Aliases &
Descriptions
for TBC1D22B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| TBC1 domain family, member 22B1 2 | | DKFZp762J01102 | | dJ744I24.21 2 | | TBC1 domain family member 22B2 | | FLJ203371 2 | | MGC1256262 | | C6orf1972 3 | | MGC1256272 | | chromosome 6 open reading frame 1971 | | RP4-744I24.22 |
Export aliases for TBC1D22B gene to outside databasesPrevious GC identifers: GC06P037334 GC06P037225 |
Summaries
for TBC1D22B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)
|
Genomic Views
for TBC1D22B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TBC1D22B
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D22B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.2 Ensembl cytogenetic band: 6p21.2 HGNC cytogenetic band: 6p21.2TBC1D22B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P036944: view genomic region
(about GC identifiers)
Start:
|
36,944,503 bp from pter |
End:
|
37,019,647 bp from pter |
Size:
|
75,145 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr6+ 37,225,548-37,300,746 |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15
|
Proteins
for TBC1D22B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19 (See
protein sequence)Recommended Name: TBC1 domain family member 22B Size: 505 amino acids; 59081 Da
Sequence caution: Sequence=BAA91099.1; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :3DZX (3D)
Secondary accessions: Q32MQ8 Q5VUK9 Q7Z6P7 Q9BPV6 Q9BUT5 Q9NXB6Explore the universe of human proteins at neXtProt for TBC1D22B: NX_Q9NU19
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060242.2
ENSEMBL proteins: ENSP00000362590
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
About this table
TBC1D22B for ontologies About GeneDecksing
Antibodies for TBC1D22B:
Assays for TBC1D22B: |
Protein
Domains/
Families
for TBC1D22B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D22B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NU19ProtoNet protein and cluster: Q9NU19 1 Blocks protein family: IPB000195 RabGAP/TBC domain
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Similarity: Contains 1 Rab-GAP TBC domain |
Gene Function
for TBC1D22B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TB22B_HUMAN, Q9NU19Function: May act as a GTPase-activating protein for Rab family protein(s) (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0005097 | Rab GTPase activator activity |
IEA | -- |
About this table
TBC1D22B for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D22B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TBC1D22B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D22B
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032313 | regulation of Rab GTPase activity |
IEA | -- |
About this table
TBC1D22B for ontologies About GeneDecksing
|
Drugs & Compounds
for TBC1D22B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TBC1D22B
|
Transcripts
for TBC1D22B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TBC1D22B gene: NM_017772.2 Additional cDNA sequence: AB449909.1 AK000344.1 AK021840.1 AK096340.1 AK292893.1 AY313781.1 AY927466.1 AY927467.1 BC000291.2 BC000743.2 BC001927.1 BC002720.2 BC047658.1 BC063523.1 BC109026.1 BC109027.1 BX648317.1 CR749710.1 12 DOTS entries: DT.453005 DT.101982439 DT.121353515 DT.427275 DT.422177 DT.422189 DT.75144988 DT.95258077 DT.100780068 DT.121353553 DT.91697826 DT.92064882 24/133 AceView cDNA sequences (see all 133): CD674134 BC047658 AL521025 BC002720 BM750148 BM725980 AA335499 AW629346 AY313781 AA948606 BI333073 BC063523 AA723807 AI279972 BQ637987 BM053100 AI278672 AI246672 CB159422 CK904001 AI366854 BQ438303 NM_017772 BQ707954
 highest scoring ESTs for TBC1D22B:AI952855 AA236607 AA237024 AA335499 AA370054 AA424773 AA424906 AA429601 AA432211 AA455390 Unigene Cluster for TBC1D22B: TBC1 domain family, member 22B Hs.485270 [show with all ESTs]Unigene Representative Sequence: BC047658
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D22B (see all 6)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TBC1D22B
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000373491(uc003ono.1 uc003onn.2 uc010jwt.2 uc003onp.2)
|
Expression
for TBC1D22B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TBC1D22B expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching TBC1D22B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 51144_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.96 |
1.12 |
AI952855 |
1.00 |
1.00 |
1.00 |
1 |
| 58530_r_at*2, 3
|
U95-C |
1 |
-- |
-- |
0.28 |
0.89 |
T66185 |
0.40 |
1.00 |
0.76 |
1 |
| 223375_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC002720 |
0.80 |
1.00 |
0.91 |
1 |
| 216549_s_at2
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223375_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 216549_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TBC1D22B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AGATGTGTGA
SOURCE GeneReport for Unigene cluster: Hs.485270
SABiosciences Custom PCR Arrays for TBC1D22B
|
Orthologs
for TBC1D22B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TBC1D22B gene from 5/19 species (see all 19)
About this table Species with no ortholog for TBC1D22B
ENSEMBL Gene Tree for TBC1D22B (if available) |
Paralogs
for TBC1D22B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TBC1D22B gene
- TBC1D132 TBC1D22A2
TBC1D22B for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D22B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TBC1D22B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TBC1D22B
1 Indel: 47115 | | QIAGEN SeqTarget long-range PCR primers for resequencing TBC1D22B |
|
Disorders & Mutations
for TBC1D22B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D22B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TBC1D22B (1 document)
Export disorders and mutations for TBC1D22B gene to outside databases
|
Medical News
for TBC1D22B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TBC1D22B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10 PubMed articles for TBC1D22B gene integrated from 7 sources:
(articles sorted by number of sources associating them with TBC1D22B)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PubMed id 19077034)1 Ishibashi K.... Fukuda M. (2009)
- Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays. (PubMed id 15998911)1 Kapranov P....Gingeras T.R. (2005)
- Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. (PubMed id 15790807)1 Cheng J....Gingeras T.R. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TBC1D22B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D22B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D22B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D22B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TBC1D22B gene:
Search GeneIP for patents involving TBC1D22B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D22B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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