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TCP11L2 Gene

protein-coding GIFtS: 41

GC12P103756

t-complex 11 (mouse)-like 2
(Previous name: t-complex 11 (mouse) like 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
t-complex 11 (mouse)-like 2¹ ²
MGC40368¹ ²
t-complex 11 (mouse) like 2¹
T-complex protein 11-like protein 2²

External Ids:	HGNC: 28627¹	Entrez Gene: 255394²	Ensembl: ENSG00000166046⁷	UniProtKB: Q8N4U5³

Export aliases for TCP11L2 gene to outside databases

Previous GC identifers: GC12P105200 GC12P106696

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TCP11L2 gene promoter:
         FOXO3b   FOXO3a   Nkx6-1   FOXF2   GATA-1   GATA-3   GATA-2   MAZR   Sp1   FOXO1a
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TCP11L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TCP11L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TCP11L2 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P103756: view genomic region (about GC identifiers)

Start:	103,756,893 bp from pter
End:	103,801,111 bp from pter
Size:	44,219 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 106,696,581-106,740,790

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5 (See protein sequence)

Recommended Name: T-complex protein 11-like protein 2

Size: 519 amino acids; 58091 Da

Explore the universe of human proteins at neXtProt for TCP11L2: NX_Q8N4U5

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_689985.1

ENSEMBL proteins:

ENSP00000299045

Human Recombinant Proteins

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Antibodies for TCP11L2:

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	Browse antibodies at Epitomics

Assays for TCP11L2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TCP11L2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TCP11L2 for domains About GeneDecksing

1 InterPro domain/family:

IPR008862 Tcp11

Graphical View of Domain Structure for InterPro Entry Q8N4U5

ProtoNet protein and cluster: Q8N4U5

UniProtKB/Swiss-Prot: T11L2_HUMAN, Q8N4U5

Similarity: Belongs to the TCP11 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for TCP11L2 Sigma-Aldrich shRNA for TCP11L2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TCP11L2 OriGene shRNA RFP (see all 2): TCP11L2 OriGene basic RS shRNA (see all 2): TCP11L2 OriGene siRNA: TCP11L2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TCP11L2

miRNA:		Sigma-Aldrich microRNA Mimics for TCP11L2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TCP11L2
		Search SABiosciences for Assays for microRNAs that regulate TCP11L2

Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: TCP11L2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TCP11L2 OriGene untagged cDNA clones in CMV expression vector: TCP11L2 OriGene 3'-UTR clone: TCP11L2 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: TCP11L2
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TCP11L2

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for TCP11L2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TCP11L2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TCP11L2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for TCP11L2 Sigma-Aldrich shRNA for TCP11L2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TCP11L2 OriGene shRNA RFP (see all 2): TCP11L2 OriGene basic RS shRNA (see all 2): TCP11L2 OriGene siRNA: TCP11L2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TCP11L2

miRNA:		Sigma-Aldrich microRNA Mimics for TCP11L2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TCP11L2
		Search SABiosciences for Assays for microRNAs that regulate TCP11L2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TCP11L2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TCP11L2 OriGene untagged cDNA clones in CMV expression vector: TCP11L2 OriGene 3'-UTR Clone: TCP11L2 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: TCP11L2

Primers:		OriGene genome-wide validated SYBR primer pairs: TCP11L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TCP11L2: PPH23738A

REFSEQ mRNAs for TCP11L2 gene:

NM_152772.1

Additional cDNA sequence:

AF306671.1 AF306672.1 AF306673.1 AF306674.1 AF306858.1 AK314055.1 BC017872.1 BC033617.1

CR607890.1

6 DOTS entries:

DT.75190745 DT.40129099 DT.91956855 DT.100020168 DT.92039012 DT.91649200

24/42 AceView cDNA sequences (see all 42):

BX099838 AI040691 CB164782 BC033617 AI040771 NM_152772 AV724671 AF306673

AL534373 CR607890 CB955581 BI917455 BM083639 BX398167 BX501162 BF589371

BE646441 AF306671 BX389653 AF306672 AF306858 BX389654 BU657756 AI088346

highest scoring ESTs for TCP11L2:

AW865130 AW865397 AW889933 AW889934 BC033617 BE646441 BM955989 CB164782 AA809352 AA969418

Unigene Cluster for TCP11L2:

T-complex 11 (mouse)-like 2

Hs.696047 [show with all ESTs]

Unigene Representative Sequence: AF306858

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 (see all 8)

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15
SP1:							-		-		-		-		-						-																-		-
SP2:							-		-		-		-		-						-
SP3:							-		-		-				-						-
SP4:																																					-
SP5:							-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for TCP11L2
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000299045(uc001tll.2 uc001tlm.2 uc001tln.2 uc001tlo.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TCP11L2 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching TCP11L2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1565525_a_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
1559413_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--
1565000_a_at*²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
1565527_x_at*²	U133Plus2	2	0.55	0.83	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

