Aliases &
Descriptions
for TBC1D3B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| TBC1 domain family, member 3B1 2 | | Rab GTPase-activating protein PRC17 duplicate2 | | PRC171 2 5 | | TBC1D3I2 | | TBC1 domain family, member 3I1 2 | | prostate cancer gene 17 duplicate2 | | FLJ783992 | | TBC1 domain family member 3B/I2 |
Export aliases for TBC1D3B gene to outside databasesPrevious GC identifer: GC17M031519 |
Summaries
for TBC1D3B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TBC1D3B:
This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p,and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There aremultiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. (provided by RefSeq)
UniProtKB/Swiss-Prot: TBC3B_HUMAN, A6NDS4Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
|
Genomic Views
for TBC1D3B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TBC1D3B gene promoter:
FOXO1a FOXF2 Lmo2 STAT3 FOXO4 HNF-4alpha2 COUP-TF1 GR-alpha GR-beta NF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TBC1D3B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.1TBC1D3B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M034492: view genomic region
(about GC identifiers)
Start:
|
34,492,877 bp from pter |
End:
|
34,503,988 bp from pter |
Size:
|
11,112 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr17-,PATCHES 34,507,296-34,518,223 |
RefSeq DNA sequence:- NC_000017.10 NT_010799.15
|
Proteins
for TBC1D3B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TBC3B_HUMAN, A6NDS4 (See
protein sequence)Recommended Name: TBC1 domain family member 3B/I Size: 549 amino acids; 62315 Da
Secondary accessions: A8K892Explore the universe of human proteins at neXtProt for TBC1D3B: NX_A6NDS4
REFSEQ proteins: NP_001001417.5
ENSEMBL proteins: ENSP00000390852 ENSP00000340678 ENSP00000381781
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
About this table
TBC1D3B for ontologies About GeneDecksing
Antibodies for TBC1D3B:
Assays for TBC1D3B: |
Protein
Domains/
Families
for TBC1D3B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TBC1D3B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NDS4ProtoNet protein and cluster: A6NDS4 UniProtKB/Swiss-Prot: TBC3B_HUMAN, A6NDS4Similarity: Contains 1 Rab-GAP TBC domain |
Gene Function
for TBC1D3B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TBC3B_HUMAN, A6NDS4Function: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0005097 | Rab GTPase activator activity |
IEA | -- |
About this table
TBC1D3B for ontologies About GeneDecksing
|
Pathways & Interactions
for TBC1D3B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TBC1D3B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TBC1D3B
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032313 | regulation of Rab GTPase activity |
IEA | -- |
About this table
TBC1D3B for ontologies About GeneDecksing
|
Drugs & Compounds
for TBC1D3B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TBC1D3B
|
Transcripts
for TBC1D3B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TBC1D3B gene: NM_001001417.5 Additional cDNA sequence: AK292257.1 19 DOTS entries: DT.92042803 DT.102843582 DT.97771291 DT.102843998 DT.120948306 DT.120994618 DT.91828704 DT.95298563 DT.212833 DT.120894916 DT.120894920 DT.120948289 DT.100742312 DT.100787971 DT.120910090 DT.120948285 DT.120948301 DT.91767081 DT.95298566 24/48 AceView cDNA sequences (see all 48): BX281608 CA394892 BF809416 BG718044 BM843014 BU526609 BF091359 BM842932 BQ942166 BM914524 AL045766 BX279913 BI753688 BI832051 BI520522 BI829764 AV650439 BM842553 BI827136 BI828272 BU542901 BQ923700 BM762465 AF540953
 highest scoring ESTs for TBC1D3B:AA444106 AA522755 AI304945 AW391897 AW795240 AW877962 BF742137 BF907952 BU660899 BX118066 Unigene Cluster for TBC1D3B: TBC1 domain family, member 3B Hs.454713 [show with all ESTs]Unigene Representative Sequence: NM_001001417
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000454519(uc002hky.2) ENST00000340106 ENST00000398801
|
Expression
for TBC1D3B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TBC1D3B expression in normal and diseased human tissues
1 / 2 / 3 1 probe-set matching TBC1D3B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 91373_at2, 3
|
U95-E |
10 |
0.88 |
0.15 |
1.00 |
1.00 |
AL042933 |
0.20 |
0.03 |
0.14 |
2 |
About this table
TBC1D3B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.454713
SABiosciences Custom PCR Arrays for TBC1D3B
|
Orthologs
for TBC1D3B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
| ENSEMBL Gene Tree for TBC1D3B (if available) |
Paralogs
for TBC1D3B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TBC1D3B gene
- TBC1D3I TBC1D3C1 2 LOC653380 TBC1D3G1 2 LOC729837 TBC1D3H1 2 TBC1D3F1 2 TBC1D3E
- TBC1D31 2 ENSG000002382832 TBC1D3P22 TBC1D262 ENSG000002487512 TBC1D10C2 GRTP12 TBC1D10A2
- TBC1D10B2 USP6NL2 TBC1D282
TBC1D3B for paralogs About GeneDecksing
|
Genomic Variants
for TBC1D3B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for TBC1D3B
15/25 CNVs (see all 25): 37558 88443 7154 72880 88435 8841 30824 35451 35450 88438 88441 5003 88440 77579 88439 | | QIAGEN SeqTarget long-range PCR primers for resequencing TBC1D3B |
|
Disorders & Mutations
for TBC1D3B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TBC1D3B for disorders About GeneDecksing
OMIM: 610144
Export disorders and mutations for TBC1D3B gene to outside databases
|
Medical News
for TBC1D3B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TBC1D3B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
5 PubMed articles for TBC1D3B gene integrated from 7 sources:
(articles sorted by number of sources associating them with TBC1D3B)- TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12. (PubMed id 16863688)1, 3 Hodzic D....Stahl P.D. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer. (PubMed id 12359748)3 Pei L.... Li J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TBC1D3B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TBC1D3B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TBC1D3B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TBC1D3B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TBC1D3B gene:
Search GeneIP for patents involving TBC1D3B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TBC1D3B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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