Aliases &
Descriptions
for TENC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| tensin like C1 domain containing phosphatase (tensin 2)1 2 | | DKFZp686D132442 | | KIAA10751 2 3 5 | | tensin 22 | | C1-TEN1 2 3 | | tensin-22 | | TNS21 2 3 | | tensin-like C1 domain-containing phosphatase2 | | tensin like C1 domain-containing phosphatase1 2 | | FLJ163202 | | C1 domain-containing phosphatase and tensin homolog2 3 | | EC 3.1.3.-3 | | C1TEN2 5 | | Tensin-23 |
Export aliases for TENC1 gene to outside databasesPrevious GC identifers: GC12P053354 GC12P053157 GC12P051727 GC12P053440 |
Summaries
for TENC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TENC1:
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actinfilaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternativesplicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.(provided by RefSeq)
UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.Lowers AKT1 kinase activity and interferes with AKT1 signaling
Gene Wiki entry for TENC1 |
Genomic Views
for TENC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TENC1 gene promoter:
CREB MEF-2A CUTL1 deltaCREB STAT5A AREB6 POU2F2 (Oct-2.1) POU2F1 oct-B2 Oct-B1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TENC1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TENC1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13TENC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P050483: view genomic region
(about GC identifiers)
Start:
|
50,483,949 bp from pter |
End:
|
50,501,247 bp from pter |
Size:
|
17,299 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 53,440,810-53,458,163 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for TENC1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2 (See
protein sequence)Recommended Name: Tensin-like C1 domain-containing phosphatase Size: 1409 amino acids; 152580 Da
Subunit: Interacts with AXL
Subcellular location: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.Note=Detected at the end of actin stress fibers
Sequence caution: Sequence=AAI29829.1; Type=Erroneous initiation; Sequence=AAI29830.1; Type=Erroneous initiation;Sequence=AAI31504.1; Type=Erroneous initiation; Sequence=BAA83027.2; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :2DKQ (3D)
2KNO (3D)
3HQC (3D)
Secondary accessions: A2VDF2 A2VDF3 A2VDI8 A5PKY4 Q2NL80 Q76MW6 Q7Z5T9 Q8NFF9 Q8NFG0 Q96P25 Q9NT29Q9UPS7Alternative splicing: 6 isoforms: Q63HR2-1 Q63HR2-2 Q63HR2-3 Q63HR2-4 Q63HR2-5 Q63HR2-6 Explore the universe of human proteins at neXtProt for TENC1: NX_Q63HR2
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_056134.2 NP_736610.2 NP_938072.1
ENSEMBL proteins: ENSP00000319756 ENSP00000319684 ENSP00000415945 ENSP00000393362 ENSP00000408441 ENSP00000398989 ENSP00000369232 ENSP00000262048
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TENC1 for ontologies About GeneDecksing
Antibodies for TENC1:
Assays for TENC1: |
Protein
Domains/
Families
for TENC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TENC1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q63HR2ProtoNet protein and cluster: Q63HR2 2 Blocks protein families: IPB000980 SH2 domain signature IPB013625 Tensin phosphotyrosine-binding domain
UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2Similarity: Contains 1 C2 tensin-type domainSimilarity: Contains 1 phorbol-ester/DAG-type zinc fingerSimilarity: Contains 1 phosphatase tensin-type domainSimilarity: Contains 1 SH2 domain |
Gene Function
for TENC1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2Function: Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation.Lowers AKT1 kinase activity and interferes with AKT1 signalingEnzyme Number (IUBMB): EC 3.1.3.-
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
TENC1 for ontologies About GeneDecksing
Animal Models: 8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tenc1):
TENC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TENC1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including TENC1: PAHS-045A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TENC1
5/7 Interacting proteins for TENC1 (Q63HR22) via UniProtKB, MINT, and/or STRING (see all 7)About this table
5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8): About this table
TENC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TENC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TENC1
|
Transcripts
for TENC1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TENC1 gene (3 alternative transcripts): NM_015319.2 NM_170754.2 NM_198316.1 Additional cDNA sequence: AB028998.2 AF417490.1 AF518728.1 AF518729.1 AK131320.1 AK172747.1 AL137564.1 BC054099.1 BC110854.1 BC129828.1 BC129829.1 BC131503.1 BC142668.1 BC142712.1 BC150259.1 BX647126.1 CR607439.1 CR614736.1 CR936725.1 20 DOTS entries: DT.100648283 DT.95295531 DT.95151181 DT.449115 DT.121118050 DT.40269374 DT.100651420 DT.101982588 DT.100724559 DT.91689288 DT.100648284 DT.92441328 DT.95151174 DT.97784943 DT.101961374 DT.121118477 DT.95101213 DT.121117936 DT.121118973 DT.92036991 24/292 AceView cDNA sequences (see all 292): NM_170754 AW237124 AL137564 BU521796 CA434026 AI040475 H97675 CN479477 AB028998 AI637839 BM693074 BU074888 BU616495 AF518729 AW169055 AA256347 BG007391 BM669797 CA390952 BE326739 AI767231 AI206151 AA548543 BQ718351
