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TAP2 Gene

protein-coding   GIFtS: 55

GC06M032531
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ABCB3)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1 2     ATP-binding cassette sub-family B member 32 3
RING111 2 3 5     APT22 3
PSF21 2 3 5     PSF-22 3
ABCB32 3 5     ABC transporter, MHC 22
D6S217E1 2     transporter 2, ABC (ATP binding cassette)2
Peptide transporter TAP22 3     ATP-binding cassette, sub-family B (MDR/TAP), member 32
Peptide transporter PSF22 3     antigen peptide transporter 22
Peptide supply factor 22 3     OTTHUMP000002187702
Really interesting new gene 11 protein2 3     ABC182
Peptide transporter involved in antigen processing 22 3     Y13

External Ids:    HGNC: 441   Entrez Gene: 68912   Ensembl: ENSG000002042677   UniProtKB: Q035193   

Export aliases for TAP2 gene to outside databases

Previous GC identifers: GC06M032786 GC06M032560 GC06M032837 GC06M032838 GC06M032897 GC06M032783


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAP2:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the
MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb
telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This
protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum.
Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac
disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of
restoration of surface expression of MHC class I molecules. (provided by RefSeq)

UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with
MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the
binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment
of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human
cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide
translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP
induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as
a tapasin inhibitor, preventing MHC class I/TAP association

Gene Wiki entry for TAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAP2 gene promoter:
         STAT1   STAT1alpha   STAT1beta   NF-kappaB1   Egr-1   SREBP-1a   SREBP-1c   SREBP-1b   AP-1   NF-kappaB   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

TAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAP2 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032531:  view genomic region     (about GC identifiers)

Start:
32,531,964 bp from pter
End:
32,548,753 bp from pter
Size:
16,790 bases
Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,ALT_REF_LOCI_5 32,737,929-32,754,845      Chr6-,ALT_REF_LOCI_6 32,718,320-32,770,839      Chr6-,ALT_REF_LOCI_7 32,809,998-32,826,783     
Chr6-,ALT_REF_LOCI_1 32,765,310-32,798,452      Chr6-,ALT_REF_LOCI_2 32,703,870-32,768,059      Chr6-,ALT_REF_LOCI_3 32,759,673-32,795,564     
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519 (See protein sequence)
Recommended Name: Antigen peptide transporter 2  
Size: 686 amino acids; 75664 Da
Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem
to form a pore in the membrane
Secondary accessions: B0V2J8 O95410 Q9UQ83
Alternative splicing: 2 isoforms:  Q03519-1   Q03519-2   

Explore the universe of human proteins at neXtProt for TAP2: NX_Q03519 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_000535.3  NP_061313.2  


    ENSEMBL proteins: 
    ENSP00000406035 ENSP00000364032 ENSP00000364034 ENSP00000392928 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TAP2 
    Novus Biologicals Proteins for TAP2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005783 endoplasmic reticulum IDA18029348
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005886 plasma membrane ISS--
    GO:0016020 membrane ----
    About this table

    TAP2 for ontologies           About GeneDecksing



    Antibodies for TAP2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAP2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TAP2 
    Novus Biologicals Antibodies for TAP2
    Browse antibodies at Epitomics

    Assays for TAP2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAP2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TAP2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TAP2 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR013306 ABC_B3
     IPR005293 Ag_transporter2
     IPR003439 ABC_transporter-like
     IPR001140 ABC_transptr_TM_dom
     IPR003593 ATPase_AAA+_core

    Graphical View of Domain Structure for InterPro Entry Q03519

    ProtoNet protein and cluster: Q03519

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
    Domain: The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2
    Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily
    Similarity: Contains 1 ABC transmembrane type-1 domain
    Similarity: Contains 1 ABC transporter domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
    Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with
    MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the
    binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment
    of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human
    cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide
    translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP
    induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as
    a tapasin inhibitor, preventing MHC class I/TAP association
    Induction: By IFNG/IFN-gamma

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for TAP2
    Sigma-Aldrich shRNA for TAP2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TAP2
    OriGene shRNA RFP (see all 2): TAP2
    OriGene basic RS shRNA (see all 2): TAP2
    OriGene siRNA (see all 2): TAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAP2 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAP2 
    2 SABiosciences Assays for microRNAs that regulate TAP2:
    hsa-miR-875-3p hsa-miR-370

