Aliases &
Descriptions
for TAS2R4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
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|
| Aliases & Descriptions |
|---|
| taste receptor, type 2, member 41 2 | | T2R41 2 3 5 | | candidate taste receptor T2R42 | | taste receptor type 2 member 42 | | MGC1633112 |
Export aliases for TAS2R4 gene to outside databasesPrevious GC identifers: GC07P139749 GC07P140808 GC07P140885 GC07P140931 GC07P141124 GC07P141479 |
Summaries
for TAS2R4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R4:
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptorsuperfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. Theseapparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. Thisgene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci thatinfluence bitter perception. (provided by RefSeq)
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bittercompounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cationchannel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentrationand stimulates ciliary beat frequency
Gene Wiki entry for TAS2R4 |
Genomic Views
for TAS2R4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
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|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R4 gene promoter:
POU3F2 NRSF form 2 NRSF form 1 PPAR-gamma2 PPAR-gamma1 RORalpha2 POU2F1 GATA-3 GATA-2 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.3-q32 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q31.3-q32TAS2R4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P135774: view genomic region
(about GC identifiers)
Start:
|
135,774,951 bp from pter |
End:
|
135,775,850 bp from pter |
Size:
|
900 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 141,478,242-141,479,235 |
RefSeq DNA sequence:- NC_000007.13 NT_007914.15 NT_079596.2
|
Proteins
for TAS2R4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5 (See
protein sequence)Recommended Name: Taste receptor type 2 member 4 Size: 299 amino acids; 33841 Da
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airwayepithelial cells, localizes to motile cilia
Miscellaneous: Several bitter taste receptors are expressed in a single taste receptor cell
Secondary accessions: Q645W5 Q75MV8Explore the universe of human proteins at neXtProt for TAS2R4: NX_Q9NYW5
REFSEQ proteins: NP_058640.1
ENSEMBL proteins: ENSP00000247881
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
Antibodies for TAS2R4:
Assays for TAS2R4: |
Protein
Domains/
Families
for TAS2R4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NYW5ProtoNet protein and cluster: Q9NYW5 UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Similarity: Belongs to the G-protein coupled receptor T2R family |
Gene Function
for TAS2R4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Function: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bittercompounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cationchannel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentrationand stimulates ciliary beat frequency
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAS2R4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
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|
TAS2R4 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for TAS2R4):
SABiosciences Custom Pathway-Focused PCR Arrays for TAS2R4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R4
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
TAS2R4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAS2R4
|
Transcripts
for TAS2R4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
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|
REFSEQ mRNAs for TAS2R4 gene: NM_016944.1 Additional cDNA sequence: AL832513.1 BC130439.1 BC136508.1 1 DOTS entry: DT.65286284 6 AceView cDNA sequences: NM_016944 AL832513 AW197234 AW590303 AI652891 BQ378653
 highest scoring ESTs for TAS2R4:BQ378653 AL832513 AI652891 AW197234 AW590303 NM_016944 BC130439 Unigene Cluster for TAS2R4: Taste receptor, type 2, member 4 Hs.669863 [show with all ESTs]Unigene Representative Sequence: AL832513
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000247881(uc003vwq.1)
|
Expression
for TAS2R4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TAS2R4 expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching TAS2R4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 221392_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_016944 |
0.40 |
0.67 |
0.55 |
1 |
| 221392_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TATAATGGAA
SOURCE GeneReport for Unigene cluster: Hs.669863
UniProtKB/Swiss-Prot: TA2R4_HUMAN, Q9NYW5Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively ingustducin-positive cells. Expressed on airway ciliated epithelium
SABiosciences Custom PCR Arrays for TAS2R4
|
Orthologs
for TAS2R4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAS2R4 gene from 3 species
About this table Species with no ortholog for TAS2R4
ENSEMBL Gene Tree for TAS2R4 (if available) |
Paralogs
for TAS2R4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAS2R4 gene
- TAS2R412 TAS2R52 TAS2R392 TAS2R382 TAS2R402 TAS2R162 TAS2R602 TAS2R12
TAS2R4 for paralogs About GeneDecksing
|
Genomic Variants
for TAS2R4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TAS2R4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAS2R4
1 CNV: 47923 | | QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R4 |
|
Disorders & Mutations
for TAS2R4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
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TAS2R4 for disorders About GeneDecksing
OMIM: 604869
Export disorders and mutations for TAS2R4 gene to outside databases
|
Medical News
for TAS2R4 gene(Possibly Related Articles in
Doctor's Guide)
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| -- |
Publications
for TAS2R4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for TAS2R4 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with TAS2R4)- A novel family of mammalian taste receptors. (PubMed id 10761934)1, 2, 3 Adler E....Zuker C.S. (2000)
- T2Rs function as bitter taste receptors. (PubMed id 10761935)1, 2, 3 Chandrashekar J.... Ryba N.J.P. (2000)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Motile cilia of human airway epithelia are chemosensory. (PubMed id 19628819)2 Shah A.S.... Welsh M.J. (2009)
- Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. (PubMed id 15744053)1 Go Y.... Takahata N. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TAS2R4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TAS2R4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
| Name | Description |
| Protein Spotlight | http://www.expasy.org/spotlight/back_issues/sptlt119.shtml |
|
| | |
About This Section
| Patent Information for TAS2R4 gene:
Search GeneIP for patents involving TAS2R4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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