Aliases &
Descriptions
for STIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| stress-induced-phosphoprotein 11 2 | | NY-REN-11 antigen2 | | STI11 2 3 | | STI1L2 | | HOP1 2 5 | | Hsp70/Hsp90-organizing protein2 | | Transformation-sensitive protein IEF SSP 35212 3 | | IEF-SSP-35212 | | Hsc70/Hsp90-organizing protein2 3 | | P602 | | Renal carcinoma antigen NY-REN-112 3 | | Hop3 |
Export aliases for STIP1 gene to outside databasesPrevious GC identifers: GC11P066389 GC11M065612 GC11P064203 GC11P063728 GC11P063729 GC11P063709 GC11P063953 |
Summaries
for STIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for STIP1:
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1;MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by bindingboth HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPaseactivity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song andMasison, 2005 (PubMed 16100115)).(supplied by OMIM)
UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)
Gene Wiki entry for STIP1 (Hop) |
Genomic Views
for STIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the STIP1 gene promoter:
GR-alpha GR-beta PPAR-gamma1 PPAR-gamma2 Sp1 TGIF Max1 CUTL1 c-Myc C/EBPbeta
Other transcription factors
Search SABiosciences Chromatin IP Primers for STIP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for STIP1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13STIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060283: view genomic region
(about GC identifiers)
Start:
|
60,281,678 bp from pter |
End:
|
60,300,086 bp from pter |
Size:
|
18,409 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 63,953,297-63,972,020 |
RefSeq DNA sequence:- NC_000011.9 NT_167190.1
|
Proteins
for STIP1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948 (See
protein sequence)Recommended Name: Stress-induced-phosphoprotein 1 Size: 543 amino acids; 62639 Da
Subunit: Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity)
PDB structures from  and Proteopedia  :1ELR (3D)
1ELW (3D)
3ESK (3D)
3FWV (3D)
Secondary accessions: Q5TZU9Explore the universe of human proteins at neXtProt for STIP1: NX_P31948
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006810.1
ENSEMBL proteins: ENSP00000305958 ENSP00000351646
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
STIP1 for ontologies About GeneDecksing
Antibodies for STIP1:
Assays for STIP1: |
Protein
Domains/
Families
for STIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
STIP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P31948ProtoNet protein and cluster: P31948 2 Blocks protein families: IPB006636 Heat shock chaperonin-binding IPB011595 TPR-related region
UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948Domain: The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain)and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90Similarity: Contains 2 STI1 domainsSimilarity: Contains 9 TPR repeats |
Gene Function
for STIP1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: STIP1_HUMAN, P31948Function: Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB)
Genatlas biochemistry entry for STIP1:stress-induced-phosphoprotein (Hsp70/Hsp90-organizing protein),localized in the Golgi apparatus and small vesicles innormal fibroblasts and in the nucleus of SV40 transformed MRC-5 fibroblasts1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
STIP1 for ontologies About GeneDecksing
|
Pathways & Interactions
for STIP1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
STIP1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for STIP1
1  Kegg Pathway (Kegg details for STIP1):
SABiosciences Custom Pathway-Focused PCR Arrays for STIP1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for STIP1
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for STIP1
5/6 Interacting proteins for STIP1 (P319481, 2 ENSP000003516463) via UniProtKB, MINT, and/or STRING (see all 6)About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
STIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for STIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
STIP1 for compounds About GeneDecksing
 Browse Tocris compounds for STIP1
3  Novoseek chemical compound relationships for STIP1 gene
About this table
|
Transcripts
