Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

ST6GAL2 Gene

protein-coding GIFtS: 45

GC02M101093

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
(Previous name: sialyltransferase 2 (monosialoganglioside sialyltransferase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SIAT2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2¹ ²		St6GalII¹
KIAA1877¹ ² ³ ⁵		FLJ37730²
sialyltransferase 2 (monosialoganglioside sialyltransferase)¹ ²		beta-galactoside alpha-2,6-sialyltransferase II²
Alpha 2,6-ST 2² ³		FLJ38334²
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2² ³		beta-galactoside alpha-2,6-sialyltransferase 2²
SIAT2² ³		FLJ30711²
hST6Gal II² ³		EC 2.4.99.1³
ST6Gal II² ³		Sialyltransferase 2³
ST6GalII² ³		ST6GALII⁵
St6gal2¹

External Ids:	HGNC: 10861¹	Entrez Gene: 84620²	Ensembl: ENSG00000144057⁷	UniProtKB: Q96JF0³

Export aliases for ST6GAL2 gene to outside databases

Previous GC identifers: GC02M106877 GC02M106789 GC02M107418

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ST6GAL2:

Sialyltransferases, such as ST6GAL2 (EC 2.4.99.1), are type II transmembrane proteins that catalyze the transfer of

sialic acid from CMP-sialic acid to an acceptor carbohydrate, usually to the terminal ends of carbohydrate

chains.(supplied by OMIM)

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor

substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc

sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins

and glycolipids

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ST6GAL2 gene promoter:
         Nkx6-1   Nkx3-1 v4   Nkx3-1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   POU3F1   STAT1alpha   STAT1beta   STAT2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for ST6GAL2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ST6GAL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2-q12.1 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q11-q12

ST6GAL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ST6GAL2 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M101093: view genomic region (about GC identifiers)

Start:	101,093,170 bp from pter
End:	101,178,717 bp from pter
Size:	85,548 bases
Orientation:	minus strand

1 alternative location:

Chr2- 107,418,056-107,503,564

RefSeq DNA sequence:

NC_000002.11 NT_022171.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0 (See protein sequence)

Recommended Name: Beta-galactoside alpha-2,6-sialyltransferase 2

Size: 529 amino acids; 60158 Da

Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity)

Sequence caution: Sequence=AAH08680.1; Type=Erroneous initiation; Sequence=BAB47506.1; Type=Erroneous initiation;

Secondary accessions: Q53QP4 Q86Y44 Q8IUG7 Q96HE4

Alternative splicing: 2 isoforms: Q96JF0-1 Q96JF0-2

Explore the universe of human proteins at neXtProt for ST6GAL2: NX_Q96JF0

REFSEQ proteins (3 alternative transcripts):

NP_001135823.1 NP_001135824.1 NP_115917.1

ENSEMBL proteins:

ENSP00000395581 ENSP00000387332 ENSP00000355386 ENSP00000386942 ENSP00000355273

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for ST6GAL2
	Novus Biologicals Protein for ST6GAL2
	Novus Biologicals Lysate for ST6GAL2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	12235148
GO:0030173	integral to Golgi membrane	IEA	--
GO:0032580	Golgi cisterna membrane	IEA	--

About this table

ST6GAL2 for ontologies About GeneDecksing

Antibodies for ST6GAL2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ST6GAL2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for ST6GAL2
	Novus Biologicals Antibody for ST6GAL2
	Browse antibodies at Epitomics

Assays for ST6GAL2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ST6GAL2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ST6GAL2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001675 Glyco_trans_29

IPR011330 Glyco_hydro/deAcase_b/a-brl

Graphical View of Domain Structure for InterPro Entry Q96JF0

ProtoNet protein and cluster: Q96JF0

1 Blocks protein family: IPB001675 Glycosyl transferase

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Similarity: Belongs to the glycosyltransferase 29 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Function: Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor

substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc

sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins

and glycolipids

Catalytic activity: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP +

alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine

Biophysicochemical properties: Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl; KM=0.71 mM for

Gal-beta-1,4-GlcNAc; KM=0.48 mM for lacto-N-neotetraose;

