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TENC1 Gene

protein-coding   GIFtS: 53

GC12P050483
tensin like C1 domain containing phosphatase (tensin 2)
(Previous name: tensin like C1 domain-containing phosphatase )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tensin like C1 domain containing phosphatase (tensin 2)1 2     DKFZp686D132442
KIAA10751 2 3 5     tensin 22
C1-TEN1 2 3     tensin-22
TNS21 2 3     tensin-like C1 domain-containing phosphatase2
tensin like C1 domain-containing phosphatase1 2     FLJ163202
C1 domain-containing phosphatase and tensin homolog2 3     EC 3.1.3.-3
C1TEN2 5     Tensin-23

External Ids:    HGNC: 197371   Entrez Gene: 233712   Ensembl: ENSG000001110777   UniProtKB: Q63HR23   

Export aliases for TENC1 gene to outside databases

Previous GC identifers: GC12P053354 GC12P053157 GC12P051727 GC12P053440


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TENC1:
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin
filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative
splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
(provided by RefSeq)

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
Lowers AKT1 kinase activity and interferes with AKT1 signaling

Gene Wiki entry for TENC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TENC1 gene promoter:
         CREB   MEF-2A   CUTL1   deltaCREB   STAT5A   AREB6   POU2F2 (Oct-2.1)   POU2F1   oct-B2   Oct-B1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TENC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TENC1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

TENC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TENC1 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P050483:  view genomic region     (about GC identifiers)

Start:
50,483,949 bp from pter
End:
50,501,247 bp from pter
Size:
17,299 bases
Orientation:
plus strand

1 alternative location:
Chr12+ 53,440,810-53,458,163     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2 (See protein sequence)
Recommended Name: Tensin-like C1 domain-containing phosphatase  
Size: 1409 amino acids; 152580 Da
Subunit: Interacts with AXL
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Note=Detected at the end of actin stress fibers
Sequence caution: Sequence=AAI29829.1; Type=Erroneous initiation; Sequence=AAI29830.1; Type=Erroneous initiation;
Sequence=AAI31504.1; Type=Erroneous initiation; Sequence=BAA83027.2; Type=Erroneous initiation;
PDB structures from and Proteopedia :
2DKQ (3D)    2KNO (3D)    3HQC (3D)    
Secondary accessions: A2VDF2 A2VDF3 A2VDI8 A5PKY4 Q2NL80 Q76MW6 Q7Z5T9 Q8NFF9 Q8NFG0 Q96P25 Q9NT29
Q9UPS7
Alternative splicing: 6 isoforms:  Q63HR2-1   Q63HR2-2   Q63HR2-3   Q63HR2-4   Q63HR2-5   Q63HR2-6   

Explore the universe of human proteins at neXtProt for TENC1: NX_Q63HR2 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_056134.2  NP_736610.2  NP_938072.1  


    ENSEMBL proteins: 
    ENSP00000319756 ENSP00000319684 ENSP00000415945 ENSP00000393362 ENSP00000408441 ENSP00000398989 
    ENSP00000369232 ENSP00000262048 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TENC1 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0005925 focal adhesion IDA16951145
    GO:0030054 cell junction IEA--
    About this table

    TENC1 for ontologies           About GeneDecksing



    Antibodies for TENC1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TENC1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TENC1 
    Epitomics antibodies for TENC1

    Assays for TENC1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TENC1 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TENC1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR014019 Phosphatase_tensin-typ
     IPR013625 PTB
     IPR008973 C2_Ca/lipid-bd_dom_CaLB
     IPR006020 PTyr_interaction_dom
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q63HR2

    ProtoNet protein and cluster: Q63HR2

    2 Blocks protein families:
    IPB000980 SH2 domain signature
    IPB013625 Tensin phosphotyrosine-binding domain


    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Similarity: Contains 1 C2 tensin-type domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 phosphatase tensin-type domain
    Similarity: Contains 1 SH2 domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.
    Lowers AKT1 kinase activity and interferes with AKT1 signaling
    Enzyme Number (IUBMB): EC 3.1.3.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TENC1
    Sigma-Aldrich shRNA for TENC1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): TENC1
    OriGene shRNA RFP (see all 4): TENC1
    OriGene basic RS shRNA (see all 4): TENC1
    OriGene siRNA (see all 3): TENC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TENC1 
    miRNA:Sigma-Aldrich microRNA Mimics for TENC1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TENC1 
    1 SABiosciences Assays for microRNA that regulate TENC1:
    hsa-miR-767-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene 3'-UTR clone (see all 3): TENC1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): TENC1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TENC1 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004721 phosphoprotein phosphatase activity IEA--
    GO:0005515 protein binding IPI17190795
    GO:0016787 hydrolase activity IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    TENC1 for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tenc1):

    adipose tissuedigestive/alimentaryhematopoietic systemhomeostasis/metabolismimmune system
    life span-post-weaning/agingrenal/urinary systemreproductive system

    TENC1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including TENC1: PAHS-045A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TENC1