 highest scoring ESTs for TENC1:AB028998 AA256204 AA256347 AA426471 AA442806 AA447688 AA447840 AA553697 AA601027 AA632320 Unigene Cluster for TENC1: Tensin like C1 domain containing phosphatase (tensin 2) Hs.6147 [show with all ESTs]Unigene Representative Sequence: BC150259
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for TENC1 (see all 14)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · |
|---|
|
| SP1: | | | - | | - | | - | | - | | - | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | - | | - | | | | - | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | |
| ExUns: | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | · | 20d | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | · | 25c | · | 25d | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TENC1
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314276(uc001sbm.2 uc001sbn.2) ENST00000314250 ENST00000420340
ENST00000451358 ENST00000443113 ENST00000438153 ENST00000379902(uc001sbl.2 uc001sbq.2 uc001sbr.2 uc009zmr.2 uc001sbs.2)
ENST00000262048(uc001sbo.1 uc001sbp.2)
|
Expression
for TENC1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TENC1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching TENC1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35358_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AB028998 |
1.00 |
1.00 |
1.00 |
1 |
| 212494_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AB028998 |
1.00 |
1.00 |
1.00 |
1 |
| 212494_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TENC1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AATAGGGGAA
SOURCE GeneReport for Unigene cluster: Hs.6147
Expression variation in blood from EXPOLDB for TENC1 UniProtKB/Swiss-Prot: TENC1_HUMAN, Q63HR2Tissue specificity: Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and smallintestine
SABiosciences Expression via Pathway-Focused PCR Array including TENC1: PAHS-045A
|
Orthologs
for TENC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TENC1 gene from 5 species
About this table Species with no ortholog for TENC1
ENSEMBL Gene Tree for TENC1 (if available) |
Paralogs
for TENC1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TENC1 gene
- PTEN2 DNAJC62 TNS12 TPTE2 TNS32 TNS42 GAK2 TPTE22
TENC1 for paralogs About GeneDecksing
|
Genomic Variants
for TENC1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TENC1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TENC1
6 CNVs: 49091 49090 49094 49089 49092 49093
1 Indel: 71512 | | QIAGEN SeqTarget long-range PCR primers for resequencing TENC1 |
|
Disorders & Mutations
for TENC1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TENC1 for disorders About GeneDecksing
OMIM: 607717
Export disorders and mutations for TENC1 gene to outside databases
|
Medical News
for TENC1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TENC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for TENC1 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with TENC1)- C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. (PubMed id 15817639)1, 2 Hafizi S.... Dahlbaeck B. (2005)
- Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. (PubMed id 11792844)1, 2 Chen H.... Lo S.H. (2002)
- Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. (PubMed id 12470648)1, 2 Hafizi S.... Dahlbaeck B. (2002)
- Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
- Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. (PubMed id 20069572)1, 7 Clark K....Critchley D.R. (2010)
- Individual domains of Tensin2 exhibit distinct subcel lular localisations and migratory effects. (PubMed id 19747564)1 Hafizi S....DahlbAock B. (2010)
- START-GAP1/DLC1 is localized in focal adhesions throu gh interaction with the PTB domain of tensin2. (PubMed id 19895840)1 Kawai K....Yagisawa H. (2010)
- Tensin2 reduces intracellular phosphatidylinositol 3, 4,5-trisphosphate levels at the plasma membrane. (PubMed id 20678486)1 Hafizi S....DahlbAock B. (2010 Aug 27)
- Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer. (PubMed id 19194507)1 Martuszewska D....Hafizi S. (2009)
- Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function. (PubMed id 19440389)1 Chan L.K....Yam J.W. (2009)
|
External Searches for TENC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TENC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TENC1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TENC1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TENC1 gene:
Search GeneIP for patents involving TENC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TENC1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for TENC1 |
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