Aliases &
Descriptions
for TBC1D28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| TBC1 domain family, member 281 2 | | FLJ402441 2 | | MGC1382172 | | TBC1 domain family member 282 | | OTTHUMP000000650772 | | MGC1382212 |
Export aliases for TBC1D28 gene to outside databasesPrevious GC identifers: GC17M018480 GC17M018482 GC17M018538 |
Summaries
for TBC1D28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TBC1D28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TBC1D28
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D28
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2TBC1D28 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M018146: view genomic region
(about GC identifiers)
Start:
|
18,146,813 bp from pter |
End:
|
18,147,797 bp from pter |
Size:
|
985 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17- 18,538,842-18,547,740 |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
|
Proteins
for TBC1D28 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TBC28_HUMAN, Q2M2D7 (See
protein sequence)Recommended Name: TBC1 domain family member 28 Size: 210 amino acids; 24072 Da
Caution: The Rab-GAP TBC domain is short and lacks the C-terminal part. It is therefore unclear whether the protein hasGTPase-activating activity
Secondary accessions: Q2M2E1Explore the universe of human proteins at neXtProt for TBC1D28: NX_Q2M2D7
REFSEQ proteins: NP_001034486.2
ENSEMBL proteins: ENSP00000385821 ENSP00000339973
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
About this table
TBC1D28 for ontologies About GeneDecksing
Antibodies for TBC1D28:
Assays for TBC1D28: |
Protein
Domains/
Families
for TBC1D28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D28 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q2M2D7ProtoNet protein and cluster: Q2M2D7 UniProtKB/Swiss-Prot: TBC28_HUMAN, Q2M2D7Similarity: Contains 1 Rab-GAP TBC domain |
Gene Function
for TBC1D28 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
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|
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
About this table
TBC1D28 for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D28 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TBC1D28
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D28
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032313 | regulation of Rab GTPase activity |
IEA | -- |
About this table
TBC1D28 for ontologies About GeneDecksing
|
Drugs & Compounds
for TBC1D28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TBC1D28
|
Transcripts
for TBC1D28 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TBC1D28 gene: NM_001039397.2 Additional cDNA sequence: AK097563.1 AK292544.1 AL137747.1 BC112012.1 BC112016.1 3 DOTS entries: DT.40298868 DT.102838138 DT.121002760 9 AceView cDNA sequences: AK097563 BX097621 AA933929 AI149683 CD676640 AI205891 AL137747 BI561256 AW119095 Unigene Cluster for TBC1D28: TBC1 domain family, member 28 Hs.434123 [show with all ESTs]Unigene Representative Sequence: AK097563
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000405044(uc002gud.2) ENST00000345096
|
Expression
for TBC1D28 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TBC1D28 expression in normal and diseased human tissues
1 / 2 1 probe-set matching TBC1D28 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 72180_at2
|
U95-E |
2 |
0.69 |
0.82 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
About this table
TBC1D28 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATCTCTTGGC
SOURCE GeneReport for Unigene cluster: Hs.434123
SABiosciences Custom PCR Arrays for TBC1D28
|
Orthologs
for TBC1D28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for TBC1D28 (if available) |
Paralogs
for TBC1D28 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TBC1D28 gene
- TBC1D261 2 ENSG000002382832 TBC1D3H2 TBC1D3P22 TBC1D32 TBC1D3F2 TBC1D3C2 ENSG000002487512
- TBC1D10C2 GRTP12 TBC1D10A2 TBC1D10B2 TBC1D3G2 USP6NL2 TBC1D3B2
TBC1D28 for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D28 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TBC1D28 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TBC1D28
4 CNVs: 30808 88369 67154 67153 | | QIAGEN SeqTarget long-range PCR primers for resequencing TBC1D28 |
|
Disorders & Mutations
for TBC1D28 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for TBC1D28 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TBC1D28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
4 PubMed articles for TBC1D28 gene integrated from 7 sources:
(articles sorted by number of sources associating them with TBC1D28)- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBC1D28 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing TBC1D28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D28 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TBC1D28 gene:
Search GeneIP for patents involving TBC1D28
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D28 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for TBC1D28 |
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