    5/7 Interacting proteins for TENC1 (Q63HR22) via UniProtKB, MINT, and/or STRING (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262MINT-74780 MINT-74778 MINT-74781 MINT-74779
    ERBB3P218602MINT-74782 MINT-74783 MINT-74784
    GFI1BQ5VTD92MINT-2870938
    ITGB1P055562MINT-45902
    ITGB3P051062MINT-61480
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822 kidney development ----
    GO:0008285 negative regulation of cell proliferation IMP16951145
    GO:0014850 response to muscle activity ----
    GO:0019725 cellular homeostasis ----
    GO:0023034 intracellular signaling pathway ----
    About this table

    TENC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TENC1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TENC1
    Sigma-Aldrich shRNA for TENC1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): TENC1
    OriGene shRNA RFP (see all 4): TENC1
    OriGene basic RS shRNA (see all 4): TENC1
    OriGene siRNA (see all 3): TENC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TENC1 
    miRNA: Sigma-Aldrich microRNA Mimics for TENC1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TENC1 
    1 SABiosciences Assays for microRNA that regulate TENC1:
    hsa-miR-767-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): TENC1
    OriGene 3'-UTR Clone (see all 3): TENC1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): TENC1 
    Primers: OriGene genome-wide validated SYBR primer pairs: TENC1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TENC1: PPH07391A

    REFSEQ mRNAs for TENC1 gene (3 alternative transcripts): 

    NM_015319.2  NM_170754.2  NM_198316.1  

    Additional cDNA sequence: 

    AB028998.2 AF417490.1 AF518728.1 AF518729.1 AK131320.1 AK172747.1 AL137564.1 BC054099.1 
    BC110854.1 BC129828.1 BC129829.1 BC131503.1 BC142668.1 BC142712.1 BC150259.1 BX647126.1 
    CR607439.1 CR614736.1 CR936725.1 

    20 DOTS entries:

    DT.100648283  DT.95295531  DT.95151181  DT.449115  DT.121118050  DT.40269374  DT.100651420  DT.101982588 
    DT.100724559  DT.91689288  DT.100648284  DT.92441328  DT.95151174  DT.97784943  DT.101961374  DT.121118477 
    DT.95101213  DT.121117936  DT.121118973  DT.92036991 

    24/292 AceView cDNA sequences (see all 292):

    NM_170754 AW237124 AL137564 BU521796 CA434026 AI040475 H97675 CN479477 
    AB028998 AI637839 BM693074 BU074888 BU616495 AF518729 AW169055 AA256347 
    BG007391 BM669797 CA390952 BE326739 AI767231 AI206151 AA548543 BQ718351 

    highest scoring ESTs for TENC1:

    AB028998 AA256204 AA256347 AA426471 AA442806 AA447688 AA447840 AA553697 AA601027 AA632320 

    Unigene Cluster for TENC1:

    Tensin like C1 domain containing phosphatase (tensin 2)
    Hs.6147  [show with all ESTs]
    Unigene Representative Sequence: BC150259


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TENC1 (see all 14)

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
    SP1:        -     -     -     -     -     -           -                 -                 -                             -                                   -   
    SP2:                          -     -     -           -                 -                 -                             -                                   -   
    SP3:                                                  -                 -                 -                             -                                   -   
    SP4:                                                  -                 -                 -                             -                                   -   
    SP5:                                                                                                                                                        -   

    ExUns: 18b ^ 19a · 19b ^ 20a · 20b · 20c · 20d ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b · 25c · 25d ^ 26 ^ 27 ^ 28a · 28b ^ 29a · 29b · 29c ^ 30 ^ 31
    SP1:              -                                                     -     -                                   -                                 
    SP2:              -                                                     -     -                                   -                                 
    SP3:              -                                                     -     -                                   -                                 
    SP4:              -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:              -                       -                             -     -                                   -                                 

    About this scheme

    ECgene alternative splicing isoforms for TENC1
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314276(uc001sbm.2 uc001sbn.2) ENST00000314250 ENST00000420340
    ENST00000451358 ENST00000443113 ENST00000438153 ENST00000379902(uc001sbl.2 uc001sbq.2 uc001sbr.2 uc009zmr.2 uc001sbs.2)
    ENST00000262048(uc001sbo.1 uc001sbp.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TENC1 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching TENC1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35358_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AB028998 1.00 1.00 1.00 1
    212494_at2, 3 U133-A 1 1.00 1.00 -- -- AB028998 1.00 1.00 1.00 1
    212494_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    TENC1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TENC1 gene expression
    TENC1 gene electronic northern expression
    TENC1 gene sage expression
    About these images

    CGAP SAGE TAG: AATAGGGGAA

    SOURCE GeneReport for Unigene cluster: Hs.6147

    Expression variation in blood from EXPOLDB for TENC1

    UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2
    Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small
    intestine

