Aliases &
Descriptions
for TAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1 2 | | ATP-binding cassette sub-family B member 32 3 | | RING111 2 3 5 | | APT22 3 | | PSF21 2 3 5 | | PSF-22 3 | | ABCB32 3 5 | | ABC transporter, MHC 22 | | D6S217E1 2 | | transporter 2, ABC (ATP binding cassette)2 | | Peptide transporter TAP22 3 | | ATP-binding cassette, sub-family B (MDR/TAP), member 32 | | Peptide transporter PSF22 3 | | antigen peptide transporter 22 | | Peptide supply factor 22 3 | | OTTHUMP000002187702 | | Really interesting new gene 11 protein2 3 | | ABC182 | | Peptide transporter involved in antigen processing 22 3 | | Y13 |
Export aliases for TAP2 gene to outside databasesPrevious GC identifers: GC06M032786 GC06M032560 GC06M032837 GC06M032838 GC06M032897 GC06M032783 |
Summaries
for TAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAP2:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes aredivided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of theMDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kbtelomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. Thisprotein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiacdisease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level ofrestoration of surface expression of MHC class I molecules. (provided by RefSeq)
UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association withMHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely thebinding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachmentof herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptidetranslocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAPinduced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts asa tapasin inhibitor, preventing MHC class I/TAP association
Gene Wiki entry for TAP2 |
Genomic Views
for TAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAP2 gene promoter:
STAT1 STAT1alpha STAT1beta NF-kappaB1 Egr-1 SREBP-1a SREBP-1c SREBP-1b AP-1 NF-kappaB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAP2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3TAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032531: view genomic region
(about GC identifiers)
Start:
|
32,531,964 bp from pter |
End:
|
32,548,753 bp from pter |
Size:
|
16,790 bases |
Orientation:
|
minus strand |
6/7 alternative locations (see all 7):
| Chr6-,ALT_REF_LOCI_5 32,737,929-32,754,845 | Chr6-,ALT_REF_LOCI_6 32,718,320-32,770,839 | Chr6-,ALT_REF_LOCI_7 32,809,998-32,826,783 | | Chr6-,ALT_REF_LOCI_1 32,765,310-32,798,452 | Chr6-,ALT_REF_LOCI_2 32,703,870-32,768,059 | Chr6-,ALT_REF_LOCI_3 32,759,673-32,795,564 | |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1
- NT_167249.1
|
Proteins
for TAP2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519 (See
protein sequence)Recommended Name: Antigen peptide transporter 2 Size: 686 amino acids; 75664 Da
Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seemto form a pore in the membrane
Secondary accessions: B0V2J8 O95410 Q9UQ83Alternative splicing: 2 isoforms: Q03519-1 Q03519-2 Explore the universe of human proteins at neXtProt for TAP2: NX_Q03519
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_000535.3 NP_061313.2
ENSEMBL proteins: ENSP00000406035 ENSP00000364032 ENSP00000364034 ENSP00000392928
Human Recombinant Proteins
5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10): About this table
TAP2 for ontologies About GeneDecksing
Antibodies for TAP2:
Assays for TAP2: |
Protein
Domains/
Families
for TAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAP2 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q03519ProtoNet protein and cluster: Q03519 UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519Domain: The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamilySimilarity: Contains 1 ABC transmembrane type-1 domainSimilarity: Contains 1 ABC transporter domain |
Gene Function
for TAP2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association withMHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely thebinding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachmentof herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by humancytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptidetranslocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAPinduced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts asa tapasin inhibitor, preventing MHC class I/TAP associationInduction: By IFNG/IFN-gamma
5/15 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 15): About this table
TAP2 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tap2):
TAP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TAP2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TAP2 for pathways About GeneDecksing
1  Millipore Pathway for TAP2
4  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for TAP2
4  Kegg Pathways (Kegg details for TAP2):