for STIP1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for STIP1 gene: NM_006819.2 Additional cDNA sequence: AK225736.1 AK291555.1 AK297319.1 BC002987.1 BC039299.1 BT020010.1 BT020011.1 CR536512.1 M86752.1 24/29 DOTS entries (see all 29): DT.451602 DT.100882073 DT.95374467 DT.97775969 DT.95374463 DT.100882075 DT.120739457 DT.120739511 DT.95374458 DT.95374465 DT.100038988 DT.120739452 DT.95374455 DT.120739455 DT.120739492 DT.99938805 DT.100882085 DT.95374456 DT.95374459 DT.97860864 DT.100882079 DT.100882082 DT.101961882 DT.120739500 24/739 AceView cDNA sequences (see all 739): BU930911 CD671643 BQ070547 CF618929 BE892798 BU839366 F05071 BU931084 BM772547 BU528559 BM757991 BM758752 BE889642 BU553536 BM045693 BM758094 BQ690191 BM555563 C21181 BM763322 BI255545 BU931948 AU142411 BM712282
 highest scoring ESTs for STIP1:M86752 AA100285 AA160517 AA161464 AA310376 AA320169 AA455112 AA559100 AA565439 AA596050 Unigene Cluster for STIP1: Stress-induced-phosphoprotein 1 Hs.337295 [show with all ESTs]Unigene Representative Sequence: BC039299
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for STIP1 (see all 9)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for STIP1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305218(uc001nyj.2 uc001nyk.1 uc010rnb.1) ENST00000358794
|
Expression
for STIP1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| STIP1 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching STIP1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 207_at2, 3
|
U95-A |
2 |
1.00 |
0.94 |
1.00 |
1.00 |
M86752 |
1.00 |
1.00 |
1.00 |
1 |
| 212009_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AL553320 |
0.60 |
1.00 |
0.82 |
1 |
| 213330_s_at2, 3
|
U133-A |
2 |
1.00 |
0.95 |
-- |
-- |
BE886580 |
0.80 |
1.00 |
0.91 |
1 |
| 212009_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213330_s_at2
|
U133Plus2 |
2 |
1.00 |
0.95 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
STIP1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTATGGGGAG
SOURCE GeneReport for Unigene cluster: Hs.337295
Expression variation in blood from EXPOLDB for STIP1 SABiosciences Custom PCR Arrays for STIP1
|
Orthologs
for STIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for STIP1 gene from 5/25 species (see all 25)
About this table Species with no ortholog for STIP1
ENSEMBL Gene Tree for STIP1 (if available) |
Paralogs
for STIP1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for STIP1 gene
- TTC122
STIP1 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for STIP1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for STIP1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for STIP1
1 CNV: 4751 | | QIAGEN SeqTarget long-range PCR primers for resequencing STIP1 |
|
Disorders & Mutations
for STIP1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
STIP1 for disorders About GeneDecksing
OMIM: 605063
1 Novoseek disease relationship for STIP1 gene
About this table
Human Genome Epidemiology (HuGE) Navigator: STIP1 (2 documents)
Export disorders and mutations for STIP1 gene to outside databases
|
Medical News
for STIP1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for STIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/78 PubMed articles for STIP1 gene, integrated from 7 sources (see all 78):
(articles sorted by number of sources associating them with STIP1)- Molecular cloning and expression of a transformation-sensitive human protein containing the TPR motif and sharing identity to the stress- inducible yeast protein STI1. (PubMed id 1569099)1, 2, 3, 7 Honore B....Celis J.E. (1992)
- Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PubMed id 10786835)1, 2, 7 Scheufler C.... Moarefi I. (2000)
- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
- Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (1999)
- Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. (PubMed id 1286667)1, 2 Rasmussen H.H....Vandekerckhove J. (1992)
- Structural studies on the co-chaperone Hop and its complexes with Hsp90. (PubMed id 18485364)1, 7 Onuoha S.C....Jackson S.E. (2008)
|
External Searches for STIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing STIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing STIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing STIP1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for STIP1 gene:
Search GeneIP for patents involving STIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for STIP1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
 | Antibodies & Assays for STIP1 (Hop) |
| | | | Search Tocris compounds for STIP1 |
| |  |  |  |  | | | | | | Recombinant Protein for STIP1 |
|
 | | | ELISAs and CLIAs for STIP1 |
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