TCP11L2 gene electronic northern expression

About these images

CGAP SAGE TAG: CTGAAACCCC

SOURCE GeneReport for Unigene cluster: Hs.696047

Primers:		OriGene genome-wide validated SYBR primer pairs: TCP11L2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TCP11L2: PPH23738A

SABiosciences Custom PCR Arrays for TCP11L2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TCP11L2 gene from 5/11 species (see all 11)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TCP11L2¹	--	t-complex 11 (mouse)-like 2	92.3(n) 92.82(a)	474532 XM_531761.2 XP_531761.2
chimpanzee (Pan troglodytes)	TCP11L2¹	--	t-complex 11 (mouse)-like 2	99.36(n) 99.04(a)	452199 XM_509333.2 XP_509333.2
cow (Bos taurus)	TCP11L2¹	--	t-complex 11 (mouse)-like 2	89.6(n) 90.94(a)	541012 XM_614083.3 XP_614083.3
rat (Rattus norvegicus)	Tcp11l2¹	--	t-complex 11 (mouse) like 2	83.17(n) 79.5(a)	314683 NM_001017458.1 NP_001017458.1
mouse (Mus musculus)	Tcp11l2^{1 , 5}	10 (41.55 cM)⁵	t-complex 11 (mouse) like 2^{1, 5}	83.43(n)¹ 79.11(a)¹	216198¹ NM_146008.2¹ NP_666120.1¹ AK040850⁵ AK088802⁵ (see all 10)

About this table Species with no ortholog for TCP11L2

ENSEMBL Gene Tree for TCP11L2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TCP11L2 gene

TCP11L1² ENSG00000215029² TCP11² ENSG00000215046²

TCP11L2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs904614^1,2	C,F,O,A,	106698334(+)	`TCTGCA/CATTTT`	1	--	int¹		10	NA EA WA	360
rs1134577^1,2	C,F,O,	106724838(-)	`TTAAAG/AACAAT`	1	--	int¹		108	NS MN NA EA PA EU CA WA	7002
rs1532586^1,2	C,F,A,	106700584(+)	`atggcA/Gagttc`	1	--	int¹		16	NS EA NA WA	1012
rs1532587^1,2	C,F,O,A,H,	106700709(+)	`TTGCAA/GTTCTG`	1	--	int¹		20	NS EA NA WA	1202
rs1921952^1,2	C,F,A,	106724694(-)	`TACTAC/TAATAT`	1	--	int¹		9	NS EA NA WA	546
rs1921953^1,2	C,F,A,	106721012(-)	`cctggG/Acaata`	1	--	int¹		6	NA WA	82
rs2077730^1,2	C,F,A,H,	106716740(-)	`acaatC/Tgtaaa`	1	--	int¹		12	NS EA NA WA	634
rs2133574^1,2	H	106699876(+)	`GTCTAG/AAAGAG`	1	--	int¹		4	NS EA	420
rs2243455^1,2	C,F,A,H,	106720856(+)	`TCTTTA/CATCAA`	1	--	int¹		16	NS EA NA WA	812
rs2243591^1,2	H	106739537(+)	`accggG/Ctggct`	1	--	int¹		4	NS EA	418

About this table

HapMap Linkage Disequilibrium images for TCP11L2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TCP11L2: --

QIAGEN SeqTarget long-range PCR primers for resequencing TCP11L2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

3 PubMed articles for TCP11L2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with TCP11L2)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 255394	HGNC: 28627	AceView: MGC40368	Ensembl:ENSG00000166046	euGenes: HUgn255394
ECgene: TCP11L2	H-InvDB: TCP11L2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for TCP11L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for TCP11L2 gene:
Search GeneIP for patents involving TCP11L2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TCP11L2
	SeqTarget long-range PCR primers for resequencing TCP11L2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TCP11L2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TCP11L2

	GenScript Custom Purified and Recombinant Proteins Services for TCP11L2		GenScript cDNA clones with any tag delivered in your preferred vector for TCP11L2
	GenScript Custom Assay Services for TCP11L2		GenScript Custom Superior Antibodies Services for TCP11L2
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TCP11L2 Gene

protein-coding GIFtS: 41

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TCP11L2 Gene

protein-coding GIFtS: 41

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for TCP11L2 gene

Proteins
for TCP11L2 gene

Protein Domains/
Families
for TCP11L2 gene

Gene Function
for TCP11L2 gene

Pathways & Interactions
for TCP11L2 gene

Drugs & Compounds
for TCP11L2 gene

Transcripts
for TCP11L2 gene

Expression
for TCP11L2 gene

Orthologs
for TCP11L2 gene

Paralogs
for TCP11L2 gene

Genomic Variants
for TCP11L2 gene

Disorders & Mutations
for TCP11L2 gene

Medical News
for TCP11L2 gene

Publications
for TCP11L2 gene

Intellectual Property
for TCP11L2 gene

Products
for TCP11L2 gene