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TAB3 Gene

protein-coding   GIFtS: 52

GC0XM028586
TGF-beta activated kinase 1/MAP3K7 binding protein 3
(Previous name: mitogen-activated protein kinase kinase kinase 7 interacting protein 3 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAP3K7IP3)
Products    

Aliases &
Descriptions
for TAB3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
TGF-beta activated kinase 1/MAP3K7 binding protein 31 2     NAP12
mitogen-activated protein kinase kinase kinase 7 interacting protein 31 2     TGF-beta-activated kinase 1 and MAP3K7-binding protein 32
TAK1-binding protein 32 3     MGC454042
TGF-beta-activated kinase 1-binding protein 32 3     OTTHUMP000000231122
TAB-32 3     NFkB activating protein 12
MAP3K7IP32 3     Mitogen-activated protein kinase kinase kinase 7-interacting protein 33
NF-kappa-B-activating protein 12 3     

External Ids:    HGNC: 306811   Entrez Gene: 2573972   Ensembl: ENSG000001576257   UniProtKB: Q8N5C83   

Export aliases for TAB3 gene to outside databases

Previous GC identifers: GC0XM030209 GC0XM030608 GC0XM030845


Summaries
for TAB3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TAB3:
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar
and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and
either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent
MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.
The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but
their biological validity has not been determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and
TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an
oncogenic factor

Gene Wiki entry for TAB3 (MAP3K7IP3)

Genomic Views
for TAB3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TAB3
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TAB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TAB3 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.2   Ensembl cytogenetic band:  Xp21.2   HGNC cytogenetic band: Xp21.2

TAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAB3 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM028586:  view genomic region     (about GC identifiers)

Start:
 28,586,659 bp from pter
End:
 28,648,837 bp from pter
Size:
 62,179 bases
Orientation:
 minus strand

1 alternative location:
ChrX- 30,845,559-30,993,201     
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  

Proteins
for TAB3 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8 (See protein sequence)
Recommended Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3  
Size: 712 amino acids; 78683 Da
Subunit: Interacts with TAB1, TAB2, MAP3K7, TRAF2 and TRAF6. The minimal TAB3-containing complex (TAB1-MAP3K7-TAB3)
appears not to contain TAB2. However, it seems sensible to consider that TAB2 may also join this complex and may act
in a cooperative manner with TAB3. Interacts with WDR34 (via the WD domains). Interacts with RBCK1
Secondary accessions: A6NDD9 Q6VQR0
Alternative splicing: 2 isoforms:  Q8N5C8-1   Q8N5C8-2   

Explore the universe of human proteins at neXtProt for TAB3: NX_Q8N5C8 

Post-translational modifications:

  • Ubiquitinated; following IL1 stimulation or TRAF6 overexpression1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_690000.2  

    ENSEMBL proteins: 
    ENSP00000411920 ENSP00000288422 ENSP00000368210 ENSP00000368212 ENSP00000368214 ENSP00000368215 
    ENSP00000395174 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TAB3 
    Novus Biologicals Proteins for TAB3
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005829 cytosol TAS--
    GO:0005886 plasma membrane TAS--
    GO:0010008 endosome membrane TAS--
    About this table

    TAB3 for ontologies           About GeneDecksing



    Antibodies for TAB3: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAB3
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TAB3 
    Novus Biologicals Antibodies for TAB3
    Browse antibodies at Epitomics

    Assays for TAB3: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAB3 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 

    Protein Domains/
    Families
    for TAB3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAB3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001876 Znf_RanBP2
     IPR003892 CUE

    Graphical View of Domain Structure for InterPro Entry Q8N5C8

    ProtoNet protein and cluster: Q8N5C8

    2 Blocks protein families:
    IPB001876 Zn-finger
    IPB003892 Ubiquitin system component Cue


    UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
    Similarity: Contains 1 CUE domain
    Similarity: Contains 1 RanBP2-type zinc finger


    Gene Function
    for TAB3 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
    Function: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and
    TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an
    oncogenic factor

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TAB3
    Sigma-Aldrich shRNA for TAB3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TAB3
    OriGene shRNA RFP (see all 3): TAB3
    OriGene basic RS shRNA (see all 3): TAB3
    OriGene siRNA (see all 2): TAB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAB3 
    miRNA:Sigma-Aldrich microRNA Mimics for TAB3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAB3 
    Search SABiosciences for Assays for microRNAs that regulate TAB3

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TAB3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TAB3
    OriGene untagged cDNA clones in CMV expression vector: TAB3
    OriGene 3'-UTR clone: TAB3 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TAB3 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for TAB3 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17158449
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    TAB3 for ontologies           About GeneDecksing


    Pathways & Interactions
    for TAB3 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TAB3 for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for TAB3):
        hsa04621 NOD-like receptor signaling pathway

        SABiosciences Custom Pathway-Focused PCR Arrays for TAB3 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAB3

