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TACSTD2 Gene

protein-coding   GIFtS: 56

GC01M057151
tumor-associated calcium signal transducer 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: M1S1)
Products    

Aliases &
Descriptions
for TACSTD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
tumor-associated calcium signal transducer 21 2     GA73312
TROP21 2 3 5     pancreatic carcinoma marker protein GA73312
GA733-11 2 3     GP502
M1S12 3 5     membrane component, chromosome 1, surface marker 12
EGP-11 2     40kD glycoprotein, identified by monoclonal antibody GA7332
Cell surface glycoprotein Trop-22 3     epithelial glycoprotein-12
Pancreatic carcinoma marker protein GA733-12 3     EGP12
Membrane component chromosome 1 surface marker 12 3     gastrointestinal tumor-associated antigen GA73312
cell surface glycoprotein TROP22     

External Ids:    HGNC: 115301   Entrez Gene: 40702   Ensembl: ENSG000001842927   UniProtKB: P097583   

Export aliases for TACSTD2 gene to outside databases

Previous GC identifers: GC01M058957 GC01M057955 GC01M058398 GC01M058411 GC01M058412 GC01M058752 GC01M058813 GC01M059041


Summaries
for TACSTD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TACSTD2:
This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces
calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.

UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
Function: May function as a growth factor receptor

Gene Wiki entry for TACSTD2

Genomic Views
for TACSTD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TACSTD2 gene promoter:
         Nkx2-2   deltaCREB   CREB   ATF6   NF-kappaB1   AhR   Arnt   POU3F2   CUTL1   LCR-F1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TACSTD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TACSTD2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32

TACSTD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TACSTD2 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M057151:  view genomic region     (about GC identifiers)

Start:
 57,151,670 bp from pter
End:
 57,153,741 bp from pter
Size:
 2,072 bases
Orientation:
 minus strand

1 alternative location:
Chr1- 59,041,099-59,043,166     
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  

Proteins
for TACSTD2 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758 (See protein sequence)
Recommended Name: Tumor-associated calcium signal transducer 2 precursor  
Size: 323 amino acids; 35709 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q15658 Q6FG48 Q7Z7Q4 Q96QD2

Explore the universe of human proteins at neXtProt for TACSTD2: NX_P09758 

Post-translational modifications:

  • The N-terminus is blocked1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002344.2  

    ENSEMBL proteins: 
    ENSP00000360269 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    R&D Systems Recombinant & Natural Proteins for TACSTD2 (TROP-2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TACSTD2
    OriGene Protein Over-expression Lysate: TACSTD2
    GenScript Custom Purified and Recombinant Proteins Services for TACSTD2 
    Novus Biologicals Proteins for TACSTD2
    Novus Biologicals Lysate for TACSTD2
    Sino Biological Recombinant Protein for TACSTD2
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol TAS10192395
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS7665234
    GO:0016020 membrane TAS8382772
    About this table

    TACSTD2 for ontologies           About GeneDecksing



    Antibodies for TACSTD2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TACSTD2
    R&D Systems Antibodies for TACSTD2 (TROP-2)
    OriGene Antibodies: TACSTD2
    GenScript Custom Superior Antibodies Services for TACSTD2 
    Novus Biologicals Antibodies for TACSTD2
    Browse antibodies at Epitomics

    Assays for TACSTD2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TACSTD2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TACSTD2 

    Protein Domains/
    Families
    for TACSTD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TACSTD2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry P09758

    ProtoNet protein and cluster: P09758

    1 Blocks protein family: IPB000716 Thyroglobulin type-1

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Similarity: Belongs to the EPCAM family
    Similarity: Contains 1 thyroglobulin type-1 domain


    Gene Function
    for TACSTD2 gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Function: May function as a growth factor receptor

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TACSTD2
    Sigma-Aldrich shRNA for TACSTD2
    OriGene 29mer shRNA kits in GFP-retroviral vector: TACSTD2
    OriGene shRNA RFP: TACSTD2
    OriGene basic RS shRNA: TACSTD2
    OriGene siRNA: TACSTD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TACSTD2 
    miRNA:Sigma-Aldrich microRNA Mimics for TACSTD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TACSTD2 
    Search SABiosciences for Assays for microRNAs that regulate TACSTD2