SABiosciences Pathway-Focused PCR Arrays including TAP2: PAHS-070A PAHS-406A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TAP2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAP2
3 Interacting proteins for TAP2 (Q035191, 2) via UniProtKB, MINT, and/or STRINGAbout this table
5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001916 | positive regulation of T cell mediated cytotoxicity |
ISS | -- | | GO:0002481 | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
ISS | -- | | GO:0002485 | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent |
ISS | -- | | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent |
ISS | -- | | GO:0002591 | positive regulation of antigen processing and presentation of peptide antigen via MHC class I |
ISS | -- |
About this table
TAP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
TAP2 for compounds About GeneDecksing
 Browse Tocris compounds for TAP2
10/12  Novoseek chemical compound relationships for TAP2 gene (see all 12)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| isoleucine |
15.1 |
2 |
15774487 (1), 9098429 (1) |
| oligonucleotide |
13.9 |
3 |
11775239 (1), 9027960 (1), 9645419 (1) |
| atp |
11.4 |
9 |
8428770 (1), 12217520 (1), 15897556 (1), 15900495 (1) (see all 5) |
| alanine |
10.4 |
8 |
7957231 (2), 10626334 (1), 8477801 (1), 9098429 (1) (see all 5) |
| forskolin |
5.98 |
5 |
8961279 (2), 1333053 (1), 11410589 (1) |
| mitoxantrone |
5.44 |
2 |
11513878 (2) |
| calcium |
0 |
2 |
1317848 (1), 15337366 (1) |
| threonine |
0 |
4 |
10626334 (1), 8477801 (1), 19721454 (1) |
| cyclic amp |
0 |
1 |
9802424 (1) |
| acth |
0 |
3 |
8961279 (1) |
About this table
|
Transcripts
for TAP2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TAP2 gene (2 alternative transcripts): NM_000544.3 NM_018833.2 Additional cDNA sequence: AB073779.1 AB208953.1 AF078671.1 AF105151.1 AF152583.1 AF176984.1 AK222823.1 AK223300.1 AK225657.1 AK225693.1 AK292963.1 AL833658.1 BC002751.2 BT009906.1 FM246456.1 L09191.1 L09271.1 L10287.1 M74447.1 M84748.1 U07844.1 Z22935.1 Z22936.1 9 DOTS entries: DT.91945568 DT.100754817 DT.310617 DT.100754819 DT.95220491 DT.97799200 DT.91686680 DT.95220496 DT.100754818 24/221 AceView cDNA sequences (see all 221): BM714492 CB267339 AL833658 AA406373 BE260238 Z22936 AA302365 BQ059987 AA768040 BM549545 BC002751 BU158047 BU174105 BM838471 AW016114 BU541101 BE675375 AW953520 AI378910 BQ957496 BQ277877 F05746 BG323656 BQ056870
 highest scoring ESTs for TAP2:M74447 AA005281 AF078671 AF105151 AL691990 AU076752 AU100442 AU132766 BE336724 BE893125 Unigene Cluster for TAP2: Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Hs.502 [show with all ESTs]Unigene Representative Sequence: NM_000544
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000458336 ENST00000374897(uc003occ.2 uc003ocd.2) ENST00000485701
ENST00000464100 ENST00000374899(uc003ocb.1) ENST00000428917
|
Expression
for TAP2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TAP2 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching TAP2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39988_at2, 3
|
U95-A |
2 |
1.00 |
0.62 |
0.97 |
0.80 |
M74447 |
1.00 |
1.00 |
1.00 |
1 |
| 55051_at2, 3
|
U95-B |
2 |
0.38 |
0.58 |
0.95 |
1.21 |
AA005281 |
0.80 |
1.00 |
0.91 |
1 |
| 204769_s_at2, 3
|
U133-A |
2 |
1.00 |
0.86 |
-- |
-- |
M74447 |
1.00 |
1.00 |
1.00 |
1 |
| 208428_at2, 3
|
U133-A |
2 |
0.82 |
0.67 |
-- |
-- |
NM_018833 |
0.60 |
1.00 |
0.82 |
1 |
| 225973_at2, 3
|
U133-B |
2 |
0.46 |
0.60 |
-- |
-- |
AA573502 |
0.60 |
1.00 |
0.82 |
1 |
| 204770_at2, 3
|
U133-A |
2 |
0.46 |
0.50 |
-- |
-- |
NM_000544 |
0.60 |
1.00 |
0.82 |
1 |
| 204769_s_at2
|
U133Plus2 |
2 |
1.00 |
0.86 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 208428_at2
|
U133Plus2 |
2 |
0.82 |
0.67 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225973_at2
|
U133Plus2 |
2 |
0.46 |
0.60 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 204770_at2
|
U133Plus2 |
2 |
0.46 |
0.50 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TAP2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.502
SABiosciences Expression via Pathway-Focused PCR Arrays including TAP2: PAHS-070A PAHS-406A
|
Orthologs
for TAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAP2 gene from 5/7 species (see all 7)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
TAP21 |
-- |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
82.12(n)
78.66(a) |
474864 XM_532099.2 XP_532099.2 |
cow
(Bos taurus) |
TAP21 |
-- |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
80.18(n)
76.79(a) |
281586 NM_174222.2 NP_776647.1 |
rat
(Rattus norvegicus) |
Tap21 |
-- |
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
78.79(n)
74.89(a) |
24812 NM_032056.1 NP_114445.1 |
mouse
(Mus musculus) |
Tap21 , 5 |
17 (17.98 cM)5
|
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1, 5 |
79.67(n)1
77(a)1 |
213551 NM_011530.21 NP_035660.21
AF0278655 AF3075135 (see all 30) |
zebrafish
(Danio rerio) |
abcb3l11 |
