Aliases &
Descriptions
for TAPBPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| TAP binding protein-like1 2 | | TAPASIN-R2 3 | | TAPBP-R1 2 3 | | tapasin-related protein2 | | TAPBPR1 2 5 | | tapasin-like2 | | FLJ101431 2 | | TAP binding protein related2 | | TAP-binding protein-like2 3 | | Tapasin-like3 | | TAP-binding protein-related protein2 3 | | |
Export aliases for TAPBPL gene to outside databasesPrevious GC identifers: GC12P006432 GC12P006561 |
Summaries
for TAPBPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAPBPL:
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibilitycomplex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in theendoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member ofthe Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.(supplied by OMIM)
|
Genomic Views
for TAPBPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAPBPL gene promoter:
IRF-1 p53 ATF6 Lmo2 GATA-1 RP58 XBP-1 IRF-7A CUTL1 CREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAPBPL
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31TAPBPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P006434: view genomic region
(about GC identifiers)
Start:
|
6,415,366 bp from pter |
End:
|
6,425,677 bp from pter |
Size:
|
10,312 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 6,561,177-6,571,484 |
RefSeq DNA sequence:- NC_000012.11 NT_009759.16
|
Proteins
for TAPBPL gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59 (See
protein sequence)Recommended Name: Tapasin-related protein precursor Size: 468 amino acids; 50183 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum membrane;Single-pass type I membrane protein (Probable). Microsome membrane; Single-pass type I membrane protein (Probable).Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface
Secondary accessions: Q9NWB8Explore the universe of human proteins at neXtProt for TAPBPL: NX_Q9BX59
REFSEQ proteins: NP_060479.3
ENSEMBL proteins: ENSP00000266556 ENSP00000394634
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TAPBPL for ontologies About GeneDecksing
Antibodies for TAPBPL:
Assays for TAPBPL: |
Protein
Domains/
Families
for TAPBPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAPBPL for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9BX59ProtoNet protein and cluster: Q9BX59 2 Blocks protein families: IPB003597 Immunoglobulin C-type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Gene Function
for TAPBPL gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- |
About this table
TAPBPL for ontologies About GeneDecksing
|
Pathways & Interactions
for TAPBPL gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TAPBPL
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAPBPL
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
IEA | -- |
About this table
TAPBPL for ontologies About GeneDecksing
|
Drugs & Compounds
for TAPBPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAPBPL
|
Transcripts
for TAPBPL gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TAPBPL gene: NM_018009.4 Additional cDNA sequence: AK001005.1 AK002056.2 AK098035.1 AK222956.1 AK223163.1 BC015017.2 CR594087.1 CR598232.1 CR604472.1 CR622967.1 22 DOTS entries: DT.92438464 DT.97862728 DT.100642876 DT.121214676 DT.100640107 DT.121214743 DT.95334218 DT.121214734 DT.317661 DT.95334214 DT.95170259 DT.121214753 DT.40312062 DT.95334217 DT.121214669 DT.92017844 DT.95334167 DT.100772134 DT.91686927 DT.92438467 DT.92438468 DT.95334215 9 AceView cDNA sequences: CR622967 CR598232 CR604472 CR594087 NM_018009 AK002056 AK001005 AK098035 BC015017
 highest scoring ESTs for TAPBPL:AK002056 BX414902 AI656132 AK222956 AK223163 AW874151 BM713720 BQ272363 BX444361 CA426664 Unigene Cluster for TAPBPL: TAP binding protein-like Hs.504597 [show with all ESTs]Unigene Representative Sequence: AK098035
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000266556(uc001qog.3 uc001qoh.3 uc001qoi.1) ENST00000431620
|
Expression
for TAPBPL gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TAPBPL expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching TAPBPL gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 64022_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.80 |
1.32 |
AA829355 |
0.60 |
0.75 |
0.68 |
1 |
| 50323_g_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.96 |
1.20 |
AI656132 |
0.60 |
1.00 |
0.82 |
1 |
| 57559_at2, 3
|
U95-C |
1 |
0.44 |
1.00 |
0.46 |
0.49 |
AA781867 |
0.20 |
1.00 |
0.72 |
1 |
| 218747_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018009 |
0.40 |
0.67 |
0.55 |
1 |
| 218746_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018009 |
0.40 |
0.67 |
0.55 |
1 |
| 218747_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 218746_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TAPBPL for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ACATTGGTAA
SOURCE GeneReport for Unigene cluster: Hs.504597
SABiosciences Custom PCR Arrays for TAPBPL
|
Orthologs
for TAPBPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAPBPL gene from 5/7 species (see all 7)
About this table Species with no ortholog for TAPBPL
ENSEMBL Gene Tree for TAPBPL (if available) |
Paralogs
for TAPBPL gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAPBPL gene
- TAPBP2
TAPBPL for paralogs About GeneDecksing
|
Genomic Variants
for TAPBPL gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TAPBPL (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TAPBPL
7 CNVs: 3872 8706 2967 9679 30577 8705 37679 | | QIAGEN SeqTarget long-range PCR primers for resequencing TAPBPL |
|
Disorders & Mutations
for TAPBPL gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAPBPL for disorders About GeneDecksing
OMIM: 607081
Human Genome Epidemiology (HuGE) Navigator: TAPBPL (3 documents)
Export disorders and mutations for TAPBPL gene to outside databases
|
Medical News
for TAPBPL gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TAPBPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for TAPBPL gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with TAPBPL)- A human TAPBP (TAPASIN)-related gene, TAPBP-R. (PubMed id 11920573)1, 2, 3, 7 Teng M.S....Trowsdale J. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469)1 Lee J.H....Mayeux R. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TAPBPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAPBPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAPBPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAPBPL gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TAPBPL gene:
Search GeneIP for patents involving TAPBPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAPBPL gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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