Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



STIP1 Gene

protein-coding   GIFtS: 66

GC11P060283
stress-induced-phosphoprotein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
stress-induced-phosphoprotein 11 2     NY-REN-11 antigen2
STI11 2 3     STI1L2
HOP1 2 5     Hsp70/Hsp90-organizing protein2
Transformation-sensitive protein IEF SSP 35212 3     IEF-SSP-35212
Hsc70/Hsp90-organizing protein2 3     P602
Renal carcinoma antigen NY-REN-112 3     Hop3

External Ids:    HGNC: 113871   Entrez Gene: 109632   Ensembl: ENSG000001684397   UniProtKB: P319483   

Export aliases for STIP1 gene to outside databases

Previous GC identifers: GC11P066389 GC11M065612 GC11P064203 GC11P063728 GC11P063729 GC11P063709 GC11P063953


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for STIP1:
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1;
MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding
both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase
activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and
Masison, 2005 (PubMed 16100115)).(supplied by OMIM)

UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948
Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

Gene Wiki entry for STIP1 (Hop)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the STIP1 gene promoter:
         GR-alpha   GR-beta   PPAR-gamma1   PPAR-gamma2   Sp1   TGIF   Max1   CUTL1   c-Myc   C/EBPbeta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for STIP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for STIP1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

STIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
STIP1 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060283:  view genomic region     (about GC identifiers)

Start:
60,281,678 bp from pter
End:
60,300,086 bp from pter
Size:
18,409 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 63,953,297-63,972,020     
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948 (See protein sequence)
Recommended Name: Stress-induced-phosphoprotein 1  
Size: 543 amino acids; 62639 Da
Subunit: Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
PDB structures from and Proteopedia :
1ELR (3D)    1ELW (3D)    3ESK (3D)    3FWV (3D)    
Secondary accessions: Q5TZU9

Explore the universe of human proteins at neXtProt for STIP1: NX_P31948 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006810.1  

    ENSEMBL proteins: 
    ENSP00000305958 ENSP00000351646 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for STIP1
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for STIP1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for STIP1 
    Novus Biologicals Proteins for STIP1
    Novus Biologicals Lysate for STIP1
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for STIP1

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus TAS16130169
    GO:0005737 cytoplasm IEA--
    GO:0005794 Golgi apparatus TAS1569099
    About this table

    STIP1 for ontologies           About GeneDecksing



    Antibodies for STIP1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for STIP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for STIP1  (Hop)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for STIP1 
    Novus Biologicals Antibodies for STIP1
    Epitomics antibodies for STIP1

    Assays for STIP1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for STIP1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for STIP1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    STIP1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006636 STI1_HS-bd
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013026 TPR-contain
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P31948

    ProtoNet protein and cluster: P31948

    2 Blocks protein families:
    IPB006636 Heat shock chaperonin-binding
    IPB011595 TPR-related region


    UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948
    Domain: The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain)
    and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90
    Similarity: Contains 2 STI1 domains
    Similarity: Contains 9 TPR repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948
    Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for STIP1
    Sigma-Aldrich shRNA for STIP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): STIP1
    OriGene shRNA RFP (see all 2): STIP1
    OriGene basic RS shRNA (see all 2): STIP1
    OriGene siRNA: STIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STIP1 
    miRNA:Sigma-Aldrich microRNA Mimics for STIP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STIP1 
    Search SABiosciences for Assays for microRNAs that regulate STIP1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: STIP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: STIP1
    OriGene untagged cDNA clones in CMV expression vector: STIP1
    OriGene 3'-UTR clone: STIP1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for STIP1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for STIP1 

    Genatlas biochemistry entry for STIP1:
    stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles in
    normal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    About this table

    STIP1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    STIP1 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  STIP1
        NRF2-mediated Oxidative Stress Response

    1 Kegg Pathway  (Kegg details for STIP1):
        hsa05020 Prion diseases

        SABiosciences Custom Pathway-Focused PCR Arrays for STIP1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for STIP1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STIP1

    5/6 Interacting proteins for STIP1 (P319481, 2 ENSP000003516463) via UniProtKB, MINT, and/or STRING (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NME2P223921EBI-1054052,EBI-713693
    WDR8Q9P2S51EBI-1054052,EBI-1054904
    CAMK2DQ135572MINT-6538664
    NEDD4LQ96PU52MINT-3975796
    HSP90AA1ENSP000003351533STRING: ENSP00000335153
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950 response to stress TAS1569099
    GO:0007411 axon guidance TAS--
    About this table

