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STC1 Gene

protein-coding GIFtS: 53

GC08M022244

stanniocalcin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: STC)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
stanniocalcin 1¹ ²
STC² ³ ⁵
STC-1² ³
stanniocalcin-1²

External Ids:	HGNC: 11373¹	Entrez Gene: 6781²	Ensembl: ENSG00000159167⁷	UniProtKB: P52823³

Export aliases for STC1 gene to outside databases

Previous GC identifers: GC08M023432 GC08M024052 GC08M023721 GC08M023755

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STC1:

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have

autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein

contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues.

The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell

metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high

serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular,

ovarian, and breast cancers. (provided by RefSeq)

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823

Function: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia

Gene Wiki entry for STC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the STC1 gene promoter:
         CREB   deltaCREB   NF-kappaB   NF-kappaB1   STAT5B   GR-alpha   GR-beta   SRF   Bach1   C/EBPalpha
         Other transcription factors

Search SABiosciences Chromatin IP Primers for STC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21-p11.2 Ensembl cytogenetic band: 8p21.2 HGNC cytogenetic band: 8p22-p12

STC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STC1 gene location

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M022244: view genomic region (about GC identifiers)

Start:	22,244,578 bp from pter
End:	22,257,479 bp from pter
Size:	12,902 bases
Orientation:	minus strand

1 alternative location:

Chr8- 23,699,428-23,712,320

RefSeq DNA sequence:

NC_000008.10 NT_167187.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823 (See protein sequence)

Recommended Name: Stanniocalcin-1 precursor

Size: 247 amino acids; 27621 Da

Subunit: Homodimer; disulfide-linked (By similarity)

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for STC1: NX_P52823

REFSEQ proteins: NP_003146.1

ENSEMBL proteins:

ENSP00000290271 ENSP00000427932

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: STC1
	GenScript Custom Purified and Recombinant Proteins Services for STC1
	Novus Biologicals Protein for STC1
	Novus Biologicals Lysate for STC1
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for STC1

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

About this table

STC1 for ontologies About GeneDecksing

Antibodies for STC1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for STC1
	R&D Systems Antibodies for STC1 (Stanniocalcin 1/STC-1)
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	GenScript Custom Superior Antibodies Services for STC1
	Novus Biologicals Antibodies for STC1
	Browse antibodies at Epitomics

Assays for STC1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for STC1 (Stanniocalcin 1/STC-1)
	GenScript Custom Assay Services for STC1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for STC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

STC1 for domains About GeneDecksing

1 InterPro domain/family:

IPR004978 Stanniocalcin

Graphical View of Domain Structure for InterPro Entry P52823

ProtoNet protein and cluster: P52823

1 Blocks protein family: IPB004978 Stanniocalcin

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823

Similarity: Belongs to the stanniocalcin family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823

Function: Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for STC1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for STC1 Sigma-Aldrich shRNA for STC1
		OriGene 29mer shRNA kits in GFP-retroviral vector: STC1 OriGene shRNA RFP: STC1 OriGene basic RS shRNA: STC1 OriGene siRNA: STC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STC1

miRNA:		Sigma-Aldrich microRNA Mimics for STC1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STC1
		8/18 SABiosciences Assays for microRNAs that regulate STC1 (see all 18):
		hsa-miR-1178 hsa-miR-142-5p hsa-miR-106a hsa-miR-93 hsa-miR-1252 hsa-miR-1208 hsa-miR-17 hsa-miR-190

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: STC1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: STC1 OriGene untagged cDNA clones in CMV expression vector (see all 2): STC1 OriGene 3'-UTR clone: STC1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: STC1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for STC1

Genatlas biochemistry entry for STC1:

stanniocalcin,homolog of a calcium regulating hormone in bony fishes,putative regulator of mineral homeostasis,likely

by stimulation of phosphate uptake by the renal tubule,expressed in both endochondral and membrane bone

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--

About this table

STC1 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Stc1):

endocrine/exocrine gland

growth/size

normal

reproductive system

STC1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for STC1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for STC1

5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0006874	cellular calcium ion homeostasis	TAS	8700837
GO:0007166	cell surface receptor linked signaling pathway	TAS	8700837
GO:0007267	cell-cell signaling	TAS	8700837
GO:0007584	response to nutrient	TAS	8700837