Induction: By IL6/interleukin-6 and IL8//interleukin-8

Enzyme Number (IUBMB): EC 2.4.99.1

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for ST6GAL2 Sigma-Aldrich shRNA for ST6GAL2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ST6GAL2 OriGene shRNA RFP (see all 4): ST6GAL2 OriGene basic RS shRNA (see all 4): ST6GAL2 OriGene siRNA (see all 3): ST6GAL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ST6GAL2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ST6GAL2
		Search SABiosciences for Assays for microRNAs that regulate ST6GAL2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ST6GAL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ST6GAL2 OriGene untagged cDNA clones in CMV expression vector: ST6GAL2 OriGene 3'-UTR clone (see all 3): ST6GAL2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ST6GAL2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for ST6GAL2

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003824	catalytic activity	--	--
GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	IDA	12235148
GO:0008373	sialyltransferase activity	--	--

About this table

ST6GAL2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

ST6GAL2 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for ST6GAL2

N-Glycan Biosynthesis

SABiosciences Custom Pathway-Focused PCR Arrays for ST6GAL2

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for ST6GAL2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ST6GAL2

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	--	--
GO:0006486	protein glycosylation	IEA	--
GO:0007275	multicellular organismal development	NAS	12235148
GO:0009311	oligosaccharide metabolic process	IDA	12235148
GO:0040007	growth	NAS	12235148

About this table

ST6GAL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ST6GAL2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for ST6GAL2 Sigma-Aldrich shRNA for ST6GAL2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): ST6GAL2 OriGene shRNA RFP (see all 4): ST6GAL2 OriGene basic RS shRNA (see all 4): ST6GAL2 OriGene siRNA (see all 3): ST6GAL2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ST6GAL2

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ST6GAL2
		Search SABiosciences for Assays for microRNAs that regulate ST6GAL2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): ST6GAL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): ST6GAL2 OriGene untagged cDNA clones in CMV expression vector: ST6GAL2 OriGene 3'-UTR Clone (see all 3): ST6GAL2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for ST6GAL2

Primers:		OriGene genome-wide validated SYBR primer pairs: ST6GAL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ST6GAL2: PPH10699A

REFSEQ mRNAs for ST6GAL2 gene (3 alternative transcripts):

NM_001142351.1 NM_001142352.1 NM_032528.2

Additional cDNA sequence:

AB058780.1 AB059555.1 AJ512141.1 AK055273.1 AK095049.1 AK095653.1 AK307784.1 BC008680.1

FJ433883.1 FJ433884.1 FJ433885.1

3 DOTS entries:

DT.40257355 DT.91665662 DT.120991405

13 AceView cDNA sequences:

BX327611 AX795201 BE613250 AX795200 AA385852 BE612797 BC008680 AB059555

NM_032528 AX795199 BF038052 BX353569 AJ512141

highest scoring ESTs for ST6GAL2:

AB059555 BC008680 BE612797 AA514734 AB058780 AJ512141 AK055273 AK095049 AK095653 AW004016

Unigene Cluster for ST6GAL2:

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

Hs.98265 [show with all ESTs]

Unigene Representative Sequence: NM_032528

GeneLoc Exon Structure

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419159 ENST00000409087(uc002tds.3) ENST00000361803 ENST00000409382(uc002tdq.2)

ENST00000361686(uc002tdr.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

ST6GAL2 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching ST6GAL2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
47621_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AW004016	0.60	1.00	0.82	1
228821_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW004016	0.60	1.00	0.82	1
228821_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555123_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

ST6GAL2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

ST6GAL2 gene electronic northern expression

About these images

CGAP SAGE TAG: TTTTCATTTG

SOURCE GeneReport for Unigene cluster: Hs.98265

UniProtKB/Swiss-Prot: SIAT2_HUMAN, Q96JF0

Tissue specificity: Weakly expressed in some tissues, such as small intestine, colon and fetal brain

Primers:		OriGene genome-wide validated SYBR primer pairs: ST6GAL2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for ST6GAL2: PPH10699A

SABiosciences Custom PCR Arrays for ST6GAL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ST6GAL2 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ST6GAL2¹	--	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	99.24(n) 99.24(a)	450198 XM_515705.2 XP_515705.2
cow (Bos taurus)	ST6GAL2¹	--	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	78.34(n) 77.39(a)	493992 NM_001008668.1 NP_001008668.1
rat (Rattus norvegicus)	St6gal2¹	--	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	79.3(n) 79.11(a)	301155 XM_236826.2 XP_236826.2
mouse (Mus musculus)	St6gal2^{1 , 5}	17 (28.82 cM)⁵	beta galactoside alpha 2,6 sialyltransferase 2^{1, 5}	77.7(n)¹ 76.09(a)¹	240119¹ NM_172829.2¹ NP_766417.1¹ AB095093⁵ AK054230⁵ (see all 10)
chicken (Gallus gallus)	ST6GAL2¹	--	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	70.71(n) 72.12(a)	403122 XM_416927.2 XP_416927.2