    STIP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    STIP1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for STIP1
    3 Novoseek chemical compound relationships for STIP1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 44.2 8 9148915 (3), 15632128 (3), 8939864 (1), 8952474 (1)
    progesterone 29.6 2 8423808 (1), 8776728 (1)
    atp 20.1 2 9774640 (1), 18485364 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA for STIP1
    Sigma-Aldrich shRNA for STIP1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): STIP1
    OriGene shRNA RFP (see all 2): STIP1
    OriGene basic RS shRNA (see all 2): STIP1
    OriGene siRNA: STIP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STIP1 
    miRNA: Sigma-Aldrich microRNA Mimics for STIP1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STIP1 
    Search SABiosciences for Assays for microRNAs that regulate STIP1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: STIP1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: STIP1
    OriGene untagged cDNA clones in CMV expression vector: STIP1
    OriGene 3'-UTR Clone: STIP1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for STIP1 
    Primers: OriGene genome-wide validated SYBR primer pairs: STIP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for STIP1: PPH05938A

    REFSEQ mRNAs for STIP1 gene: 

    NM_006819.2  

    Additional cDNA sequence: 

    AK225736.1 AK291555.1 AK297319.1 BC002987.1 BC039299.1 BT020010.1 BT020011.1 CR536512.1 
    M86752.1 

    24/29 DOTS entries (see all 29):

    DT.451602  DT.100882073  DT.95374467  DT.97775969  DT.95374463  DT.100882075  DT.120739457  DT.120739511 
    DT.95374458  DT.95374465  DT.100038988  DT.120739452  DT.95374455  DT.120739455  DT.120739492  DT.99938805 
    DT.100882085  DT.95374456  DT.95374459  DT.97860864  DT.100882079  DT.100882082  DT.101961882  DT.120739500 

    24/739 AceView cDNA sequences (see all 739):

    BU930911 CD671643 BQ070547 CF618929 BE892798 BU839366 F05071 BU931084 
    BM772547 BU528559 BM757991 BM758752 BE889642 BU553536 BM045693 BM758094 
    BQ690191 BM555563 C21181 BM763322 BI255545 BU931948 AU142411 BM712282 

    highest scoring ESTs for STIP1:

    M86752 AA100285 AA160517 AA161464 AA310376 AA320169 AA455112 AA559100 AA565439 AA596050 

    Unigene Cluster for STIP1:

    Stress-induced-phosphoprotein 1
    Hs.337295  [show with all ESTs]
    Unigene Representative Sequence: BC039299


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 (see all 9)

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ·
    SP1:        -     -     -     -     -                                         -     -                                                                           
    SP2:                          -     -                                         -     -                                                                           
    SP3:                                                                                                                                                            
    SP4:                          -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -                     
    SP5:                                                                                                                                                            

    ExUns: 18c · 18d
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for STIP1
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305218(uc001nyj.2 uc001nyk.1 uc010rnb.1) ENST00000358794


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    STIP1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching STIP1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    207_at2, 3 U95-A 2 1.00 0.94 1.00 1.00 M86752 1.00 1.00 1.00 1
    212009_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL553320 0.60 1.00 0.82 1
    213330_s_at2, 3 U133-A 2 1.00 0.95 -- -- BE886580 0.80 1.00 0.91 1
    212009_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    213330_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    About this table

    STIP1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    STIP1 gene expression
    STIP1 gene electronic northern expression
    STIP1 gene sage expression
    About these images

    CGAP SAGE TAG: TTATGGGGAG

    SOURCE GeneReport for Unigene cluster: Hs.337295

    Expression variation in blood from EXPOLDB for STIP1

    Primers: OriGene genome-wide validated SYBR primer pairs: STIP1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for STIP1: PPH05938A
        SABiosciences Custom PCR Arrays for STIP1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for STIP1 gene from 5/25 species (see all 25)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    STIP11   -- stress-induced-phosphoprotein 1 91.16(n)
    97.61(a)
    474837  XM_849867.1  XP_854960.1 
    chimpanzee
    (Pan troglodytes)
    STIP11   -- stress-induced-phosphoprotein 1 99.82(n)
    100(a)
    451286  XM_508521.2  XP_508521.2 
    cow
    (Bos taurus)
    STIP11   -- stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing more 90.18(n)
    97.61(a)
    617109  NM_001035492.1  NP_001030569.1 
    rat
    (Rattus norvegicus)
    Stip11   -- stress-induced phosphoprotein 1 88.77(n)
    97.61(a)
    192277  NM_138911.2  NP_620266.1 
    mouse
    (Mus musculus)
    Stip11 , 5 19 (5.15 cM)5
    stress-induced phosphoprotein 11, 5 88.21(n)1
    97.42(a)1
    208671  NM_016737.11  NP_058017.11 
     AK0759885  AK0884945  (see all 24)
    About this table        Species with no ortholog for STIP1