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TACSTD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TACSTD2
    OriGene untagged cDNA clones in CMV expression vector: TACSTD2
    OriGene 3'-UTR clone: TACSTD2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TACSTD2 
    Sino Biological Human cDNA Clone for TACSTD2

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for TACSTD2 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity TAS7665234
    About this table

    TACSTD2 for ontologies           About GeneDecksing


    Pathways & Interactions
    for TACSTD2 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for TACSTD2 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TACSTD2

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166 cell surface receptor linked signaling pathway TAS7665234
    GO:0007601 visual perception IEA--
    GO:0008283 cell proliferation TAS7665234
    GO:0050896 response to stimulus IEA--
    About this table

    TACSTD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TACSTD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TACSTD2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TACSTD2
    3 Novoseek chemical compound relationships for TACSTD2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aspartate 9.35 3 15254496 (1), 11687514 (1)
    calcium 2.1 4 15305371 (1), 20454699 (1), 16232198 (1), 19693293 (1)
    alanine 2.07 3 15254496 (1), 11687514 (1)
    About this table



    Transcripts
    for TACSTD2 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TACSTD2
    Sigma-Aldrich shRNA for TACSTD2
    OriGene 29mer shRNA kits in GFP-retroviral vector: TACSTD2
    OriGene shRNA RFP: TACSTD2
    OriGene basic RS shRNA: TACSTD2
    OriGene siRNA: TACSTD2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TACSTD2 
    miRNA: Sigma-Aldrich microRNA Mimics for TACSTD2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TACSTD2 
    Search SABiosciences for Assays for microRNAs that regulate TACSTD2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TACSTD2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TACSTD2
    OriGene untagged cDNA clones in CMV expression vector: TACSTD2
    OriGene 3'-UTR Clone: TACSTD2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TACSTD2 
    Primers: OriGene genome-wide validated SYBR primer pairs: TACSTD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TACSTD2: PPH05688A

    REFSEQ mRNAs for TACSTD2 gene: 

    NM_002353.2  

    Additional cDNA sequence: 

    BC009409.1 BT007255.1 CR542260.1 X13425.1 X77753.1 

    7 DOTS entries:

    DT.450146  DT.95276450  DT.99927981  DT.121426551  DT.97813372  DT.92440454  DT.95183330 

    24/302 AceView cDNA sequences (see all 302):

    AI004919 AW070311 AW261984 AW006838 AI738946 AI741714 BF916400 W68600 
    BE122900 BE736713 AA371367 BM825095 CB850579 BG260715 AA035667 BU683241 
    BM129041 H22330 AA468519 BG259850 H29722 AA041184 AA056370 AA429148 

    highest scoring ESTs for TACSTD2:

    X77753 AA045944 AA115151 AA159538 AA235686 AA291648 AA320951 AA401708 AA401961 AA411472 

    Unigene Cluster for TACSTD2:

    Tumor-associated calcium signal transducer 2
    Hs.23582  [show with all ESTs]
    Unigene Representative Sequence: X77753


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371225(uc001cyz.3)

    Expression
    for TACSTD2 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TACSTD2 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching TACSTD2 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    291_s_at2, 3 U95-A 1 0.94 1.00 1.00 1.30 J04152 0.20 1.00 0.72 1
    41286_at2, 3 U95-A 1 0.50 1.00 0.89 0.74 X77753 1.00 1.00 1.00 1
    202286_s_at2, 3 U133-A 1 0.82 1.00 -- -- J04152 0.20 1.00 0.72 1
    202285_s_at2, 3 U133-A 1 0.64 1.00 -- -- AI627697 0.80 1.00 0.91 1
    202286_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    202285_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    TACSTD2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TACSTD2 gene expression
    TACSTD2 gene electronic northern expression
    TACSTD2 gene sage expression
    About these images