About this table

STC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

STC1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for STC1
10/12 Novoseek chemical compound relationships for STC1 gene (see all 12)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	57.3	94	9458778 (5), 7829534 (5), 12663264 (4), 18828660 (3) (see all 40)
progesterone	26.6	6	15131261 (4), 14512426 (1), 16391703 (1)
estradiol	5.83	3	15131261 (2), 11832417 (1)
gtp	4.37	1	17092635 (1)
dexamethasone	3.71	8	18187254 (3), 11739016 (1), 12933688 (1)
estrogen	1.28	4	18355956 (1), 15062564 (1), 14503913 (1)
atp	0	8	20422040 (4), 17092635 (2)
glucose	0	1	19389948 (1)
steroid	0	2	10854706 (1), 15476934 (1)
potassium	0	1	16640646 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for STC1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for STC1 Sigma-Aldrich shRNA for STC1
		OriGene 29mer shRNA kits in GFP-retroviral vector: STC1 OriGene shRNA RFP: STC1 OriGene basic RS shRNA: STC1 OriGene siRNA: STC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STC1

miRNA:		Sigma-Aldrich microRNA Mimics for STC1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STC1
		8/18 SABiosciences Assays for microRNAs that regulate STC1 (see all 18):
		hsa-miR-1178 hsa-miR-142-5p hsa-miR-106a hsa-miR-93 hsa-miR-1252 hsa-miR-1208 hsa-miR-17 hsa-miR-190

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: STC1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: STC1 OriGene untagged cDNA clones in CMV expression vector (see all 2): STC1 OriGene 3'-UTR Clone: STC1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: STC1

Primers:		OriGene genome-wide validated SYBR primer pairs: STC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for STC1: PPH08618A

REFSEQ mRNAs for STC1 gene:

NM_003155.2

Additional cDNA sequence:

AK297734.1 AK309366.1 AK312589.1 BC029044.1 S50179.1 S50184.1 U25997.1 U46768.1

2 DOTS entries:

DT.413453 DT.203705

24/186 AceView cDNA sequences (see all 186):

BX490288 AI564094 BM686190 CA424944 BF434960 CA842388 BM720350 AI492382

BE048556 CA434552 CB126047 BM727706 AU279405 BQ000658 AI634794 BU729854

AW001652 AW771275 AI521159 BM662762 AA912316 BE349059 BQ011881 CA842913

highest scoring ESTs for STC1:

U25997 AL710960 AU279405 AW954342 AW965863 BC029044 BI764976 BI918756 BM311087 BM311682

Unigene Cluster for STC1:

Stanniocalcin 1

Hs.25590 [show with all ESTs]

Unigene Representative Sequence: U25997

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000290271(uc003xdw.1) ENST00000524323

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

STC1 expression in normal and diseased human tissues

¹ / ² / ³

7 probe-sets matching STC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41354_at²^{, 3}	U95-A	1	0.88	1.00	1.00	1.00	U25997	1.00	1.00	1.00	1
204597_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_003155	0.60	1.00	0.82	1
204596_s_at²^{, 3}	U133-A	1	0.64	1.00	--	--	U46768	0.80	1.00	0.91	1
204595_s_at²^{, 3}	U133-A	1	0.46	1.00	--	--	AI300520	0.40	1.00	0.76	1
204597_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
204596_s_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
204595_s_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

STC1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

STC1 gene electronic northern expression

About these images

CGAP SAGE TAG: GTAATGACAG

SOURCE GeneReport for Unigene cluster: Hs.25590

Expression variation in blood from EXPOLDB for STC1

UniProtKB/Swiss-Prot: STC1_HUMAN, P52823

Tissue specificity: Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid.

In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the

collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla

Primers:		OriGene genome-wide validated SYBR primer pairs: STC1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for STC1: PPH08618A

SABiosciences Custom PCR Arrays for STC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for STC1 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	STC1¹	--	stanniocalcin 1	94.47(n) 98.38(a)	486112 XM_543238.2 XP_543238.2
chimpanzee (Pan troglodytes)	STC1¹	--	stanniocalcin 1	99.6(n) 100(a)	472719 XM_528091.2 XP_528091.1
cow (Bos taurus)	STC1¹	--	stanniocalcin 1	92.04(n) 95.14(a)	338078 NM_176669.3 NP_788842.2
rat (Rattus norvegicus)	Stc1¹	--	stanniocalcin 1	91.5(n) 95.95(a)	81801 NM_031123.2 NP_112385.1
mouse (Mus musculus)	Stc1^{1 , 5}	14 (35.98 cM)⁵	stanniocalcin 1^{1, 5}	91.63(n)¹ 96.36(a)¹	20855¹ NM_009285.3¹ NP_033311.3¹ AF099098⁵ AK134260⁵ (see all 13)

About this table Species with no ortholog for STC1

ENSEMBL Gene Tree for STC1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for STC1 gene

STC2²

STC1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs61053^1,2	C,F,O,A,H,	23704295(+)	`ACATTT/GTCCAA`	1	--	int¹		108		NA NS EA PA EU CA WA	6676
rs167458^1,2	--	23711712(-)	`CTGGAC/TGCTCT`	1	--	int¹		3		EA NA	60
rs183385^1,2	--	23709383(-)	`CTAGCA/GTACTA`	1	--	int¹		5		EA NA MN	334
rs310311^1,2	C,F,A,H,	23699321(+)	`TATGTC/GAAATT`	1	--	ng3¹		9		EA NA WA	264
rs310313^1,2	--	23703264(+)	`GCCAAA/TTCCTA`	1	--	int¹		0	--	--	--	--
rs310314^1,2	C,A,H,	23704157(+)	`GTGGCC/ACAGCA`	1	--	int¹		7		NA WA	14
rs310328^1,2	--	23710615(-)	`GCATAA/GGGAGG`	1	--	int¹		0	--	--	--	--
rs310329^1,2	--	23710774(+)	`TTCTCC/TTCTGA`	1	--	int¹		0	--	--	--	--
rs423432^1,2	C,F,O,H,	23707047(+)	`ATAATG/AGCCTG`	1	--	int¹		14		EA NA WA	372
rs433613^1,2	--	23712216(+)	`gtgccG/Tccgct`	1	--	ut5¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for STC1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for STC1: --

