Aliases &
Descriptions
for TACR3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| tachykinin receptor 31 2 3 | | MGC1480612 | | NK3R1 2 3 5 | | neurokinin beta receptor2 | | Neurokinin B receptor2 3 | | neuromedin-K receptor2 | | NKR2 3 | | TAC3RL2 | | NK-3R2 3 | | MGC1480602 | | NK-3 receptor2 3 | | TAC3R3 |
Export aliases for TACR3 gene to outside databasesPrevious GC identifers: GC04M104909 GC04M104969 GC04M104868 GC04M104730 GC04M104507 |
Summaries
for TACR3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TACR3:
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified byvariations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactionswith G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin3, also referred to as neurokinin B. (provided by RefSeq)
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with Gproteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of thisreceptor to tachykinins is: neuromedin-K > substance K > substance P
 summary
for TACR3: The neurokinin (NK) 3 receptor is a member of the tachykinin family of G-protein-coupled receptors which
also includes NK1 and NK2 receptors. The NK3 receptor is predominantly expressed in the CNS (hippocampus,
hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery.
NK3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The
receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P
(NKB > NKA > SP). The human gene encoding the NK3 receptor has been localized on chromosome 4 (4q25).
Gene Wiki entry for TACR3 (Tachykinin receptor 3) |
Genomic Views
for TACR3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TACR3 gene promoter:
E2F-3a E2F E2F-1 E2F-2 E2F-4 E2F-5 HOXA9B Meis-1 POU3F2 POU3F2 (N-Oct-5a)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TACR3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q25 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q25TACR3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M100245: view genomic region
(about GC identifiers)
Start:
|
100,245,509 bp from pter |
End:
|
100,375,866 bp from pter |
Size:
|
130,358 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr4- 104,507,188-104,640,973 |
RefSeq DNA sequence:- NC_000004.11 NT_016354.19
|
Proteins
for TACR3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371 (See
protein sequence)Recommended Name: Neuromedin-K receptor Size: 465 amino acids; 52202 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q0P510Explore the universe of human proteins at neXtProt for TACR3: NX_P29371
Post-translational modifications:
The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue1
REFSEQ proteins: NP_001050.1
ENSEMBL proteins: ENSP00000303325
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TACR3 for ontologies About GeneDecksing
Antibodies for TACR3:
Assays for TACR3: |
Protein
Domains/
Families
for TACR3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TACR3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P29371ProtoNet protein and cluster: P29371 2 Blocks protein families: IPB001013 Neurokinin NK3 receptor signature IPB001681 Neurokinin receptor signature
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Similarity: Belongs to the G-protein coupled receptor 1 family |
Gene Function
for TACR3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NK3R_HUMAN, P29371Function: This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with Gproteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of thisreceptor to tachykinins is: neuromedin-K > substance K > substance P
Cell
Lines: |  | GenScript TACR3-overexpressing Cell Line for Assay |
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
IEA | -- | | GO:0004995 | tachykinin receptor activity |
IEA | -- |
About this table
TACR3 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tacr3):
TACR3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TACR3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TACR3 for pathways About GeneDecksing
1  Millipore Pathway for TACR3
2  Kegg Pathways (Kegg details for TACR3):  | hsa04020 Calcium signaling pathway | | hsa04080 Neuroactive ligand-receptor interaction |
SABiosciences Pathway-Focused PCR Array including TACR3: PAHS-3009A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TACR3
5/6 Interacting proteins for TACR3 (ENSP000003033253) via UniProtKB, MINT, and/or STRING (see all 6)About this table
5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0007217 | tachykinin receptor signaling pathway |
TAS | 8990205 | | GO:0007568 | aging |
IEA | -- | | GO:0010460 | positive regulation of heart rate |
IEA | -- | | GO:0032355 | response to estradiol stimulus |
IEA | -- |
About this table
TACR3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TACR3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
TACR3 for compounds About GeneDecksing
Compounds for TACR3 available from Tocris Bioscience
| Compound | Action |
CAS
number |
|---|
| SB 222200 | Potent, selective non-peptide NK3 antagonist. Brain penetrant | [174635-69-9] | | SB 218795 | Potent, selective non-peptide NK3 antagonist | [174635-53-1] | | Senktide | Tachykinin NK3 agonist | [106128-89-6] |
About this table
10/32  Novoseek chemical compound relationships for TACR3 gene (see all 32)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| senktide |
96.5 |