    CGAP SAGE TAG: GCCTACCCGA

    SOURCE GeneReport for Unigene cluster: Hs.23582

    Expression variation in blood from EXPOLDB for TACSTD2

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758
    Tissue specificity: Placenta, pancreatic carcinoma cell lines

    Primers: OriGene genome-wide validated SYBR primer pairs: TACSTD2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TACSTD2: PPH05688A
        SABiosciences Custom PCR Arrays for TACSTD2 


    Orthologs
    for TACSTD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TACSTD2 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TACSTD21   -- tumor-associated calcium signal transducer 2 88.3(n)
    84.04(a)    		 610286  XM_847749.1  XP_852842.1 
    chimpanzee
    (Pan troglodytes)    		 TACSTD21   -- tumor-associated calcium signal transducer 2 99.69(n)
    99.69(a)    		 456890  XM_513439.2  XP_513439.2 
    cow
    (Bos taurus)    		 TACSTD21   -- tumor-associated calcium signal transducer 2 86.31(n)
    80.56(a)    		 539853  XM_589840.3  XP_589840.1 
    rat
    (Rattus norvegicus)    		 Tacstd21   -- tumor-associated calcium signal transducer 2 81.6(n)
    80.76(a)    		 494343  NM_001009540.2  NP_001009540.2 
    mouse
    (Mus musculus)    		 Tacstd21 , 5 6 (30.88 cM)5
    		 tumor-associated calcium signal transducer 21, 5 81.28(n)1
    79.81(a)1    		 567531  NM_020047.31  NP_064431.21 
     AA3873195  AI3241755  (see all 18)
    About this table        Species with no ortholog for TACSTD2

    ENSEMBL Gene Tree for TACSTD2 (if available)

    Paralogs
    for TACSTD2 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TACSTD2 gene
    EPCAM2  

    TACSTD2 for paralogs           About GeneDecksing



    Genomic Variants
    for TACSTD2 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/74 NCBI SNPs in TACSTD2 are shown (see all 74)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs10201,2
    		--59041592(-) CAGTGA/C/TAGGAA 1 -- ut31 trp31--10
    rs35511,2
    		C,F,A,59041577(-) TGGCAT/CAGCGT 1 -- ut318Minor allele frequency- C:0.43MN NA EA WA 770
    rs73331,2
    		C,F,A,59041220(-) TTACTG/ACCACT 1 -- ut31 ese314Minor allele frequency- A:0.23MN NS EA NA WA 1210
    rs95831,2
    		C,F,59041436(-) ATTTGA/GTGAGT 1 -- ut319Minor allele frequency- G:0.11MN NS EA NA WA 904
    rs132671,2
    		F59042430(-) GGCGTG/CCGCCG 2 /V syn1 ref1 ese31Minor allele frequency- C:0.01MN 184
    rs140081,2
    		C,F,A,59042181(-) GGTGAC/AGTGGA 2 /E /D mis1 ref1 ese314Minor allele frequency- A:0.10MN EA NS NA WA 2826
    rs2328321,2
    		C,F,59045119(-) gagacG/Atagct 1 -- ng511Minor allele frequency- A:0.04WA 50
    rs2328331,2
    		C,F,A,H59044561(-) aaaaAG/AAAATT 1 -- ng512Minor allele frequency- A:0.33NA WA 6
    rs2328341,2
    		C,A,H59044408(-) caggcG/Ttgatg 1 -- ng516Minor allele frequency- T:0.08NA WA 12
    rs2328351,2
    		C,A,59042882(-) CCCCGA/CCGAGT 1 -- ut51 ese33Minor allele frequency- C:0.04EA NA WA 26
    About this table

    HapMap Linkage Disequilibrium images for TACSTD2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TACSTD2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing TACSTD2 

    Disorders & Mutations
    for TACSTD2 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TACSTD2 for disorders           About GeneDecksing

    OMIM: 137290   disorders: 204870  

    UniProtKB/Swiss-Prot: TACD2_HUMAN, P09758

  • Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD) [MIM:204870]; also known as
    • lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid
    deposits that cause severe visual impairment