    Primers: OriGene genome-wide validated SYBR primer pairs: TENC1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TENC1: PPH07391A
        SABiosciences Expression via Pathway-Focused PCR Array including TENC1: PAHS-045A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TENC1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TENC11   -- tensin like C1 domain containing phosphatase (tensin 2) less 80.92(n)
    82.34(a)
    477599  XM_534792.2  XP_534792.2 
    chimpanzee
    (Pan troglodytes)
    TENC11   -- tensin like C1 domain containing phosphatase (tensin 2) less 99.53(n)
    99.57(a)
    451927  XM_509087.2  XP_509087.2 
    rat
    (Rattus norvegicus)
    Tenc11   -- tensin like C1 domain containing phosphatase (tensin 2) less 86.32(n)
    90.56(a)
    315326  XM_235710.4  XP_235710.3 
    mouse
    (Mus musculus)
    Tenc11 , 5 15 (57.29 cM)5
    tensin like C1 domain-containing phosphatase1, 5 86.28(n)1
    90.64(a)1
    2090391  NM_153533.21  NP_705761.21 
     AF4247895  AI8547945  (see all 16)
    zebrafish
    (Danio rerio)
    LOC7991091   -- similar to Tensin-like C1 domain-containing phosphatase (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-2) less 56.3(n)
    54.6(a)
    799109  XM_001921008.1  XP_001921043.1 
    About this table        Species with no ortholog for TENC1

    ENSEMBL Gene Tree for TENC1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TENC1 gene
    PTEN2  DNAJC62  TNS12  TPTE2  TNS32  TNS42  GAK2  TPTE22  

    TENC1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/141 NCBI SNPs in TENC1 are shown (see all 141)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8831791,2
    H53444223(+) GGTTAG/AAGTAG 2 -- int11Minor allele frequency- A:0.00NS 120
    rs9601001,2
    C,F,A,H,53439537(+) TACTGA/GCTGCT 1 -- ng517Minor allele frequency- G:0.25NA WA 132
    rs14023961,2
    C,A,H,53439540(+) TGGCTG/ACTTTG 1 -- ng517Minor allele frequency- A:0.13NA WA 62
    rs21397741,2
    C53450625(-) tgttgG/Agcctc 2 -- int13Minor allele frequency- A:0.01NA 142
    rs22720011,2
    C,F53439762(+) CTCCAC/TCTTCT 1 -- ng511Minor allele frequency- T:0.01EA 736
    rs22804461,2
    C,F,A,53451952(-) TGACTA/GTGCCG 2 -- int117Minor allele frequency- N:0.00EA NA NS WA 2364
    rs22930611,2
    C,F,A,53452738(-) CAGCTG/CTCGGG 2 -- int12Minor allele frequency- C:0.35EA NA 1566
    rs22930621,2
    C,F,53449597(-) TAGGCA/GGAAAC 4 S syn1 ref1 ese39Minor allele frequency- G:0.14EA NA NS 2138
    rs23641531,2
    C,F,A,H,53449735(+) GTCCTT/CTGCTG 2 -- int122Minor allele frequency- C:0.29NS EA NA WA 1530
    rs49197281,2
    C,A,H,53440029(+) ccagcC/Actttg 1 -- ng516Minor allele frequency- A:0.08NA WA 12
    About this table

    HapMap Linkage Disequilibrium images for TENC1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for TENC1
         6 CNVs: 49091 49090 49094 49089 49092 49093
         1 Indel: 71512

    QIAGEN SeqTarget long-range PCR primers for resequencing TENC1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TENC1 for disorders           About GeneDecksing

    OMIM: 607717


    Export disorders and mutations for TENC1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/25 PubMed articles for TENC1 gene, integrated from 7 sources (see all 25):
    (articles sorted by number of sources associating them with TENC1)
    1. C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PubMed id 15817639)1, 2 Hafizi S.... Dahlbaeck B. (2005)
    2. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PubMed id 11792844)1, 2 Chen H.... Lo S.H. (2002)
    3. Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    5. Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PubMed id 20069572)1, 7 Clark K....Critchley D.R. (2010)
    6. Individual domains of Tensin2 exhibit distinct subcel lular localisations and migratory effects. (PubMed id 19747564)1 Hafizi S....DahlbAock B. (2010)
    7. START-GAP1/DLC1 is localized in focal adhesions throu gh interaction with the PTB domain of tensin2. (PubMed id 19895840)1 Kawai K....Yagisawa H. (2010)
    8. Tensin2 reduces intracellular phosphatidylinositol 3, 4,5-trisphosphate levels at the plasma membrane. (PubMed id 20678486)1 Hafizi S....DahlbAock B. (2010 Aug 27)
    9. Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. (PubMed id 19194507)1 Martuszewska D....Hafizi S. (2009)
    10. Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function. (PubMed id 19440389)1 Chan L.K....Yam J.W. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23371 HGNC: 19737 AceView: TENC1 Ensembl:ENSG00000111077 euGenes: HUgn23371
    ECgene: TENC1 H-InvDB: TENC1

    (According to HUGE)
    About This Section
    HUGE: KIAA1075

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TENC1 gene:
    Search GeneIP for patents involving TENC1

    GeneCards and IP:
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     Regulatory tfbs in TENC1 promoter
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    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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