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene 3'-UTR clone (see all 2): TAP2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TAP2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TAP2 

    5/15 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 15):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005215 transporter activity IDA10835348
    GO:0005515 protein binding IPI12213826
    GO:0005524 ATP binding IDA7673167
    GO:0015197contributes to peptide transporter activity IGI7673167
    About this table

    TAP2 for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tap2):

    hematopoietic systemimmune system

    TAP2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TAP2 for pathways           About GeneDecksing

    1 Millipore Pathway for TAP2
        Immune response Antigen presentation by MHC class I

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TAP2
        Antigen Presentation Pathway
    Lysine Biosynthesis
    Protein Ubiquitination Pathway
    Primary Immunodeficiency Signaling

    4 Kegg Pathways  (Kegg details for TAP2):
        hsa02010 ABC transporters
    hsa04145 Phagosome
    hsa04612 Antigen processing and presentation
    hsa05340 Primary immunodeficiency

        SABiosciences Pathway-Focused PCR Arrays including TAP2: PAHS-070A PAHS-406A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TAP2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAP2

    3 Interacting proteins for TAP2 (Q035191, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAP1Q035181, 2EBI-780781,EBI-747259 MINT-2838330
    TAPBPO155331EBI-780781,EBI-874801
    --Q5STL12MINT-2838347
    About this table

    5/16 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 16):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916 positive regulation of T cell mediated cytotoxicity ISS--
    GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent ISS--
    GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent ISS--
    GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent ISS--
    GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I ISS--
    About this table

    TAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TAP2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAP2
    10/12 Novoseek chemical compound relationships for TAP2 gene (see all 12)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 15.1 2 15774487 (1), 9098429 (1)
    oligonucleotide 13.9 3 11775239 (1), 9027960 (1), 9645419 (1)
    atp 11.4 9 8428770 (1), 12217520 (1), 15897556 (1), 15900495 (1) (see all 5)
    alanine 10.4 8 7957231 (2), 10626334 (1), 8477801 (1), 9098429 (1) (see all 5)
    forskolin 5.98 5 8961279 (2), 1333053 (1), 11410589 (1)
    mitoxantrone 5.44 2 11513878 (2)
    calcium 0 2 1317848 (1), 15337366 (1)
    threonine 0 4 10626334 (1), 8477801 (1), 19721454 (1)
    cyclic amp 0 1 9802424 (1)
    acth 0 3 8961279 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for TAP2
    Sigma-Aldrich shRNA for TAP2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TAP2
    OriGene shRNA RFP (see all 2): TAP2
    OriGene basic RS shRNA (see all 2): TAP2
    OriGene siRNA (see all 2): TAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAP2 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAP2 
    2 SABiosciences Assays for microRNAs that regulate TAP2:
    hsa-miR-875-3p hsa-miR-370
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): TAP2
    OriGene 3'-UTR Clone (see all 2): TAP2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TAP2 
    Primers: OriGene genome-wide validated SYBR primer pairs: TAP2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TAP2: PPH05588A

    REFSEQ mRNAs for TAP2 gene (2 alternative transcripts): 

    NM_000544.3  NM_018833.2  

    Additional cDNA sequence: 

    AB073779.1 AB208953.1 AF078671.1 AF105151.1 AF152583.1 AF176984.1 AK222823.1 AK223300.1 
    AK225657.1 AK225693.1 AK292963.1 AL833658.1 BC002751.2 BT009906.1 FM246456.1 L09191.1 
    L09271.1 L10287.1 M74447.1 M84748.1 U07844.1 Z22935.1 Z22936.1 

    9 DOTS entries:

    DT.91945568  DT.100754817  DT.310617  DT.100754819  DT.95220491  DT.97799200  DT.91686680  DT.95220496 
    DT.100754818 

    24/221 AceView cDNA sequences (see all 221):

    BM714492 CB267339 AL833658 AA406373 BE260238 Z22936 AA302365 BQ059987 
    AA768040 BM549545 BC002751 BU158047 BU174105 BM838471 AW016114 BU541101 
    BE675375 AW953520 AI378910 BQ957496 BQ277877 F05746 BG323656 BQ056870 

    highest scoring ESTs for TAP2:

    M74447 AA005281 AF078671 AF105151 AL691990 AU076752 AU100442 AU132766 BE336724 BE893125 

    Unigene Cluster for TAP2:

    Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
    Hs.502  [show with all ESTs]
    Unigene Representative Sequence: NM_000544


    GeneLoc Exon Structure

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458336 ENST00000374897(uc003occ.2 uc003ocd.2) ENST00000485701
    ENST00000464100 ENST00000374899(uc003ocb.1) ENST00000428917

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TAP2 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching TAP2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39988_at2, 3 U95-A 2 1.00 0.62 0.97 0.80 M74447 1.00 1.00 1.00 1
    55051_at2, 3 U95-B 2 0.38 0.58 0.95 1.21 AA005281 0.80 1.00 0.91 1
    204769_s_at2, 3 U133-A 2 1.00 0.86 -- -- M74447 1.00 1.00 1.00 1
    208428_at2, 3 U133-A 2 0.82 0.67 -- -- NM_018833 0.60 1.00 0.82 1
    225973_at2, 3 U133-B 2 0.46 0.60 -- -- AA573502 0.60 1.00 0.82 1
    204770_at2, 3 U133-A 2 0.46 0.50 -- -- NM_000544 0.60 1.00 0.82 1
    204769_s_at2 U133Plus2 2 1.00 0.86 -- -- -- -- -- -- --
    208428_at2 U133Plus2 2 0.82 0.67 -- -- -- -- -- -- --
    225973_at2 U133Plus2 2 0.46 0.60 -- -- -- -- -- -- --
    204770_at2 U133Plus2 2 0.46 0.50 -- -- -- -- -- -- --
    About this table

    TAP2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TAP2 gene expression
    TAP2 gene electronic northern expression
    TAP2 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.502
    Primers: OriGene genome-wide validated SYBR primer pairs: TAP2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TAP2: PPH05588A
        SABiosciences Expression via Pathway-Focused PCR Arrays including TAP2: PAHS-070A PAHS-406A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TAP2 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAP21   -- transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 82.12(n)
    78.66(a)
    474864  XM_532099.2  XP_532099.2 
    cow
    (Bos taurus)
    TAP21   -- transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 80.18(n)
    76.79(a)
    281586  NM_174222.2  NP_776647.1 
    rat
    (Rattus norvegicus)
    Tap21   -- transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 78.79(n)
    74.89(a)
    24812  NM_032056.1  NP_114445.1 
    mouse
    (Mus musculus)
    Tap21 , 5 17 (17.98 cM)5
    transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1, 5 79.67(n)1
    77(a)1
    213551  NM_011530.21  NP_035660.21 
     AF0278655  AF3075135  (see all 30)
    zebrafish
    (Danio rerio)
    abcb3l11   -- ATP-binding cassette, sub-family B (MDR/TAP), member more 54.72(n)
    49.83(a)
    368771  NM_001006594.1  NP_001006594.1 
    About this table        Species with no ortholog for TAP2

    ENSEMBL Gene Tree for TAP2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TAP2 gene
    ABCB102  ENSG000002502642  ABCB82  ABCB92  TAP12  

    TAP2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
    Polymorphism: 4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E),
    TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified:
    TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F,
    TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01
    Polymorphism: The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with
    susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva,
    cornea and mouth due to exocrine glands dysfunction


    10/426 NCBI SNPs in TAP2 are shown (see all 426)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs135011,2
    C,F,A32793523(+) GTGGAG/ATCAGG 3 -- ut31 int118Minor allele frequency- A:0.39MN NS EA NA WA 1616
    rs170341,2
    C,F,A,H32796521(-) TTGCAG/AGCACG 3 -- int1 ut31 ese314Minor allele frequency- A:0.28MN EA NS NA 1080
    rs1178211,2
    C,F,O,A32798711(-) TTAAAG/AGTGGA 4 -- int19Minor allele frequency- A:0.48NA WA 170
    rs1835851,2
    C,F32799673(-) ttccaC/Tttgtg 4 -- int19Minor allele frequency- T:0.24NS EA NA 838
    rs2414241,2
    C,F,A32804934(-) CACTCT/CCTCAG 4 -- int122Minor allele frequency- C:0.49EA NA MN NS 2220
    rs2414251,2
    C,F,A,H32804909(-) TCCCTC/TTCACT 4 -- int1 trp310Minor allele frequency- T:0.39MN NS EA NA 1026
    rs2414261,2
    C,F,A32804553(-) aacgaT/Agttta 4 -- int117Minor allele frequency- A:0.40NS EA NA WA 1432
    rs2414271,2
    C,F,A32804414(-) gcagtC/Tatatg 4 -- int117Minor allele frequency- T:0.32NS EA NA WA 1276
    rs2414281,2
    C,F,O32804070(-) GATGAA/CAGATG 4 -- int114Minor allele frequency- C:0.04MN NS EA NA 1250
    rs2414291,2
    C,F,O,A32803840(-) GTAGTC/TTTCTA 4 -- int130Minor allele frequency- N:0.00NS EA NA WA 2254
    About this table