QIAGEN SeqTarget long-range PCR primers for resequencing STC1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

STC1 for disorders About GeneDecksing

OMIM: 601185

10/14 Novoseek disease relationships for STC1 gene (see all 14)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypercalcemia	58.6	10	8700837 (1), 9041047 (1), 12406069 (1), 11134638 (1) (see all 9)
dwarfism	37.5	1	16377640 (1)
minimal residual disease	25.2	3	15383693 (2), 16637567 (1)
breast cancer	23	19	12684415 (6), 18355956 (2), 16637567 (1), 15062564 (1) (see all 8)
fibrosarcoma	19	3	10947959 (3)
tumors	14.8	16	16109785 (3), 12684415 (2), 10717250 (2), 18355956 (1) (see all 11)
pheochromocytoma	10.2	2	10937775 (1)
ovarian cancer	8.13	8	20484106 (3), 16109785 (1), 14503913 (1)
cancer	7.94	29	16109785 (3), 12684415 (3), 10717250 (3), 17395153 (3) (see all 12)
metastasis	2.73	8	12684415 (1), 16330944 (1), 18355956 (1), 19515379 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: STC1 (4 documents)

Export disorders and mutations for STC1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/109 PubMed articles for STC1 gene, integrated from 7 sources (see all 109):
(articles sorted by number of sources associating them with STC1)

Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. (PubMed id 9480753)^{1, 3, 7} Chang A.C....Reddel R.R. (1998)
Human stanniocalcin: a possible hormonal regulator of mineral metabolism. (PubMed id 8700837)^{1, 2, 7} Olsen H.S....Wagner G.F. (1996)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel human cDNA highly homologous to the fish hormone stanniocalcin. (PubMed id 7489828)^{1, 2} Chang A.C.-M.... Reddel R.R. (1995)
Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. (PubMed id 15131261)^{1, 7} Luo C.W....Hsueh A.J. (2004)
Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. (PubMed id 18309109)^{1, 7} Chen C....Yao Q. (2008)
Upregulated expression of stanniocalcin-1 during adipogenesis. (PubMed id 15149855)^{1, 7} Serlachius M. and Andersson L.C. (2004)
Stanniocalcin 1 and ovarian tumorigenesis. (PubMed id 20484106)^{1, 7} Liu G....Liu J. (2010 Jun 2)
Low-resolution structural studies of human Stanniocal cin-1. (PubMed id 19712479)^{1, 7} Trindade D.M....Kobarg J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6781	HGNC: 11373	AceView: STC1	Ensembl:ENSG00000159167	euGenes: HUgn6781
ECgene: STC1	H-InvDB: STC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for STC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for STC1 gene:
Search GeneIP for patents involving STC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for STC1		Antibodies for STC1
	Super-pooled esiRNAs for STC1		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for STC1		microRNA Mimics for STC1
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Nano Scale siRNA for STC1
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies for STC1 (Stanniocalcin 1/STC-1)		Cell Culture Products
	ELISAs for STC1 (Stanniocalcin 1/STC-1)		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
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	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STC1
	SeqTarget long-range PCR primers for resequencing STC1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STC1

	GenScript Custom Purified and Recombinant Proteins Services for STC1		GenScript cDNA clones with any tag delivered in your preferred vector for STC1
	GenScript Custom Assay Services for STC1		GenScript Custom Superior Antibodies Services for STC1
	GenScript Custom overexpressing Cell Line Services for STC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in STC1 promoter
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	RT² qPCR Primer Assay for STC1
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for STC1
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Browse antibodies at Epitomics

Recombinant Protein for STC1

ELISAs and CLIAs for STC1

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

STC1 gene at Home site.

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STC1 Gene

protein-coding GIFtS: 53

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STC1 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor STC1 gene

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Protein Domains/Familiesfor STC1 gene

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for STC1 gene

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for STC1 gene

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for STC1 gene

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for STC1 gene

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for STC1 gene

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for STC1 gene

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for STC1 gene

Transcripts
for STC1 gene

Expression
for STC1 gene

Orthologs
for STC1 gene

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for STC1 gene

Genomic Variants
for STC1 gene

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for STC1 gene

Medical News
for STC1 gene

Publications
for STC1 gene

Intellectual Property
for STC1 gene

Products
for STC1 gene