58 |
8751080 (3), 7530208 (2), 8990205 (2), 15145080 (2) (see all 37) |
| sr 142801 |
89.7 |
10 |
7616392 (3), 14718265 (1), 11602685 (1), 9723948 (1) (see all 7) |
| talnetant |
86.5 |
6 |
17728699 (3), 18822303 (1), 15023866 (1) |
| sr48968 |
86.4 |
6 |
8117304 (1), 14718265 (1), 7616392 (1), 9831720 (1) (see all 5) |
| gr 73632 |
85.2 |
1 |
16077032 (1) |
| eledoisin |
83.1 |
3 |
16127708 (1), 7824047 (1) |
| septide |
81.8 |
2 |
8583573 (1), 9846636 (1) |
| gr 82334 |
76.2 |
1 |
12906840 (1) |
| atropine |
65.6 |
2 |
7516254 (1), 11691869 (1) |
| capsaicin |
64.5 |
9 |
10807884 (2), 10543438 (1), 16328494 (1), 12906840 (1) (see all 7) |
About this table
|
Transcripts
for TACR3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TACR3 gene: NM_001059.2 Additional cDNA sequence: AY462099.1 BC095527.1 BC121806.1 BC122551.1 M89473.1 2 DOTS entries: DT.304094 DT.101980157 3 AceView cDNA sequences: AL700003 NM_001059 M89473
 highest scoring ESTs for TACR3:M89473 AY462099 CD246197 CD013878 NM_001059 AL700003 BC095527 BC121806 BC122551 CO960674 Unigene Cluster for TACR3: Tachykinin receptor 3 Hs.942 [show with all ESTs]Unigene Representative Sequence: M89473
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304883(uc003hxe.1)
|
Expression
for TACR3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TACR3 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching TACR3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32446_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
1.00 |
1.00 |
M89473 |
1.00 |
1.00 |
1.00 |
1 |
| 208183_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_001059 |
0.60 |
1.00 |
0.82 |
1 |
| 208183_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TACR3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTAGCCTCCA
SOURCE GeneReport for Unigene cluster: Hs.942
Expression variation in blood from EXPOLDB for TACR3 SABiosciences Expression via Pathway-Focused PCR Array including TACR3: PAHS-3009A
|
Orthologs
for TACR3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TACR3 gene from 5/9 species (see all 9)
About this table Species with no ortholog for TACR3
ENSEMBL Gene Tree for TACR3 (if available) |
Paralogs
for TACR3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TACR3 gene
- GPR832 PROKR22 CCKBR2 TACR22 TACR12 PROKR12 CCKAR2
TACR3 for paralogs About GeneDecksing
|
Genomic Variants
for TACR3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 4 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TACR3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TACR3
1 CNV: 63911 | | QIAGEN SeqTarget long-range PCR primers for resequencing TACR3 |
|
Disorders & Mutations
for TACR3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TACR3 for disorders About GeneDecksing
OMIM: 162332 disorders: 146110
5 Novoseek disease relationships for TACR3 gene
About this table
GeneTests: TACR3
Hypogonadotropic Hypogonadism
Human Gene Mutation Database (HGMD): TACR3
Human Genome Epidemiology (HuGE) Navigator: TACR3 (6 documents)
Export disorders and mutations for TACR3 gene to outside databases
|
Medical News
for TACR3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TACR3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/213 PubMed articles for TACR3 gene, integrated from 7 sources (see all 213):
(articles sorted by number of sources associating them with TACR3)- cDNA sequence and heterologous expression of the human neurokinin-3 receptor. (PubMed id 1374246)1, 2, 3 Huang R.-R.C.... Fong T.M. (1992)
- The primary structure and gene organization of human substance P and neuromedin K receptors. (PubMed id 1312928)1, 2, 7 Takahashi K.... Nakanishi S. (1992)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular characterisation, expression and localisation of human neurokinin-3 receptor. (PubMed id 1312036)1, 2 Buell G.... Kawashima E. (1992)
- The tachykinin receptor 3 is associated with alcohol and cocaine dependence. (PubMed id 18422838)1, 7 Foroud T....Edenberg H.J. (2008)
- An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population. (PubMed id 18287949)1, 7 Saito S....Ozaki N. (2008)
- Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists. (PubMed id 8990205)1, 7 Krause J.E....Karpitskiy V.V. (1997)
- Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. (PubMed id 19755480)1, 7 Guran T....Topaloglu A.K. (2009)
- TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. (PubMed id 19079066)1, 7 Topaloglu A.K....Semple R.K. (2009)
- Expression and coupling of neurokinin receptor subtypes to inositol phosphate and calcium signaling pathways in human airway smooth muscle cells. (PubMed id 18203813)1, 7 Mizuta K....Emala C.W. (2008)
|
External Searches for TACR3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TACR3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TACR3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TACR3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TACR3 gene:
Search GeneIP for patents involving TACR3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TACR3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
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 |  |  |  | |
| |  | Tocris compounds for TACR3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for TACR3 |
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