    HapMap Linkage Disequilibrium images for TAP2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TAP2
         2 Indels: 11278 28285

    QIAGEN SeqTarget long-range PCR primers for resequencing TAP2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TAP2 for disorders           About GeneDecksing

    OMIM: 170261

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519

  • Defects in TAP2 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also called HLA class I
  • deficiency. BLS1 is a class I antigen deficiency that is not accompanied by particular pathologic manifestations
    during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often
    beginning in the first decade of life, are restricted to the respiratory tract

    10/50 Novoseek disease relationships for TAP2 gene (see all 50)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 70.9 2 20083708 (1), 10074494 (1)
    diabetes mellitus insulin-dependent 49 12 8002038 (2), 8477801 (2), 7871524 (1), 9599304 (1) (see all 8)
    genetic susceptibility 43.1 3 7759306 (1), 9361175 (1), 9844767 (1)
    spondylitis ankylosing 38.3 5 8770637 (2), 1570316 (1), 19480848 (1), 11096258 (1)
    autoimmune diseases 34.9 5 18851734 (1), 8847232 (1)
    cervical carcinoma 34 11 17366619 (3), 19202550 (2), 19263211 (1), 17622526 (1) (see all 6)
    burkitt lymphoma 31.4 4 11799186 (1), 11119603 (1), 10430223 (1), 7796675 (1)
    sjogrens syndrome 30.1 2 9599304 (1), 9324024 (1)
    tumors 29.2 26 10687135 (2), 11196471 (2), 12694570 (2), 18519766 (2) (see all 17)
    melanoma 27.1 23 8851724 (5), 10079252 (2), 17999701 (2), 11241306 (2) (see all 8)
    About this table

    Locus Specific Mutation Databases (LSDB): TAP2
    Human Gene Mutation Database (HGMD): TAP2
    Genetic Association Database (GAD): TAP2
    Human Genome Epidemiology (HuGE) Navigator: TAP2 (80 documents)

    Export disorders and mutations for TAP2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/362 PubMed articles for TAP2 gene, integrated from 7 sources (see all 362):
    (articles sorted by number of sources associating them with TAP2)
    1. Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans. (PubMed id 11294565)1, 2, 4, 7 Tang J.... Kaslow R.A. (2001)
    2. Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome. (PubMed id 9324024)1, 2, 4, 7 Kumagai S.... Saji H. (1997)
    3. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. (PubMed id 1946428)1, 2, 3, 7 Bahram S.... Spies T. (1991)
    4. Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. (PubMed id 8162639)1, 2, 4, 7 Singal D.P.... D'Souza M. (1994)
    5. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. (PubMed id 8428770)1, 2, 7 Powis S.H....Trowsdale J. (1993)
    6. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (PubMed id 12634240)1, 4, 7 Correa P.A....Anaya J.M. (2003)
    7. TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. (PubMed id 16216677)1, 4, 7 Alvarado-Guerri R....Lopez-Nevot M.A. (2005)
    8. Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. (PubMed id 14749980)1, 4, 7 Yu M.C....Tsai F.J. (2004)
    9. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. (PubMed id 12507827)1, 4, 7 Penfornis A....Faustman D.L. (2003)
    10. TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis. (PubMed id 11096258)1, 4, 7 Fraile A....Nieto A. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6891 HGNC: 44 AceView: TAP2 Ensembl:ENSG00000204267 euGenes: HUgn6891
    ECgene: TAP2 Kegg: 6891 H-InvDB: TAP2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    TAP2basehttp://bioinf.uta.fi/TAP2base/

    (Patent information from GeneIP,
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    Patent Information for TAP2 gene:
    Search GeneIP for patents involving TAP2

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