    4 Interacting proteins for TAB3 (ENSP000002884223 Q8N5C81, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7O433182STRING: ENSP00000358335 MINT-49237 MINT-48036
    C21orf7P570772MINT-67362
    TRAF6ENSP000003378533STRING: ENSP00000337853
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187 activation of MAPK activity TAS--
    GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0007254 JNK cascade TAS--
    GO:0034138 toll-like receptor 3 signaling pathway TAS--
    GO:0045087 innate immune response TAS--
    About this table

    TAB3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAB3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TAB3 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAB3
    1 Novoseek chemical compound relationship for TAB3 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-2 97.5 25 14670075 (6), 14633987 (5), 19927120 (3), 19955178 (3) (see all 7)
    About this table



    Transcripts
    for TAB3 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TAB3
    Sigma-Aldrich shRNA for TAB3
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TAB3
    OriGene shRNA RFP (see all 3): TAB3
    OriGene basic RS shRNA (see all 3): TAB3
    OriGene siRNA (see all 2): TAB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAB3 
    miRNA: Sigma-Aldrich microRNA Mimics for TAB3
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAB3 
    Search SABiosciences for Assays for microRNAs that regulate TAB3
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TAB3
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TAB3
    OriGene untagged cDNA clones in CMV expression vector: TAB3
    OriGene 3'-UTR Clone: TAB3 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TAB3 
    Primers: OriGene genome-wide validated SYBR primer pairs: TAB3
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for TAB3

    REFSEQ mRNAs for TAB3 gene: 

    NM_152787.3  

    Additional cDNA sequence: 

    AK096786.1 AK297274.1 AL832071.1 AY371491.1 AY437560.1 BC032526.1 

    6 DOTS entries:

    DT.97806119  DT.97799162  DT.75130520  DT.101981398  DT.121304684  DT.86840948 

    24/71 AceView cDNA sequences (see all 71):

    BQ025617 CB163503 BG493286 BX456736 AY371491 C00236 AW518138 BP375414 
    BM450259 BU688642 AW148358 AI470410 AI421406 AI419265 AI733853 BG436116 
    BC032526 BU861012 BF939787 BI493769 BU849692 AW614074 AY331591 BI092372 

    Unigene Cluster for TAB3:

    TGF-beta activated kinase 1/MAP3K7 binding protein 3
    Hs.188256  [show with all ESTs]
    Unigene Representative Sequence: AL832071


    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TAB3

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                          
    SP2:                          -               

    About this scheme

    ECgene alternative splicing isoforms for TAB3
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000452127 ENST00000288422 ENST00000378928 ENST00000378930 ENST00000378932
    ENST00000378933(uc004dcj.2 uc004dck.2 uc010ngl.2) ENST00000427195
    ENST00000467136

    Expression
    for TAB3 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TAB3 expression in normal and diseased human tissues

    1  / 2

    8 probe-sets matching TAB3 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    47843_at2 U95-B 1 1.00 1.00 0.73 0.86 -- -- -- -- --
    88365_at2 U95-E 1 0.88 1.00 0.78 0.56 -- -- -- -- --
    76839_at2 U95-E 1 0.62 1.00 0.85 1.59 -- -- -- -- --
    227357_at2 U133-B 1 0.46 1.00 -- -- -- -- -- -- --
    1552928_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    1552927_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    227357_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    1558518_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    About this table

    TAB3 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TAB3 gene expression
    TAB3 gene electronic northern expression
    TAB3 gene sage expression
    About these images

    CGAP SAGE TAG: CATCGTACCT

    SOURCE GeneReport for Unigene cluster: Hs.188256

    UniProtKB/Swiss-Prot: TAB3_HUMAN, Q8N5C8
    Tissue specificity: Widely expressed. Constitutively overexpressed in certain tumor tissues. Isoform 1 is a major
    transcript while isoform 2 is a minor transcript

    Primers: OriGene genome-wide validated SYBR primer pairs: TAB3
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for TAB3
        SABiosciences Custom PCR Arrays for TAB3 


    Orthologs
    for TAB3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TAB3 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 MAP3K7IP31   -- mitogen-activated protein kinase kinase kinase 7 interacting more 94.76(n)
    97.75(a)    		 491807  XM_548926.2  XP_548926.1 
    mouse
    (Mus musculus)    		 Tab35
    Map3k7ip31    		 X (39.32 cM)5
    		 TGF-beta activated kinase 1/MAP3K7 binding protein more5
    mitogen-activated protein kinase kinase kinase 7 interacting more1    		 92.51(n)1
    95.22(a)1    		 667241  NM_025729.31  NP_080005.21 
     AK0108185  AK0149705  (see all 16)
    chicken
    (Gallus gallus)    		 MAP3K7IP31   -- mitogen-activated protein kinase kinase kinase 7 interacting more 81.77(n)
    84.94(a)    		 418588  XM_416787.2  XP_416787.2 
    zebrafish
    (Danio rerio)    		 Dr.112502   -- Transcribed sequence with weak similarity to protein more 76.19(n)  57096212 
    African clawed frog
    (Xenopus laevis)    		 AF549911.12   --   -- 77.34(n)  AF549911.1 
    About this table        Species with no ortholog for TAB3