About this table Species with no ortholog for ST6GAL2

ENSEMBL Gene Tree for ST6GAL2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ST6GAL2 gene

ST6GALNAC3² ST6GALNAC5² ST6GAL1² ST6GALNAC4² ST6GALNAC6²

ST6GAL2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs877693^1,2	C,F,A,H,	107446396(+)	`agaaaC/Tacttc`	3	--	int¹		12		NS EA NA WA	552
rs935565^1,2	C,F,H,	107446430(-)	`gttgaG/Aaatac`	3	--	int¹		12		NS EA NA WA	592
rs973116^1,2	F,H	107498502(+)	`ATAATG/AACTGC`	3	--	int¹		4		NS EA	420
rs982913^1,2	C,A,	107496482(+)	`ACATAT/CCTAAT`	3	--	int¹		1		NA	2
rs1034811^1,2	C,F,A,	107503324(+)	`AGTGAC/TTGCAG`	3	--	int¹ ng5¹		6		MN EA NS NA	486
rs1034812^1,2	C,F,A,	107503356(+)	`GCGGGG/ACAGCA`	3	--	int¹ ng5¹		1		MN	184
rs1034813^1,2	C,F,A,	107503532(+)	`CGGCCA/GGGAGG`	3	--	ut5¹ ng5¹ ese³		4		NA EA	362
rs1080210^1,2	--	107435054(+)	`ACCTAG/TAAAGC`	3	--	int¹		0	--	--	--	--
rs1345198^1,2	C,F,O,A,H,	107418036(-)	`TTCGTA/GGAAGT`	2	--	ng3¹		15		NS EA NA WA	1048
rs1349064^1,2	H	107432914(+)	`ACTCAG/AGTTTC`	3	--	int¹		4		NS EA	420

About this table

HapMap Linkage Disequilibrium images for ST6GAL2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ST6GAL2: --

QIAGEN SeqTarget long-range PCR primers for resequencing ST6GAL2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ST6GAL2 for disorders About GeneDecksing

OMIM: 608472

Human Genome Epidemiology (HuGE) Navigator: ST6GAL2 (4 documents)

Export disorders and mutations for ST6GAL2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/17 PubMed articles for ST6GAL2 gene, integrated from 7 sources (see all 17):
(articles sorted by number of sources associating them with ST6GAL2)

Identification and functional expression of a second human beta- galactoside alpha2,6-sialyltransferase, ST6Gal II. (PubMed id 12603328)^{1, 2} Krzewinski-Recchi M.A....Delannoy P. (2003)
Characterization of the second type of human beta-galactoside alpha2,6-sialyltransferase (ST6Gal II) that sialylates Galbeta1,4GlcNAc structures on oligosaccharides preferentially. (PubMed id 12235148)^{1, 2} Takashima S.... Tsujimoto M. (2002)
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)^{1, 2} Nagase T.... Ohara O. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)¹ Ikeda M....Iwata N. (2010)
Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. (PubMed id 19768537)¹ Lehoux S....Krzewinski-Recchi M.A. (2010)
Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)¹ Flachsbart F....Nebel A. (2010 Dec 10)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)² Groux-Degroote S.... Delannoy P. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84620	HGNC: 10861	AceView: ST6GalII	Ensembl:ENSG00000144057	euGenes: HUgn84620
ECgene: ST6GAL2	H-InvDB: ST6GAL2

(According to HUGE)
About This Section

HUGE: KIAA1877

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL2

Intellectual Property for ST6GAL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for ST6GAL2 gene:
Search GeneIP for patents involving ST6GAL2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ST6GAL2		Antibodies for ST6GAL2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ST6GAL2		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of ST6GAL2
	SeqTarget long-range PCR primers for resequencing ST6GAL2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for ST6GAL2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of ST6GAL2

