrium images for SSH1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SSH1
         1 CNV: 5312
         4 Indels: 71575 76146 86560 76147

    QIAGEN SeqTarget long-range PCR primers for resequencing SSH1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SSH1 for disorders           About GeneDecksing

    OMIM: 606778

    Human Gene Mutation Database (HGMD): SSH1
    Human Genome Epidemiology (HuGE) Navigator: SSH1 (1 document)

    Export disorders and mutations for SSH1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/32 PubMed articles for SSH1 gene, integrated from 7 sources (see all 32):
    (articles sorted by number of sources associating them with SSH1)
    1. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. (PubMed id 11832213)1, 2, 3 Niwa R.... Uemura T. (2002)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. (PubMed id 15159416)1, 2, 7 Nagata-Ohashi K.... Mizuno K. (2004)
    4. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. (PubMed id 15671020)1, 2, 7 Wang Y.... Mizuno K. (2005)
    5. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. (PubMed id 12684437)1, 2, 7 Endo M....Mizuno K. (2003)
    6. Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. (PubMed id 12807904)1, 2, 7 Kaji N.... Mizuno K. (2003)
    7. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. (PubMed id 15660133)1, 2, 7 Soosairajah J.... Bernard O. (2005)
    8. Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. (PubMed id 16230460)1, 2, 7 Nishita M.... Mizuno K. (2005)
    9. Efficient Salmonella entry requires activity cycles of host ADF and cofilin. (PubMed id 15056216)1, 2 Dai S.... Zhou D. (2004)
    10. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. (PubMed id 14645219)1, 2 Nishita M....Mizuno K. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54434 HGNC: 30579 AceView: SSH1 Ensembl:ENSG00000084112 euGenes: HUgn54434
    ECgene: SSH1 Kegg: 54434 H-InvDB: SSH1

    (According to HUGE)
    About This Section
    HUGE: KIAA1298

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for SSH1 gene:
    Search GeneIP for patents involving SSH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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     ELISAs and CLIAs for SSH1
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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