-- |
ATP-binding cassette, sub-family B (MDR/TAP), member more |
54.72(n)
49.83(a) |
368771 NM_001006594.1 NP_001006594.1 |
About this table Species with no ortholog for TAP2
ENSEMBL Gene Tree for TAP2 (if available) |
Paralogs
for TAP2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAP2 gene
- ABCB102 ENSG000002502642 ABCB82 ABCB92 TAP12
TAP2 for paralogs About GeneDecksing
|
Genomic Variants
for TAP2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519Polymorphism: 4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E),TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified:TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F,TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01Polymorphism: The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated withsusceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva,cornea and mouth due to exocrine glands dysfunction
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TAP2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TAP2
2 Indels: 11278 28285 | | QIAGEN SeqTarget long-range PCR primers for resequencing TAP2 |
|
Disorders & Mutations
for TAP2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAP2 for disorders About GeneDecksing
OMIM: 170261UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
Defects in TAP2 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class Ideficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestationsduring the first years of life. Systemic infections have not been described. Chronic bacterial infections, oftenbeginning in the first decade of life, are restricted to the respiratory tract
10/50 Novoseek disease relationships for TAP2 gene (see all 50)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| bare lymphocyte syndrome |
70.9 |
2 |
20083708 (1), 10074494 (1) |
| diabetes mellitus insulin-dependent |
49 |
12 |
8002038 (2), 8477801 (2), 7871524 (1), 9599304 (1) (see all 8) |
| genetic susceptibility |
43.1 |
3 |
7759306 (1), 9361175 (1), 9844767 (1) |
| spondylitis ankylosing |
38.3 |
5 |
8770637 (2), 1570316 (1), 19480848 (1), 11096258 (1) |
| autoimmune diseases |
34.9 |
5 |
18851734 (1), 8847232 (1) |
| cervical carcinoma |
34 |
11 |
17366619 (3), 19202550 (2), 19263211 (1), 17622526 (1) (see all 6) |
| burkitt lymphoma |
31.4 |
4 |
11799186 (1), 11119603 (1), 10430223 (1), 7796675 (1) |
| sjogrens syndrome |
30.1 |
2 |
9599304 (1), 9324024 (1) |
| tumors |
29.2 |
26 |
10687135 (2), 11196471 (2), 12694570 (2), 18519766 (2) (see all 17) |
| melanoma |
27.1 |
23 |
8851724 (5), 10079252 (2), 17999701 (2), 11241306 (2) (see all 8) |
About this table
Locus Specific Mutation Databases (LSDB): TAP2
Human Gene Mutation Database (HGMD): TAP2
Genetic Association Database (GAD): TAP2
Human Genome Epidemiology (HuGE) Navigator: TAP2 (80 documents)
Export disorders and mutations for TAP2 gene to outside databases
|
Medical News
for TAP2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/362 PubMed articles for TAP2 gene, integrated from 7 sources (see all 362):
(articles sorted by number of sources associating them with TAP2)- Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans. (PubMed id 11294565)1, 2, 4, 7 Tang J.... Kaslow R.A. (2001)
- Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome. (PubMed id 9324024)1, 2, 4, 7 Kumagai S.... Saji H. (1997)
- Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. (PubMed id 1946428)1, 2, 3, 7 Bahram S.... Spies T. (1991)
- Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. (PubMed id 8162639)1, 2, 4, 7 Singal D.P.... D'Souza M. (1994)
- Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. (PubMed id 8428770)1, 2, 7 Powis S.H....Trowsdale J. (1993)
- TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (PubMed id 12634240)1, 4, 7 Correa P.A....Anaya J.M. (2003)
- TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. (PubMed id 16216677)1, 4, 7 Alvarado-Guerri R....Lopez-Nevot M.A. (2005)
- Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. (PubMed id 14749980)1, 4, 7 Yu M.C....Tsai F.J. (2004)
- Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. (PubMed id 12507827)1, 4, 7 Penfornis A....Faustman D.L. (2003)
- TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis. (PubMed id 11096258)1, 4, 7 Fraile A....Nieto A. (2000)
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External Searches for TAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TAP2 gene
(According to HUGE)
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Specialized Databases showing TAP2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| TAP2base | http://bioinf.uta.fi/TAP2base/ |
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| Patent Information for TAP2 gene:
Search GeneIP for patents involving TAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TAP2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
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