Aliases &
Descriptions
for TAS2R13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| taste receptor, type 2, member 131 2 | | T2R131 2 3 5 | | TRB31 2 3 5 | | Taste receptor family B member 32 3 | | taste receptor type 2 member 132 | | taste receptor, family B, member 32 |
Export aliases for TAS2R13 gene to outside databasesPrevious GC identifers: GC12M011205 GC12M010961 GC12M010952 GC12M011060 |
Summaries
for TAS2R13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R13:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptorsuperfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia.They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception inmice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the tastereceptor gene cluster on chromosome 12p13. (provided by RefSeq)
UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5
Gene Wiki entry for TAS2R13 |
Genomic Views
for TAS2R13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R13 gene promoter:
POU2F2 POU2F2C POU2F2B POU2F2 (Oct-2.1) POU2F1 oct-B3 oct-B2 Oct-B1 MEF-2A FOXC1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R13
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13TAS2R13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010765: view genomic region
(about GC identifiers)
Start:
|
10,789,153 bp from pter |
End:
|
10,790,789 bp from pter |
Size:
|
1,637 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 11,060,525-11,062,161 |
RefSeq DNA sequence:- NC_000012.11 NT_009714.17
|
Proteins
for TAS2R13 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9 (See
protein sequence)Recommended Name: Taste receptor type 2 member 13 Size: 303 amino acids; 35118 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells candiscriminate among bitter stimuli
Secondary accessions: Q4G0I5 Q502V8 Q645X2Explore the universe of human proteins at neXtProt for TAS2R13: NX_Q9NYV9
REFSEQ proteins: NP_076409.1
ENSEMBL proteins: ENSP00000375095
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
NAS | -- |
About this table
TAS2R13 for ontologies About GeneDecksing
Antibodies for TAS2R13:
Assays for TAS2R13: |
Protein
Domains/
Families
for TAS2R13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R13 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NYV9ProtoNet protein and cluster: Q9NYV9 UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9Similarity: Belongs to the G-protein coupled receptor T2R family |
Gene Function
for TAS2R13 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
TAS2R13 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAS2R13 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TAS2R13 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for TAS2R13):
SABiosciences Custom Pathway-Focused PCR Arrays for TAS2R13
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R13
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0008150 | biological_process |
ND | -- | | GO:0050896 | response to stimulus |
IEA | -- | | GO:0050909 | sensory perception of taste |
IEA | -- |
About this table
TAS2R13 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAS2R13
|
Transcripts
for TAS2R13 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
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|
REFSEQ mRNAs for TAS2R13 gene: NM_023920.2 Additional cDNA sequence: BC069376.1 BC095518.1 BC115402.1 BC115403.1 1 DOTS entry: DT.91820695 10 AceView cDNA sequences: NM_023920 BC069376 CN842919 CN832082 CN838637 CN836477 CN838521 CN843042 CN832121 CN836512
 highest scoring ESTs for TAS2R13:CN832121 CN836512 CN838521 CN843042 BC069376 BC095518 CN832082 CN836477 CN838637 CN842919 Unigene Cluster for TAS2R13: Taste receptor, type 2, member 13 Hs.679407 [show with all ESTs]Unigene Representative Sequence: BC095518
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000390677(uc001qzg.1)
|
Expression
for TAS2R13 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TAS2R13 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching TAS2R13 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 221395_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
NM_023920 |
0.40 |
0.67 |
0.55 |
1 |
| 221395_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.679407
UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively ingustducin-positive cells
SABiosciences Custom PCR Arrays for TAS2R13
|
Orthologs
for TAS2R13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
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|
Orthologs for TAS2R13 gene from 3 species
About this table Species with no ortholog for TAS2R13
ENSEMBL Gene Tree for TAS2R13 (if available) |
Paralogs
for TAS2R13 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAS2R13 gene
- TAS2R422 TAS2R92 TAS2R72 TAS2R192 TAS2R32 TAS2R202 TAS2R82 TAS2R102
- TAS2R502 TAS2R312 TAS2R142
TAS2R13 for paralogs About GeneDecksing
Pseudogenes
- 4 related pseudogenes
|
Genomic Variants
for TAS2R13 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAS2R13
1 CNV: 3875 | | QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R13 |
|
Disorders & Mutations
for TAS2R13 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
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TAS2R13 for disorders About GeneDecksing
OMIM: 604792
Export disorders and mutations for TAS2R13 gene to outside databases
|
Medical News
for TAS2R13 gene(Possibly Related Articles in
Doctor's Guide)
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| -- |
Publications
for TAS2R13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
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|
10/13 PubMed articles for TAS2R13 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with TAS2R13)- A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
- T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
|
External Searches for TAS2R13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TAS2R13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R13 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TAS2R13 gene:
Search GeneIP for patents involving TAS2R13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R13 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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