	GenScript Custom Purified and Recombinant Proteins Services for ST6GAL2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ST6GAL2
	GenScript Custom Assay Services for ST6GAL2		GenScript Custom Superior Antibodies Services for ST6GAL2
	GenScript Custom overexpressing Cell Line Services for ST6GAL2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ST6GAL2 promoter
	Search Chromatin IP Primers for ST6GAL2
	RT² qPCR Primer Assay for ST6GAL2
	Search GNC Networks for ST6GAL2
	Search for Assays for microRNAs that regulate ST6GAL2
	SABiosciences Custom PCR Arrays for ST6GAL2

Search Tocris compounds for ST6GAL2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for ST6GAL2
	Proteins for ST6GAL2
	Lysates for ST6GAL2

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

Browse ELISAs and CLIAs at Uscn

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

ST6GAL2 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

ST6GAL2 Gene

protein-coding GIFtS: 45

Aliases &
Descriptions
for ST6GAL2 gene

Summaries
for ST6GAL2 gene

Genomic Views
for ST6GAL2 gene

Proteins
for ST6GAL2 gene

Protein Domains/
Families
for ST6GAL2 gene

Gene Function
for ST6GAL2 gene

Pathways & Interactions
for ST6GAL2 gene

Drugs & Compounds
for ST6GAL2 gene

Transcripts
for ST6GAL2 gene

Expression
for ST6GAL2 gene

Orthologs
for ST6GAL2 gene

Paralogs
for ST6GAL2 gene

Genomic Variants
for ST6GAL2 gene

Disorders & Mutations
for ST6GAL2 gene

Medical News
for ST6GAL2 gene

Publications
for ST6GAL2 gene

External Searches for ST6GAL2 gene

Genome Databases showing ST6GAL2 gene

Other Databases showing ST6GAL2 gene

Specialized Databases showing ST6GAL2 gene

Intellectual Property
for ST6GAL2 gene

Products
for ST6GAL2 gene

View Random Gene

ST6GAL2 (Gene Symbol)
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
KIAA1877
sialyltransferase 2 (monosialoganglioside sialyltransferase)
Alpha 2,6-ST 2
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
SIAT2
hST6Gal II
ST6Gal II
ST6GalII
St6gal2
St6GalII
FLJ37730
beta-galactoside alpha-2,6-sialyltransferase II
FLJ38334
beta-galactoside alpha-2,6-sialyltransferase 2
FLJ30711
EC 2.4.99.1
Sialyltransferase 2
ST6GALII

Advanced Search

Export list of displayed genes

ST6GAL2 Gene

protein-coding GIFtS: 45

Aliases & Descriptionsfor ST6GAL2 gene

Summariesfor ST6GAL2 gene

Genomic Viewsfor ST6GAL2 gene

Proteinsfor ST6GAL2 gene

Protein Domains/Familiesfor ST6GAL2 gene

Gene Functionfor ST6GAL2 gene

Pathways & Interactionsfor ST6GAL2 gene

Drugs & Compoundsfor ST6GAL2 gene

Transcriptsfor ST6GAL2 gene

Expression for ST6GAL2 gene

Orthologsfor ST6GAL2 gene

Paralogsfor ST6GAL2 gene

Genomic Variantsfor ST6GAL2 gene

Disorders & Mutationsfor ST6GAL2 gene

Medical Newsfor ST6GAL2 gene

Publicationsfor ST6GAL2 gene

External Searches for ST6GAL2 gene

Genome Databases showing ST6GAL2 gene

Other Databases showing ST6GAL2 gene

Specialized Databases showing ST6GAL2 gene

Intellectual Propertyfor ST6GAL2 gene

Productsfor ST6GAL2 gene

View Random Gene

Aliases &
Descriptions
for ST6GAL2 gene

Summaries
for ST6GAL2 gene

Genomic Views
for ST6GAL2 gene

Proteins
for ST6GAL2 gene

Protein Domains/
Families
for ST6GAL2 gene

Gene Function
for ST6GAL2 gene

Pathways & Interactions
for ST6GAL2 gene

Drugs & Compounds
for ST6GAL2 gene

Transcripts
for ST6GAL2 gene

Expression
for ST6GAL2 gene

Orthologs
for ST6GAL2 gene

Paralogs
for ST6GAL2 gene

Genomic Variants
for ST6GAL2 gene

Disorders & Mutations
for ST6GAL2 gene

Medical News
for ST6GAL2 gene

Publications
for ST6GAL2 gene

Intellectual Property
for ST6GAL2 gene

Products
for ST6GAL2 gene