    ENSEMBL Gene Tree for TAB3 (if available)

    Paralogs
    for TAB3 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TAB3 gene
    TAB22  

    TAB3 for paralogs           About GeneDecksing



    Genomic Variants
    for TAB3 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/258 NCBI SNPs in TAB3 are shown (see all 258)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs14828331,2
    		C,A,30858827(+) tgtgaT/Ggcccg 1 -- int13Minor allele frequency- G:0.00NA 4
    rs19052041,2
    		C,F,O,H,30854525(+) TAACAT/GCAAGC 1 -- int1 ese310Minor allele frequency- G:0.12MN NS EA NA WA 614
    rs23065301,2
    		C,F30848628(-) TTGGAA/TATCTT 1 -- ut313Minor allele frequency- T:0.11EA NS 298
    rs28679741,2
    		C,F,A,H30863641(+) ttgaaA/Gcacaa 1 -- int1 ese37Minor allele frequency- G:0.47NS EA NA 302
    rs38167571,2
    		C,F30848956(-) ACAAAC/GAAAAT 1 -- ut317Minor allele frequency- G:0.21NS EA NA 533
    rs39231111,2
    		C,F,A,H,30908845(-) CTCTGC/TGATAC 1 -- ng517Minor allele frequency- T:0.38NS EA NA WA 428
    rs42870881,2
    		C,F30904584(+) ATTGCC/TCATCA 1 -- int17Minor allele frequency- T:0.06NS EA NA 509
    rs44560191,2
    		C,A,30882924(+) TGTTTG/TTTTTT 1 -- int1 trp31Minor allele frequency- T:0.50NA 2
    rs45017411,2
    		C,H30884845(+) ggtggG/Cgggag 1 -- int14Minor allele frequency- C:0.00NS EA 418
    rs45781231,2
    		C,F,H30897188(+) taaaaA/Tggtat 1 -- int14Minor allele frequency- T:0.01NS EA 418
    About this table

    HapMap Linkage Disequilibrium images for TAB3 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TAB3
         1 CNV: 3265

    QIAGEN SeqTarget long-range PCR primers for resequencing TAB3 

    Disorders & Mutations
    for TAB3 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAB3 for disorders           About GeneDecksing

    OMIM: 300480

    2 Novoseek disease relationships for TAB3 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 44.7 3 14766965 (2), 18021073 (1)
    tumors 13.3 2 14766965 (2)
    About this table

    Locus Specific Mutation Databases (LSDB): TAB3

    Export disorders and mutations for TAB3 gene to outside databases

    Medical News
    for TAB3 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for TAB3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/20 PubMed articles for TAB3 gene, integrated from 7 sources (see all 20):
    (articles sorted by number of sources associating them with TAB3)
    1. TAB3, a new binding partner of the protein kinase TAK1. (PubMed id 14670075)1, 2, 3, 7 Cheung P.C.... Cohen P. (2004)
    2. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. (PubMed id 14633987)1, 2, 3, 7 Ishitani T....Matsumoto K. (2003)
    3. Identification of a human NF-kappaB-activating protein, TAB3. (PubMed id 14766965)1, 2, 7 Jin G.... Sherf B. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PubMed id 17449468)2, 7 Tian Y....Shu H.B. (2007)
    6. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. (PubMed id 17158449)1, 7 Besse A....Darnay B.G. (2007)
    7. WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)2 Gao D....Chen D.Y. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    External Searches for TAB3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing TAB3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 257397 HGNC: 30681 AceView: TAB3 Ensembl:ENSG00000157625 euGenes: HUgn257397
    ECgene: TAB3 Kegg: 257397 H-InvDB: TAB3

    Other Databases showing TAB3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAB3 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for TAB3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for TAB3 gene:
    Search GeneIP for patents involving TAB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TAB3 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TAB3 Antibodies for TAB3
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     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAB3
     SeqTarget long-range PCR primers for resequencing TAB3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TAB3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAB3
     GenScript Custom Purified and Recombinant Proteins Services for TAB3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TAB3
     GenScript Custom Assay Services for TAB3 GenScript Custom Superior Antibodies Services for TAB3
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     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for TAB3
     Search Chromatin IP Primers for TAB3
     Search RT2 qPCR Primer Assays for TAB3
     Search GNC Networks for TAB3
     Search for Assays for microRNAs that regulate TAB3
     SABiosciences Custom PCR Arrays for TAB3
     Search Tocris compounds for TAB3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for TAB3
     Proteins for TAB3
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

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