    ENSEMBL Gene Tree for STIP1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for STIP1 gene
    TTC122  

    STIP1 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/181 NCBI SNPs in STIP1 are shown (see all 181)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs147881,2
    C,F63971880(+) AGTTGG/TTTTTT 1 -- ut315Minor allele frequency- T:0.01MN NS EA 604
    rs10496901,2
    --63971805(+) GGTCTC/TTTCAC 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
    rs20702321,2
    C,F,63970625(+) GCTGCA/GCTGGA 2 A syn1 ref1 ese315Minor allele frequency- T:0.00NA NS EA 1386
    rs22366471,2
    C,F,A,H,63964605(+) GCTGAC/TTGATG 1 -- int124Minor allele frequency- T:0.47EA NA NS WA 3292
    rs22366481,2
    C,F,A,H,63964657(+) AGTTGC/TATTTC 1 -- int120Minor allele frequency- T:0.34EA NA MN NS WA 4108
    rs22824901,2
    C,F,63962152(+) TCCTGC/TAACCT 1 -- int128Minor allele frequency- N:0.00EA NA NS 4846
    rs25152391,2
    C,63964944(+) TCCTTC/TTTAAC 1 -- int10--------
    rs27015271,2
    F,63954970(+) TTTTGG/ATGTGA 1 -- int11Minor allele frequency- A:0.05NA 90
    rs27015281,2
    C,F,63957070(+) CCACAA/GTGATA 1 -- int16Minor allele frequency- G:0.04NS EA NA WA 560
    rs27015391,2
    C,F,63963378(+) GACCAT/GGATTA 1 -- int12Minor allele frequency- G:0.05NA EA 160
    About this table

    HapMap Linkage Disequilibrium images for STIP1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for STIP1
         1 CNV: 4751

    QIAGEN SeqTarget long-range PCR primers for resequencing STIP1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    STIP1 for disorders           About GeneDecksing

    OMIM: 605063

    1 Novoseek disease relationship for STIP1 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 51.9 12 8776728 (2), 11281722 (1), 16894550 (1), 17267421 (1) (see all 8)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: STIP1 (2 documents)

    Export disorders and mutations for STIP1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/78 PubMed articles for STIP1 gene, integrated from 7 sources (see all 78):
    (articles sorted by number of sources associating them with STIP1)
    1. Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress- inducible yeast protein STI1. (PubMed id 1569099)1, 2, 3, 7 Honore B....Celis J.E. (1992)
    2. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PubMed id 10786835)1, 2, 7 Scheufler C.... Moarefi I. (2000)
    3. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
    8. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
    9. Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
    10. Structural studies on the co-chaperone Hop and its complexes with Hsp90. (PubMed id 18485364)1, 7 Onuoha S.C....Jackson S.E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10963 HGNC: 11387 AceView: STIP1 Ensembl:ENSG00000168439 euGenes: HUgn10963
    ECgene: STIP1 Kegg: 10963 H-InvDB: STIP1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for STIP1 gene:
    Search GeneIP for patents involving STIP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for STIP1 Antibodies for STIP1
     Explore super-pooled esiRNAs Proteins for STIP1
     Lentivirus-delivered shRNAs for STIP1 microRNA Mimics for STIP1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of STIP1
     SeqTarget long-range PCR primers for resequencing STIP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for STIP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of STIP1
     GenScript Custom Purified and Recombinant Proteins Services for STIP1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for STIP1
     GenScript Custom Assay Services for STIP1 GenScript Custom Superior Antibodies Services for STIP1
     GenScript Custom overexpressing Cell Line Services for STIP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for STIP1  (Hop)

     Regulatory tfbs in STIP1 promoter
     Search Chromatin IP Primers for STIP1
     RT2 qPCR Primer Assay for STIP1
     GNC Network for STIP1
     Search for Assays for microRNAs that regulate STIP1
     SABiosciences Custom PCR Arrays for STIP1
     Search Tocris compounds for STIP1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Proteins for STIP1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for STIP1
     Proteins for STIP1
     Lysates for STIP1
     Antibodies for STIP1
     Recombinant Protein for STIP1

     ELISAs and CLIAs for STIP1
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    STIP1 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4