    9 Novoseek disease relationships for TACSTD2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    amyloidosis, corneal 97.3 15 11004271 (4), 15295654 (2), 17653040 (2), 19693293 (2) (see all 8)
    corneal dystrophy 87.9 10 17721311 (2), 12614764 (2), 11687514 (2), 15013888 (1) (see all 7)
    lattice corneal dystrophy 81 1 12700042 (1)
    gastrointestinal carcinoma 64 1 11058587 (1)
    ovarian carcinoma 37.2 1 19053170 (1)
    carcinoma 30 5 7665234 (2), 2333300 (1), 15355929 (1), 14999147 (1)
    pancreatic cancer 17.4 1 10473862 (1)
    tumors 1.99 2 9586666 (1), 10881691 (1)
    adenocarcinoma 0 1 16232198 (1)
    About this table

    Human Gene Mutation Database (HGMD): TACSTD2
    Genetic Association Database (GAD): TACSTD2

    Export disorders and mutations for TACSTD2 gene to outside databases

    Medical News
    for TACSTD2 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for TACSTD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/64 PubMed articles for TACSTD2 gene, integrated from 7 sources (see all 64):
    (articles sorted by number of sources associating them with TACSTD2)
    1. Retroposition in a family of carcinoma-associated antigen genes. (PubMed id 8382772)1, 2, 3, 7 Linnenbach A.J.... Huebner K. (1993)
    2. A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. (PubMed id 11687514)1, 2, 7 Tasa G.... Lang A. (2001)
    3. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. (PubMed id 7665234)1, 2, 7 Fornaro M.... Alberti S. (1995)
    4. Compound heterozygous mutations of M1S1 gene in gelatinous droplike corneal dystrophy. (PubMed id 15013888)1, 4, 7 Tian X....Liu Z. (2004)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. (PubMed id 11306819)1, 3 Calabrese G....Alberti S. (2001)
    8. Identification of the gene responsible for gelatinous drop-like corneal dystrophy. (PubMed id 10192395)1, 2 Tsujikawa M.... Nakamura Y. (1999)
    9. Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. (PubMed id 2911574)1, 2 Linnenbach A.J.... Koprowski H. (1989)
    10. Four mutations (three novel, one founder) in TACSTD2 among Iranian GDLD patients. (PubMed id 17898270)1, 7 Alavi A....Amini S.S. (2007)

    External Searches for TACSTD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TACSTD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4070 HGNC: 11530 AceView: TACSTD2 Ensembl:ENSG00000184292 euGenes: HUgn4070
    ECgene: TACSTD2 H-InvDB: TACSTD2

    Other Databases showing TACSTD2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TACSTD2 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TACSTD2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TACSTD2

    Intellectual Property
    for TACSTD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for TACSTD2 gene:
    Search GeneIP for patents involving TACSTD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TACSTD2 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TACSTD2 Antibodies for TACSTD2
     Super-pooled esiRNAs for TACSTD2 Browse proteins at Sigma-Aldrich
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     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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     Antibodies for TACSTD2 (TROP-2)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
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     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
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     Tagged/untagged cDNA clones
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     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TACSTD2
     SeqTarget long-range PCR primers for resequencing TACSTD2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TACSTD2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TACSTD2
     GenScript Custom Purified and Recombinant Proteins Services for TACSTD2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TACSTD2
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     Search for Antibodies & Assays

     Regulatory tfbs in TACSTD2 promoter
     Search Chromatin IP Primers for TACSTD2
     RT2 qPCR Primer Assay for TACSTD2
     GNC Network for TACSTD2
     Search for Assays for microRNAs that regulate TACSTD2
     SABiosciences Custom PCR Arrays for TACSTD2
     Search Tocris compounds for TACSTD2
     Proteins and Antibodies for TACSTD2
     cDNA Clones for TACSTD2
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for TACSTD2
     Proteins for TACSTD2
     Lysates for TACSTD2
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for TACSTD2
           

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