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TAS2R13 Gene

protein-coding   GIFtS: 42

GC12M010765
taste receptor, type 2, member 13
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
taste receptor, type 2, member 131 2
T2R131 2 3 5
TRB31 2 3 5
Taste receptor family B member 32 3
taste receptor type 2 member 132
taste receptor, family B, member 32

External Ids:    HGNC: 149191   Entrez Gene: 508382   Ensembl: ENSG000002121287   UniProtKB: Q9NYV93   

Export aliases for TAS2R13 gene to outside databases

Previous GC identifers: GC12M011205 GC12M010961 GC12M010952 GC12M011060


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAS2R13:
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor
superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia.
They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in
mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste
receptor gene cluster on chromosome 12p13. (provided by RefSeq)

UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in
sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha
gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Gene Wiki entry for TAS2R13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAS2R13 gene promoter:
         POU2F2   POU2F2C   POU2F2B   POU2F2 (Oct-2.1)   POU2F1   oct-B3   oct-B2   Oct-B1   MEF-2A   FOXC1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TAS2R13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.2   HGNC cytogenetic band: 12p13

TAS2R13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAS2R13 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M010765:  view genomic region     (about GC identifiers)

Start:
10,789,153 bp from pter
End:
10,790,789 bp from pter
Size:
1,637 bases
Orientation:
minus strand

1 alternative location:
Chr12- 11,060,525-11,062,161     
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9 (See protein sequence)
Recommended Name: Taste receptor type 2 member 13  
Size: 303 amino acids; 35118 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can
discriminate among bitter stimuli
Secondary accessions: Q4G0I5 Q502V8 Q645X2

Explore the universe of human proteins at neXtProt for TAS2R13: NX_Q9NYV9 

REFSEQ proteins: NP_076409.1  

ENSEMBL proteins: 
ENSP00000375095 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016020 membrane IEA--
GO:0016021 integral to membrane NAS--
About this table

TAS2R13 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAS2R13 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR007960 TAS2_rcpt

Graphical View of Domain Structure for InterPro Entry Q9NYV9

ProtoNet protein and cluster: Q9NYV9

UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9
Similarity: Belongs to the G-protein coupled receptor T2R family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9
Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in
sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha
gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5

Inhib.
RNA:
    
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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Gene
Editing:
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Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TAS2R13
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Cell
Lines:
  
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3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity ----
GO:0008527 taste receptor activity TAS10761934
About this table

TAS2R13 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


TAS2R13 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for TAS2R13):
    hsa04742 Taste transduction

    SABiosciences Custom Pathway-Focused PCR Arrays for TAS2R13 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R13

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007186 G-protein coupled receptor protein signaling pathway ----
GO:0008150 biological_process ND--
GO:0050896 response to stimulus IEA--
GO:0050909 sensory perception of taste IEA--
About this table

TAS2R13 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAS2R13


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for TAS2R13
Sigma-Aldrich shRNA Panels and shRNA for TAS2R13
OriGene 29mer shRNA kits in GFP-retroviral vector: TAS2R13
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OriGene basic RS shRNA: TAS2R13
OriGene siRNA: TAS2R13
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAS2R13 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TAS2R13 
Search SABiosciences for Assays for microRNAs that regulate TAS2R13
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: TAS2R13
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TAS2R13
OriGene untagged cDNA clones in CMV expression vector: TAS2R13
Browse 3'-UTR reporter clones for miRNA target validation 
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GenScript cDNA clone with any tag delivered in your preferred vector: TAS2R13 
Primers: OriGene genome-wide validated SYBR primer pairs: TAS2R13
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TAS2R13: PPH02540A

REFSEQ mRNAs for TAS2R13 gene: 

NM_023920.2  

Additional cDNA sequence: 

BC069376.1 BC095518.1 BC115402.1 BC115403.1 

1 DOTS entry:

DT.91820695 

10 AceView cDNA sequences:

NM_023920 BC069376 CN842919 CN832082 CN838637 CN836477 CN838521 CN843042 
CN832121 CN836512 

highest scoring ESTs for TAS2R13:

CN832121 CN836512 CN838521 CN843042 BC069376 BC095518 CN832082 CN836477 CN838637 CN842919 

Unigene Cluster for TAS2R13:

Taste receptor, type 2, member 13
Hs.679407  [show with all ESTs]
Unigene Representative Sequence: BC095518


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000390677(uc001qzg.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TAS2R13 expression in normal and diseased human tissues

1  / 2  / 3

2 probe-sets matching TAS2R13 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
221395_at2, 3 U133-A 1 0.82 1.00 -- -- NM_023920 0.40 0.67 0.55 1
221395_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
TAS2R13 gene expression
TAS2R13 gene electronic northern expression
TAS2R13 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.679407

UniProtKB/Swiss-Prot: T2R13_HUMAN, Q9NYV9
Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in
gustducin-positive cells

Primers: OriGene genome-wide validated SYBR primer pairs: TAS2R13
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TAS2R13: PPH02540A
    SABiosciences Custom PCR Arrays for TAS2R13 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAS2R13 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
TAS2R131   -- taste receptor, type 2, member 13 98.57(n)
96.37(a)
493891  NM_001009141.1  NP_001009141.1 
rat
(Rattus norvegicus)
Tas2r1211   -- taste receptor, type 2, member 121 70.4(n)
57.63(a)
78983  NM_023997.1  NP_076487.1 
mouse
(Mus musculus)
Tas2r1211 , 5 6 (64.03 cM)5
taste receptor, type 2, member 1211, 5 72.32(n)1
58.98(a)1
3873491  NM_207024.11  NP_996907.11 
 BC1044105  BC1044115  (see all 6)
About this table        Species with no ortholog for TAS2R13

ENSEMBL Gene Tree for TAS2R13 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for TAS2R13 gene
TAS2R422  TAS2R92  TAS2R72  TAS2R192  TAS2R32  TAS2R202  TAS2R82  TAS2R102  
TAS2R502  TAS2R312  TAS2R142  

TAS2R13 for paralogs           About GeneDecksing


Pseudogenes
4 related pseudogenes



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAS2R13
     1 CNV: 3875
QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R13 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAS2R13 for disorders           About GeneDecksing

OMIM: 604792


Export disorders and mutations for TAS2R13 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/13 PubMed articles for TAS2R13 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with TAS2R13)
  1. A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
  2. Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
  5. Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
  6. Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
  7. A family of candidate taste receptors in human and mo use. (PubMed id 10766242)1, 3 Matsunami H....Buck L.B. (2000)
  8. T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2 Chandrashekar J.... Ryba N.J.P. (2000)
  9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 50838 HGNC: 14919 AceView: TAS2R13 Ensembl:ENSG00000212128 euGenes: HUgn50838
ECgene: TAS2R13 Kegg: 50838 H-InvDB: TAS2R13

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for TAS2R13 gene:
Search GeneIP for patents involving TAS2R13

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TAS2R13
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