Aliases &
Descriptions
for TAS2R50 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| taste receptor, type 2, member 501 2 | | TAS2R512 5 | | T2R511 2 3 5 | | OTTHUMP000002225782 | | T2R502 3 5 | | MGC1383052 | | Taste receptor type 2 member 512 3 | | taste receptor type 2 member 502 |
Export aliases for TAS2R50 gene to outside databasesPrevious GC identifers: GC00U991259 GC12M011038 GC12M011029 GC12M011138 |
Summaries
for TAS2R50 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAS2R50:
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells andmediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 (PubMed12584440)). See also TAS2R10 (MIM 604791).(supplied by OMIM)
UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
Gene Wiki entry for TAS2R50 |
Genomic Views
for TAS2R50 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAS2R50 gene promoter:
POU2F2B POU2F2C POU2F2 (Oct-2.1) Oct-B1 POU2F2 oct-B2 POU2F1 oct-B3 POU3F1 FOXD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAS2R50
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.2 HGNC cytogenetic band: 12p13.2TAS2R50 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010866: view genomic region
(about GC identifiers)
Start:
|
10,866,889 bp from pter |
End:
|
10,867,888 bp from pter |
Size:
|
1,000 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 11,138,512-11,139,511 |
RefSeq DNA sequence:- NC_000012.11 NT_009714.17
|
Proteins
for TAS2R50 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544 (See
protein sequence)Recommended Name: Taste receptor type 2 member 50 Size: 299 amino acids; 34558 Da
Subcellular location: Membrane; Multi-pass membrane protein
Miscellaneous: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells candiscriminate among bitter stimuli
Secondary accessions: P59545 Q2M255 Q645Y0Explore the universe of human proteins at neXtProt for TAS2R50: NX_P59544
REFSEQ proteins: NP_795371.2
ENSEMBL proteins: ENSP00000375093 ENSP00000424040
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
TAS2R50 for ontologies About GeneDecksing
Antibodies for TAS2R50:
Assays for TAS2R50: |
Protein
Domains/
Families
for TAS2R50 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAS2R50 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59544ProtoNet protein and cluster: P59544 UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544Similarity: Belongs to the G-protein coupled receptor T2R family |
Gene Function
for TAS2R50 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544Function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role insensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alphagustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
About this table
TAS2R50 for ontologies About GeneDecksing
|
Pathways & Interactions
for TAS2R50 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TAS2R50 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for TAS2R50):
SABiosciences Custom Pathway-Focused PCR Arrays for TAS2R50
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAS2R50
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0050896 | response to stimulus |
IEA | -- | | GO:0050909 | sensory perception of taste |
IEA | -- |
About this table
TAS2R50 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAS2R50 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAS2R50
|
Transcripts
for TAS2R50 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TAS2R50 gene: NM_176890.2 Additional cDNA sequence: BC112100.1 1 DOTS entry: DT.100702958 1 AceView cDNA sequence: NM_176890
 highest scoring ESTs for TAS2R50:NM_176890 BC112100 Unigene Cluster for TAS2R50: Taste receptor, type 2, member 50 Hs.688194 Unigene Representative Sequence: NM_176890
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000390675 ENST00000506868(uc001qzl.2)
|
Expression
for TAS2R50 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TAS2R50 expression in normal and diseased human tissues
1 / 2 / 3 1 probe-set matching TAS2R50 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1553561_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGAAGGATC
SOURCE GeneReport for Unigene cluster: Hs.688194
UniProtKB/Swiss-Prot: T2R50_HUMAN, P59544Tissue specificity: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positivecells
SABiosciences Custom PCR Arrays for TAS2R50
|
Orthologs
for TAS2R50 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAS2R50 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
TAS2R501 |
-- |
taste receptor, type 2, member 50 |
99.11(n)
98.32(a) |
493897 NM_001009143.1 NP_001009143.1 |
About this table Species with no ortholog for TAS2R50
ENSEMBL Gene Tree for TAS2R50 (if available) |
Paralogs
for TAS2R50 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TAS2R50 gene
- TAS2R422 TAS2R92 TAS2R72 TAS2R192 TAS2R32 TAS2R202 TAS2R82 TAS2R102
- TAS2R132 TAS2R312 TAS2R142
TAS2R50 for paralogs About GeneDecksing
|
Genomic Variants
for TAS2R50 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TAS2R50
3 CNVs: 3875 86212 4769 | | QIAGEN SeqTarget long-range PCR primers for resequencing TAS2R50 |
|
Disorders & Mutations
for TAS2R50 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAS2R50 for disorders About GeneDecksing
OMIM: 609627
Human Gene Mutation Database (HGMD): TAS2R50
Genetic Association Database (GAD): TAS2R50
Human Genome Epidemiology (HuGE) Navigator: TAS2R50 (5 documents)
Export disorders and mutations for TAS2R50 gene to outside databases
|
Medical News
for TAS2R50 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TAS2R50 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for TAS2R50 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with TAS2R50)- Identification of four gene variants associated with myocardial infarction. (PubMed id 16175505)1, 3, 4 Shiffman D.... Kane J.P. (2005)
- Identification and characterization of human taste receptor genes belonging to the TAS2R family. (PubMed id 12584440)1, 2, 3 Conte C.... Andres-Barquin P.J. (2002)
- The human TAS2R16 receptor mediates bitter taste in response to beta- glucopyranosides. (PubMed id 12379855)1, 2, 3 Bufe B.... Meyerhof W. (2002)
- Evolution of bitter taste receptors in humans and apes. (PubMed id 15496549)1, 2 Fischer A.... Paeaebo S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. (PubMed id 12581520)1, 2 Zhang Y.... Ryba N.J. (2003)
- Receptors for bitter and sweet taste. (PubMed id 12139982)1, 2 Montmayeur J.-P. and Matsunami H. (2002)
- Molecular mechanisms of bitter and sweet taste transduction. (PubMed id 11696554)1, 2 Margolskee R.F. (2002)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Variations of specific non-candidate genes and risk o f myocardial infarction: A replication study. (PubMed id 19709766)1 Koch W....Kastrati A. (2009)
|
External Searches for TAS2R50 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAS2R50 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAS2R50 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAS2R50 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TAS2R50 gene:
Search GeneIP for patents involving TAS2R50
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAS2R50 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for TAS2R50 |
| |  |  |  |  | | | | |
 | | |
|
|
